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Association of novel mutations and heplotypes in the preSregion of hepatitis B virus with hepatocellular carcinoma

Frontiers of Medicine 2010年第4期4卷 419-429页

作者： Jia-Xin XIE Jun ZHAO Jian-Hua YIN Qi zhang Rui PU Wen-Ying LU hong-wei zhang hong-Yang WANG Guang-Wen CAO Department of Epidemiology Second Military Medical UniversityShanghai 200433China Department of Hepatobiliary Surgery the 3rd Affiliated HospitalSecond Military Medical UniversityShanghai 200433China International Laboratory for Signal Transduction the 3rd Affiliated HospitalSecond Military Medical UniversityShanghai 200433China

The association of viral mutations and haplo-typic carriages with mutations in the preS region of hepatitis B virus(HBV)genotypes B and C with hepatocellular carcinoma(HCC)is of great signiﬁcance for the prediction of this malignancy,but it remains *** analyzed the preS sequences of HBV genotypes B and C from 1172 HBV-infected subjects including 231 patients with *** compared with the HBV-infected subjects without HCC,C2875T,G2946C,A3054C,C3060A,T3066C,C3116T,A3120C,G3191A,A1C,C7A,C10A,A31C,C76T,G105C,and G147C in both genotypes were signiﬁcantly associated with increased risks of HCC.C2875A,G2950A,G2951A,A3054T,C3060T,T3066A,T3069G,A3120T,and G3191C were signiﬁcantly associated with increased risks of HCC in genotype C,whereas these mutations were inversely associated with HCC in genotype *** regression analyses showed that C76A/T was a novel factor independently associated with an increased risk of HCC,as compared with those without *** frequencies of haplotypes 2964A-3116T-preS2 start codon wild-type-7C,2964C-3116T-7A-76C,and 2964A-3116T-7C-76A/T were signiﬁcantly higher in the patients with HCC(P<0.001),whereas a haplotypic carriage with a single mutation and another three wild-types were inversely associated with ***,the association of HBV mutations in the preS region with HCC depends on HBV genotype and haplotypic carriage with two or more mutations that are each associated with an increased risk of HCC independently.

关键词： hepatitis B virus hepatocellular carcinoma mutation genotype haplotype

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Both host and diet shape bacterial communities of predatory mites

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Insect Science 2024年第2期31卷 551-561页

作者： hong Yan Endong Wang Guo-Shu wei Bo zhang Xuenong Xu Institute of Plant Protection Chinese Academy of Agricultural SciencesBejingChina College of Plant Protection Hebei Agricultural UniversityBaodingHebei ProvinceChina Key Laboratory of Natural Enemies Insects Ministry of Agriculture and Rural AffairsBeijingChina

Microbial communities,derived from food,ambient,and inner,can affect host ecological adaption and *** with most phytophagous arthropods,predators may have more opportunities to develop specific microbiota depending on the level of prey *** explore how diet sources affect host microbial communities and vary across predator species,we considered 3 types of predators from Phytoseiidae(Acari:Mesostigmata):polyphagous(Amblyseius orientalis Ehara,Neoseiulus barkeri Hughes,and Amblyseius swirski Athias-Henrio),oligophagous(Neoseiulus californicus McGregor),and monophagous(Phytoseiulus persimilis Athias-Henriot)predatory *** polyphagous species were fed on 2 types of diets,natural prey and alternative *** using 16S rRNA sequencing,we found that diet was the main source of microbiota in predatory mites,while there was no clear pattern affected by prey *** 3 polyphagous predators,host species had a larger impact than prey on microbial *** *** or *** which showed consistency in their microbiota,prey switching significantly affectedβ-diversity of bacterial composition in ***,with 56%of the microbial *** short,our results confirmed the substantial influence of diet on host microbial construction in predatory species,and highlighted species differences in shaping the microbiota which are not necessarily related to prey specialization.

