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Comparative proteomes change and possible role in different pathways of micro RNA-21a-5p in a mouse model of spinal cord injury

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Neural Regeneration Research 2020年第6期15卷 1102-1110页

作者： Almaghalsa-Ziad Mohammed hong-Xia Du hong-liang song Wei-Ming Gong Bin Ning Tang-hong Jia Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University

Our previous study found that microRNA-21 a-5 p(miR-21 a-5 p)knockdown could improve the recovery of motor function after spinal cord injury in a mouse model,but the precise molecular mechanism remains poorly *** this study,a modified Allen's weight drop was used to establish a mouse model of spinal cord injury.A proteomics approach was used to understand the role of differential protein expression with miR-21 a-5 p knockdown,using a mouse model of spinal cord injury without gene knockout as a negative control *** found that after introducing miR-21 a-5 p knockdown,proteins that played an essential role in the regulation of inflammatory processes,cell protection against oxidative stress,cell redox homeostasis,and cell maintenance were upregulated compared with the negative control *** Encyclopedia of Genes and Genomes pathway enrichment analysis identified enriched pathways in both groups,such as the oxidative phosphorylation pathway,which is relevant to Parkinson's disease,Huntington's disease,Alzheimer's disease,and cardiac muscle *** also found that miR-21 a-5 p could be a potential biomarker for amyotrophic lateral sclerosis,as miR-21 a-5 p becomes deregulated in this *** results indicate successful detection of some important proteins that play potential roles in spinal cord *** the relationship between these proteins and the recovery of spinal cord injury will provide a reference for future research of spinal cord injury *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Shandong University of China on March 5,2014.

关键词： bioinformatics biomarker inflammation micro RNA mitochondria mouse pathway analysis proteomics spinal cord injury stathmin

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Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway

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Neural Regeneration Research 2018年第1期13卷 128-134页

作者： hong-liang song Xiang Zhang Wen-zhao Wang Rong-han Liu Kai Zhao Ming-yuan Liu Wei-ming Gong Bin Ning Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University Hospital Pharmacy Jinan Central Hospital Affiliated to Shandong University Department of Gynecology and Obstetrics Jinan Maternity and Child Care Hospital

Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects. However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 mitogen activated protein kinase （p38 MAPK） pathway is the most important member of the MAPK family that controls inflammation. We assumed that the mechanism of rutin in the repair of spinal cord injury is associated with the inhibition of p38 MAPK pathway. Allen’s method was used to establish a rat model of spinal cord injury. The rat model was intraperitoneally injected with rutin （30 mg/kg） for 3 days. After treatment with rutin, Basso, Beattie and Bresnahan locomotor function scores increased. Water content, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 levels, p38 MAPK protein expression and caspase-3 and -9 activities in T8–9 spinal cord decreased. Oxidative stress related markers superoxide dismutase and glutathione peroxidase levels increased in peripheral blood. Rutin exerts neuroprotective effect through anti-oxidation, anti-inflammation, anti-apoptosis and inhibition of p38 MAPK pathway.

关键词： nerve regeneration spinal cord injury rutin oxidative stress antioxidant anti-inflammation p38 mitogen activated protein kinase pathway anti-apoptosis caspase-3 caspase-9 neural regeneration

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Disordered hyperuniformity and thermal transport in monolayer amorphous carbon

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 145-152页

作者： Nianjie liang Yuxi Wang Bai song Department of Energy and Resources Engineering Peking UniversityBeijing 100871China Department of Advanced Manufacturing and Robotics Peking UniversityBeijing 100871China

Disordered hyperuniformity(DHU)is a recently discovered novel state of amorphous systems characterized by strongly suppressed density fluctuations at large length scales as in crystalline materials,which offers great potential for achieving unusual mechanical,electronic,and photonic ***,despite the fundamental and technological importance of thermal transport in amorphous solids,the effect of DHU remains largely ***,we theoretically study thermal transport in a class of two-dimensional DHU materials—monolayer amorphous carbon(MAC).Beginning with a perfect graphene lattice,we continuously apply Stone-Wales transformations to generate a series of MAC models with varied degrees of disorder and defects,which are quantified through comprehensive structural analysis including the so-called hyperuniformity index(H),where a smaller H indicates a higher degree of ***,we conduct molecular dynamics simulations to obtain the thermal conductivity(κ).A significant correlation between the thermal transport behavior and degree of hyperuniformity is observed,with the room-temperatureκdecreasing from 26.3 to 5.3 W m^(-1)K^(-1)while H is tuned from 0.0004 to ***,two distinct transport regimes are identified,including a nearly-DHU regime at small H(<0.005)whereκdrops sharply and a non-DHU region at larger H whereκbecomes relatively ***-resolved analysis reveals longer lifetime and higher participation ratio for the heat carriers in nearly-DHU MAC,implying that the hidden long-range correlations could support extended modes that enhance *** work highlights the impact of DHU on the thermal properties of amorphous materials and represents a conceptual advancement that is worthy of future exploration.

