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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 58-64页

作者： Zhang, Zhen-hai Wu, Shuo-Dong Su, Yang Jin, Jun-Zhe fan, Ying Yu, hong Zhang, Li-Kui China Med Univ Affiliated Hosp 2 Dept Gen Surg Shenyang 110004 Peoples R China

BACKGROUND: The disorders of gallbladder motility may play an important role in the formation of gallstones. Many neural and hormonal factors and their interactions regulate gallbladder motility and bile flow into the duodenum. Further study in these factors may help to reveal the etiology of gallbladder diseases. This study was undertaken to assess the relationship of the levels of motilin, vasoactive intestinal peptide (VIP) and gastrin in blood and gallbladder tissues with the formation of cholelithiasis. METHODS: The levels of motilin, gastrin and VIP in blood and gallbladder tissues of 36 patients with gallbladder stones, 14 patients with gallbladder polyps, 10 healthy volunteers and 10 patients with common bile duct stones were measured by radioimmunoassay. RESULTS: The level of motilin in plasma and gallbladder tissues of the gallbladder stone group was higher than that of the control and gallbladder polyp groups (P<0.05). The levels of plasma VIP and serum gastrin were much higher than those of the other three groups (P<0.01). The level of VIP in gallbladder tissues was higher than that of the control and gallbladder polyp groups (P<0.01). CONCLUSIONS: The abnormal excretion of hormonal factors is closely related to gallstone formation. The high level of VIP in gallbladder tissues may be an important cause of gallbladder hypomotility. The abnormal level of serum gastrin may be related to the gastrointestinal symptoms of patients with gallstones.

关键词： motilin vasoactive intestinal peptide gastrin gallbladder radioimmunoassay

Small-cell carcinoma of the prostate with negative CD56,NSE,Syn,and CgA indicators:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1630-1638页

作者： hong-Jin Shi Zhi-Nan fan Jin-Song Zhang Bo-Bo Xiong hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting for<1%of all prostate ***,negativity for all SCCP neuroendocrine markers is ***,we report a case of SCCP with completely negative neuroendocrine markers and explore its clinicopathologic features,thus improving the understanding of its clinical diagnosis and *** SUMMARY We report the case of a 48-year-old patient with SCCP negative for common sensitive neuroendocrine-staining *** was the first symptom,and rectal examination revealed a hard prostate,palpable nodules,diffuse prostate enlargement,no pressure pain,no blood staining in the finger sleeve,1.33 ng/mL total prostate-specific antigen level,and a free-to-total prostate-specific antigen ratio of 0.21 ng/*** suggested a prostate size of 5.3 cm×5.8 cm×5.6 cm,and magnetic resonance imaging suggested prostate *** lower posterior bladder wall,rectal mesentery,and bilateral seminal vesicles were invaded,with multiple lymph node metastases in the pelvis.A whole-body bone scan suggested an abnormally active multiple bone metabolism and possible bone *** and lungs computed tomography revealed no significant nodal *** a pathological diagnosis of SCCP after a prostate puncture,with negative indicators of common sensitive neuroendocrine staining,chemotherapy was administered;the patient died 4-5 mo after SCCP *** SCCP is a rare disease characterized by atypical clinical symptoms,limited treatment options,a short survival period,and a poor prognosis.

关键词： Prostate cancer Small cell carcinoma Neuroendocrine tumor Therapeutics Diagnosis Case report

Primary adrenal diffuse large B-cell lymphoma with normal adrenal cortex function:A case report

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World Journal of Clinical Cases 2022年第2期10卷 709-716页

作者： Zhi-Nan fan hong-Jin Shi Bo-Bo Xiong Jin-Song Zhang hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma,which accounts for about approximately 30%to 40%of non-Hodgkin's lymphomas,is the most common type and is a class of aggressive B-cell ***,diffuse large B-cell lymphomas primary to the adrenal gland are *** SUMMARY A 73-year-old man was admitted with abdominal pain and *** admission,enhanced adrenal computed tomography indicated irregular masses on both adrenal glands,with the larger one on the left side,approximately 8.0 cm×4.3 cm in *** boundary was irregular,and surrounding tissues were *** obvious enhancement was observed in the arterial *** of the left adrenal gland was *** diagnosis revealed diffuse large B-cell *** surgery,the patient received RCHOP *** the fourth immunochemotherapy,patient condition deteriorated,and he eventually died of respiratory *** R-CHOP is the conventional immunochemotherapy for primary adrenal diffuse large B-cell *** is mainly used to diagnose the ***,the ideal treatment plan remains to be confirmed.

关键词： Large B-cell lymphoma Adrenal glands Immunochemotherapy Surgical procedures Case report

Non-surgical contraindication for acute appendicitis with secondary thrombocytopenia: A case report

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World Journal of Gastroenterology 2015年第9期21卷 2836-2839页

作者： hai-hong Zhang Guo-Li Gu Xiang-Yang Zhang Qin fan Xin-Yan Wang Xue-Ming Wei Department of General Surgery Air Force General Hospital of PLA Department of Intelligence Air Force General Hospital of PLA

A 26-year-old man presented with migrated right lower abdominal pain and without any history of hematological systemic *** routine test showed a leukocyte count of 22.74 × 109/L, with91.4% neutrophils, and a platelet count of 4 × 109/L before *** case question was whether the team should proceed with ***, a differential diagnosis is essential before making such a *** appendicitis was easily diagnosed based on clinical findings, including migrating abdominal pain, a leukocyte count of 22.74 × 109/L and the result of abdominal computed tomography ***, it was not clear whether the severe thrombocytopenia was primary or *** smear of peripheral blood and aspiration of bone marrow were ordered to exclude hematological *** of the tests indicated obvious pathological hematological *** was no hepatosplenomegaly found by ultrasound examination of the liver and ***, operative intervention may be a unique clinical scenario in acute severe appendicitis patients with secondary thrombocytopenia.

关键词： Thrombocytopenia Appendicitis Infection Fever Appe

Design,synthesis and preliminary bio-evaluation of glucose-cholesterol derivatives as ligands for brain targeting liposomes

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Chinese Chemical Letters 2011年第7期22卷 831-834页

作者： fan Lei Wei fan Xian Kun Li Shan Wang Li hai Yong Wu Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University Chengdu 610041 China

A series of glucose-cholesterol derivatives 8a-8e as ligands for brain targeting liposomes were synthesized. The preparation of compound 6 involved temporary protection of glucose with chlorotrimethylsilicane and hexamethyldisilazane followed by selectively hydrolyzed. The known cholesteryl tosylate 1 were coupled to ethylene glycols to afford alcohol 2a-2e. Substitution and deprotection of alcohol 2a-2e furnished the acids 4a-4e, which was condensed with compound 6 to get compounds 7a-7e, and then was deprotected in tetrahydrofuran with TFA to obtain the title compounds. As a model drug, tegafur was entrapped by liposomes coupled with 8b, and preliminary in vivo evaluation shown 8b could enhance the ability of liposomes delivering tegafur across the blood brain barrier.

关键词： Liposome ligands Brain target GLUTt transporter Tegafur Synthesis

Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis

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World Journal of Gastroenterology 2023年第14期29卷 2153-2171页

作者： Cai-Song Chen Yao-Gang Zhang hai-Jiu Wang hai-Ning fan Research Center for High Altitude Medicine of Qinghai University Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Qinghai Province Research Key Laboratory for Echinococcosis Affiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Qinghai Province Research Key Laboratory for EchinococcosisAffiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

BACKGROUND The NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic ***,its role in hepatic alveolar echinococcosis(HAE)remains *** To investigate the NLRP3 inflammasome and its mechanism of activation in *** We assessed the expression of NLRP3,caspase-1,interleukin(IL)-1β,and IL-18 in the marginal zone and corresponding normal liver of 60 patients with HAE.A rat model of HAE was employed to investigate the role of the NLRP3 inflammasome in the marginal zone of *** experiments were conducted to investigate the effect of Echinococcus multilocularis(***)in stimulating Kupffer cells and ***,immunohistochemistry,Western blotting,and enzyme-linked immunosorbent assay were used to evaluate NLRP3,caspase-1,IL-1β,and IL-18 expression;flow cytometry was used to detect apoptosis and reactive oxygen species(ROS).RESULTS NLRP3 inflammasome activation was significantly associated with *** of ROS production decreased NLRP3-caspase-1-IL-1βpathway activation and mitigated hepatocyte damage and *** *** induces hepatocyte damage and inflammation by activating the ROS-mediated NLRP3-caspase-1-IL-1βpathway in Kupffer cells,indicating that ROS may serve as a potential target for the treatment of HAE.