关键词： diet switching feeding habits host-microbial interactions invertebrate microbiota 16S rRNA

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Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第38期17卷 4258-4270页

作者： Yi-Fang Han Jun Zhao Li-Ye Ma Jian-Hua Yin Wen-Jun Chang hong-wei zhang Guang-Wen Cao Department of Epidemiology Second Military Medical University Shanghai 200433 China Department of Hepatobiliary Surgery the 3rd Affiliated Hospital Second Military Medical University Shanghai200433 China Department of General Surgery the 1st Affiliated Hospital Second Military Medical University Shanghai200433 China

Primary liver cancer is an important cause of cancer death, and hepatocellular carcinoma （HCC） accounts for 70%-85% of total liver cancer worldwide. Chronic hepatitis B virus （HBV） infection contributes to 〉 75% of HCC cases. High serum viral load is the most reliable indicator of viral replication in predicting development of HCC. HBV genotype C is closely associated with HCC in cirrhotic patients aged 〉 50 years, whereas genotype B is associated with development of HCC in non-cirrhotic young patients and postoperative relapse of HCC. Different HBV subgenotypes have distinct patterns of mutations, which are clearly associated with increased risk of HCC. Mutations accumulate during chronic HBV infection and predict occurrence of HCC. Chronic inflammation leads to increased frequency of viral mutation via cellular cytidine deaminase induction. Mutations are negatively selected by host immunity, whereas some immuno-escaped HBV mutants are active in hepatocarcinogenesis. Inflammatory pathways contribute to the inflammation-necrosis-regeneration process, ultimately HCC. Their hallmark molecules can predict malignancy in HBV-infected subjects. Continuing inflammation is involved in hepatocarcinogenesis and closely related to recurrence and metastasis. HBV load, genotype C, viral mutations and expression of inflammatory molecules in HBV-related HCC tissues are significantly associated with poor prognosis. Imbalance between intratumoral CD8^＋T cells and regulatory T cells or Thl and Th2 cytokines in peritumoral tissues can predict prognosis of HBV-related HCC. These factors are important for developing active prevention and surveillance of HBV-infected subjects who are more likely to develop HCC, or for tailoring suitable treatment to improve survival or postpone postoperative recurrence of HCC.

关键词： Hepatitis B virus Hepatocellular carcinoma Viral load Genotype Mutation Immune cells Signal-ing pathway Cytokine Prognosis

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Spectrum of Diseases in Female Children and Adolescents Admitted to the Obstetrics and Gynecology Hospital, Shanghai, between 2003 and 2017

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Reproductive and Developmental Medicine 2019年第1期3卷 54-59页

作者： Hai-Xia Huang Ming-Xing zhang hong-wei zhang Meng zhang Yi Yu Yu Kang Gui-Ling Li Cong-Jian Xu Department of Gynecology Obstetrics and GynecologyHospital of Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Objective:To investigate the spectrum of diseases in female children and adolescents hospitalized for obstetric and gynecological ***:This retrospective study included patients(age≤19 years)admitted to the Obstetrics and Gynecology Hospital of Fudan University,Shanghai,between January 2003 and December *** medical records-age,principal diagnosis,and treatment-were reviewed and *** were divided into eight disease *** between groups was analyzed with Student’s ***:This study enrolled 4,628 *** number of inpatients increased each year,especially in the groups of gynecologic tumors,pregnancy-related conditions,and disorders of the *** mean age was 16.33±2.42 years(range:2-19 years).Of all the inpatients,41.9%(n=1,939)were hospitalized for gynecologic tumors,and 85.5%(n=1,657)of the tumors were ***,ovarian cysts(28.66%,n=1,325)were the most common disease observed in this *** addition,32.9%(n=1,524)of the inpatients were hospitalized for pregnancy,childbirth,and puerperium;within this group,21.9%(n=1,014)were hospitalized for artificial ***:The efforts of all stakeholders toward the implementation of government policies to promote sexual and reproductive health among children and adolescents in China have been effective.

关键词： Children and Adolescents Disease Attributes Hospitalized Reproductive Health Education

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Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles

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Chinese Chemical Letters 2024年第3期35卷 252-256页

作者： Yu zhang De-Rui Han Dan Ye hong Lu Hao wei Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry&Materials ScienceNorthwest UniversityXi'an 710069China

An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused *** key pre-aromatic spirocyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagentⅡpromoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C–C *** using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.

