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Clinical, sonographic characteristics and long-term prognosis of valvular heart disease in elderly patients

Journal of Geriatric Cardiology 2019年第1期16卷 33-41页

作者： Feier SONG Fang-Zhou LIU Yuan-Feng LIANG Gary Tse Xin LI hong-tao liao Ji-Yan CHEN Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina Guangdong Geriatric Institute Guangdong Provincial People s Hospital and Guangdong Academy of Medical SciencesGuangzhouChina Department of Medicine and Therapeutics Faculty of MedicineChinese University of Hong KongHong KongChina Iinstitute of Health Sciences Faculty of MedicineChinese University of Hong KongHong KongChina

Background Valvular heart disease(VHD)is expected to become more prevail as the population ages and disproportionately affects older ***,direct comparison of clinical characteristics,sonographic diagnosis,and outcomes in VHD patients aged over 65 years is *** objective of this study was to evaluate the differences in clinical characteristics and prognosis in two age-groups of geriatric patients with *** We retrospectively enrolled consecutive individuals aged>65 years from Guangdong Provincial Peopled Hospital and screened for VHD using transthoracic echocardiography(TTE)or transesophageal echocardiography(TEE).Finally,260(48.9%)patients were in the 65-74 years group,and 272(51.1%)were in the>75-year *** that affected long-term survival was explored.A multivariable Cox hazards regression was performed to identify the predictors of major adverse cardiac events(MACEs)in each *** In our population,the older group were more likely to have chronic obstructive pulmonary disease(COPD),degenerative VHD,but with less rheumatic VHD,aortic stenosis(AS)and mitral stenosis(MS).Compared with those aged 65-74 years,the older group had a higher incidence of all-cause death(10.0%vs.16.5%,P=0.027),ischemic stroke(13.5%vs.20.2%,P=0.038)and MACEs(37.3%vs.48.2%,P=0.011)at long-term *** multivariable Cox regression analysis,mitral regurgitation,a history of COPD,chronic kidney disease,diabetes,hypertension,atrial fibrillation and New York Heart Association(NYHA)functional class were identified as independent predictors of MACEs in the older *** Advanced age profoundly affect prognosis and different predictors were associated with MACEs in geriatric patients with VHD.

关键词： Echocardiography Geriatrics Mortality Prognosis The aged Valvular heart disease

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Left atrial enlargement and non-paroxysmal atrial fibrillation as risk factors for left atrial thrombus/spontaneous Echo contrast in patients with atrial fibrillation and low CHA2DS2-VASc score

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Journal of Geriatric Cardiology 2020年第3期17卷 155-159页

作者： Wei-Dong LIN Yu-Mei XUE Fang-Zhou LIU Xian-hong FANG Xian-Zhang ZHAN hong-tao liao Gary Tse Shu-Lin WU Guangdong Cardiovascular Institute Guangdong General HospitalGuangzhouChina Department of Medicine and Therapeutics Faculty of MedicineChinese University of Hong KongHong KongChina Li Ka Shing Institute of Health Sciences Faculty of MedicineChinese University of Hong KongHong KongChina

Objective To determine the risk factors for thromboembolism in lower risk patients with non-valvular atrial fibrillation(AF)and low CHA2DS2-VASc scores,which remain *** We retrospectively analyzed the baseline clinical characteristics,routine laboratory parameters,and echocardiographic measurements of 705 patients(71.1%male;mean age:52.10±9.64 years)with low CHA2DS2-VASc score(0 or 1;1 point for female sex)out of 1346 consecutive patients with non-valvular AF who underwent transesophageal echocardiography(TEE)at Guangdong Cardiovascular Institute between January 2013 and December *** Patients with left atrial thrombus(LAT)or spontaneous echo contrast(SEC)on TEE(24/705,4%)showed a higher incidence rate of vascular disease(54.2%vs.32.9%,P=0.045)and non-paroxysmal AF(79.2%vs.29.4%,P<0.001),larger left atrial diameter(43.08±4.59 vs.36.02±5.53 mm,P<0.001),and lower left ventricular ejection fraction(58.23±8.82%vs.64.15±7.14%,P<0.001)than those *** logistic regression analysis identified left atrial diameter[odds ratio(OR)=1.171,95%confidence interval(CI):1.084–1.265,P<0.001]and non-paroxysmal AF(OR=3.766,95%CI:1.282–11.061,P=0.016)as independent risk factors for LAT/*** ROC curve analysis,a left atrial dimeter cutoff of 37.5 mm yielded 95.0%sensitivity and 62.7%specificity(AUC:0.847,P<0.0001,95%CI:0.793–0.914).Conclusion In patients with non-valvular AF with low CHA2DS2-VASc score,the presence of LAT or SEC was associated with left atrial enlargement,which had moderate predictive value,and non-paroxysmal AF.

