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基于网络药理学与动物实验探究扶肾颗粒调控TLR4/NF⁃κB通路防治腹膜透析相关性腹膜炎的机制

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中国中药杂志 2024年第6期49卷 1621-1631页

作者：邢海涛丁凤玫李佳琦周千艺杨洪涛天津中医药大学第一附属医院天津300193 国家中医针灸临床研究中心天津300193

基于网络药理学与动物实验探究扶肾颗粒(Fushen Granules,FSG)抑制腹膜透析(peritoneal dialysis,PD)大鼠炎症状态,防治腹膜透析相关性腹膜炎(peritoneal dialysis⁃related peritonitis,PDRP)的机制。通过中药系统药理学数据库与分析平台筛选扶肾颗粒主要活性成分并进行靶点预测,通过DisGeNET等数据库筛选PDRP相关靶点,利用在线软件作图工具平台获得药物与疾病靶点的交集靶点,并构建可视化扶肾颗粒⁃PDRP核心靶点蛋白⁃蛋白互作(PPI)网络,将得到的276个扶肾颗粒⁃PDRP的“药物⁃疾病”共同靶点导入DAVID数据库进行基因本体(Gene Ontology,GO)功能与京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,筛选出扶肾颗粒治疗PDRP的主要信号通路为TLR4/NF⁃κB;创建5/6肾切除尿毒症大鼠模型,术后2周起,每日定时给予实验大鼠腹腔注射20 mL 1.25%葡萄糖透析液建立PD大鼠模型,假手术组、模型组每日灌胃2 mL生理盐水,扶肾颗粒低(0.54 g·kg^(-1))、中(1.08 g·kg^(-1))、高(2.16 g·kg^(-1))剂量组每日灌胃2 mL,培菲康组每日灌胃2 mL(113.4 mg·kg^(-1))培菲康溶液,干预8周。试剂盒检测大鼠肾功能指标[血肌酐(Scr)、尿素氮(BUN)]含量,EliSA检测血清炎症因子[超敏C反应蛋白(hs⁃CRP)、肿瘤坏死因子⁃α(TNF⁃α)、白细胞介素(IL)⁃6]、脂多糖(LPS)、脂多糖结合蛋白(LBP)含量,苏木精⁃伊红(HE)染色观察结肠组织病理形态,蛋白免疫印迹法(Western blot)检测结肠组织TLR4/NF⁃κB信号通路关键因子LBP、Toll样受体4(TLR4)、NF⁃κB p65蛋白(NF⁃κB p65)、核因子抑制蛋白(IκBα)、TNF⁃α、IL⁃1β蛋白表达。结果显示,与假手术组比较,模型组结肠组织各层结构异常,肠绒毛稀疏、变短,黏膜层可见水肿,间隙变宽,局部发现炎症细胞明显浸润,体质量显著下降(P<0.01),肾功能指标(Scr、BUN)含量均显著升高(P<0.01),血清炎症因子(hs⁃CRP、TNF⁃α、IL⁃6)、LPS、LBP含量均显著升高(P<0.01),LBP、TLR4、NF⁃κB p65、TNF⁃α、IL⁃1β蛋白表达显著升高(P<0.01),IκBα蛋白表达显著降低(P<0.01);与模型组比较,扶肾颗粒低、中、高剂量组与培菲康组大鼠结肠组织肠绒毛受损有不同程度减轻,黏膜下层水肿减轻,间隙变窄,固有层炎症细胞浸润减少,扶肾颗粒中、高剂量组及培菲康组肾功能指标(Scr、BUN)含量均显著降低(P<0.05或P<0.01),血清炎症因子(hs⁃CRP、TNF⁃α、IL⁃6)含量均显著降低(P<0.05或P<0.01),扶肾颗粒组与培菲康组血清LPS、LBP含量显著降低(P<0.01),扶肾颗粒组LBP、TLR4、NF⁃κB p65、TNF⁃α、IL⁃1β蛋白表达显著降低(P<0.05或P<0.01),IκBα蛋白表达显著升高(P<0.01),培菲康组LBP蛋白表达显著降低(P<0.01)。结果提示,扶肾颗粒可保护PD大鼠残余肾功能,减轻炎症反应,保护结肠组织。基于网络药理学筛选出TLR4/NF⁃κB通路可能是扶肾颗粒治疗PDRP的主要信号通路。结果表明,扶肾颗粒通过调节PD大鼠结肠TLR4/NF⁃κB通路关键因子蛋白表达,改善肠道炎症反应、保护肠屏障防治PDRP。

关键词：扶肾颗粒腹膜透析腹膜炎网络药理学 TLR4/NF⁃κB通路

Comprehensive insights:unraveling the mechanisms of gut commensals in glucose metabolism regulation

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Science China(life Sciences) 2024年第2期67卷 414-417页

作者： Zhipeng li Qixing Nie Shao-Ping Nie State Key Laboratory of Food Science and Resources China-Canada Joint Lab of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang 330047China

The prevalence of type 2 diabetes(T2D)has escalated to a global epidemic,garnering widespread *** research utilizing germ-free(GF)mice,antibiotic treatments,and fecal microbiota transplantation approaches has established the critical role of gut microbiota in modulating glucose *** microbiota interacts with diets and the mucosal immune system,influencing intestinal permeability and the penetration of microbial products.

