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Three new pyrrolizidine alkaloids derivatives from Liparis nervosa

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Chinese Chemical Letters 2016年第5期27卷 757-760页

作者： Shuai Huang De-Xin Zhong Lian-Hai Shan Ye-Zi Zheng Zhi-Kuan Zhang Ya-Heng Bu hong-wen ma Xian-Li Zhou School of Life Science and Engineering Southwest Jiaotong University

Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.

关键词： Orchidaceae Liparis nervosa Pyrrolizidine alkaloids Nervogenic acid derivatives

Effects of changing the control ovarian stimulation protocol in patients without a transplantable embryo in the previous in vitro fertilization/intracytoplasmic sperm injection cycle

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Reproductive and Developmental Medicine 2023年第4期7卷 218-223页

作者： Shan-Jia Yi Yi-Hua Yang Yin Bi Zhong-hong Zeng Xi Wang Mu-Jun Li wen-hong ma Guangxi Reproductive Medical Center The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Reproductive Medicine Center Affiliated Hospital of Guilin Medical UniversityGuilin 541001China Reproductive Medicine Center Liuzhou Maternity and Child Healthcare Hospital Liuzhou 545001China

Objective:Some patients fail to obtain an embryo for transplantation during previousin vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)cycles,and require multiple reproductive *** study aimed to evaluate whether changing the control ovarian stimulation(COS)protocol during the subsequent stimulation cycle could improve laboratory and clinical outcomes in these ***:Patients without a transplantable embryo(TE)in the previous IVF/ICSI cycles were recruited during their second *** were classified into two groups according to their first cycle protocol:Group A,patients treated with a gonadotropinreleasing hormone agonist(GnRH-a),and Group B,patients treated with a gonadotropin-releasing hormone antagonist(GnRH-ant).The study group included patients whose stimulation protocols were changed,whereas the control group consisted of patients who used the same stimulation protocol in the second *** then compared the numbers of oocytes collected(OC)and TE,the incidence of non-TE,the pregnancy rate(PR),and the live birth rate(LBR).Results:In Group A,the numbers of OC and TE were significantly lower(6.0±4.7vs.9.4±6.4,2.3±2.2vs.4.5±3.8,P<0.05)in the study group compared with those in the control *** Group B,the numbers of OC and TE were higher(7.0±5.5vs.4.0±4.3,3.5±3.4vs.1.8±2.1,P<0.05)in the study *** was a significant increase in the incidence of non-TE(adjusted odds ratio(AOR)=2.12,95%CI:1.04–4.69)of the study group in Group A but not in Group *** significant differences in the PR or LBR were found between the study and control groups in either Group A or ***:Changing the COS protocol from GnRH-ant to GnRH-a or continuing the GnRH-a protocol can improve laboratory outcomes in patients with no TE in the previous IVF/ICSI cycle.

关键词： GnRH agonist GnRH antagonist Transplantable embryo Pregnancy rate Live birth rate

Reaction behaviour of Al_2O_3 and SiO_2 in high alumina coal fly ash during alkali hydrothermal process

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Transactions of Nonferrous Metals Society of China 2015年第6期25卷 2065-2072页

作者：蒋周青杨静马鸿文王乐马玺中国地质大学(北京)材料科学与工程学院北京100083 昊青薪材(北京)技术有限公司北京100083

The reaction behaviours of A1203 and SiO2 in high alumina coal fly ash under various alkali hydrothermal conditions were studied. The means of XRD, XRF, FTIR and SEM were used to measure the mineral phase and morphology of the solid samples obtained by different alkali hydrothermal treatments as well as the leaching ratio of SiO2 to A1203 in alkali solution. The results showed that with the increase of the hydrothermal treating temperature from 75 to 160 ~C, phillipsite-Na, zeolite A, zeolite P, and hydroxysodalite were produced sequentially while the mullite and corundum phase still remained. Zeolite P was massively formed at low-alkali concentration and the hydroxysodalite was predominantly obtained at high-alkali concentration. By the dissolution of aluminosilicate glass and the formation of zeolites together, the leaching efficiency of SiO2 can reach 42.13% with the mass ratio of A1203/SIO2 up to 2.19：1.

