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LIGAND-PROTEIN INVERSE DOCKING AS A POTENTIAL TOOL IN THE COMPUTER SEARCH OF PROTEIN TARGETS OF MYCOEDIKETOPIPERAZINE,A NOVEL FUNGAL METABOLITE FROM A PAPULARIA SP

第六届全国化学生物学学术会议

作者： hongmingcheng~1,Rongqiang Zhuang~1,Meijuan Fang~2,zhen wu~*2,yufen zhao~(1,2*) 1.department of chemistry and key laboratory for chemical biology of fujian province, College of chemistry and chemical Engineering,xiamen university. xiamen 361005,china. 2.department of pharmaceutical science,College of Medical,xiamen university. xiamen,168 Daxue Road,xiamen,361005,P.R.china.

＜正＞（+）-Brefeldin A（BFA） is a macrocyclic lactone antibiotic,it possesses a diverse array of biological activities including antiviral,antifungal,nematocidal and antitumor ***,it is used widely as an important molecular tool for studying signal transduction pathways in mammalian cells. National Cancer Institute discovered that BFA can induce the differentiation and apoptosis of human

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LIGAND-PROTEIN INVERSE DOCKING AS A POTENTIAL TOOL IN THE CO...

Deciphering the high-carbonization-temperature triggered enzymatic activity of wool-derived N,S-co-doped carbon nanosheets

第17届国际磷化学大会

作者： Fang Meijuan1* Fang Hua2 Ji Zhiliang3 Luo Shuna2 zhao yufen1 2 1 department of pharmaceutical science Medical College xiamen university xiamen 361005 People’s Republic of china.xiamen university. 2 department of chemistry The key laboratory for chemical biology of fujian province College of chemistry and chemical Engineering xiamen university xiamen 361005 People’s Republic of china.3 Bioinformatics Research Group School of Life sciences xiamen university xiamen 361005 fujian province PR china

＜正＞Mycoediketopiperazine, a novel fungal metabolite from a Papularia sp., which was isolated from a highly organicphosphorous polluted environment. Mycoediketopiperazine exhibited low potent

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Chinese chemical Letters 2024年第3期35卷 182-188页

作者： Jiachen zhao Deshuai Yu Jianmin Chen Shihao Lin Yonghua Tang Chaoyu Fan Dongfang Zhou Youhui Lin department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China School of Pharmacy and Medical Technology Putian UniversityPutian 351100China key laboratory of Mental Health of the Ministry of Education NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China key laboratory of pharmaceutical Analysis and laboratory Medicine(Putian university) Fujian Province UniversityPutian 351100China

It is well-established that high carbonization temperature will trigger the enzyme-like activity of carbon-based ***,the catalytic mechanism is still ambiguous,which hinders the further rational design of nanomaterials as enzyme ***,N,S-rich carbonized wool nanosheets(CWs)were synthesized at different pyrolysis *** expected,only CWs treated with high-temperature possess intrinsic oxidase-and peroxidase-like ***,density functional theory(DFT)calculations demonstrate that graphitic nitrogen and the co-existence of nitrogen and sulfur in the carbon matrix serve as the active sites for the enzyme-like *** importantly,combining theoretical calculations and experimental observations,the high-temperature triggered catalytic mechanism can be ascribed to the fact that an appropriate high-temperature maximizes the graphitization degree to a certain extent,at which most of the catalytic active sites are well retained rather than ***,coupling with excellent photothermal conversion efficiency and catalytic performance,CWs can be applied to photothermal-catalytic cancer therapy under near-infrared region(NIR)light *** believe this work will contribute to understanding the catalytic mechanism of carbon-based nanozymes and promote the development of new biomedical and pharmaceutical applications.

关键词： Carbon-based nanozyme Catalytic mechanism Density functional theory High-temperature carbonization

An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system

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science china.chemistry 2022年第3期65卷 630-640页

作者： zhen Sun Kang-Feng Lin Ze-Hang zhao Yang Wang Xin-Xin Hong Jian-Guang Guo Qing-Yu Ruan Lian-Yu Lu Xiao Li Rui Zhang Chao-Yong Yang Bo-An Li State key laboratory of Cellular Stress biology Innovation Center for Cell Signaling Network and Engineering Research Center of Molecular Diagnostics of the Ministry of EducationSchool of Life SciencesXiamen UniversityXiamen 361005China MOE key laboratory of Spectrochemical Analysis&Instrumentation Key Laboratory of Chemical Biology of Fujian ProvinceState Key Laboratory of Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy MaterialsDepartment of Chemical EngineeringDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China department of Thoracic Surgery The First Affiliated HospitalXiamen UniversityXiamen 361005China

