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Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke

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Neural Regeneration Research 2021年第2期16卷 312-318页

作者： Jun Zhong Rong-Wei Li Ju Wang Ying Wang hong-fei ge Ji-Shu Xian Hua Feng Liang Tan Department of Neurosurgery Southwest HospitalThe Third Military Medical University(Army Medical University)ChongqingChina Department of Neurosurgery Hanzhong Central HospitalHanzhongShaanxi ProvinceChina Department of Oncology Hanzhong Central HospitalHanzhongShaanxi ProvinceChina State Key Laboratory of Power Transmission Equipment and System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqingChina

Cattle encephalon glycoside and ignotin(CEGI)injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules,such as polypeptides,monosialotetrahexosyl ganglioside(GM-1),free amino acids,hypoxanthine and *** has been approved by the Chinese State Food and Drug Administration and widely used in the treatments of various diseases,such as stroke and Alzheimer's ***,the neuroprotective effects of CEGI beyond the time window of thrombolysis(within 4.5 hours)on acute ischemic stroke remain *** study constructed a rat middle cerebral artery occlusion model by suture-occluded method to simulate ischemic *** first daily dose was intraperitoneally injected at 8 hours post-surgery and the CEGI treatments continued for 14 *** of the modified five-point Bederson scale,beam balance test and rotameric test showed the neurological function of ischemic stroke rats treated with 4 m L/kg/d CEGI improved significantly,but the mortality within 14 days did not change *** MRI and 2,3,5-triphenyltetrazolium chloride staining confirmed that the infarct size in the 4 m L/kg/d CEGI-treated rats was significantly reduced compared with ischemic insult *** results of transmission electron microscopy and double immunofluorescence staining showed that the hippocampal neuronal necrosis in the ischemic penumbra decreased whereas the immunopositivity of new neuronal-specific protein doublecortin and the percentage of Ki67/doublecortin positive cells increased in CEGI-treated rats compared with untreated *** results suggest that CEGI has an effective neuroprotective effect on ischemic stroke when administered after the time window of *** study was approved by the Animal Ethics Committee of The Third Military Medical University,China.

关键词： apoptosis brain cattle encephalon glycoside and ignotin central nervous system neurological function plasticity rat regeneration stroke

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A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats

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Neural Regeneration Research 2022年第11期17卷 2512-2517页

作者： Xuan-Yu Fang Da-Wei Zhao Chao Zhang hong-fei ge Xu-Yang Zhang Feng-Chun Zhao Yi-Bin Jiang Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalArmy Medical UniversityChongqingChina

Brain lesions can cause neural stem cells to activate,proliferate,diffe rentiate,and migrate to the injured ***,after traumatic brain injury,brain tissue defects and microenvironment changes greatly affect the survival and growth of neural stem cells;the resulting reduction in the number of neural stem cells impedes effective repair of the injured *** can promote the survival,proliferation,and differentiation of neural stem cells under adverse conditions such as oxidative stress or hypoxia that can occur after traumatic brain ***,we investigated the therapeutic effects of melatonin combined with neural stem cells on traumatic brain injury in ***,in vitro studies confirmed that melatonin promoted the survival of neural stem cells deprived of oxygen and ***,we established a three-dimensional Matrigel-based transplantation system containing melatonin and neural stem cells and then used it to treat traumatic brain injury in *** found that treatment with the Matrigel system containing melatonin and neural stem cells decreased brain lesion volume,increased the number of surviving neuro ns,and improved recove ry of neurological function compared with treatment with Matrigel alone,neural stem cells alone,Matrigel and neural stem cells combined,and Matrigel and melatonin *** findings suggest that the three-dimensional Matrigelbased transplantation system containing melatonin and neural stem cells is a potential treatment for traumatic brain injury.

