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Chinese Chemical Letters 2007年第12期18卷 1447-1450页

作者： hong She wang jun E. Zeng Shaanxi Key Laboratory for Phytochemistry Baoji University of Arts and Sciences Baoji 721007 China

Synthesis of symmetrical diaryl sulfoxides from arenes and thionyl chloride in the presence of a catalytic amount of iodine at room temperature under solvent-free conditions is described. Mild reaction conditions, eas... 详细信息

关键词： Aryl sulfoxides Arenes Thionyl chloride

Construction of prokaryotic expression system of TGF-β1 epitope gene and identification of recombinant fusion protein immunity

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World Journal of Gastroenterology 2005年第40期11卷 6389-6394页

作者： Yong-hong Guo Zhi-Ming Hao Jin-Yan Luo jun-hong wang The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004Shannxi Province China The Post Doctor Xijing Hospital of FourthMilitary Medical University Xi'an 710004 Shannxi ProvinceChina

AIM： To insert the constructed TGF-β1 epitope gene into the el loop of C-terminus of truncated hepatitis B core antigen to increase TGF-β1 antigenicity in its prokaryotic expression system and to identify immunity of the expressed recombinant protein in order to exploit the possibility for obtaining anti- TGF-β1 vaccine. METHODS： The TGF-β1 encoding epitope gene （the mature TGF-β1 from 78-109 amino acid residues, TGF-β1^32） was amplified by polymerase chain reaction from the recombinant pGEM-7z/ TGF-β1 ^32 vector. The HBcAg gene fragments （encoding HBcAg from 1-71 and 89-144 amino acid residues） were amplified from PYTAI- HBcAg vector. The recombinant vector pGEMEX-1 was used to insert HBcAg1-71, TGF-β1^32 and HBcAg89-144 into restrictive endonuclease enzyme and ligated with T4 Ugase. The fusion gene fragments ***1-71-TGF-β1^32 HBcAg89-144 were recloned to pET28a（＋） and the DNA sequence was confirmed by the dideoxy chain termination method. The recombinant vector pET28a （＋）/ CTC was transformed and expressed in E. coli BL21 （DE3） under induction of IPTG. After purification with Ni^＋2 NTA agarose resins, the antigenicity of purified protein was detected by ELISA and Western blot and visualized under electron microscope. RESULTS： Enzyme digestion analysis and sequencing showed that TGF-β1 epitope gene was inserted into the el loop of C-terminus of truncated hepatitis B core antigen. SDS-PAGE analysis showed that relative molecular mass （Mr） of the expressed product by pET28a （＋）/CTC was Mr 24 *** output of the target recombinant protein was approximately 34.8% of the total bacterial protein,mainly presented in the form of inclusion body. Western blotting and ELISA demonstrated that the fusion protein could combine with anti-TGF-β1 polyclonal IgG but not with anti-HBcAg. The purity of protein was about 90 % and the protein was in the form of self-assembling particles visualized under electron microscope. This fusion protein had good anti-TGF-β1 antigenicity and

关键词： Prokaryotic expression system TGF-β1 epitope Immunogenicity Antigenicity

Ibuprofen induced drug loaded polymeric micelles

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Chinese Chemical Letters 2011年第9期22卷 1123-1126页

作者： Song Wei Tan hong jun wang Ke Hua Tu hong Liang Jiang Li Qun wang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly （N-isopropylacrylamide） and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.

关键词： Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide)

Inverse Spin Hall Effect in Two-Terminal Device with Rashba Spin-Orbit Coupling

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Communications in Theoretical Physics 2009年第12期52卷 1107-1112页

作者： ZHANG Jing-Jing LIANG Feng YANG Yong-hong wang jun Department of Physics Southeast University Nanjing 211189 China

We report a theoretic study on the inverse spin-Hall effect （ISHE） in a two-terminal nano-device that consists of a two-dimensional electron gas （2DEG） with Rashba spin-orbit coupling （RSOC） and two ideal leads. Based on a two-site toy model and Keldysh Green＇s function method, we derive an analytic result of ISHE, which shows clearly that a nonzero transverse charge current stems from the combined effect of the RSOC, the spin bias, and its spin polarization direction in spin space. Our further numerical calculations in a larger system other than two-site lattice model demonstrate that the transverse charge current, dependent on the strength of the RSOC, the Fermi energy of the system, as well as the system size, can exhibit oscillating behavior and even reverse its sign due to Rashba spin precession. These properties may be helpful for eficient detection of the spin current （spin bias） by measuring the transverse charge current in a spin-orbital coupling system.

关键词： spin Hall effect spin-orbital coupling inverse spin-Hall effect Keldysh Green's function

Effect of V and N on Microstructures and Properties of Grade-70 Tire Cord Steel during Cold Drawing

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Journal of Iron and Steel Research International 2015年第2期22卷 171-178页

作者： hong-yu LIU Bao-yi WAN Xiao-yu ZENG Chong LIN hong-jun wang College of Science Wuhan University of Science and Technology Hubei Province Key Laboratory of Systems Science in Metallurgical Process Department of Physics and Astronomy Clemson University

Commercial grade-70 tire cord steel was microalloyed with V and N to explore the possibility of substitu- ting V for C and the effect of V and N on cementite dissolution during cold drawing process. Tensile strength, elon- gation and torsion laps of cold-drawn wires were determined. Microstructures of secondary phases were studied by transmission electron microscopy （TEM） and energy dispersive spectroscopy （EDS）. Saturation magnetization was measured by using a vibrating sample magnetometer （VSM） to evaluate cementite dissolution during cold drawing process. Experimental results showed that with the increase of V content, tensile strength increased, elongation slightly decreased, and the torsion laps of the cold-drawn wires decreased. Results also showed that with the increase of N content, a peak （increasing first and then decreasing） appeared in the tensile strength graph, and an increase of elongation and a decrease of torsion laps of the cold-drawn wires occured. N is soluble in ferrite when its content is low. The increase in the content of N to 82 × 10^-6 will result in the precipitation of the V-containing secondary pha- ses. Also, cementite tended to be stable during cold drawing process with the increase of V and N contents. Grade-80 tire cord steel can be replaced by grade 70 tire cord steel microalloyed with 0. 086 mass% V.

关键词： tire cord steel cold-drawn wire cementite dissolution vanadium nitrogen

Electron Transport Behavior of Multiferroic Perovskite BiMnO_3 Prepared by Co-Precipitation Method

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Chinese Physics Letters 2018年第2期35卷 84-87页

作者： hong-jun wang Yuan-Yuan Zhu Jing Zhou Department of Physics Shaanxi University of Science and Technology

Perovskite BiMnO_3 samples are successfully synthesized by the co-precipitation method at relatively low pressure and moderate *** temperature dependences of resistivity are measured and systematically *** is shown that the electrical resistivity increases sharply with the decrease of temperature above 210 K and the fitted results demonstrate that the thermally activated conduction model is the dominant conduction mechanism for the electron transport behaviors in this temperature region.A dual conducting mechanism,i.e.,the variable range hopping and thermal activated conduction,is suggested to be responsible for the transport behaviors of BiMnO_3 in the region of 180-200 ***,the resistivity increases slightly with the decrease of temperature below 180 K and the transport is governed by the variable range hopping mechanism.

关键词： Bi Electron Transport Behavior of Multiferroic Perovskite BiMnO3 Prepared by Co-Precipitation Method

Synthesis and biological evaluation of hydrazino-containing polyamine skeletons as drug delivery system

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Chinese Chemical Letters 2011年第1期22卷 119-122页

作者： Jian hong wang jun jun Zhou Song Qing Xie Qian Li Jin Zhao Chao Jie wang Key Lab of Natural Medicinal and Immunotechnology of Henan Province Henan University Kaifeng 475004 China

A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.

