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Evaluation of the effects of health education interventions for hypertensive patients based on the health belief model

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World Journal of Clinical Cases 2024年第15期12卷 2578-2585页

作者： hong-mei wang Ying Chen Yan-Hua Shen Xiao-mei wang Department of Emergency Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Pancreatic and Biliary Surgery The First Affiliated Hospital of China Medical UniversityShenyang 110002Liaoning ProvinceChina

BACKGROUND Hypertension is a major risk factor for cardiovascular disease and stroke,and its prevalence is increasing *** education interventions based on the health belief model(HBM)can improve the knowledge,attitudes,and behaviors of patients with hypertension and help them control their blood *** To evaluate the effects of health education interventions based on the HBM in patients with hypertension in *** Between 2021 and 2023,140 patients with hypertension were randomly assigned to either the intervention or control *** intervention group received health education based on the HBM,including lectures,brochures,videos,and counseling sessions,whereas the control group received routine *** were measured at baseline,three months,and six months after the intervention and included blood pressure,medication adherence,self-efficacy,and perceived benefits,barriers,susceptibility,and *** The intervention group had significantly lower systolic blood pressure[mean difference(MD):-8.2 mmHg,P<0.001]and diastolic blood pressure(MD:-5.1 mmHg,P=0.002)compared to the control group at six *** intervention group also had higher medication adherence(MD:1.8,P<0.001),self-efficacy(MD:12.4,P<0.001),perceived benefits(MD:3.2,P<0.001),lower perceived barriers(MD:-2.6,P=0.001),higher perceived susceptibility(MD:2.8,P=0.002),and higher perceived severity(MD:3.1,P<0.001)than the control group at six *** Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.

关键词： Hypertension Health education Health belief model Blood pressure control Randomized controlled trial

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Temporal and Spatial Variations of Microbial Carbon Utilization in Water Bodies from the Dajiuhu Peatland, Central China

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Journal of Earth Science 2018年第4期29卷 969-976页

作者： Rui-Cheng wang hong-mei wang Xing Xiang Yu Gao Qing-Wei Song Lin-Feng Gong State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Wuhan 430074 China State Key Laboratory Breeding Base of Marine Genetic Resources Key Laboratory of Marine Genetic Resources Third Institute of Oceanography SOA Key Laboratory of Marine Genetic Resources of Fujian Province Xiamen 361005 China

To investigate the microbial utilization of organic carbon in peatland ecosystem, water samples were collected from the Dajiuhu Peatland and nearby lakes, central China across the year of 2014. The acridine orange （AO） staining and Biolog Eco microplates were used to numerate microbial counts and determine the carbon utilization of microbial communities. Meanwhile, physicochemical characteristics were measured for subsequent analysis of the correlation between microbial carbon utilization and environmental factors. Results indicated that total microbial counts were between 106107 cells/L. Microbial diversities and carbon utilization rates showed a similar pattern, highest in September and lowest in November. Microbial communities in the peat pore waters preferred to utilize N-bearing carbon sources such as amines and amino acids compared with microbial communities in lakes. The network analysis of microbial utilization of 31 carbon substrates clearly distinguished microbial communities from peat pore waters and those from lakes. Redundancy analysis （RDA） showed the total organic nitrogen content （P=-0.03, F=2.5） and daily average temperature （P=0.034, F=2.4） significantly controlled microbial carbon utilization throughout the sampling period. Our report is the first one to address the temporal and spatial variations of carbon uti- lization of microbial communities which are closely related to the decomposition of organic matter in the Dajiuhu Peatland in context of climate warming.

关键词： carbon source microbial carbon utilization average temperature Dajiuhu Peatland.