关键词： Atrial fibrillation Left atrial diameter Left atrial spontaneous echo contrast Left atrial thrombus

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Prevalence and modifiable risk factors of degenerative valvular heart disease among elderly population in southern China

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Journal of Geriatric Cardiology 2021年第7期18卷 523-533页

作者： Shang-Fei HE Jun-Rong JIANG Fang-Zhou LIU hong-tao liao Yu-Mei XUE Mu-Rui ZHENG Huo-Xing LI Hai DENG Shu-Lin WU South China University of Technology School of Medicine GuangzhouChina Department of Cardiology Guangdong Provincial People’s HospitalGuangzhouChina Guangzhou Center for Disease Control and Prevention GuangzhouChina Qinghai Province Cardio Cerebrovascular Disease Specialist Hospital XiningChina

Objective To investigate the prevalence and modifiable risk factors of degenerative valvular heart disease(DVHD)among elderly population in southern *** A stratified multistage sampling method was used to recruit *** contents of the survey included the questionnaire,laboratory examination,echocardiography,and other auxiliary *** possible risk factors of DVHD were analyzed by logistic regression *** A total of 3538 subjects≥65 years of age were *** thousand three hundred and seven subjects(36.9%)were diagnosed with *** was the most common etiology of *** of DVHD increased with advancing *** prevalence of DVHD differed by living region(χ^(2)=45.594,P<0.001),educational level(χ^(2)=50.557,P<0.001),and occupation(χ^(2)=36.961,P<0.001).Risk factors associated with DVHD included age(two-fold increased risk for each 10-year increase in age),elevated level C-reactive protein(OR=1.346,95%CI:1.100-1.646),elevated level low density lipoprotein(OR=1.243,95%CI:1.064-1.451),coronary artery disease(OR=1.651,95%CI:1.085-2.513),smoking(OR=1.341,95%CI:1.132-1.589),and hypertension(OR=1.414,95%CI:1.221-1.638).Other significant risk factors included reduced or elevated level red blood cell(OR=1.347,95%CI:1.031-1.761;OR=1.599,95%CI:1.097-2.331;respectively),elevated level platelets(OR=1.891,95%CI:1.118-3.198),elevated level uric acid(OR=1.282,95%CI:1.112-1.479),and stroke(OR:1.738,95%CI=1.085-2.513).Conclusions The survey characterized the baseline conditions of DVHD cohort of elderly population in Guangzhou *** established and emerging risk factors for DVHD may represent challenges and opportunities for therapy.

关键词： elevated degenerative occupation

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Automated Ultra-High Density Mapping in atrial fibrillation hybrid procedure

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Journal of Geriatric Cardiology 2018年第5期15卷 379-381页

作者： Fang-Zhou LIU hong-tao liao Jian LIU Yu-Mei XUE Xian-Zhang ZHAN Wei-Dong LIN Hui-Ming GUO Shu-Lin WU Department of Cardiology Atrial fibrillation center Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Province Key Labora- tory of Structural Heart Disease Guangdong Academy of Medical Sciences Guangdong China Department of Cardiac surgery Atrial fibrillation center Guangdong Cardiovascular Institute Guangdong General Hospital Cruangdong Province Key Laboratory of Structural Heart Disease Guangdong Academy of Medical Sciences Guangdong China

A 70-year-old female visited our hospital due to a 5-year history of long-standing persistent atrial fibrillation （LSPsAF） refractory to medical treatment. Chest x-ray and echocardiography were free of abnormalities and did not detect manifest structural heart disease. A hybrid AF pro- cedure （Epicardial thoracoscopic ablation ＋ appendage re- section, and endocardial catheter ablation） was referred to patient.

