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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： hong-Ju sun Bo Jiao Yan Wang yue-Hua Zhang Ge Chen Zi-Xuan Wang hong Zhao Qing Xie Xiao-Hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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Pd(I)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access toα-ketoamide peptidomimetics

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Chinese Chemical Letters 2024年第6期35卷 320-326页

作者： yue sun Liming Yang Yaohang Cheng Guanghui An Guangming Li School of Chemistry and Materials Science Heilongjiang UniversityHarbin 150080China

We report the unprecedent Pd(I)catalyzed ring-opening arylation of cyclopropyl-α-*** protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product *** selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal *** investigations reveals a distinct domino radical ring-opening process through Pd(I)catalysis.

关键词： Pd(I)catalysis Ring-opening arylation Domino reactions Oligopeptides Late-stage functionalization

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Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces

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Chinese Medical Sciences Journal 2024年第2期39卷 131-139页

作者： Xue-Qin Wang hong-Qiang sun Jia-yue Si Zi-Yan Lin Xiao-Mei Zhai Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Chinese Academy of Medical Sciences Research Unit(No.2018RU006)Beijing 100191China Department of Psychology University of CaliforniaDavis 95616USA Department of Psychology University of TorontoToronto M5S 1A1Canada School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Academy for Advanced Interdisciplinary Studies Peking-Tsinghua Centre for Life Sciences and Peking University-International Development Group/McGovern Institute for Brain ResearchPeking UniversityBeijing 100871China

Brain-computer interface(BCI)technology is rapidly advancing in medical research and *** an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental ***,BCI also raises several challenges and ethical concerns in clinical *** this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical *** the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in *** ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested.

关键词： brain-computer interface clinical research bioethics ethical governance ethical review

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Integrated bound-state-in-the-continuum photon-pair source

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Photonics Research 2024年第6期12卷 1322-1327页

作者： FAN YE yue QIN CHENFEI CUI XIANKAI sun HON KI TSANG Department of Electronic Engineering The Chinese University of Hong KongHong KongChina

Integrated photon-pair sources based on spontaneous parametric down conversion(SPDC)in novel high-χ^((2))materials are used in quantum photonic systems for quantum information processing,quantum metrology,and quantum ***,the need for extensive fabrication process development and optimization of dry-etching processes significantly impedes the rapid exploration of different material platforms for low-loss quantum photonic ***,bound states in the continuum(BICs)have emerged as a promising approach for realizing ultralow-loss integrated photonic circuits without requiring an etching *** realizations of BIC photonic circuits have,however,been limited primarily to the classical ***,we explore the BIC phenomena in the quantum regime and show that the etchless BIC platform is suitable for use in integrated entangled photon-pair sources based on the SPDC process in high-χ^((2))*** lithium niobate as an example,we demonstrate photon-pair generation at telecommunication wavelengths,attaining a maximum internal generation rate of 3.46 MHz,a coincidence-to-accidental ratio of 5773,and an experimental two‐photon interference visibility of 94%.Our results demonstrate that the BIC platform can be used for quantum photonic circuits,and this will enable the rapid exploration of different emergingχ^((2))materials for possible use in integrated quantum photonics in the future.

关键词： process. quantum continuum

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Apatite Fission Track Thermochronology of Granite from the Xiazhuang Uranium Ore Field,South China:Implications for Exhumation History and Ore Preservation

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 430-440页

作者： sun yue CHEN Zhengle PAN Jiayong HUO Hailong LI Haidong sun Junjie XU Guangchun State Key Laboratory of Nuclear Resources and Environment School of Earth SciencesEast China University of TechnologyNanchang 330013China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China No.290 Research Institute CNNCShaoguanGuangdong 512029China

Xiazhuang uranium ore field,located in the southern part of the Nanling Metallogenic Belt,is considered one of the largest granite-related U regions in South *** this paper,we contribute new apatite fission track data and thermal history modeling to constrain the exhumation history and evaluate preservation potential of the Xiazhuang Uranium ore *** Triassic outcrop granite samples collected from different locations of Xiazhuang Uranium ore field yield AFT ages ranging from 43 to 24 Ma with similar mean confined fission track lengths ranging from 11.8±2.0 to 12.9±1.9μm and Dpar values between 1.01 and 1.51μ*** robustness time-temperature reconstructions of samples from the hanging wall of Huangpi fault show that the Xiazhuang Uranium ore field experienced a time of monotonous and slow cooling starting from middle Paleocene to middle Miocene(~60-10 Ma),followed by relatively rapid exhumation in the late Miocene(~10-5 Ma)and nearly thermal stability in the Pliocene-Quaternary(~5-0 Ma).The amount of exhumation after U mineralization since the Middle Paleogene was estimated as~4.3±1.8 km according to the integrated thermal history *** studies indicate that the ore-forming ages of U deposits in the Xiazhuang ore field are mainly before Middle Paleocene and the mineralization depths are more than 4.4±1.2 ***,the exhumation history since middle Paleocene plays important roles in the preservation of the Xiazhuang Uranium ore field.