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Chiral Discrimination in N-(O, O-dialkyl)phosphoamino Acid Monolayers at the Air-water Interface

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Chinese Chemical Letters 2000年第8期11卷 717-718页

作者： Ning XU Zhou ZHOU hong mei wang Chang Hui DENG Yan mei LI Yu Fen ZHAO Ling Xuan wang Tian Kai LI Bioorg.Phosph.Chem.Lab Department of ChemistryTsinghua UniversityBeijing 100084 Institute of Photographic Chemistry Chinese Academy of SciencesBeijing 100101

In this paper, chiral discrimination in N-(O,O-dialkyl)phosphoamino acid monolayers at the air/water interface was studied and it was revealed that the D:L=1:1 racemic monolayer of N-(O, O-dihexadecyl)phosphoalanine i... 详细信息

关键词： chiral discrimination N-(O,O-dialkyl)phosphoamino acid monolayer

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Clinical characteristics,molecular epidemiology and antimicrobial susceptibility of pertussis among children in southern China

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World Journal of Pediatrics 2020年第2期16卷 185-192页

作者： Jiao-Sheng Zhang hong-mei wang Kai-Hu Yao Ying Liu Yan-Ling Lei Ji-Kui Deng Yong-hong Yang Laboratory of Microbiology and Immunology Beijing Children's Hospital Affiliated to Capital Medical University56 Nanlishi RoadBeijing 100045China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China

Background Increasing numbers of pertussis cases have been reported in recent *** reported cases from Shenzhen Children's Hospital were close to one tenth of all cases in *** epidemiology of antigenic genotype and antibiotic resistance of circulating strains in children have been unknown in Shenzhen,southern *** aim of this study was to describe the clinical features and explore the genotypes and antimicrobial susceptibility of circulating Bordetella pertussis among children in *** Data of hospitalized children with pertussis in Shenzhen Children's Hospital from August 2015 to April 2017 were *** genetic variability of isolates was investigated and Etest was performed for phenotypic susceptibility to erythromycin,azithromycin,clarithromycin,clindamycin,and trimethoprim/*** 469 children with pertussis confirmed by real-time quantitative polymerase chain reaction were hospitalized and strains were isolated from 105 *** blood cell count≥20×10^9/L and lymphocyte proportion≥60%were observed in 39.29%of infants younger than 3 *** two predominant profiles of virulence-associated allelic genes were ptxA1/ptxC1/ptxPl/prnl(48.6%)and ptxA1/ptxC2/ptxP3/prn2(44.8%).Among the isolates,48.6%(51/105)were found resistant to *** These findings indicate that leukocytosis is not a sensitive indicator of *** with the gene profile ptxP3/prn2 were highly circulating in Shenzhen and less resistant to macrolides,different from patterns observed in other parts of China.

关键词： Antimicrobial susceptibility Bordetella pertussis Children Genotype Virulence

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1-Imino Nitroxide Pyrene, a Burst-type H^(+) Fluorescent Switch

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Chinese Chemical Letters 2005年第8期16卷 1125-1128页

作者： Jun LI hong mei wang Hui Min MA De Qing ZHANG Shao Xiang XIONG Center for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100080

1-Imino nitroxide pyrene 1 has been characterized as a H^＋ fluorescent switch. The effects of various interfering species, solvents and the irradiation of ultraviolet light on the fluorescence intensity of 1 are also investigated. 1 fluoresces weakly in the 85% ethanol media containing no more than 4.5x10-5 mol/L of H^＋（HCI）, but can produce a burst increase of about 4 times in the fluorescence intensity when the concentration of H＋ is increased to or over 4.9×10^-5mol/L. The extremely sharp response of 1 to H＋ occurs only within such a narrow concentration range. Moreover, the decrease of H^＋ concentration through adding sodium hydroxide causes the fluorescence quenching, suggesting that 1 may serve as a fluorescent switch for monitoring the concentration change of H＋ around the point of 4.5×10^-5 mol/L.

关键词： Fluorescent switch l-imino nitroxide pyrene H^+

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New Approach to Detecting Phenoxyl Free Radicals Generated in Enzyme Reaction by Stopped-flow Spectrophotometry

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Chinese Chemical Letters 2006年第7期17卷 949-952页

作者： Jing XU Lan Hua ZHAO Xin Guo WU hong mei wang Ru Xiu CAI College of Chemistry and Molecular Science Wuhan University Wuhan 430072 Stuff of Chemistry Yunyang Medical College Shiyan 442000 College of Resources and Environmental Science Wuhan University Wuhan 430072

A highly sensitive stopped-flow spectrophotometry kinetic method was proposed for quantification phenoxyl radicals based on their accelerating effect on the oxidation of nicotinamide adenine dinucleotide （NADH）. Phenoxyl radicals generated from as low as 1×10^-8 mol/L 2,4-DCP can be readily detected with the proposed method and the detecting limit was 2.5×10^-9 mol/L.

