检索结果-南通市图书馆

Irinotecan-vs oxaliplatin-based regimens for neoadjuvant chemotherapy in colorectal liver metastasis patients:A retrospective study

引用

World Journal of Gastrointestinal Surgery 2022年第9期14卷 904-917页

作者： wei Liu Feng-Lin Chen Kun wang Quan Bao hong-wei wang Ke-Min Jin Bao-Cai Xing Department of Hepatopancreatobiliary Surgery Peking University School of OncologyBeijing Cancer HospitalBeijing 100142China Department of Hepatopancreatobiliary Surgery Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University School of OncologyBeijing Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Neoadjuvant chemotherapy(NC)improves the survival outcomes of selected patients with colorectal liver metastasis(CRLM).The benefits of irinotecan-based regimens in these patients are still under *** To compare the benefits of irinotecan-and oxaliplatin-based regimens in patients with resectable *** From September 2003 to August 2020,554 patients received NC and underwent hepatectomy for *** on a 1:1 propensity score matching(PSM)model,175 patients who received irinotecan were matched to 175 patients who received oxaliplatin to obtain two balanced groups regarding demographic,therapeutic,and prognostic *** Chemotherapy was based on oxaliplatin in 353(63.7%)patients and irinotecan in 201(36.3%).After PSM,the 5-year progression-free survival(PFS)and overall survival(OS)rates with irinotecan were 18.0%and 49.7%,respectively,while the 5-year PFS and OS rates with oxaliplatin were 26.0%and 46.8%,*** blood loss,operating time,and postoperative complications differed significantly between the two *** the multivariable analysis,carbohydrate antigen 19-9,RAS mutation,response to NC,tumor size>5 cm,and tumor number>1 were inde-pendently associated with *** In NC in patients with CRLM,irinotecan is similar to oxaliplatin in survival outcomes,but irinotecan is superior regarding operating time,intraoperative blood loss,and postoperative complications.

关键词： Colorectal cancer Liver metastasis Liver resection Neoadjuvant chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effective extraction of photoneutron cross-section distribution using gamma activation and reaction yield ratio method

引用

Nuclear Science and Techniques 2023年第11期34卷 103-111页

作者： Zhi‑Cai Li Yue Yang Zong‑wei Cao Xin‑Xiang Li Yun Yuan Zong‑Qing Zhao Gong‑Tao Fan hong‑wei wang Wen Luo School of Nuclear Science and Technology University of South ChinaHengyang 421001China Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Photoneutron cross-section(PNCS)data are important in various current and emerging *** a few sophis-ticated methods have been developed,there is still an urgent need to study the PNCS *** this study,we propose the extraction of PNCS distributions using a combination of gamma activation and reaction yield ratio *** verify the validity of the proposed extraction method,experiments for generating^(62,64)Cu and^(85m,87m)Sr isotopes via laser-induced pho-toneutron reactions were performed,and the reaction yields of these isotopes were *** the proposed extraction method,the PNCS distributions of^(63)Cu and^(86)Sr isotopes(leading to^(85m)Sr isotope production)were successfully *** extracted PNCS distributions were benchmarked against available PNCS data or TALYS calculations,demonstrating the validity of the proposed extraction *** applications for predicting the PNCS distributions of the 30 iso-topes are further *** conclude that the proposed extraction method is an effective complement to the available sophisticated methods for measuring and evaluating PNCS data.

关键词： Photonuclear data Photoneutron cross section Gamma activation Reaction yield TALYS calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The application of Corr SightTM in correlative light and electron microscopy of vitrified biological specimens

引用

Biophysics Reports 2018年第3期4卷 143-152页

作者： Xiaomin Li Jianlin Lei hong-wei wang Technology Center for Protein Sciences Ministry of Education Key Laboratory of Protein Sciences School of Life Sciences Tsinghua University Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University

Correlative light and electron microscopy is a powerful technique for identification and determination of the structures of interested macromolecules in situ. Combined with sample vitrification, it would be much easier to preserve the native state of macromolecule complexes and distinguish them from the crowded structure environment. In this article, we present a detailed process for the application of the Corr Sight system, a light microscope equipped with a cryo module, in combination with a cryo-electron microscope. A relatively long course of up to 7–8 h for cryo module preparation and multichannel light microscopy imaging of vitrified specimen can be sustained. Correlation of light and electron microscopy images at both grid levels to locate squares and square level to locate target particles, and verification of target particles can be performed with the help of Auto EMation software. Cryo-electron tomography is used for obtaining the three-dimensional structure information.