关键词： metabolism utilizing insight

Upregulation of the glycine-rich protein-encoding gene GhGRPL enhances plant tolerance to abiotic and biotic stressors by promoting secondary cell wall development

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Journal of Integrative Agriculture 2024年第10期23卷 3311-3327页

作者： Wanting Yu Yonglu Dai Junmin Chen Aimin liang yiping Wu Qingwei Suo Zhong Chen Xingying Yan Chuannan Wang Hanyan Lai Fanlong Wang Jingyi Zhang Qinzhao liu yi Wang Yaohua li lingfang Ran Jie Xiang Zhiwu Pei Yuehua Xiao Jianyan Zeng College of Agronomy and Biotechnology Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China Chongqing Key Laboratory of Crop Molecular Improvement Chongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China

Abiotic and biotic stressors adversely affect plant survival,biomass generation,and crop *** the global availability of arable land declines and the impacts of global warming intensify,such stressors may have increasingly pronounced effects on agricultural ***,researchers face the overarching challenge of comprehensively enhancing plant resilience to abiotic and biotic *** secondary cell wall plays a crucial role in bolstering the stress resistance of *** increase plant resistance to stress through genetic manipulation of the secondary cell wall,we cloned a cell wall protein designated glycine-rich protein-like(GhGRPL)from cotton fibers,and found that it is specifically expressed during the period of secondary cell wall ***,this protein differs from its Arabidopsis homolog,AtGRP,since its glycine-rich domain is deficient in glycine *** is involved in secondary cell wall *** of GhGRPL enhances lignin accumulation and,consequently,the thickness of the secondary cell walls,thereby increasing the plant’s resistance to abiotic stressors,such as drought and salinity,and biotic threats,including Verticillium dahliae ***,interference with GhGRPL expression in cotton reduces lignin accumulation and compromises that *** together,our findings elucidate the role of GhGRPL in regulating secondary cell wall development through its influence on lignin deposition,which,in turn,reinforces cell wall robustness and *** findings highlight the promising near-future prospect of adopting GhGRPL as a viable,effective approach for enhancing plant resilience to abiotic and biotic stress factors.

关键词： glycine-rich protein-like secondary cell wall abiotic stress biotic stress stress resistance

The CLAVATA signaling:a roadmap to optimize grain shape in rice

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Journal of Genetics and Genomics 2024年第7期51卷 677-679页

作者： Shaoyan Shen Bingyang Jiao Yunhai li Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Advanced Agriculture University of Chinese Academy of SciencesBeijing 100039China

The shoot apical meristem(SAM)is the source of all postembryonic cells in aerial parts of a plant,and large shoot meristems with an increased stem cell population hold promise for enhancing yield(li et al.,2022).

关键词： grain shape shoot

Rapid and real-time detection of municipal sludge moisture content based on microwave reflection principle

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Waste Disposal and Sustainable Energy 2024年第2期6卷 259-269页

作者： Yan Zhang Yanhong Jiao Jun li Long Deng Binqi Rao Hao Xu Peng Xu lijiang Hu Chunping li College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018China New Energy Engineering and Automotive College Huzhou Vocational and Technical CollegeHuzhou 313099China College of Electronics and Information Engineering Wuxi UniversityWuxi214105China National Institute of Metrology Beijing 100029China College of Science China Jiliang UniversityHangzhou 310018China Anji Guoqian Environment Co. LtdHuzhou 313300China Zhejiang hongshi Environmental Protection Co. LtdJinhua 321100China

The moisture content(MC)of municipal sludge is the key factor affecting sludge treatment and disposal technologies,while the vast majority of existing measurement methods are off-line and *** realize rapid online detection for the MC of sludge,a detection method based on the microwave reflection principle is proposed:experiments are carried out and the MC computation model of the sludge is derived using the resonant frequency and the permittivity(e').The results reveal that the detection accuracy of granular sludge with a thickness of 10 mm is *** theoretical model between the MC and the real part of e'is developed,and the relationship between the resonant frequency and e'is expressed by a cubic *** average error and the root mean square error(RMSE)of sludge are 2.06%and 2.49%,*** prediction model for the MC of sludge is also given,and the determination coefficient and RMSE are 0.981 and 2.06%,respectively.