关键词： apatite fission track exhumation history ore preservation Xiazhuang Uranium ore field South China

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An end‐to‐end infant brain parcellation pipeline

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Intelligent Medicine 2024年第2期4卷 65-74页

作者： Limei Wang yue sun Weili Lin Gang Li Li Wang Department of Radiology and Biomedical Research Imaging Center UNC-Chapel HillNew Caledonia27599USA

Objective Accurate infant brain parcellation is crucial for understanding early brain development;however,it is challenging due to the inherent low tissue contrast,high noise,and severe partial volume effects in infant magnetic resonance images(MRIs).The aim of this study was to develop an end-to-end pipeline that enabled accurate parcellation of infant brain *** We proposed an end-to-end pipeline that employs a two-stage global-to-local approach for accurate parcellation of infant brain ***,in the global regions of interest(ROIs)localization stage,a combination of transformer and convolution operations was employed to capture both global spatial features and fine texture features,enabling an approximate localization of the ROIs across the whole *** the local ROIs refinement stage,leveraging the position priors from the first stage along with the raw MRIs,the boundaries of the ROIs are refined for a more accurate *** We utilized the Dice ratio to evaluate the accuracy of parcellation *** on 263 subjects from National Database for Autism Research(NDAR),Baby Connectome Project(BCP)and Cross-site datasets demonstrated the better accuracy and robustness of our method than other competing *** Our end-to-end pipeline may be capable of accurately parcellating 6-month-old infant brain MRIs.

关键词： Infant brain parcellation Isointense magnetic resonance image Convolutional neural networks Transformer

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Characteristics and triggering mechanisms of early negative Indian Ocean Dipole

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Acta Oceanologica Sinica 2024年第3期43卷 59-65页

作者： yue Fang Shuangwen sun Yongcan Zu Jianhu Wang Lin Feng First Institute of Oceanography and Key Laboratory of Marine Science and Numerical ModelingMinistry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Qingdao Marine Science and Technology CenterQingdao 266237China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China

Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in *** nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related ***,the characteristics and triggering mechanisms of early nIOD are *** results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six *** two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal *** early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related *** spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian *** to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon *** results of this study are helpful for improving the prediction skill of IOD and its climate impacts.

关键词： Indian Ocean Dipole(IOD) triggering mechanism Indian summer monsoon seasonal cycle negative IOD

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Recent advances in stretchable triboelectric nanogenerators for use in wearable bioelectronic devices

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Bio-Design and Manufacturing 2024年第4期7卷 566-590页

作者： Yaling Wang Pengcheng Zhu yue sun Pan Li Yanchao Mao College of Science Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of Materials Physics of Ministry of Education School of PhysicsZhengzhou UniversityZhengzhou 450001China

Wearable bioelectronic devices have the capacity for real-time human health monitoring,the provision of tailored services,and natural interaction with smart ***,these wearable bioelectronic devices rely on conventional rigid batteries that are frequently charged or replaced and are incompatible with the skin,leading to a discontinuity in complex therapeutic tasks related to human health monitoring and human-machine *** triboelectric nanogenerator(TENG)is a high-efficiency energy harvesting technology that converts mechanical into electrical energy,effectively powering wearable bioelectronic *** study comprehensively overviews recent advances in stretchable TENG for use in wearable bioelectronic *** working mechanism of stretchable TENG is initially explained.A comprehensive discussion presents the approaches for fabricating stretchable TENG,including the design of stretchable structures and the selection of stretchable ***,applications of wearable bioelectronic devices based on stretchable TENG in human health monitoring(body movements,pulse,and respiration)and human-machine interaction(touch panels,machine control,and virtual reality)are ***,the challenges and developmental trends regarding wearable bioelectronic devices based on stretchable TENG are elaborated.

关键词： Stretchable Triboelectric nanogenerators Structure Human health monitoring Human-machine interaction

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Sustainable management of campus fallen leaves through low-temperature pyrolysis and application in Pb immobilization

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Journal of Environmental Sciences 2024年第5期139卷 281-292页

作者： Rongli Tan Ke Li yue sun Xiaoliang Fan Zhengtao Shen Lingyi Tang School of Environment Nanjing UniversityNanjing 210023China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Earth and Engineering Sciences Nanjing UniversityNanjing 210023China Department of Earth and Atmospheric Sciences University of AlbertaEdmonton T6G 2E3Canada

Realizing campus sustainability requires the environmental-friendly and economical treatment of tremendous fallen *** fallen leaf biochar at a low temperature is a candidate *** this study,six common types of fallen leaves on the campus were pyrolyzed at 300℃.The obtained biochars were characterized and the adsorption mechanisms of lead(Pb)by the fallen leaf biochars were *** adsorption capacity of leaf biochar for Pb was relatively high,up to 209 mg/g(Yulania denudata leaf biochar).Adsorption of Pb onto active sites was the rate-limiting step for most leaf *** for Platanus leaf biochar,intraparticle diffusion of Pb^(2+)dominated owing to the lowest adsorption ***,the highest exchangeable Pb fraction(27%)indicated its potential for removing aqueous Pb^(2+).Ginkgo and Prunus cerasifera leaf biochar immobilized Pb by surface complexation and precipitation as lead ***,they were suitable for soil heavy metal *** study shed the light on the sustainable utilization of campus fallen leaves and the application of fallen leaf biochars in heavy metal remediation.

关键词： Fallen leaves Waste management Biochar Lead removal Sorption Circular campus

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Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-Jie Wang hong-Hua Fang Zhen-Ze Li Dan Wang hong-Bo sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size of<5 nm is *** underlying physics is that the uncertainty of local atom thermal motion dominates electron excitation,rather than the power density slope of the incident *** show that the colour centre yield in hexagonal boron nitride is transformed from stochastic to deterministic,and the emission from individual sites becomes polychromatic to *** a result,single colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

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