关键词： Phenoxyl radicals moleculary probe stopped-flow spectrophotometry.

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Selenocysteine antagonizes oxygen glucose deprivation-induced damage to hippocampal neurons

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Neural Regeneration Research 2018年第8期13卷 1433-1439页

作者： Xian-Jun wang mei-hong wang Xiao-Ting Fu Ya-Jun Hou wang Chen Da-Chen Tian Su-Yun Bai Xiao-Yan Fu Department of Neurology People's Hospital of Linyi Linyi Shandong Province China Department of Neurology People's Hospital of Yishui Linyi Shandong Province China School of Basic Medicine Taishan Medical University Taian Shandong Province China

Designing and/or searching for novel antioxidants against oxygen glucose effective strategy for the treatment of human isdlemic stroke. Selenium is deprivation （OGD）-induced oxidative damage represents an an essential trace dement, which is beneficial in the chemo- prevention and chemotherapy of cerebral ischemic stroke. The underlying mechanisms for its therapeutic effects, however, are not well documented. Selenocysteine （SeC） is a selenium-containing amino acid with neuroprotective potential. Studies have shown that SeC can reduce irradiation-induced DNA apoptosis by reducing DNA damage. In this study, the in vitro protective potential and mechanism of action of SeC against OGD-induced apoptosis and neurotoxicity were evaluated in HT22 mouse hippocampal neurons. We cultured HT22 cells in a glucose-free medium containing 2 mM Na2S402, which formed an OGD environment, for 90 minutes. Findings from MTT, flow cytometry and TUNEL staining showed obvious cytotoxicity and apoptosis in HT22 cells in the OGD condition. The activation of Caspa se-7 and Caspase-9 further revealed that OGD-induced apoptosis of HT22 cells was mainly achieved by triggering a mitochondrial-medi- ated pathway. Moreover, the OGD condition also induced serious DNA damage through the accumulation of reactive oxygen species and superoxide anions. However, SeC pre-treatment for 6 hours effectively inhibited OGD-induced cytotoxicity and apoptosis in HT22 cells by inhibiting reactive oxygen species-mediated oxidative damage. Our findings provide evidence that SeC has the potential to suppress OGD-induced oxidative damage and apoptosis in hippocampal neurons.

关键词： selenium selenocysteine ischemic stroke oxygen glucose deprivation hippocampal neuron mitochondria reaction oxygen species superoxide anion oxidative damage apoptosis

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Improved Fertility Following Enucleation of Intramural Myomas in Infertile Women

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Chinese Medical Journal 2017年第14期130卷 1648-1653页

作者： Yu-Cui Tian Jian-hong Wu hong-mei wang Yin-mei Dai Department of Perinatal Medicine Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China Department of Gynecology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China Department of Minimal Invasive Gynecology Center Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Background：The relationship between intramural myomas and fertility remains *** main debate rests on whether cavity-distorting intramural lnyomas （CDMs） adversely affect fertility more than *** aimed to compare the effects ofenucleating non-CDMs and CDMs on fertility improvement in females with unexplained ***：We prospectively recruited 83 women undergoing myomectomy for unexplained infertility with intramural myomas between June 2008 and November 2012 and classified them into non-CDMs group （n =45） and CDMs group （n =38）.We then compared postoperative infertility rates,spontaneous pregnancy rates,pregnancy outcomes,live birth rates,and obstetric *** continuous variables,we calculated the mean ± standard deviation,median and interquartile range,and analyzed the data using Student＇s t-test and the Mann-Whitney *** categorical variables,the Pearson＇s Chi-square test,the continuity correction test,and Fisher＇s exact test were ***：Patients＇ demographics and myoma characteristics were comparable between the two *** overall spontaneous pregnancy rate increased from 0% to 68.42% following *** postoperative infertility rate was significantly higher in the non-CDMs group than that in the CDMs group （50.00% vs.23.53%,t =5.579,P =0.018）,whereas the postoperative spontaneous pregnancy rate was significantly lower in the non-CDMs group than that in the CDMs group （47.62% vs.70.59%,t 4.067,P =0.044）.Compared with the enucleation ofnon-CDM,the enucleation of CDM patients was a protective factor for the fertility restoration （risk ratio [RR] =3.717,95% confidence interval [CI]：1.284-10.753,P =0.015）,although postoperative fertility restoration declined with age （RR =1.141,95% CI：1.005-1.295,P =0.041）.Conclusions：Intramural myomas are associated with impaired *** experiencing unexplained infertility,and possessing intramural myomas,have a better chance of conception following myomectomy,and t