关键词： Municipal sludge Moisture content Resonator Real-time detection Resonant frequency

Dt1-SWEET10a partner:Photoperiodic control of seed weight in soybean

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Molecular Plant 2024年第6期17卷 839-841页

作者： li-Qing Chen Lalit Dev Tiwari Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA DOE Center for Advanced Bioenergy and Bioproducts Innovation University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Institute for Sustainability Energyand EnvironmentUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Seed weight and size are critical agronomic traits essential for determining yield and composition,receiving significant attention throughout domestication(Meyer et al.,2012).Seed weight serves as a reliable indicator of average seed size due to their positive *** of seed weight involves both developmental and environmental cues,affecting cell proliferation or expansion(li et al.,2019).

关键词： soybean SWEET1 weight

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并网型退役动力电池储能系统优化控制策略

科学技术与工程 2024年第25期24卷 10815-10824页

作者：黄志礼蔺红新疆大学电气工程学院乌鲁木齐830017

为实现并网型退役动力电池储能系统的安全可靠运行,基于长短期记忆网络(long short-term memory,LSTM)、模型预测控制(model predictive control,MPC)和载波移相调制,提出了一种LSTM-MPC耦合控制与载波移相调制方法相结合的退役动力电... 详细信息

为实现并网型退役动力电池储能系统的安全可靠运行,基于长短期记忆网络(long short-term memory,LSTM)、模型预测控制(model predictive control,MPC)和载波移相调制,提出了一种LSTM-MPC耦合控制与载波移相调制方法相结合的退役动力电池储能系统优化控制策略。首先,利用实时电流电压,通过LSTM网络和离散模型持续预测下一时刻不同开关状态下的各相的荷电状态(state of charge,SOC)、电压、电流、输出功率;其次,计算变换器所有开关状态下对应的成本函数,建立成本函数最小的优化控制目标,将成本函数值最小的变换器状态作为下一时刻的输入状态;再次,利用系统离散模型计算出最优输出电压与系统单相总电压之比,并将其作为载波移相调制算法的占空比,生成子模块开关信号,在一个调度周期内不断迭代此过程,进行反馈校正,从而实现最优控制。最后,针对电网电压平衡和不平衡工况,从功率跟踪、SOC跟踪、负序电流抑制、功率波动抑制等方面验证了所提控制策略的有效性。仿真结果表明:所提控制策略能够有效实现并网型退役动力电池储能系统的功率跟踪、SOC跟踪。

关键词：电池储能长短期记忆网络模型预测控制荷电状态

A rare case of hepatic vein-portal vein fistula with hepatolithiasis presenting as cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 538-540页

作者： Wei li Wen lin Le Xiao General Surgery Center The General Hospital of Western Theater CommandChengdu 610083China

To the Editor: We sincerely applaud the work by Tang et al., in which they described caudate lobe-sparing subtotal hepatectomy as treatment for intrahepatic arterioportal fistulas [ 1 ]. Compared to intrahepatic arterioportal fistulas, portal vein-hepatic vein fistulas are rarely reported. Patients typically lack clinical symptoms such as hyperammonemia, cholestatic jaundice, and hypoglycemia, unless the shunt becomes relatively large [ 2, 3 ]. Herein, we describe partial hepatectomy as a treatment for cases of left portal vein-middle hepatic vein fistulas.

关键词： hepatic clinical

Timing effect of high temperature exposure on the plasticity of internode and plant architecture in maize

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Journal of Integrative Agriculture 2024年第2期23卷 551-565页

作者： Binbin li Xianmin Chen Tao Deng Xue Zhao Fang li Bingchao Zhang Xin Wang Si Shen Shunli Zhou College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China China Tobacco Hunan Industrial Corporation Changsha 410019China Innovation Center of Agricultural Technology for Lowland Plain of Hebei Wuqiao 061802China

The occurrence of high temperature(HT)in crop production is becoming more frequent and unpredictable with global warming,severely threatening food *** state of an organ’s growth and development is largely determined by the temperature conditions it is exposed to over *** is the main cereal crop,and its stem growth and plant architecture are closely related to lodging resistance,and especially sensitive to ***,systematic research on the timing effect of HT on the sequentially developing internode and stem is currently *** identify the timing effect of HT on the morphology and plasticity of the stem in maize,two hybrids(Zhengdan 958(ZD958),Xianyu 335(XY335))characterized by distinct morphological traits in the stem were exposed to a 7-day HT treatment from the V6 to V17 stages(Vn presents the vegetative stage with n leaves fully expanded)in *** results demonstrated that exposure to HT during V6-V12 accelerated the rapid elongation of *** instance,HT occurring at V7 and V12 specifically promoted the lengths and weights of the 3rd-5th and 9th-11th internodes,***,HT slowed the growth of internodes adjacent to the promoted ***,compared with control,the plant height was significantly increased soon after HT treatment,but the promotion effect became narrower at the subsequent flowering stage,demonstrating a self-adjusting mechanism in the maize plant in response to ***,HT altered the plant architectures,including a rising of the ear position and increase in the ear position ***335 exhibited greater sensitivity in stem development than ZD958 under HT *** findings improve our systematic understanding of the plasticity of internode and plant architecture in response to the timing of HT exposure.

关键词： maize high temperature internode growth plasticity plant architecture