Outbreaks of both influenza virus and the novel coronavirus SARS-CoV-2 are serious threats to human health and life. It is very important to establish a rapid, accurate test with large-scale detection potential to prevent the further spread of the epidemic. An optimized RPA-Cas12a-based platform combined with digital microfluidics(DMF), the RCD platform, was established to achieve the automated, rapid detection of influenza viruses and SARS-CoV-2. The probe in the RPA-Cas12a system was optimized to produce maximal fluorescence to increase the amplification signal. The reaction droplets in the platform were all at the microliter level and the detection could be accomplished within 30 min due to the effective mixing of droplets by digital microfluidic technology. The whole process from amplification to recognition is completed in the chip, which reduces the risk of aerosol contamination. One chip can contain multiple detection reaction areas, offering the potential for customized *** RCD platform demonstrated a high level of sensitivity, specificity(no false positives or negatives), speed(≤30 min),automation and multiplexing. We also used the RCD platform to detect nucleic acids from influenza patients and COVID-19 patients. The results were consistent with the findings of q PCR. The RCD platform is a one-step, rapid, highly sensitive and specific method with the advantages of digital microfluidic technology, which circumvents the shortcomings of manual operation. The development of the RCD platform provides potential for the isothermal automatic detection of nucleic acids during epidemics.

关键词： nucleic acid detection digital microfluidics Cas12a influenza virus SARS-CoV-2

Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities

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chemical Research in Chinese Universities 2016年第5期32卷 792-796页

作者： CHEN Qing LIN Jianhong zhao Dan ZHU Xuan department of Pharmacy School of Pharmaceutical Science Xiamen University Xiamen 361102 P. R. China

In this paper, a new diterpene together with seven known diterpenes was isolated from Wedelia prostrata. The chemical structure of the new compound was elucidated via 1D and 2D nuclear magnetic resonance（NMR） tech- niques and mass spectrometry and identified to be 3a-phenylpropionoyloxy-ent-kaur-16-en-oic acid（l）. The isolated diterpenes were tested for their cytotoxicity activities via 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bro- mide（MTT） assay. The results show that compounds 1, 2, 3, 4 and 6 exhibit different levels of cytotoxic activities. Especially, compound 2 shows significant cytotoxicity toward HeLa and A549 cell lines（IC50=6.14 and 8.76 μmol/L）.

关键词： Wedelia prostrata 3a-Phenylpropionoyloxy-ent-kaur-16-en-oic acid chemical constituent Cytotoxicityactivity

Indocyanine green-/TLR7 agonist-constructed thermosensitive liposome for low-temperature PTT induced synergistic immunotherapy of colorectal cancer

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Chinese chemical Letters 2023年第5期34卷 499-504页

作者： Xiang Sun Yanmin Wang Tao Du Qiang Zhang Shuo Li Qinda Chen Miao Wang Xiumin Wang Lei Ren Xueqin zhao department of Biomaterials Higher Educational Key Laboratory for Biomedical Engineering of Fujian ProvinceResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China Zhejiang Provincial key laboratory of Silkworm Bioreactor and Biomedicine College of Life Science and MedicineZhejiang Sci-Tech UniversityHangzhou 310018China School of pharmaceutical sciences Xiamen UniversityXiamen 361102China State key laboratory of Physical chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Colorectal cancer(CRC)is a lethal malignancy with a high mortality rate due to its low immunogenicity,the strong immunosuppressive milieu and poor drug *** overcome these obstacles,a cascade synergistic nanosystem(denoted as R837/ICG@Lip)was developed via self-assembly of heater indocyanine green(ICG)and toll-like receptor-7 agonist imiquimod(R837)into thermosensitive liposome for simultaneous induction of immunogenic cell death(ICD)and reversing of suppressive tumor *** obtained nanoparticles exhibited NIR-triggered drug release,good photothermal conversion efficiency and phototoxicity towards CT26 colorectal cancer *** vivo results reveal that the R837/ICG@Lip could be effectively accumulated in CT26 subcutaneous tumors and the draining lymph *** importantly,R837/ICG@Lip-mediated low-temperature photothermal therapy triggers ICD,promotes the maturation of host dendritic cells(DCs),and subsequently amplifies adaptive antitumor T-cell responses,resulting in‘Cold to Hot'*** directly affecting immune cells,the secretion of some immune-related cytokines further indirectly boosted anti-cancer *** combining with the indoleamine 2,3-dioxygenase(IDO)inhibitor,the systemic antitumor immune response was further augmented,achieving best tumor inhibition ***,low-temperature mediated photoimmunotherapy targeting multiple antitumor immune pathways boost synergistic antitumor immunity of tolerance tumors.

关键词： Colorectal cancer Liposomes Photothermal therapy Immunotherapy Indocyanine green

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Biomarkers of aging

science china.Life sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-wu Zhang Zhuohua Zhang Tongbiao zhao Yuzheng zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State key laboratory of Stem Cell and Reproductive biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan key laboratory of Aging biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei key laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai key laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China key laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock