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Effects of Hemp seed soft capsule on colonic ion transport in rats

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World Journal of Gastroenterology 2017年第42期23卷 7563-7571页

作者： Xiao-Fang lu Meng-Di Jia sheng-sheng Zhang lu-Qing Zhao Digestive Disease Center Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University

AIM To investigate the effect of Hemp seed soft capsule(HSCC) on colonic ion transport and its related mechanisms in constipation *** Sprague-Dawley male rats were randomly divided into three groups: normal group, constipation group and HSSC group. Rats in the constipation and HSSC groups were administrated loperamide 3 mg/kg per day orally for 12 d to induce the constipation model. Then, the HSSC group was given HSSC 0.126 g/kg per day by gavage for 7 d. The normal and constipation groups were treated with distilled water. After the treatment, the fecal wet weight and water content were measured. The basal short-circuit current(Isc) and resistance were measured by an Ussing Chamber. Besides the in vivo drug delivery experiment above, an in vitro drug application experiment was also conducted. The accumulative concentrations of HSSC(0.1 mg/m L, 0.5 mg/m L, 1.0 mg/m L, 2.5 mg/m L, 5.0 mg/m L, 10.0 mg/m L and 25.0 mg/m L) were added to the normal isolatedcolonic mucosa and the Isc was recorded. Further, after the application of either ion(Cl^-or HCO_3^-) substitution, ion channel-related inhibitor(N-phenylanthranilic acid, glybenclamide, 4,4-diisothiocyano-2,2-stilbenedisulfonic acid or bumetanide) or neural pathway inhibitor [tetrodotoxin(TTX), atropine, or hexamethonium], the Isc induced by HSSC was also measured. RESULTS In the constipation group, the fecal wet weight and the water content were decreased in comparison with the normal group(P < 0.01). After the treatment with HSSC, the fecal wet weight and the water content in the HSSC group were increased, compared with the constipation group(P < 0.01). In the constipation group, the basal Isc was decreased and resistance was increased, in comparison with the normal group(P < 0.01). After the treatment with HSSC, the basal Isc was increased(P < 0.05) and resistance was decreased(P < 0.01) in the HSSC group compared with the constipation group. In the in vitro experiment, beginning with the concentration of

关键词： Hemp seed soft capsule Constipation Ion transport Cl^- HCO3-

Gossypol detoxification in the rumen and Helicoverpa armigera larvae:A review

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Animal Nutrition 2021年第4期7卷 967-972页

作者： Wei-Kang Wang hong-Jian Yang Yan-lu Wang Kai-lun Yang Lin-Shu Jiang sheng-Li Li State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China College of Animal Sciences Xinjiang Agricultural UniversityUrumuqi830052China College of Animal Science and Technology Beijing University of AgricultureBeijing102206China

Gossypol,a phenolic compound found in the cotton plant,is widely distributed in cottonseed *** ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation,the actual mechanisms of detoxification remain *** contrast,the metabolic detoxification of gossypol by Helicoverpa armigera(Lepidoptera:Noctuidae)larvae has achieved great *** present review discusses the clinical signs of go ssypol in ruminant animals,as well as summarizing advances in the study of gossypol detoxification in the *** also examines the regulatory roles of several key enzymes in gossypol detoxification and transformation known in *** the rapid development of modern molecular biotechnology and-omics technology strategies,evidence increasingly indicates that research into the biological degradation of gossypol in *** larvae and some microbes,in terms of these key enzymes,could provide scientific insights that would underpin future work on microbial gossypol detoxification in the rumen,with the ultimate aim of further alleviating gossypol toxicity in ruminant animals.

关键词： Detoxification Gossypol Helicoverpa armigera Rumen

Improved time-optimal B-spline feedrate scheduling for NURBS tool paths in CNC machining

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Advances in Manufacturing 2023年第1期11卷 111-129页

作者： Yang Li Fu-sheng Liang Lei lu Cheng Fan School of Mechanic Engineering Northeast Electric Power UniversityJilin132012JilinPeople’s Republic of China Jiangsu Provincial Key Laboratory of Advanced Robotics and Collaborative Innovation Center of Suzhou Nano Science and Technology College of Mechanical and Electrical EngineeringSoochow UniversitySuzhou215021JiangsuPeople’s Republic of China