关键词： Infertility Myoma Pregnancy Outcome Uterine Myomectomy

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HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer

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World Journal of Gastroenterology 2017年第33期23卷 6100-6110页

作者： Wen-Ming Chen Wei-Dong Chen Xue-mei Jiang Xue-Feng Jia hong-mei wang Qiu-Jie Zhang Yong-Qian Shu Hai-Bo Zhao Department of Oncology Jining NO.1 People’s Hospital Traditional Chinese Medicine Hospital of Jining City The Special Hospital Serving the Municipal Officials of Jining City Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province Hospital

AIM To clarify the mechanisms of HOX transcript antisense intergenic RNA(HOTAIR) in gastric cancer(GC) migration and *** Quantitative real-time polymerase chain reaction(qp CR) was used to detect the expression level of HOTAIR in GC tissues. The correlation of its expression with clinicopathological features was analyzed. Area under receiver operating characteristic curve(AUCROC) was constructed to evaluate the diagnostic value of HOTAIR. Wound-healing assay and Transwell assay were performed to detect the biological effects of HOTAIR in GC cells. qp CR,western blot and immunohistochemistry were used to evaluate the m RNA and protein expression of E-cadherin. RNAbinding protein immunoprecipitation was used for the analysis of EZH2 interactions with HOTAIR. Chromatin immunoprecipitation assay was performed to investigate direct interactions between EZH2 and *** The expression of HOTAIR was up-regulated in GC tumorous tissues compared with the para-tumorous tissues(p < 0.001). Its over-expression was correlated with tumor-node-metastasis(TNM) stage(p = 0.024),tumor invasion(p = 0.018),lymph node metastasis(p = 0.023),and poor prognosis(p < 0.001). Multivariate Cox regression analysis confirmed expression of HOTAIR as an independent predictor of overall survival(p = 0.033),together with TNM stage(p = 0.002) and lymph node metastasis(p = 0.002). The AUCROC was up to 0.709(95%CI: 0.623-0.785,p < 0.001). Knockdown of HOTAIR by si RNA in GC cells suppressed the migration and invasion of GC cells. Significantly negative correlation between HOTAIR and E-cadherin was found in GC tissues and cell lines,and HOTAIR contributed to the regulation of E-cadherin through binding to EZH2 with the E-cadherin promoter. CONCLUSION HOTAIR may play a pivotal role in tumor cell migration and invasion. It can be used as a potential diagnostic and prognostic biomarker for GC.

关键词： Long noncoding RNA HOX transcript antisense intergenic RNA Gastric cancer Migration and invasion E-cadherin

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Study on promoting quantum mechanics-teaching modernization by information technology

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Natural Science 2010年第2期2卷 112-114页

作者： hong-mei wang 不详

Quantum mechanics, one of the important theories of modern physics, is fairly esoteric and abstract. Based on the characteristics of the quantum mechanics course, the article studies the modernization of quantum mechan-ics teaching in four aspects: the modernization of the teaching idea, Computer-Aided Instruc-tion, the development of Information technology software and the establishment of three-di-mensional digital curriculum teaching resource library.

关键词： Quantum Mechanics Information Technology Modernization of Teaching

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