关键词： CorrSight system Vitrified biological specimens Light microscope Cryo-electron microscope

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Particle segmentation algorithm for flexible single particle reconstruction

引用

Biophysics Reports 2017年第Z1期3卷 43-55页

作者： Qiang Zhou Niyun Zhou hong-wei wang State Key Laboratory of Biomembrane and Membrane Biotechnology Center for Structural Biology School of Life Sciences Tsinghua University Ministry of Education Key Laboratory of Protein Science Tsinghua-Peking Joint Center for Life Sciences Center for Structural Biology School of Life Sciences Tsinghua University

As single particle cryo-electron microscopy has evolved to a new era of atomic resolution, sample heterogeneity still imposes a major limit to the resolution of many macromolecular complexes, especially those with continuous conformational flexibility. Here, we describe a particle segmentation algorithm towards solving structures of molecules composed of several parts that are relatively flexible with each other. In this algorithm, the different parts of a target molecule are segmented from raw images according to their alignment information obtained from a preliminary 3 D reconstruction and are subjected to single particle processing in an iterative manner. This algorithm was tested on both simulated and experimental data and showed improvement of 3 D reconstruction resolution of each segmented part of the molecule than that of the entire molecule.

关键词： Cryo-EM Local reconstruction Particle segmentation Single particle reconstruction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase(FKP)in Bacteroides fragilis

引用

Protein & Cell 2019年第5期10卷 365-369页

作者： Ying Liu Huifang Hu Jia wang Qiang Zhou Peng Wu Nieng Yan hong-wei wang Jia-wei Wu Linfeng Sun Tsinghua-Peking Joint Center for Life Sciences School of Life SciencesTsinghua UniversityBeijing 100084China School of Life Sciences Tsinghua UniversityBeijing 100084China Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA Ministry of Education Key Laboratory of Protein Sciences Beijing Advaneed Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China CAS Center for Excellence in Molecular Cell Science Hefei National Laboratory for Physical Sciences at MicroscaleSchool of Life Scien cesUniversity of Science and Tech no logy of ChinaHefei 230027China

Dear Editor,L-Fucose(6-deoxy-L-galactose,fucose)is the basic compone nt of a variety of glyca n *** fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognition,selectin-mediated leukocyteendothelial adhesion and the formation of Lewis blood group antigens(Ma et al.,2006).GDP-fucose is an important fucose donor in the process of fucosylated oligosaccharides *** pathways of GDP-fucose synthesis are present in the cytosol of mammalian cells,including the de novo pathway and the salvage pathway(Becker et al.,2003).In the salvage pathway,cells use fucose from the extracellular or lysosomal sources to synthesize GDP-fucose.

关键词： Cryo-EM structure pyrophosphorylase Bacteroides fragilis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancement of the geomagnetic field reduces the phototaxis of rice brown planthopper Nilaparvata lugens associated with frataxin down-regulation

引用

Insect Science 2020年第5期27卷 1043-1052页

作者： Ying-Chao Zhang Gui-Jun Wan wei-hong wang Yue Li Yang Yu Yu-Xia Zhang Fa-Jun Chen wei-Dong Pan Beijing Key Laboratory of Bioelectromagnetics Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Entomology College of Plant ProtectionNanjing Agricultural UniversityNanjingChina

The geomagnetic field(GMF)is an environmental cue that provides directional information for *** intensity of GMF is varied over space and *** in the GMF intensity afect the navigation of animals and their *** this study,the phototaxis of the migratory insect rice planthopper Nilaparvata lugens(***)and frataxin in ***(NI-fh),which is a mitochondrial protein required for cellular iron homeostasis and iron-sulfur cluster assembly,were investigated by using different intensities of magnetic *** the results,individuals of *** showed decreased phototaxis when reared and tested in a behavioral arena under a strong magnetic *** the reduction in performance,an accompanying ffect of the strong magnetic field condition was a reduced level of Nl-fh-messenger RNA,and a NI-fh knockdown indeed impaired the phototactic behavior in a tested sample of *** leads to the conclusion that the expression of frataxin is dependent on the strength of the surrounding magnetic field and that functional frataxin facilitates phototactic behavior in ***.

关键词： frataxin ma gnetic field migratory Nilaparvata lugens phototaxis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasmablastic lymphoma of the small intestine:Case report and literature review

引用

World Journal of Gastroenterology 2012年第45期18卷 6677-6681页

作者： hong-wei wang Wen Yang Jun-Zhong Sun Jiang-Yang Lu Min Li Lin Sun Department of Pathology the First Affiliated Hospital of General Hospital of People's Liberation Army Department of Gynaecology and Obstetrics the General Hospital of People's Liberation Army Department of Pathology Peking University Health Science Center

Plasmablastic lymphoma(PBL) is a rare aggressive B-cell lymphoproliferative disorder,which has been characterized by the World Health Organization as a new *** PBL is most commonly seen in the oral cavity of human immunodeficiency virus(HIV)-positive patients,it can also be seen in extraoral sites in immunocompromised patients who are *** we present a rare case of PBL of the small intestine in a 55-year-old HIV-negative *** examination of the excisional lesion showed a large cell lymphoma with plasmacytic differentiation diffusely infiltrating the small intestine and involving the surrounding *** neoplastic cells were diffusely positive for CD79a,CD138 and CD10 and partly positive for CD38 and epithelial membrane *** 80% of the tumor cells were positive for Ki-67.A monoclonal rearrangement of the kappa light chain gene was *** patient died approximately 1.5 mo after diagnosis in spite of receiving two courses of the CHOP chemotherapy *** a review of the literature,this is the first case report of PBL with initial presentation in the small intestine without HIV and Epstein-Barr virus infection,and a history of hepatitis B virus infection and radiotherapy probably led to the iatrogenic immunocompromised state.

