Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities
Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities作者机构：Department of Pharmacy School of Pharmaceutical Science Xiamen University Xiamen 361102 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2016年第32卷第5期
页 面：792-796页
核心收录：
基 金：Supported by the National Natural Science Foundation of China(No.31300285) the Natural Science Foundation of Fujian Province China(No.2015J01348) the Specialized Research Fund for the Doctoral Program of Higher Education of China (No.20110073120072) and the Fujian Province Development Guidance(Key) Project China(No.2014Y0074)
主 题：Wedelia prostrata 3a-Phenylpropionoyloxy-ent-kaur-16-en-oic acid Chemical constituent Cytotoxicityactivity
摘 要：In this paper, a new diterpene together with seven known diterpenes was isolated from Wedelia prostrata. The chemical structure of the new compound was elucidated via 1D and 2D nuclear magnetic resonance（NMR） tech- niques and mass spectrometry and identified to be 3a-phenylpropionoyloxy-ent-kaur-16-en-oic acid（l）. The isolated diterpenes were tested for their cytotoxicity activities via 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bro- mide（MTT） assay. The results show that compounds 1, 2, 3, 4 and 6 exhibit different levels of cytotoxic activities. Especially, compound 2 shows significant cytotoxicity toward HeLa and A549 cell lines（IC50=6.14 and 8.76 μmol/L）.
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