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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong li Faqin li Zhaoyi chen Erwen Wu Xiaoxi Dai Danni li Haojie An Shiyi Zeng Chunyan Wang li Yang cheng Long School of life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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基于FLUENT的UDS和UDF功能的中子扩散耦合计算研究与快堆应用分析

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四川大学学报（自然科学版） 2020年第2期57卷 324-332页

作者：张雪贝王驰陈红丽中国科学技术大学物理学院

随着计算机性能的不断提高,用CFD与中子学相结合的方法分析复杂的流动与传热现象引起了人们的广泛关注.本文基于FLUENT的UDF(User Defined Function)和UDS(User Defined Scalar)功能对中子扩散方程进行定义,利用FLUENT内基于有限容积法... 详细信息

随着计算机性能的不断提高,用CFD与中子学相结合的方法分析复杂的流动与传热现象引起了人们的广泛关注.本文基于FLUENT的UDF(User Defined Function)和UDS(User Defined Scalar)功能对中子扩散方程进行定义,利用FLUENT内基于有限容积法的求解器对中子扩散方程进行迭代求解,耦合质量、动量、能量方程的迭代求解,在每次迭代计算时,将中子扩散方程迭代计算得到的功率分布(中子通量分布)传递给热工水力计算作为热源项,同时将热工水力计算得到的温度分布传递给中子扩散计算,修正材料的宏观反应截面,实现中子扩散和热工水力在同一求解器和同一套网格下的耦合计算.通过对5×5压水堆组件模型进行建模和计算,将计算结果与其他程序计算结果进行对比,验证该耦合计算方法的可行性和数据传递的正确性.然后将该耦合方法应用到模块化铅冷快堆(M^2LFR-1000)热组件计算中,证明热工水力学参数(燃料最高温度,包壳外表面最高温度)在设计限值范围内.

关键词：核热耦合 UDS UDF 5×5压水堆组件 M^2LFR-1000热组件

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent liCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing Dong Dong chen Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(liBs),properly recycling spent liBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of liB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to liCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/liCoO_(2)mass ratio of 3:1,the leaching efficiency of li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in liCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of liB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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瑞苏伐他汀与阿托伐他汀对2型糖尿病并发冠心病患者血管内皮功能的影响

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中华老年医学杂志 2009年第10期28卷 816-819页

作者：王政李为民陈红丽周宏艳常慧颖哈尔滨医科大学附属第一医院心内一科 150001 哈尔滨医科大学附属第一医院普外四科 150001

目的观察2型糖尿病并发冠心病患者给予瑞苏伐他汀和阿托伐他汀治疗后血管内皮功能的变化。方法收集2008年1-4月门诊及病房临床确诊为2型糖尿病并发冠心病患者73例，随机给予瑞苏伐他汀（10mg／d）或阿托伐他汀（20mg／d），分别测定用... 详细信息

目的观察2型糖尿病并发冠心病患者给予瑞苏伐他汀和阿托伐他汀治疗后血管内皮功能的变化。方法收集2008年1-4月门诊及病房临床确诊为2型糖尿病并发冠心病患者73例，随机给予瑞苏伐他汀（10mg／d）或阿托伐他汀（20mg／d），分别测定用药前及用药3个月后血脂、血清超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）、一氧化氮（NO）、内皮素（ET-1）及内皮依赖性血流介导的血管舒张功能（EDF）。结果用药后3个月后，瑞苏伐他汀组和阿托伐他汀组EDF水平增加[（5．2±2．4）％至（7．9±3．1）％和（5．0±2．8）％至（7．6±3．6）％，p=0．008和0．024]，NO水平增加[（46．6±14．5）pmmol／L至（73．3±18．5）“mmol／I，和（51．7±14．0）μmmol／L至（79．8±16．0）μmmol／L，均为P〈0．001]，ET-1水平下降[（108．2±29．6）Pg／L至（77．5±26．4）Pg／L和（117．1±34．5）Pg／L至（80．7±28．2）pg／L，P=0．005和0．003]，hsCRP水平下降[3．17（1．33～6．32）mg／L至1．39（0．81～2．58）mg／L和3．43（1．51～7．02）mg／L至1．63（0．69～3．11）mg／L，P=0．006和0．001]；但两组间进行比较，差异无统计学意义；血管舒张功能与hs-CRP呈负相关。结论瑞苏伐他汀和阿托伐他汀均可降低hs-CRP，减轻血管内局部炎症反应，改善2型糖尿病并发冠心病患者的血管舒张功能。

关键词：冠状动脉疾病糖尿病 2型降血脂药内皮血管

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Construction of Ni single-atom coordinated with doped N and S elements for mild hydrogenation of methyl acrylate to methyl propionate

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Nano Research 2025年第1期18卷 217-224页

作者： Taolue Sun chen Jian Gang Wang Hui Zhao Guoliang Zhang Zengxi li Chunshan li State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Huizhou Institute of Green Energy and Advanced Materials Huizhou 516081China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516081China

Although the nickel-based catalyst is able toexhibit comparative catalytic activity to noble metal formethyl acrylate hydrogenation,it requires strict reactioncondition,which can be improved by regulation ofcoordination *** this study,we constructed akind of Ni single-atom coordinated with N and S(Ni-NSC)through the pyrolysis of organic Ni-based precursors at600℃.The existence and fine structure of Ni single-atom were confirmed by the spherical electron microscopicobservation in combination with the X-ray absorption spectroscopy(XAS)*** addition,the catalytichydrogenation assessment suggested that the as-prepared Ni-NSC catalyst exhibited higher activity and stability than theNi/NSC supported catalyst prepared by incipient wetness impregnation *** remarkable catalytic activity was dueto the high dispersion and density of Ni single-atom and weak adsorption energy of intermediates on these Ni sites.