关键词： cell therapy magnetic resonance imaging Matrigel melatonin neural stem cells neurological function recovery three-dimensional transplantation traumatic brain injury

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Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a

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Neural Regeneration Research 2016年第4期11卷 641-645页

作者： Wang-sheng Duanmu Liu Cao Jing-yu Chen hong-fei ge Rong Hu Hua Feng Department of Neurosurgery General Hospital of Tibet Military Area Command Department of Neurosurgery Southwest Hospital of Third Military Medical University

Ischemic postconditioning renders brain tissue tolerant to brain ischemia,thereby alleviating ischemic brain ***,the exact mechanism of action is still *** this study,a rat model of global brain ischemia was subjected to ischemic postconditioning treatment using the vessel occlusion *** 2 hours of ischemia,the bilateral common carotid arteries were blocked immediately for 10 seconds and then perfused for 10 *** procedure was repeated six *** postconditioning was found to mitigate hippocampal CA1 neuronal damage in rats with brain ischemia,and up-regulate acid-sensing ion channel 2a expression at the m RNA and protein *** findings suggest that ischemic postconditioning up-regulates acid-sensing ion channel 2a expression in the rat hippocampus after global brain ischemia,which promotes neuronal tolerance to ischemic brain injury.

关键词： neural regeneration brain injury ischemic brain injury acid-sensing ion channels neuroprotection ischemic postconditioning neuroprotection protein expression neuronal density ischemic tolerance molecular mechanism gene expression nerve regeneration

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G Protein-Coupled Estrogen Receptor 1 Negatively Regulates the Proliferation of Mouse-Derived Neural Stem/Progenitor Cells via Extracellular Signal-regulated Kinase Pathway

G Protein-Coupled Estrogen Receptor 1 Negatively Regulates t...

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第十四届中国医师协会神经外科医师年会

作者： Jun Zhong hong-fei ge Chao Zhang Jing-yu Chen Huan-huan Li Xuan-yu Fang Liang Tan Xin Liu Zheng-cai Jia Hua Feng Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University （Army Medical university）

G protein-coupled estrogen receptor 1（GPER1, also known as GPR30） has been reported to play a wide range of function in the central nervous system（CNS）. However, whether GPER1 is expressed by neural stem/progenitor cells（NSPCs） and its role has not been established. Here, we found the expression of GPER1 in mouse-derived NSPCs via western blot and immunofluorescent staining. Moreover, we revealed that specific activation of GPER1 by the agonist G1 decreased the proliferation of NSPCs in a dose-dependent manner. The neurosphere formation assay and Ki67 staining further demonstrated that activation of GPER1 inhibited the proliferation of NSPCs. Additionally, the inhibitory effect of G1 on the proliferation of NSPCs could be blocked by the specific GPER1 antagonist G15. Intriguingly, ERK pathway was involved in the negative effect of GPER1 on the proliferation of NSPCs, because the phosphorylation level of ERK in NSPCs was remarkably decreased during G1 treatment. However, the antagonist G15 reversed the down-regulated level of p-ERK. Knock-down GPER1 also reversed the inhibitory effect of G1 on NSPCs proliferation. Together, our results provide the first evidence that GPER1 is expressed by NSPCs and its activation negatively modulates the proliferation of NSPCs, highlighting the importance of GPER1 in regulating NSPC behaviors.

关键词： Neural stem/progenitor cells G protein-coupled estrogen receptor 1 Proliferation Extracellular signal-regulated kinase

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Feasibility study on buoyancy-weight ratios of a submerged floating tunnel prototype subjected to hydrodynamic loads

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Acta Mechanica Sinica 2015年第5期31卷 750-761页

作者： Xu Long fei ge Youshi hong School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical University State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

The research progress of a novel traffic solution,a submerged floating tunnel（SFT）,is reviewed in terms of a study approach and loading *** existing publications,the buoyancy-weight ratio（BWR） is usually ***,BWR is a critical structural parameter that tremendously affects the dynamic behaviour of not only the tunnel tube itself but also the cable *** the context of a SFT prototype（SFTP） project in Qiandao Lake（Zhejiang Province,China）,the importance of BWR is illustrated by finite element analysis and subsequently,an optimized BWR is proposed within a reasonable range in the present *** the numerical model,structural damping is identified to be of *** damping and the corresponding Rayleigh coefficients are attained through a sensitivity study,which shows that the adopted damping ratios are fairly suitable for ***,the human sense of security is considered by quantifying the comfort index,which helps further optimize BWR in the SFTP structural parameter design.