关键词： disordered hyperuniformity thermal transport amorphous material two-dimensional monolayer amorphous carbon

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Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei ZHU Di LI Xing HU liang song Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Tracking of CFSE-labeled endothelial progenitor cells in laser-injured mouse retina

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Chinese Medical Journal 2011年第5期124卷 751-757页

作者： SHI Hui YANG Wei CUI Zhi-hua LU Cheng-wei LI Xiao-hong liang Ling-ling song E Department of Ophthalmology First Hospital Jilin University Changchun Jilin 130021 China

Background Endothelial progenitor cells （EPCs） transplantation is a promising therapeutic strategy for ischemic retinopathy. The current study aimed to establish a simple, reliable and fluorescent labeling method for tracking EPCs with 5-（and-6）-carboxyfluorescein diacetate succinimidyl ester （CFSE） in laser-injured mouse retina. Methods EPCs were isolated from human umbilical cord blood mononuclear cells, cultivated, and labeled with various concentrations of CFSE. Based on fluorescence intensity and cell morphology, a 15 minutes incubation with 5 μmol/L CFSE at 37℃ was selected as the optimal labeling condition. The survival capability and the apoptosis rate of CFSE-labeled EPCs were measured by Trypan blue staining and Annexin V/PI staining assay respectively. Fluorescence microscopy was used to observe the label stability during the extended culture period. Labeled EPCs were transplanted into the vitreous cavity of pigmented mice injured by retinal laser photocoagulation. Evans Blue angiography and flat mounted retinas were examined to track the labeled *** EPCs labeled with 5 μmol/L CFSE presented an intense green fluorescence and maintained normal morphology, with no significant changes in the survival capability or apoptosis rate after being labeled for 2 days, 1 and 4 weeks, The fluorescence intensity gradually decreased in the cells at the end of 4 weeks. Evans Blue angiography of the retina displayed the retinal capillarity network clearly and fluorescence leakage was observed around photocoagulated spots in the laser-injured mouse model. One week after transplantation of labeled EPCs, the fluorescent cells were identified around the photocoagulated lesions. Four weeks after transplantation, fluorescent tube-like structures were observed in the retinal vascular *** EPCs could be labeled by CFSE in vitro and monitored in vivo for at least 4 weeks, and participate in the repair of injured retinal vessels.

关键词： endothelial progenitor cells 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester cell tracking retina laser photocoagulation cell transplantation

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Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-Wen Pan Jun Lin Jin-liang song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

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Synthesis of intermetallic PtCo fuel cell catalysts from bimetallic core@shell structured nanoparticles

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Journal of Energy Chemistry 2025年第2期101卷 1-6页

作者： Le Zhang Lei Tong Shuai Li Chang-song Ma Kun-Ze Xue Hai-Wei liang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China

The high activity and stability of intermetallic PtCo nanocatalysts toward oxygen reduction reaction make them a top candidate as low-Pt cathode catalysts in proton exchange membrane fuel cells（PEMFCs）.However,forming intermetallic structures typically requires high-temperature annealing,posing a challenge for achieving well-size control and highly ordered *** we report the design and synthesis of bimetallic co re@shell structured precursors for affording high-performance intermetallic PtCo *** fabrication of the core@shell precursor involves using a molecular ligand containing both sulfur and oxygen donors to selectively bind with Pt colloidal nanoparticles as the core and chelate Co ions as the *** high-temperature annealing,the ligand transforms into carbon coatings around alloy nanoparticles,preventing particle sintering;meanwhile,Co ions in the shell can easily diffuse into the Pt core,which helps to increase the thermodynamic driving force for forming intermetallic *** benefits enable us to obtain the catalyst with finely dispersed nanoparticles（～3.5 nm）and a high ordering degree of 72%.With 0.1 mgPt/cm2cathode loading,the catalyst delivers superior performance and durability in PEMFCs,showing an initial mass activity of 0.56 A/mgPt,an initial power density of 1.05 W/cm2at 0.67 V（H2-air）,and a voltage loss of 26 mV at 0.8 A/cm2after the accelerated durability test.