关键词： methyl acrylate mild hydrogenation Ni single-atom coordination environment adsorption energy

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基于学习分析的在线学习测评建模与应用——教师综合评价参考模型研究

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电化教育研究 2016年第10期37卷 35-41页

作者：陈耀华郑勤华孙洪涛陈丽北京师范大学远程教育研究中心北京100875 中央民族大学现代教育技术部北京100081

学习支持服务是影响在线教育质量的重要因素。教师作为学习支持服务的主要提供者,扮演着在线教育的重要角色。学习分析技术强调基于数据的学习描述、诊断、预测和干预,使得对学生学习过程的描绘成为可能,从而使我们可以通过对学生学习... 详细信息

学习支持服务是影响在线教育质量的重要因素。教师作为学习支持服务的主要提供者,扮演着在线教育的重要角色。学习分析技术强调基于数据的学习描述、诊断、预测和干预,使得对学生学习过程的描绘成为可能,从而使我们可以通过对学生学习状态变化的衡量来判断和评价教师提供的学习支持服务的效果。本研究以教师的综合评价为目标。我们首先构建了教师综合评价的参考理论模型,包括促进度、投入度、联通度、认可度和调控度五个方面。其次,基于上述理论模型,我们实现了完整的算法构建。最后,我们在网络教育学院的实践中对该理论和算法模型进行了应用和验证。本研究为在线学习中对教师的综合测评提供了理论上的参考,为学习分析技术的实践应用提供了方法和思路上的借鉴。

关键词：学习分析技术教师综合评价参考模型 T-SERI 教师评价

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin li Jian Xiang Lu Qiu Xiaohan chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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微米级MEL分子筛聚集体的制备(英文)

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物理化学学报 2014年第9期30卷 1727-1735页

作者：陈红丽朱树燕何建琴王一萌华东师范大学化学系上海市绿色化学与化工过程绿色化重点实验室上海200062

使用四丁基氢氧化铵-正硅酸四乙酯-水(TBAOH-TEOS-H2O)简单体系一步水热制备了具有多级孔道的微米级MEL结构分子筛聚集体.得到的silicalite-2微米球直径大于10μm且具有高达460 m2·g-1的比表面积和0.74 cm3·g-1的孔体积.微米球的生成... 详细信息

使用四丁基氢氧化铵-正硅酸四乙酯-水(TBAOH-TEOS-H2O)简单体系一步水热制备了具有多级孔道的微米级MEL结构分子筛聚集体.得到的silicalite-2微米球直径大于10μm且具有高达460 m2·g-1的比表面积和0.74 cm3·g-1的孔体积.微米球的生成一定程度上解决了催化应用过程中催化剂的分离和回收问题.同时,水热晶化过程中由纳米粒子自组装而成的晶间介孔缩短了反应物分子的扩散路径,保持了分子筛纳米晶粒的优势.此外,钛活性位的引入并未明显影响MEL微米球的形貌和结构,含钛的MEL微米球TS(钛硅分子筛)-2在苯酚羟基化反应中具有与纳米尺寸TS-1(100-200 nm)相当的催化活性,且TS-2可以通过简单过滤得到,简化了纳米级TS-1的分离和回收过程.

关键词： MEL结构纳米粒子聚集体多级孔道苯酚羟基化

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生物素化壳聚糖修饰的PLGA纳米粒的制备及表征

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高等学校化学学报 2010年第8期31卷 1682-1687页

作者：陈红丽唐红波杨文智陈汉王银松梅林张彤熊青青张其清新乡医学院生命科学技术系河南省遗传性疾病与分子靶向药物重点实验室培育基地新乡453003 中国医学科学院生物医学工程研究所天津市生物材料重点实验室天津300192 天津医科大学药学院天津300070 清华大学深圳研究生院深圳518055 大连医科大学药学院大连116027

合成了生物素化壳聚糖(Bio-CS),并通过核磁共振(1HNMR)及电感耦合等离子体光质谱法(ICP-MS)对其进行结构确证.采用溶剂挥发法(W1/O/W2)制备聚乳酸-羟基乙醇酸(PLGA)纳米粒,并通过共价交联法对纳米粒进行Bio-CS表面修饰.未修饰的PLGA纳... 详细信息

合成了生物素化壳聚糖(Bio-CS),并通过核磁共振(1HNMR)及电感耦合等离子体光质谱法(ICP-MS)对其进行结构确证.采用溶剂挥发法(W1/O/W2)制备聚乳酸-羟基乙醇酸(PLGA)纳米粒,并通过共价交联法对纳米粒进行Bio-CS表面修饰.未修饰的PLGA纳米粒在扫描电镜下观察呈规则球状形态,平均粒径为(248.4±21.0)nm,Zeta电势为-(21.21±2.13)mV,Bio-CS修饰后的PLGA纳米粒保持球状形态,平均粒径为(268.3±23.4)nm,Zeta电势为(25.45±2.59)mV.采用X射线光电子能谱(XPS)以及试剂盒对纳米粒表面生物素进行定性及定量研究,结果显示,经过Bio-CS修饰后的纳米粒表面含有N,S元素,生物素取代度为31%的Bio-CS修饰的PLGA纳米粒,其表面生物素含量为(1.36±0.34)μmol/100mg纳米粒.

关键词：纳米粒聚乳酸-羟基乙醇酸生物素化壳聚糖抗肿瘤

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong li Yuewei chen Nian liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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