Feedrate scheduling in computer numerical control(CNC)machining is of great importance to fully develop the capabilities of machine tools while maintaining the motion stability of each *** and time-optimal feedrate scheduling plays a critical role in improving the machining efficiency and precision of complex surfaces considering the irregular curvature characteristics of tool paths and the limited drive capacities of machine *** study develops a general feedrate scheduling method for non-uniform rational B-splines(NURBS)tool paths in CNC machining aiming at minimizing the total machining time without sacrificing the smoothness of feed *** feedrate profile is represented by a B-spline curve to flexibly adapt to the frequent acceleration and deceleration requirements of machining along complex tool *** time-optimal B-spline feedrate is produced by continuously increasing the control points sequentially from zero positions in the bidirectional scanning and sampling *** required number of knots for the time-optimal B-spline feedrate can be determined using a progressive knot insertion *** improve the computational efficiency,the B-spline feedrate profile is divided into a series of independent segments and the computation in each segment can be performed *** proposed feedrate scheduling method is capable of dealing with not only the geometry constraints but also high-order drive constraints for any complex tool path with little computational *** and machining experiments are conducted to verify the effectiveness and superiorities of the proposed method.

关键词： B-spline feedrate Non-uniform rational B-splines(NURBS)tool path Knot insertion Bidirectional scanning Computer numerical control(CNC)machining

A CONSERVATIVE COUPLED FLOW/TRANSPORT MODEL WITH ZERO MASS ERROR

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Journal of Hydrodynamics 2009年第2期21卷 166-175页

作者： BAI lu-hai JIN sheng State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024China

A fully conservative form applied to a coupled system of two-dimensional water flow and solute motion is presented. A cell-centred finite volume method based on Roe＇s approximate Riemann solver with unstructured grids is formulated. The bed slope source terms are discretized following an upwind approach and a semi-implicit treatment is used for the friction source terms. The centered discretization of the diffusion terms is in an implicit way. It is shown that this numerical technique reproduces almost exactly the steady state of still water and enables to achieve zero numerical errors in unsteady flow over configurations with strong variations on bed slope. The model ensures a global conservation and positive values of both water level and solute concentration. Numerical results show the effectiveness of the model in solute transport over real complex geometries.

关键词： transport model shallow water flow coupled model wetting/drying conditions conservation complex topography

Preparation of NiCoFe-hydroxide/polyaniline composite for enhanced-performance supercapacitors

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Journal of Materials Science & Technology 2019年第8期35卷 1691-1699页

作者： lu Liu Xi Hu hong-Yan Zeng Mo-Yu Yi Shi-Gen Shen sheng Xu Xi Cao Jin-Ze Du College of Chemical Engineering Xiangtan University

Ternary NiCoFe layer hydroxides with different Ni/Co/Fe molar ratios were prepared using simple urea *** finely tuning Ni/Co/Fe molar ratio,the optimized hydroxide(LDH(2.0)),a Ni/Co/Fe molar ratio of 2.0/1.0/1.0,provided high specific capacitance(408 F g^-1at 2.0 A g^-1)and good stability(90.9%retention over 1000 cycles)due to maximum crystallinity(91.35%crystallinity)and specific surface area(160 m^2g^-1).In order to further improve the electrochemical performances,the LDH(2.0)was made into a composite(LDH/PANI)with polyaniline(PANI)via in situ polymerization of aniline *** LDH/PANI composite had a much higher specific capacitance(717 F g^-1at 2.0 A g^-1)compared with the LDH(2.0),and a significant improvement of cycleability(84.7%retention over 1000 cycles).The results indicated that the LDH/PANI had a synergistic effect of both components due to the complementary properties,which guaranteed a good electric contact and consequently increased the specific *** provided a new approach for designing organic-inorganic composite materials with potential application in supercapacitors.

关键词： NiCoFe hydroxide Polyaniline Composite Supercapacitors

Fully differential optoelectronic integrated receiver implemented by 0.35μm standard CMOS process

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Optoelectronics Letters 2008年第6期4卷 395-398页

作者： YU Chang-liang MAO lu-hong XIAO Xin-dong XIE sheng ZHANG Shi-lin School of Electronic Information Engineering Tianjin University Tianjin 300072 China

A high-bandwidth, high-sensitivity fully differential optoelectronic integrated receiver is implemented in a chartered 3.3 V standard 0.35μm analbg CMOS process. To convert the incident light into a pair of fully differential photo-currents, a novel fully differential photodetector is proposed, which is composed of two completely identical photodiodes. The mea- surement results show that the receiver achieves a 1.11 GHz 3 dB bandwidth and a -13 dBm sensitivity for a 10-12 bit error at 1.5 Gb/s data rate under illumination by 850 nm incident lights.

