Progress in the development of techniques based on light scattering for single nanoparticle detection
Progress in the development of techniques based on light scattering for single nanoparticle detection作者机构：Department of Chemical Biology College of Chemistry and Chemical Engineering Key Laboratory for Chemical Biology of Fujian Province Key Laboratory of Analytical Science Xiamen University Xiamen China
出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)
年 卷 期：2011年第54卷第8期
页 面：1244-1253页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：supported by the National Natural Science Foundation of China (20675070, 20975087, 90913015 & 21027010) Program for New Century Excellent Talents in University (NCET-07-0729) Research Fund for the Doctoral Program of Higher Education of China (20090121120008 & 20090121110009) the National Fund for Fostering Talents of Basic Science (J1030415)
主 题：light scattering single particle detection nanoparticles confocal correlation spectroscopy flow cytometry
摘 要：Nanoparticles have recendy attracted extensive attention in view of their great potential in biomedicine and bioanalytical applications. Single particle detection via light scattering offers a simple and efficient approach for the size, size distribution, and concentration analysis of nanoparticles. In particular, intrinsic heterogeneity or rare events masked by ensemble averaging can be revealed. However, the sixth power dependence of Rayleigh scattering on particle size makes it very challenging to detect individual nanoparficles of small sizes. This article is intended to provide an overview of recent progress in the development of techniques based on light scattering for the detection of single nanoparticles.
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