检索结果-南通市图书馆

Progress in the development of techniques based on light scattering for single nanoparticle detection

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science china.chemistry 2011年第8期54卷 1244-1253页

作者： ZHU ShaoBin, WANG Shuo, YANG LingLing, HUANG TianXun & YAN XiaoMei department of chemical biology, college of chemistry and chemical engineering key laboratory for chemical biology of fujian province key laboratory of Analytical Science, xiamen university, xiamen 361005, china department of chemical biology College of Chemistry and Chemical Engineering key laboratory for chemical biology of fujian province key laboratory of Analytical Science Xiamen University Xiamen China

Nanoparticles have recently attracted extensive attention in view of their great potential in biomedicine and bioanalytical ap- plications. Single particle detection via light scattering offers a simple and efficient approach for the size, size distribution, and concentration analysis of nanoparticles. In particular, intrinsic heterogeneity or rare events masked by ensemble averaging can be revealed. However, the sixth power dependence of Rayleigh scattering on particle size makes it very challenging to detect individual nanoparticles of small sizes. This article is intended to provide an overview of recent progress in the development of techniques based on light scattering for the detection of single nanoparticles.

关键词：光散射技术纳米粒子检测基础生物医学分析应用粒子分析粒度分布

Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMR and molecular modeling

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Science china.chemistry 2010年第9期53卷 1987-1993页

作者： LIU Yan1,SHI YanHong2,LIU XiaoXia1,LIN MingKun1,LIN DongHai1,2 & zhao yufen1,3 1key laboratory for chemical biology of fujian province,department of chemical biology,department of chemistry,college of chemistry and chemical engineering,xiamen university,xiamen 361005,china.2Shanghai Institute of Materia Medica,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,china.3key laboratory for Bioorganic Phosphorus chemistry and chemical biology,Ministry of Education,department of chemistry,School of Life Sciences and engineering,Tsinghua university,Beijing 100084,china key laboratory for chemical biology of fujian province Department of Chemical Biology Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen China Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai China key laboratory for Bioorganic Phosphorus chemistry and chemical biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing China

Seryl-Histidine dipeptide(Ser-His) has been previously reported to be capable of cleaving DNAs and carboxyl esters,as well as *** protein cleavage mechanism has not been addressed *** an initial step of protein cleavage activity,the non-covalent binding affinity of Ser-His for proteins is a crucial *** this work,we took cyclophilin A(CyPA) as a substrate protein,and evaluated the non-covalent interaction between CyPA and Ser-His using a combination of NMR spectroscopy and molecular modeling *** independent Ser-His binding sites on CyPA were detected using 15N-1H heteronuclear single-quantum coherence(HSQC) *** binding site binds one Ser-His *** constants,Kd1 and Kd2,were estimated to be 2.07 and 6.66 mmol/L,respectively,indicative of the weak non-covalent interaction between Ser-His and *** on molecular modeling results,we suggest that both the α-amino and the side chain hydroxyl group of Ser-His are crucial for the non-covalent interaction between Ser-His and *** work sheds light on the molecular mechanism of Ser-His and its analogues cleaving proteins.

关键词： Ser-His cyclophilin A HSQC non-covalent interaction binding sites

High CHIP Expression Is Associated With The Generation Of Esophageal Carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High CHIP Expression Is Associated With The Generation Of Es...

第六届全国化学生物学学术会议

作者： Fangfang Zheng,chengyan wu,yufen zhao~**,xueji wu~* department of chemical biology and The key laboratory for chemical biology of fujian province, college of chemistry and chemical engineering,xiamen university,xiamen 361005,china.

＜正＞Background and Objectives:C-terminus of Hsp70 interacting protein（CHIP） ubiquitinates the abnormal proteins which could not be refolded exactly by *** ubiquitinated protein should be degraded by the *** abnormal proteins should be expressed in cancer cell because of disordered regulation in the *** carcinoma is one of the most lethal tumors,and many people all over the

关键词：

ATP-ADP exchange activity and molecular chaperone activity of Hsp70

在线全文

cnki会议

学校读者我要写书评

暂无评论

ATP-ADP exchange activity and molecular chaperone activity o...

第六届全国化学生物学学术会议

作者： Huawei Jin,chengyan wu,Fangfang Zheng,yufen zhao~**,xueji wu~* department of chemical biology and The key laboratory for chemical biology of fujian province, college of chemistry and chemical engineering,xiamen university,xiamen 361005,china.

Hsp70 is a multifunctional molecular chaperone whose interactions with protein substrates are regulated by ATP hydrolysis and ATP-ADP ***70 exists weakly ATPase activity and locates at the N-teminal 44-kD ***,the wide-type and mutant(K71A,T204A and H227S) human Hsp70 were expressed in *** and purified on HisTrap Ni-agarose column and then

关键词：

Copper-dependent strand scission in DNA induced by Shikonin

在线全文

cnki会议

学校读者我要写书评

暂无评论

Copper-dependent strand scission in DNA induced by Shikonin

第六届全国化学生物学学术会议

作者： HongMingCheng,Zhen wu~*,yufen zhao~* department of chemistry,department of Pharmaceutical Science,and key laboratory for chemical biology of fujian province,xiamen university,xiamen 361005,china.