关键词：光电子联合接收器 CMOS 高灵敏度光电二极管

Wronskian Form Solutions for a Variable Coefficient Kadomtsev-Petviashvili Equation

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Communications in Theoretical Physics 2014年第3期61卷 339-343页

作者： lu Zhuo-sheng REN Wen-Xiu School of Science Beijing University of Posts and Telecommunications Beijing 100876 China School of Science Inner Mongolia University of Technology Hohhot 010051 China

Starting from a simple transformation, and with the aid of symbolic computation, we establish the relationship between the solution of a generalized variable coefficient Kadomtsev–Petviashvili(vKP) equation and the solution of a system of linear partial differential equations. According to this relation, we obtain Wronskian form solutions of the vKP equation, and further present N-soliton-like solutions for some degenerated forms of the vKP equation. Moreover,we also discuss the influences of arbitrary constants on the soliton and N-soliton solutions of the KPII equation.

关键词： variable coefficient KP equation wronsian form solution multi-soliton-like solution symboliccomputation

Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma

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World Journal of Gastroenterology 2021年第21期27卷 2871-2894页

作者： Zai-sheng Ye Miao Zheng Qin-Ying Liu Yi Zeng sheng-hong Wei Yi Wang Zhi-Tao Lin Chen Shu Qiu-hong Zheng lu-Chuan Chen Department of Gastrointestinal Surgical Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Clinical Laboratory Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Fujian Provincial Key Laboratory of Tumor Biotherapy Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina

BACKGROUND Alternative splicing(AS)increases the diversity of mRNA during transcription;it might play a role in alteration of the immune microenvironment,which could influence the development of immunotherapeutic strategies against *** To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma(STAD)from the *** overall survival data associated with AS events were used to construct a signature prognostic model for *** Differentially expressed immune-related genes were identified between subtypes on the basis of the prognostic *** STAD,2042 overall-survival-related AS events were significantly enriched in various pathways and influenced several cellular ***,the network of splicing factors and overallsurvival-associated AS events indicated potential regulatory mechanisms underlying the AS events in *** An eleven-AS-signature prognostic model(CD44|14986|ES,PPHLN1|21214|AT,RASSF4|11351|ES,KIAA1147|82046|AP,PPP2R5D|76200|ES,LOH12CR1|20507|ES,CDKN3|27569|AP,UBA52|48486|AD,CADPS|65499|AT,SRSF7|53276|RI,and WEE1|14328|AP)was constructed and significantly related to STAD overall survival,immune cells,and cancer-related *** differentially expressed immune-related genes between the high-and low-risk score groups were significantly enriched in cancer-related *** This study provided an AS-related prognostic model,potential mechanisms for AS,and alterations in the immune microenvironment(immune cells,genes,and pathways)for future research in STAD.

关键词： Stomach adenocarcinoma Alternative splicing Tumor microenvironment Immune-related genes and pathways

Synthesis and Crystal Structure of a New Glycinato Copper Compound

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Chinese Journal of Structural Chemistry 2006年第5期25卷 631-635页

作者： XIANG sheng-Chang sheng Tian-lu FU Rui-Biao HU sheng-Min WU Xin-Tao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

A glycinato copper compound {Cu（NH2CH2COO）（H2O）ClO4} crystallizes in monoclinic, space group P21/n with a = 7.8299（9）, b = 10.3807（10）, c = 9.4775（12）A, β = 109.659（6）°, V = 725.43（12）A^3, Z = 4, Mr = 255.07, Dc = 2.335 g/cm^3, F（000） = 508,μ = 3.381 mm^-1, R = 0.0270 and wR = 0.0707 for 1677 observed reflections with Ⅰ 〉 2σ（Ⅰ）. The title compound contains a chain in the syn-anti conformation, which is generated by the glide-plane operation. The adjacent layers made up of the chains through the connection of perchlorate are related by inversion center operation, which links with each other through the hydrogen bonds.

关键词： glycinato copper complex chain hydrogen bonds