关键词： Atrial fibrillation Hybrid Ultra-high density

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Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non-valvular atrial fibrillation

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Journal of Geriatric Cardiology 2018年第6期15卷 408-412页

作者： Xian-Zhang ZHAN Wei-Dong LIN Fang-Zhou LIU Yu-Mei XUE hong-tao liao Xin LI Xian-hong FANG Hai DENG Jun HUANG Yang-Qiu LI Jo-Jo HAI Hung-Fat Tse Shu-Lin WU Department of Hematology the First Affiliated Hospital Jinan University Guangzhou China Department of Cardiology Atrial Fibrillation Center Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou China Cardiology Division Department of Medicine Queen Mary Hospital the University of Hong Kong Hong Kong China Division of Cardiology Department of Medicine the University of Hong Kong Shenzhen Hospital Shenzhen China

Objective To evaluate the predictive value of red cell distribution width （RDW） on left atrial thrombus （LAT） or left atrial spontane- ous echo contrast （LASEC） in patients with non-valvular atrial fibrillation （AF）. Methods We reviewed 692 patients who were diagnosed as non-valvular AF and underwent transesophageal echocardiography （TEE） in Guangdong Cardiovascular Institute from April 2014 to December 2015. The baseline clinical characteristics, laboratory test of blood routine, electrocardiograph measurements were analyzed. Results Eighty-four patients were examined with LAT/LASEC under TEE. The mean RDW level was significantly higher in LAT/LASEC patients compared with the non-LAT/LASEC patients （13.59% ± 1.07% ws. 14.34% ± 1.34%; P 〈 0.001）. Receiver-operating characteristic curve analysis was performed and indicated the best RDW cut point was 13.16%. Furthermore, multivariate logistic regression analysis indicated that RDW level 〉 13.16% could be an independent risk factor for LAT/LASEC in patients with AF. Conclusion Elevated RDW level is associated with the presence of LAT/LASEC and could be with moderate predictive value for LAT/LASEC in patients with non-valvular AF.

关键词： Atrial fibrillation Left atrial spontaneous echo contrast Left atrial thrombus Red cell distribution width

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Predictive value of serum uric acid on left atrial spontaneous echo contrast in non-valvular atrial fibrillation patients

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Journal of Geriatric Cardiology 2015年第6期12卷 641-646页

作者： hong-tao liao Fang-Zhou LIU Yu-Mei XUE Xian-Zhang ZHAN Xian-hong FANG Jun HUANG Wei WEI Fang RAO Hai DENG Yang LIU Wei-Dong LIN Shu-Lin WU Department of Cardiovascular Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Science GuangzhouGuangdong China Research Center of Medical Science Guangdong General Hospital Guangdong Academy of Medical Science Guangzhou Guangdong China

Objectives To investigate the relationship between serum uric acid （SUA） and left atrial spontaneous echo contrast （LA-SEC） in non-valvular atrial fibrillation （AF） patients. Methods We retrospectively screened 1,476 consecutive hospitalized patients with AF who underwent transesophageal echocardiography prior to radiofrequency catheter ablation, left atrial appendage closure and electric cardiover- sion at Guangdong General Hospital. Data on the clinical baseline characteristics of all patients were collected from electronic medical re- cords and analyzed. Results After exclusion of patients with left atrial thrombus, 1,354 patients entered into present study and 57 were LA-SEC. The mean female SUA level （380.88 ± 94.35 μmol/L vs. 323.37 ± 72.19μmol/L, P 〈 0.001） and male SUA level （416.97 ± 98.87 μmol/L vs. 367.88 ＋ 68.50 μmol/L, P = 0.008） were both significantly higher in patients with LA-SEC than in the controls. The mean left atrial dimension （41.32 ± 5.12 mm vs. 36.12 ± 5.66 mm, P 〈 0.001） was markedly larger in patients with LA-SEC. In multivariate regression analysis, SUA level was an independent risk factor for LA-SEC （OR： 1.008, P 〈 0.001）. In receiver operating characteristic curve analysis, the corresponding area under the curve for SUA predicting LA-SEC in female and male were 0.670 and 0.657, respectively. SUA level is significantly higher in non-valvular AF patients with LA-SEC. Conclusion SUA level is an independent risk factor and has a moderate predictive value for LA-SEC among non-valvular AF patients in Southern China.