＜正＞Shikonin（β-alkannin）,a naphthazarin derivative extracted from Lithospermum erythrorhizon *** Zucc,has shown a variety of abilities such as accelerating tissue granulation proliferation and exerting antibacterial,anti-inflammatory,and anti-tumor *** the presence of Cu（Ⅱ）,shikonin caused breakage of calf thymus and supercoiled plasmid pBR322 *** metal ions tested（Mg（Ⅱ）,Ca（Ⅱ）,and Ni（Ⅱ）） were ineffective and only Fe（Ⅱ） has the same ability in the DNA breakage *** involvement of active oxygen in the reaction was established by the inhibition of DNA breakage by superoxide dismutase,catalase,thiourea,sodium azide,potassium iodide and sodium ***（Ⅰ） was shown to be an essential intermediate by using the Cu（Ⅰ）-specific sequestering reagent *** induced HeLa cell apoptosis involved in the mechanism of increasing in intracellular reactive oxygen *** was suggested that shikonin generated reactive oxygen species as a prooxidant in the presence of transition metals in cells which resulting in DNA damage.

关键词： DNA cleavage Cu(Ⅱ) reduction shikonin

PEPTIDE BOND FORMATION ON C-TERMINAL OF PEPTIDES IN ORGANIC SOLUTION BY INDUCEMENT OF N-PHOSPHORYL AMINO ACID

在线全文

cnki会议

学校读者我要写书评

暂无评论

PEPTIDE BOND FORMATION ON C-TERMINAL OF PEPTIDES IN ORGANIC ...

第17届国际磷化学大会

作者： Liu Xiaoxia Liu Yan zhao yufen* The key laboratory for chemical biology of fujian province department of chemistry and college of chemistry and chemical engineering xiamen university xiamen 361005 P. R. china

＜正＞Peptide formation is one of the most important reactions in prebiotic evolution. And N-phosphoryl-α-amino acids were proposed as model for the co-evolution of proteins and nucleic

关键词：

Direct Synthesis of α-Aminophosphonates from Amines,Alcohols,and White Phosphorus

在线全文

cnki会议

学校读者我要写书评

暂无评论

CCS chemistry 2024年第1期6卷 91-99页

作者： Mengpei Bai Yinwei Cao Junwei Huang Yan Liu Guo Tang yufen zhao~* department of chemistry and key laboratory for chemical biology of fujian province College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005

Developing practical strategies for the synthesis of organophosphorus compounds(OPCs)from white phosphorus(P_(4))without the use of Cl_(2) and PCl_(3) remains a significant *** first multicomponent oxidative α-phosphonylation of amines with P_(4) and alcohols has been *** the use of copper(Ⅱ)as the catalyst and air as the safe oxidant,structurally sophisticated α-aminophosphonates have been prepared in high ***,this method is also suitable for selective construction of P-O-P *** reaction is characterized by a complete conversion of P_(4).The activation of P_(4) with transition metals often leads to formation of complexes[M_(x)P_(y)]_(n) associated with the deactivation of transition *** breakthrough showcases the potential of transition-metal-catalyzed reactions in elemental phosphorus chemistry.

关键词： white phosphorus P-C bonds dialkyl phosphites aminophosphonates pyrophosphates

Observation of high ionic conductivity of polyelectrolyte microgels in salt-free solutions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese chemical Letters 2024年第4期35卷 255-259页

作者： Qiangwei Wang Huijiao Liu Mengjie Wang Haojie Zhang Jianda xie Xuanwei Hu Shiming Zhou Weitai wu State key laboratory for Physical chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsThe Key Laboratory for Chemical Biology of Fujian Provinceand Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Materials Science and engineering Xiamen University of TechnologyXiamen 361024China Hefei National laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of chemistry and chemical engineering Ningxia UniversityYinchuan 750021China

Here, we report an observation that illustrate the potential of polyelectrolyte microgels in salt-free solutions to display a high ionic conductivity. Laser light scattering and ionic conductivity tests on very dilute aqueous dispersions of the microgels indicate that both small size and swollen state of gel particles play vital roles, which should favor the counterions to freely penetrate and leave gel particles, and thus can contribute to the ion-conducting property. Upon discovering this on microgels that are composed of imidazolium-based poly(ionic liquid), we also illustrate the generality of the finding to single lithium-ion polyelectrolyte microgels that are of more technically relevant features for applications, for instance, as injectable liquid “microgel-in-solution” electrolytes of high conductivity(ca. 8.2 × 10^(-2)S/m at 25.0 ℃ for1.0 × 10^(-2)g/m L of microgels in a LiNO_(3)-free 1:1 v/v mixture of 1,2-dioxolane and dimethoxymethane) and high lithium-ion transference number(0.87) for use in the rechargeable lithium-sulfur battery.

关键词： Polyelectrolhyte Stimuli-responsive Single-ion conducting Liquid electrolyte Lithium metal battery

STUDIES ON THE NONCOVALENT BONDING BETWEEN ATP AND α-AMINOPHOSPHONIC ACIDS DERIVATIVES BY ESI-MS AND MOLECULAR MODELING

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

STUDIES ON THE NONCOVALENT BONDING BETWEEN ATP AND α-AMINOP...

第17届国际磷化学大会

作者： Liu Xiaoxia Fang Hua Liu Yan zhao yufen* The key laboratory for chemical biology of fujian province department of chemistry and college of chemistry and chemical engineering xiamen university xiamen 361005 P. R. china

＜正＞To investigate molecular recognition of ATP with proteins or structured peptide-based receptor is very important for understanding enzymatic mechanisms and drug design [1,2].

关键词：