关键词： high alumina coal fly ash A1203 SiO2 alkali hydrothermal treatment reaction behaviour

Improving job satisfaction of Chinese nurses: the positive effects of structural empowerment and psychological capital

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TMR Integrative Nursing 2018年第4期2卷 169-177页

作者： Xin Dan Qiao-Mei Zhang Jun-Jie Shi Su-Huan Xu Jing-Ying Liu Yan-Hui Liu hong-wen ma School of Nursing Tianjin University of Traditional Chinese Medicine Tianjin China Chief Superintendent nurse TianjinUnion Medical Center Tianjin China

Objectives:This study examined the influence of Chinese nurses’personal resources(psychological capital)and access to workplace resources(structural empowerment)on their job ***:A cross-sectional study was designed during the period of January to April *** anonymous questionnaire containing demographic characteristics sheet,Minnesota Satisfaction Questionnaire,Conditions for Work Effectiveness Questionnaire-II and psychological capital(PsyCap)was issued to 480 registered nurses in Tianjin,China.A total of 462 respondents became our *** regression was performed to explore the factors associated with job ***:The average Minnesota Satisfaction Questionnaire score was 65.68±12.35 in our study *** regression analysis showed that structural empowerment(β=0.421,P<0.01),PsyCap(β=0.227,P<0.01) and educational level(β=0.061,P<0.05) were positively associated with job ***:The job satisfaction of Chinese nurses was at a moderate *** empowerment was the most crucial predictor of job satisfaction,followed by ***,nursing administrators should take measures such as building an authorized work environment and improving nurses’PsyCap in order to promote job satisfaction among Chinese nurses.

关键词： Empowerment Job satisfaction Nursing Psychological capital

Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis:A post-consensus systematic review and metaanalysis

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World Journal of Clinical Cases 2024年第21期12卷 4691-4702页

作者： Jin-Tao Zhang Nan Zhang Xue-Tao Dong Xiao-Ran Wang hong-wen ma Yan-Di Liu Mu-Ran Li Department of Clinical Medicine School of MedicineNankai UniversityTianjin 300071China Department of Gastroenterology Tianjin Union Medical CenterTianjin 300122China

BACKGROUND Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation(FMT)as a therapy for ulcerative colitis(UC).However,the treatment processes and outcomes of these studies *** To evaluate the efficacy and safety of FMT for treating UC by conducting a systematic *** The inclusion criteria involved reports of adult patients with UC treated with FMT,while studies that did not report clinical outcomes or that included patients with infection were *** remission(CR)and endoscopic remission(ER)were the primary and secondary outcomes,*** We included nine studies retrieved from five electronic *** FMT group had better CR than the control group[relative risk(RR)=1.53;95%confidence interval(CI):1.19-1.94;Pmance and safety;however,well-designed randomized clinical trials are still needed before the widespread use of FMT can be ***,standardizing the FMT process is urgently needed for improved safety and efficacy.

关键词： Fecal microbiota transplantation Randomized clinical trials Remission Ulcerative colitis Meta-analysis

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng ma wen ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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东方百合养分吸收规律和分配特点的研究

土壤通报 2004年第6期35卷 753-757页

作者：郭友红马文奇河北农业大学资源与环境科学学院河北保定071001

本文通过温室田间实验,研究了东方百合的养分吸收规律和分配特点。结果表明,现蕾以前,以消耗鳞茎中的养分为主,供应百合植株生长;由现蕾开始,历时30天,为百合吸收氮素的高峰期,现蕾始历时45天为百合吸收磷的高峰期,钾的吸收较早,由展叶... 详细信息

本文通过温室田间实验,研究了东方百合的养分吸收规律和分配特点。结果表明,现蕾以前,以消耗鳞茎中的养分为主,供应百合植株生长;由现蕾开始,历时30天,为百合吸收氮素的高峰期,现蕾始历时45天为百合吸收磷的高峰期,钾的吸收较早,由展叶期开始,直至切花期,共计75天。氮、磷、钾在各器官的分布:现蕾以前以叶片为主,茎秆次之,地下部最少;随着百合的生长,地下部养分比重上升,进入切花期后,茎、叶养分降低,以地下部和花蕾为主。百合吸收氮、磷、钾的比值:现蕾以前为1∶0.17∶1.08,现蕾以后为1∶0.15∶1.45。

关键词：东方百合切花养分吸收分配生理

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun hong Guo School of materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response