关键词： Phosphine catalysis Acyl-transfer N-Fused heterocycles C–C bond activation Aromatization

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Functional reconstruction of ischemic contracture in the lower limb

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Chinese Journal of Traumatology 2011年第2期14卷 96-99页

作者： TANG Hao zhang Shao-cheng TAN zhang-yong ZHU hong-wei zhang Qiu-lin LI Ming Department of Orthopedics Changhai Hospital Second Military University Shanghai 200433 China

Objective： To discuss the method of functional reconstruction of ischemic contracture in the lower limb and propose a classification protocol for ischemic contracture in the lower limb based on its severity and prognosis. Methods： Atotal of 42 patients with ischemic contracture in the lower limb were included in this study. According to different types of disturbance and degrees of severity, surgical reconstructions consisting of nerve decompression, tendon lengthening or transfer, intrinsic foot muscle release and sural-tibial nerve anastomosis were performed in every patient. Results： Postoperatively, all patients were able to walk on flat ground. Drop foot was corrected in 10 patients, and 5 patients still felt some difficulty during stair activity. Split Achilles tendon transfer to flexor hallucis longus tendon was performed in 12 patients, and their walking stability was improved. Seven patients accepted ipsilateral suraltibial nerve anastomosis, and sensitivity recovery reached to S2 in 2 patients and S3 in 5 patients. Conclusions： Iscbemic contracture in the lower limb is a devastating complication after lower limb trauma. The prevention of contracture is much more important than the treatment of an established contracture. Split Achilles tendon transfer to flexor hallucis longus tendon and sural-tibial nerve anastomosis, which was initially implemented by us, could improve the functional recovery of ischemic contracture in lower limbs, and thus provides a new alternative for functional reconstruction of ischemic contracture in the lower limb.

关键词： Ischemic contracture Classification Recovery of function

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Acaricidal effect of the antimicrobial metabolite xenocoumacin 1 on spider mite control

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Journal of Integrative Agriculture 2024年第3期23卷 948-959页

作者： Jiaxing wei hong Yan Jie Ren Guangyue Li Bo zhang Xuenong Xu Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory for Biology of Plant Diseases and Insect Pests Beijing 100193China Key Laboratory of Natural Enemies Insects Ministry of Agriculture and Rural AffairsBeijing 100193China

The two-spotted spider mite,Tetranychus urticae Koch,is one of the most harmful pests in many agroecosystems *** effectively manage this pest,there is an urgent need to develop novel bio-active acaricides that support integrated pest management strategies targeting *** this study,we explored the acaricidal effects of xenocoumacin 1 (Xcn1) on *** and its predator Neoseiulus californicus using the highly puri?ed ***1 was extracted and purified from the cell-free supernatant of the Xenorhabdus nematophila CB6 mutant constructed by the easy promoter activated compound identi?cation (easyPACId) *** the concentration of Xcn1 exceeded 100μg mL~(–1),the survival rate of spider mite adults declined to below 40%and the fecundity was decreased by 80%at six days *** concentrations of 25 and 50μg mL~(–1),Xcn1 signi?cantly impeded spider mite development by inhibiting the ***,neither concentration had any adverse effects on the survival or reproduction of the predatory mite *** results from laboratory and semi-?eld experiments consistently demonstrated the effectiveness of the antimicrobial metabolite Xcn1 in controlling pest mites at both the molecular and physiological *** study offers a promising possibility that combines the compatible biocontrol agents of Xcn1 and predatory mites for integrated pest mite control.

关键词： pest management predatory mite Xcn1 morphology developmental inhibition transcriptome

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Environmental characteristics of trace metals in seawater from the Ninety East Ridge in the Indian Ocean

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Journal of Oceanology and Limnology 2024年第4期42卷 1119-1129页

作者： Jingxi LI Di zhang Fenghua JIANG hong CHEN wei CAO Chengjun SUN Key Laboratory of Marine Eco-Environmental Science and Technology First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Laoshan Laboratory of Marine Science and Technology Laboratory of Marine Drugs and Biological ProductsQingdao 266071China