关键词： Plasmablastic lymphoma Small intestine Human immunodeficiency virus Differential diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of unconventional gas and technologies adopted in China

引用

Energy Geoscience 2020年第1期1卷 55-68页

作者： Yang Li De-Hua Zhou wei-hong wang Ting-Xue Jiang Zhao-Jie Xue China Petroleum&Chemical Corporation Beijing100728China Sinopec Exploration&Production Research Institute Beijing100083China Sinopec Research Institute of Petroleum Engineering Beijing100101China

This study analyses the geological characteristics and development progress of unconventional gas in China,summarizes the development theories and technologies,discusses the prospects and challenges of unconventional gas development,and puts forward the future trends of development *** technologies of unconventional gas development are available in *** gas development technologies include comprehensive geological evaluation,volume fracturing of cluster horizontal wells under complex stress conditions,and factory-like operation of horizontal wells in complex mountainous area et *** gas development technologies include fluid identification and quantitative prediction,optimization of well patterns,multi-layer fracturing in vertical well,staged fracturing in horizontal well,and drainage gas *** methane(CBM)development technologies include the prediction of medium-high-and medium-low-rank CBM enrichment areas,rate-variable hydraulic fracturing,and quantitative drainage recovery with five stages,three pressures,and four *** economic and effective development of unconventional gas,further efforts should be ***,intensified studies should be conducted on high-precision prediction and fine characterization technologies of high-quality shale reservoirs in deep marine,continental,and transitional ***,key theories and technologies such as fast drilling and completion of wells with long laterals as well as large-scale volume fracturing should be developed to improve well ***,new technologies such as multiple well-type development,fluid injection,and nano-flooding should be developed to enhance the ***,effort should be made to identify the accumulation mechanism and large-scale effective development technologies for ***,the application of large amounts of data and artificial intelligence in the entire process of unconventional gas development should be considered to reduce the dev

关键词： Unconventional gas Geologic characteristics Development history Integrated development technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The SLEGS beamline of SSRF

引用

Nuclear Science and Techniques 2024年第7期35卷 20-30页

作者： Long-Xiang Liu hong-wei wang Gong-Tao Fan Hang-Hua Xu Yue Zhang Zi-Rui Hao Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The Shanghai Laser Electron Gamma Source(SLEGS, located in BL03SSID) beamline at the Shanghai Synchrotron Radiation Facility(SSRF) is a Laser Compton Scattering(LCS) gamma source used for the investigation of nuclear structure, which is in extensive demand in fields such as nuclear astrophysics, nuclear cluster structure, polarization physics, and nuclear energy. The beamline is based on the inverse Compton scattering of 10640 nm photons on 3.5 GeV electrons and a gamma source with variable energy by changing the scattering angle from 20° to 160°. γ rays of 0.25-21.1 MeV can be extracted by the scheme consisting of the interaction chamber, coarse collimator, fine collimator, and attenuator. The maximum photon flux for 180° is approximately 10~7 photons/s at the target at 21.7 MeV, with a 3-mm-diameter beam. The beamline was equipped with four types of spectrometers for experiments in( γ,γ'),( γ,n),( γ,p), and( γ,α). At present, Nuclear Resonance Fluorescence(NRF) spectrometry, Flat-Efficiency neutron Detector(FED) spectrometry, neutron Time-Of-Flight(TOF) spectrometry, and Light-Charged Particle(LCP) spectrometry methods have been developed.

关键词： Shanghai Synchrotron Radiation Facility SLEGS Nuclear astrophysics Nuclear structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

引用

Signal Transduction and Targeted Therapy 2023年第7期8卷 3498-3511页

作者： Sheng-yuan Zhang Qiu-ping Xu Li-na Shi Shih-wen Li wei-hong wang Qing-qing wang Liao-xun Lu Hui Xiao Jun-hong wang Feng-ying Li Yin-ming Liang Si-tang Gong Hao-ran Peng Zheng Zhang hong Tang CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 210031China The Third People’s Hospital of Shenzhen Shenzhen 518112China University of Chinese Academy of Sciences Beijing 100101China The Laboratory of Genetic Regulators in The Immune System Xin-xiang Medical UniversityXin-xiangHenan Province 453003China The Joint Center of Translational Medicine Guangzhou Women and Children’s Medical Center and Institut Pasteur of ShanghaiGuangzhou 510623China Department of Microbiology Naval Medical UniversityShanghai 200433China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Centre for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

T lymphopenia,occurring in the early phase of sepsis in response to systemic inflammation,is commonly associated with morbidity and mortality of septic *** have previously shown that a sufficient number of T cells is required to constrain Toll-like receptors(TLRs)mediated ***,the underlying mechanisms remains ***,we unveil that CD4^(+)T cells engage with MHC II of macrophages to downregulate TLR pro-inflammatory signaling.

关键词： CD4 TLR infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：