关键词： Bimetallic structure Fuel cells Intermetallic PtCo Oxygen reduction reaction

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苹果产业龙头企业组织创新动因的实证研究

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湖北农业科学 2011年第1期50卷 202-208页

作者：梁洪松霍学喜西北农林科技大学经济管理学院陕西杨凌712100

在2008年全球金融风暴的负面影响下,我国大多数企业遭到了不同程度的冲击。随着经济形势的好转,部分企业的经营状况得到了一些改善,但仍未彻底摆脱困境,苹果产业也不例外。金融危机使越来越多的企业认识到了自身存在的众多问题,苹果产... 详细信息

在2008年全球金融风暴的负面影响下,我国大多数企业遭到了不同程度的冲击。随着经济形势的好转,部分企业的经营状况得到了一些改善,但仍未彻底摆脱困境,苹果产业也不例外。金融危机使越来越多的企业认识到了自身存在的众多问题,苹果产业要想获得长足、稳定的发展,也迫切需要解决这些问题,而组织创新是企业进行自身改造和持续发展的有效措施之一。本文以现有组织创新动因相关文献为研究基础,根据OIM问卷,通过因子分析等实证方法,在对数据信度和效度的检验分析的基础上,对影响苹果产业龙头企业组织创新的动因进行了识别,实证了苹果产业龙头企业组织创新动因的识别模型,把影响苹果产业龙头企业组织创新的内部动因定位于苹果产业龙头企业战略的调整、组织规模发展以及苹果产业龙头企业文化变迁,把影响苹果产业龙头企业组织创新的外部动因定位于技术推动、市场需求以及政府调控。继而,分析了组织创新内部动因和外部动因之间的关系,研究了组织创新动因的耦合对组织创新的作用机理。

关键词：苹果产业龙头企业组织创新动因危机视角

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农技培训、技术获取与农户节水灌溉技术采纳行为——基于同伴效应的有调节的中介效应

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节水灌溉 2024年第2期 95-104页

作者：李现康梁洪松西北农林科技大学经济管理学院陕西杨凌712100

为探究农技培训、技术获取、同伴效应和农户节水灌溉技术采纳的影响关系和机制路径,使用课题组在水资源匮乏代表区——内蒙古地区2022年的505份微观农户数据,基于中介效应模型、调节效应模型、有调节的中介效应模型开展研究。研究发现:... 详细信息

为探究农技培训、技术获取、同伴效应和农户节水灌溉技术采纳的影响关系和机制路径,使用课题组在水资源匮乏代表区——内蒙古地区2022年的505份微观农户数据,基于中介效应模型、调节效应模型、有调节的中介效应模型开展研究。研究发现:(1)调研农户采用节水灌溉行为较多,但农户实际节水灌溉的耕地面积占家庭总耕地面积的比例较低;(2)参加农技培训、降低技术获取难度、高同伴效应均能促进农户采纳节水灌溉技术和增加采纳面积;(3)农户可以通过参加农业技术培训,降低节水灌溉技术的获取难度,进而促进对节水灌溉技术的采纳行为,另外同伴效应还对技术获取具有替代作用,同时高同伴效应还会提高农业技术培训对农户节水灌溉采纳的影响,但不会促进农户的采纳面积增加。基于以上分析,建议多渠道、多形式、多方位创新政府培训方式,吸引更多农户参与;降低农户获取节水灌溉技术的经济成本和技术成本;发挥同伴效应的积极作用,引领更多农户参与使用节水灌溉技术。

关键词：农技培训技术获取同伴效应节水灌溉技术采纳行为

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A binuclear iron(III) Schiff base complex doubly bridged by water molecule:synthesis and characterization

A binuclear iron(III) Schiff base complex doubly bridged by ...

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河南省化学会2014年学术年会

作者： Jun Ling Chen Ai Qin Tian Xun Feng hong liang song Li Ya Wang School of Life Science and Technology Nanyang Normal University College of Chemistry and Chemical Engineering Luoyang Normal University Department of basic education Henan Forestry Vocational College

A novel binuclear iron(III)Schiff base complex[Fe(NO2-salpn)·H2O](NO2-salpn=5-nitro salicylaldehyde,1,3-propanediamine)has been obtained through one-pot refluxing and *** complex was established by single-crystal X-ray diffraction analysis and further characterized by elemental analysis,IR spectroscopy,electrochemical and magnetochemical *** single-crystal analysis revealed that title complex consists of two pseudo-octahedral high-spin iron(III)units doubly bridged by two water *** inter hydrogen bonding interactions connect the adjacent binuclear units into one dimensional(1D)infinite chain,and these 1D chains are further propagated into the two dimensional(2D)supramolecular network by weak intermolecular *** temperature magnetic measurements in the range 2-300 K of the complex indicate the presence of strong antiferromagnetic interactions between the two adjacent iron(III)ions.

关键词： Binuclear iron(III) Schiff base electrochemical antiferromagnetic property

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