关键词： Atrial fibrillation Echo contrast Left atrium Serum uric acid Thromboembolic events

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Journal of Geriatric Cardiology 2016年第04期 368页

作者： Fang-Zhou LIU hong-tao liao Yu-Mei XUE Shu-Lin WU Department of Cardiovascular Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences

Thank you very much for the excellent comments from ***'s group on our recently published *** the article,we demonstrated the relationship between SUA and left atrial spontaneous echo contrast(LA-SEC)screened by transesophageal echocardiography(TEE)in a total of 1345non-valvular atrial fibrillation(AF)*** clinical practice,most of AF patients had taken amiodarone for long-term rhythm *** catheter ablation candidates discontinued at least five half-life peri-

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao Sha liao Yu-Jiao Gao Xi Wang Li-hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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Predictive value of serum uric acid on left atrial spontaneous echo contrast in non-valvular atrial fibrillation patients

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Journal of Geriatric Cardiology 2015年第06期 641-646页

作者： hong-tao liao Fang-Zhou LIU Yu-Mei XUE Xian-Zhang ZHAN Xian-hong FANG Jun HUANG Wei WEI Fang RAO Hai DENG Yang LIU Wei-Dong LIN Shu-Lin WU Department of Cardiovascular Guangdong Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Science Research Center of Medical Science Guangdong General HospitalGuangdong Academy of Medical Science

Objectives To investigate the relationship between serum uric acid(SUA)and left atrial spontaneous echo contrast(LA-SEC)in non-valvular atrial fibrillation(AF)*** We retrospectively screened 1,476 consecutive hospitalized patients with AF who underwent transesophageal echocardiography prior to radiofrequency catheter ablation,left atrial appendage closure and electric cardioversion at Guangdong General *** on the clinical baseline characteristics of all patients were collected from electronic medical records and *** After exclusion of patients with left atrial thrombus,1,354 patients entered into present study and 57 were *** mean female SUA level(380.88±94.35μmol/L vs.323.37±72.19μmol/L,P<0.001)and male SUA level(416.97±98.87μmol/L vs.367.88±68.50μmol/L,P=0.008)were both significantly higher in patients with LA-SEC than in the *** mean left atrial dimension(41.32±5.12 mm vs.36.12±5.66 mm,P<0.001)was markedly larger in patients with *** multivariate regression analysis,SUA level was an independent risk factor for LA-SEC(OR:1.008,P<0.001).In receiver operating characteristic curve analysis,the corresponding area under the curve for SUA predicting LA-SEC in female and male were 0.670 and 0.657,*** level is significantly higher in non-valvular AF patients with *** SUA level is an independent risk factor and has a moderate predictive value for LA-SEC among non-valvular AF patients in Southern China.

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DISCRETE ENERGY ANALYSIS OF THE THIRD-ORDER VARIABLE-STEP BDF TIME-STEPPING FOR DIFFUSION EQUATIONS

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Journal of Computational Mathematics 2023年第2期41卷 325-344页

作者： hong-lin liao tao Tang tao Zhou Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing 211106China Division of Science and Technology BNU-HKBU United International CollegeZhuhai 519087China Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China

This is one of our series works on discrete energy analysis of the variable-step BDF *** this part,we present stability and convergence analysis of the third-order BDF(BDF3)schemes with variable steps for linear diffusion equations,see,e.g.,[SIAM ***.,58:2294-2314]and[***.,90:1207-1226]for our previous works on the BDF2 *** this aim,we first build up a discrete gradient structure of the variable-step BDF3 formula under the condition that the adjacent step ratios are less than 1.4877,by which we can establish a discrete energy dissipation ***-robust stability and convergence analysis in the L^(2) norm are then *** the mesh robustness means that the solution errors are well controlled by the maximum time-step size but independent of the adjacent time-step *** also present numerical tests to support our theoretical results.

关键词： Diffusion equations Variable-step third-order BDF scheme Discrete gradient structure Discrete orthogonal convolution kernels Stability and convergence

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