关键词： Polyamine conjugates Polyamine transporter Synthesis Biological activity

Fast Computation of Electrostatic Interactions for a Charged Polymer with Applied Field

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Chinese Journal of Polymer Science 2020年第6期38卷 665-672页

作者： Hao Lin Zi-Tong Lei Ming-Ming Ding hong-jun wang Tong-Fei Shi School of Mathematics Jilin Normal UniversityChangchun 130103China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 730022China College of Computer Jilin Normal UniversitySi ping 136000China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China

Using a hybrid simulation approach that combines a finite difference method with a Brownian dynamics,we investigated the motion of charged *** to the fact that polymer-solution systems often contain a large number of particles and the charged palymer chains are in a state of random motion,it is a time consuming task to calculate the electrostatic interaction of the ***,we propose a new strategy to shorten the CPU time by reducing the iteration *** simulation results ilustrate the effect of preset parameters on CPU time and accuracy,and demonstrate the feasibility of the"local iteration"***,we find that the increase in the number of charged beads has no signifiant infuence on the time of global iterations and local *** a number of 80×80×80 grids,when the relative error is controlled below 1.5%,the computational efficiency is increased by 8.7 times in the case that contains 500 charged *** adition,for a number of 100×100×100 grids with 100 charged beads,the computational efciency can be increased up to 12 *** work provides new insights for the optimization of iterative algorithms in special problems.

关键词： Finite dfference method Brownian dynamics Charged polymers Electrostatic interaction Local iteration

Novel empirical model for predicting residual flexural capacity of corroded steel reinforced concrete beam

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 888-906页

作者： Zhao-Hui LU hong-jun wang Fulin QU Yan-Gang ZHAO Peiran LI Wengui LI Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Bejing University of TechnologyBeijing 100124China School of Civil Engineering Central South UniversityChangsha 410075China School of Civil and Environmental Engineering University of Technology SydneyNSW 2007Australia

In this study,a total of 177 flexural experimental tests of corroded reinforced concrete(CRC)beams were collected from the published *** database of flexural capacity of CRC beam was established by using unified and standardized experimental *** this database,the effects of various parameters on the flexural capacity of CRC beams were discussed,including beam width,the effective height of beam section,ratio of strength between longitudinal reinforcement and concrete,concrete compressive strength,and longitudinal reinforcement corrosion *** results indicate that the corrosion of longitudinal reinforcement has the greatest effect on the residual flexural capacity of CRC beams,while other parameters have much less *** addition,six available empirical models for calculating the residual flexural strength of CRC beams were also collected and compared with each other based on the established *** indicates that though five of six existing empirical models underestimate the flexural capacity of CRC beams,there is one model overestimating the flexural ***,a newly developed empirical model is proposed to provide accurate and effective predictions in a large range of corrosion ratio for safety assessment of flexural failure of CRC beams confirmed by the comparisons.

关键词： CRC beams flexural capacity steel corrosion database empirical models

Exponential stability and periodic solution for fuzzy BAM Neural networks with time varying delays

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Applied Mathematics(A Journal of Chinese Universities) 2009年第2期24卷 157-166页

作者： XIANG hong-jun wang Jin-hua Department of Mathematics, Xiangnan University, Chenzhou 423000, China Department of Mathematics Xiangnan University Chenzhou China

In this paper, a class of fuzzy BAM neural networks with time varying delays is discussed. By using the properties of M-matrix, Linear Matrix Inequality（LMI） approach and general Lyapunov-Krasovskii functional, some new sufficient conditions are derived to ensure the existence of periodic solutions and the global exponential stability of the fuzzy BAM neural networks with time varying delays. These results have important significance in the design of global exponential stable BAM networks with delays. Moreover, an example is given to illustrate that the conditions of the results in the paper are feasible.

关键词： fuzzy BAM neural network periodic solution exponential stability linear matrix inequality(LMI) Lyapunov-Krasovskii functional