关键词： Submerged floating tunnel Buoyancy-weight ratio Water wave and current loads Dynamic response Human security sense Comfort index

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港口物流信息系统评价原则及方法

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上海海运学院学报 2003年第1期24卷 1-6页

作者：杨静蕾丁以中费红英戈闻怡上海海运学院经济管理学院上海200135

讨论了港口物流信息系统的含义 ,并采用模糊评价方法对物流信息系统的发展程度进行评价 ,提出了评价港口物流信息系统的 3个原则 ;最后。

关键词：港口物流信息系统诊断评价

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An experimental investigation of dual-resonant and non-resonant responses for vortex-induced vibration of a long slender cylinder

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Science China(Physics,Mechanics & Astronomy) 2014年第2期57卷 321-329页

作者： WU XiaoDong ge fei hong YouShi College of Mechanics Taiyuan University of Technology State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

Experimental results of the dual-resonant and non-resonant responses are presented for vortex-induced vibrations(VIV)of a long slender *** cylinder has a diameter of 10mm and a length of 3.31 m,giving an aspect ratio of *** cylinder was towed by a carriage with the velocity up to 1.5 m/s,with the Reynolds number varying from 2500 to *** different weights were used to provide the initial *** resonance means that resonance occurs simultaneously in both the cross-flow(CF)and in-line(IL)*** experiments were conducted in two *** the first stage,dual-resonant dynamic features of the cylinder subjected to vortex-induced excitation were *** features of CF and IL vibration amplitude,motion orbits,phase angle differences,dominant frequencies and mode order numbers are *** the second stage of the experiments,particular emphasis was placed on non-resonant dynamic *** variation of multi-mode modal displacement amplitudes was investigated in detail.

关键词： vortex-induced vibrations long slender cylinder dual-resonant responses non-resonant responses

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Effects of tension on vortex-induced vibration(ⅥⅤ) responses of a long tensioned cylinder in uniform flows

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Acta Mechanica Sinica 2017年第1期33卷 1-9页

作者： Ling Kang fei ge Xiaodong Wu Youshi hong Institute of Mechanics Chinese Academy of SciencesNo. 15 Beisihuan Xi Road Beijing 100190 China

The effects of tension on vortex-induced vibration (VIV) responses for a tension-dominated long cylinder with an aspect ratio of 550 in uniform flows are experimentally investigated in this paper. The results show that elevated tension suppresses fluctuations of maximum displacement with respect to flow velocity and makes chaotic VIV more likely to appear. With respect to periodic VIV, if elevated tension is applied, the dominant vibration frequency in the in-line (IL) direction will switch from a fundamental vibration frequency to twice the value of the fundamental vibration frequency, which results in a ratio of the dominant vibration frequency in the IL direction to that in the cross-flow direction of 2.0. The suppression of the elevated tension in the fluctuation of the maximum displacement causes the axial tension to become an active control parameter for the VIV maximum displacement of a tension-dominated long riser or tether of an engineering structure in deep oceans. However, the axial tension must be optimized before being used since the high dominant vibration frequency due to the elevated tension may unfavorably affect the fatigue life of the riser or tether.

关键词： Tension effect Maximum displacement Dominant vibration frequency Chaos

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Shear flow induced vibrations of long slender cylinders with a wake oscillator model

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Acta Mechanica Sinica 2011年第3期27卷 330-338页

作者： fei ge Wei Lu Lei Wang You-Shi hong State Key Laboratory of Nonlinear Mechanics Institute of Mechanics CAS 100190 Beijing China

A time domain model is presented to study the vibrations of long slender cylinders placed in shear flow. Long slender cylinders such as risers and tension legs are widely used in the field of ocean engineering. They are subjected to vortex-induced vibrations（VIV） when placed within a transverse incident flow. A three dimensional model coupled with wake oscillators is formulated to describe the response of the slender cylinder in cross-flow and in-line directions. The wake oscillators are distributed along the cylinder and the vortex-shedding frequency is derived from the local current velocity. A non-linear fiuid force model is accounted for the coupled effect between cross-flow and in-line vibrations. The comparisons with the published experimental data show that the dynamic features of VIV of long slender cylinder placed in shear flow can be obtained by the proposed model,such as the spanwise average displacement,vibration frequency,dominant mode and the combination of standing and traveling waves. The simulation in a uniform flow is also conducted and the result is compared with the case of nonuniform flow. It is concluded that the flow shear characteristic has significantly changed the cylinder vibration behavior.

关键词： Vortex-induced vibration Vortex-induced wave Shear flow Wake oscillator Long slender cylinder

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