The Ninety East Ridge in the Indian Ocean has complex and unique *** concentrations and distribution characteristics of 10 trace metals(V,Cr,Mn,Fe,Co,Ni,Cu,Cd,Pb,and U)in seawater from the Ninety East Ridge in the Indian Ocean were *** show that the average concentrations of different trace metals in all the collected seawater samples were 1.134μg/L for V,0.158μg/L for Cr,0.489μg/L for Mn,0.427μg/L for Fe,0.011μg/L for Co,0.395μg/L for Ni,0.403μg/L for Cu,0.097μg/L for Cd,0.139μg/L for Pb,and 3.470μg/L for *** in the horizontal and vertical distributions of all measured trace metals were revealed,and the occurrence of high concentrations was *** addition,the significant differences in the concentration distribution of different trace metals in seawater on both sides of the Ninety East Ridge present regional segmentation in the area for various trace metals in deep sea *** study provided basic data for future investigations on the environmental and ecological impact of trace metals in the Indian Ocean and the potential water mass transport mechanism.

关键词： trace metal environmental characteristic Ninety East Ridge seawater Indian Ocean

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Efficient wide-bandgap perovskite solar cells with open-circuit voltage deficit below 0.4 V via hole-selective interface engineering

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Science China Chemistry 2024年第6期67卷 2102-2110页

作者： Xiaoyu Ji Shuo zhang Furong Yu Huidong zhang Liqing Zhan Yue Hu wei-hong Zhu Yongzhen Wu Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials ChemistryFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China School of Chemistry University of EdinburghKing’s BuildingsEdinburghEH93FJUK

Wide-bandgap mixed-halide perovskite solar cells(WBG-PSCs)are promising top cells for efficient tandem photovoltaics to achieve high power conversion efficiency(PCE)at low ***,the open-circuit voltage(V_(OC))of WBG-PSCs is still unsatisfactory as the V_(OC)-deficit is generally larger than 0.45 ***,we report a buried interface engineering strategy that substantially improves the V_(OC)of WBG-PSCs by inserting amphiphilic molecular hole-selective materials featuring with a cyanovinyl phosphonic acid(CPA)anchoring group between the perovskite and *** assembly and redistribution of CPA-based amphiphilic molecules at the perovskite-substrate buried interface not only promotes the growth of a low-defect crystalline perovskite thin film,but also suppresses the photo-induced halide phase *** energy level alignment between wide-bandgap perovskite and the hole-selective layer is further improved by modulating the substituents on the triphenylamine donor moiety(methoxyls for MPA-CPA,methyls for Me PA-CPA,and bare TPA-CPA).Using a 1.68 e V bandgap perovskite,the Me PA-CPA-based devices achieved an unprecedentedly high V_(OC)of 1.29 V and PCE of 22.3%under standard AM 1.5 *** V_(OC)-deficit(<0.40 V)is the lowest value reported for *** work not only provides an effective approach to decreasing the V_(OC)-deficit of WBG-PSCs,but also confirms the importance of energy level alignment at the charge-selective layers in PSCs.

关键词： cyanovinyl phosphonic acid energy level alignment hole-selective material open-circuit voltage wide-bandgap perovskite

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Strong light–matter interactions based on excitons and the abnormal all-dielectric anapole mode with both large field enhancement and low loss

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Photonics Research 2024年第4期12卷 854-864页

作者： YAN-HUI DENG YU-wei LU HOU-JIAO zhang Zhong-hong SHI zhang-KAI ZHOU XUE-HUA WANG State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong–hong Kong–Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The room temperature strong coupling between the photonic modes of micro/nanocavities and quantum emitters(QEs) can bring about promising advantages for fundamental and applied *** the electric fields(EFs) by using plasmonic modes and reducing their losses by applying dielectric nanocavities are widely employed approaches to achieve room temperature strong ***,ideal photonic modes with both large EFs and low loss have been ***,we propose the abnormal anapole mode (AAM),showing both a strong EF enhancement of~70-fold (comparable to plasmonic modes) and a low loss of 34 meV,which is much smaller than previous records of isolated all-dielectric *** realizing strong coupling,we further show that by replacing the normal anapole mode with the AAM,the lasing threshold of the AAM-coupled QEs can be reduced by one order of magnitude,implying a vital step toward on-chip integration of nanophotonic devices.

关键词： dielectric mode coupling

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