关键词： Hepatic alveolar echinococcosis Inflammasome Inflammation Kupffer cell NLR family pyrin domain-containing 3 protein Reactive oxygen species

Entropy Function-Based Algorithms for Solving a Class of Nonconvex Minimization Problems

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Journal of the Operations Research Society of China 2015年第4期3卷 441-458页

作者： Yu-fan Li Zheng-hai Huang Min Zhang Department of Mathematics School of ScienceTianjin UniversityTianjin 300072China Center for Applied Mathematics of Tianjin University Tianjin 300072China

Recently,the l_(p)minimization problem(p∈(0,1))for sparse signal recovery has been studied a lot because of its *** this paper,we propose a general smoothing algorithmic framework based on the entropy function for solving a class of l_(p)minimization problems,which includes the well-known unconstrained l_(2)-l_(p)problem as a special *** show that any accumulation point of the sequence generated by the proposed algorithm is a stationary point of the l_(p)minimization problem,and derive a lower bound for the nonzero entries of the stationary point of the smoothing *** implement a specific version of the proposed algorithm which indicates that the entropy function-based algorithm is effective.

关键词： l_(p)minimization problem Entropy function Smoothing conjugate gradient method

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

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Biomedical and Environmental Sciences 2011年第6期24卷 678-682页

作者： fanG Guo Feng fan Xue Yun SHEN Fu hai Department of Occupational and Environmental Health School of Public Health Hebei United UniversityTangshan 063000 Hebei China

Objective To explore the relationship between polymorphisms of interleukin-4 （IL-4） gene （-33, ＋45, intron3, ＋429, ＋448） and the susceptibility of silicosis. Methods A case-control study was carried out. 101 silicosis patients were selected as cases. As strictly matching, 121 of non silicosis workers were selected as the controls. The polymophisms of IL-4 （five locus） were detected by the method of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） techniques. Results The GA genotype in the IL-4＋429 locus and the CC genotype in the IL-4＋448 locus were found. The frequencies ofAA, GG and AG of IL-4＋45 locus in the cases were 55.4%, 10.9%, and 33.7% and in the controls were 62.0%, 12.6%, and 26.4%. The differences between cases and controls were not significant. The frequencies of B1B1, B2B2, and B1B2 of intron3 VNTR locus in the cases were 73.3%, 1.0%, and 25.7% and in the controls were 68.6%, 1.7%, and 29.8%. The differences were not significant. The frequencies of TT, CC, and CT in -33 locus in the cases were 55.4%, 11.9%, and 32.7% and in the controls were 69.4%, 4.1%, and 26.4%. The differences were significant （P=0.034）. Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.

关键词： Silicosis Interleukin-4 Polymorphism Susceptibility

Evolution of Quantum State for Mesoscopic Circuits with Dissipation

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Communications in Theoretical Physics 2005年第6X期44卷 1045-1049页

作者： WAN Hua-Ming LUO hai-Mei WANG Yi-fan University of Science & Technology of Suzhou Suzhou 215011 China Department of Physics Jiangxi Normal University Nanchang 330027 China Nanchang Institute of Aeronautical Technology Nanchang 330034 China

Based on the maximum entropy principle, we present a density matrix of mesoscopic RLC circuit to make it possible to analyze the connection of the initial condition with temperature. Our results show that the quantum state evolution is closely related to the initial condition, and that the system evolves to generalized coherent state if it is in ground state initially, and evolves to squeezed state if it is in excited state initially.

关键词： mesoscopic RLC circuit the maximum entropy principle density matrix

A GPU-based multi-resolution algorithm for simulation of seed dispersal

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第11期13卷 816-827页

作者： Jing fan hai-feng JI Xin-xin GUAN Ying TANG School of Computer Science and Technology Zhejiang University of TechnologyHangzhou 310023China

In forest dynamics models, the intensive computation and load involved in the simulation of seed dispersal can become unbearably huge for large-scale forest analysis. To solve this problem, we propose a multi-resolution algorithm to compute seed dispersal on GPU. By exploiting the computation parallelism of seed dispersal, the computation of the whole forest plot is divided into multiple small plot cells, which are computed independently by parallel threads on GPU. To further improve the calculation efficiency with limited threads scale for GPU computation, we propose a hierarchical method to cluster the plot cells into a multi-resolution form according to the biological curves of tree seed dispersal. Experimental results show that our algorithm not only greatly reduces computational time but also obtains comparably correct results as compared to the naive GPU algorithm, which makes it especially suitable for large-scale forest modeling.

关键词： GPU Seed dispersal Large-scale Multi-resolution Data clustering