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Freeze-induced acceleration of iodide oxidation and consequent iodination of dissolved organic matter to form organoiodine compounds

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Journal of Environmental Sciences 2024年第10期144卷 67-75页

作者： Xuexin Gong mei He Zhineng Hao Rusong Zhao Jingfu Liu School of Resources and Environment Yangtze UniversityWuhan 430100China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Qilu University of Technology(Shandong Academy of Sciences) Shandong Analysis and Test CenterKey Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong ProvinceJinan 250014China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Freeze-induced acceleration of I–oxidation and the consequent iodination of dissolved organic matter(DOM)contribute to the formation of organoiodine compounds(OICs)in cold *** formed OICs may be a potentially important source of risk and are very closely with the environment and human ***,we investigated the acceleration effects of the freeze process on I–oxidation and the formation of *** comparison to reactive iodine species(RIS)formed in aqueous solutions,I–oxidation and RIS formation were greatly enhanced in frozen solution and were affected by pH,and the content of I–and ***-thaw process further promoted I–oxidation and the concentration of RIS reached 45.7μmol/L after 6 freeze-thaw *** consequent products of DOM iodination were greatly promoted in terms of both concentration and *** total content of OICs ranged from 0.02 to 2.83μmol/L under various *** 183–1197 OICs were detected by Fourier transform ion cyclotron resonance mass spectrometry,and more than 96.2%contained one or two iodine *** OICs had aromatic structures and were formed via substitution and addition *** findings reveal an important formation pathway for OICs and shed light on the biogeochemical cycling of iodine in the natural aquatic environment.

关键词： Freeze process Dissolved organic matter(DOM) Iodination Organoiodine compounds(OICs) Ultrahigh resolution mass spectrometry

Structural and magnetic properties of micropolycrystalline cobalt thin films fabricated by direct current magnetron sputtering

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 384-394页

作者： Kerui Song Zhou Li mei Fang Zhu Xiao Qian Lei School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Hunan Key Laboratory of Super-Microstructure and Ultrafast Process School of Physics and electronicsCentral South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metal Materials Science and Engineering Ministry of EducationChangsha 410083China

Pure cobalt(Co)thin films were fabricated by direct current magnetron sputtering,and the effects of sputtering power and pres-sure on the microstructure and electromagnetic properties of the films were *** the sputtering power increases from 15 to 60 W,the Co thin films transition from an amorphous to a polycrystalline state,accompanied by an increase in the intercrystal pore ***,the resistivity decreases from 276 to 99μΩ·cm,coercivity increases from 162 to 293 Oe,and in-plane magnetic aniso-tropy *** the sputtering pressure decreases from 1.6 to 0.2 Pa,grain size significantly increases,resistivity significantly de-creases,and the coercivity significantly increases(from 67 to 280 Oe),which can be attributed to the increase in defect ***-pondingly,a quantitative model for the coercivity of Co thin films was *** polycrystalline films sputtered under pressures of 0.2 and 0.4 Pa exhibit significant in-plane magnetic anisotropy,which is primarily attributable to increased microstress.

关键词： cobalt thin film magnetron sputtering microstructure electromagnetic properties

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong LIANG Qi mei Li-yan LIANG You-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

Microstructure Regulation and Combustion Performance Optimization of PVDF/Al Composite Powder by Non-covalent Functionalized Graphenes

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 904-911页

作者：易卓然 DENG Haoyuan QIN mei 孙一 LUO Guoqiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Graphene prepared by non-covalent modification of sulfonated poly(ether-ether-ketone)(SPG)was combined with polyvinylidene fluoride(PVDF)/Al to improve the PVDF/Al thermal conductivity while reducing the effect of the thermal resistance at the graphene-polymer *** regulation rule of SPG with different contents on the energy release of fluorine-containing system was *** the content of SPG is 4%,the peak pressure and rise rate of SPG/PVDF/Al composite powder during ignition reach the maximum of 4845.28 kPa and 8683.58 kPa/*** the content of SPG is 5%,the PVDF/Al composite powder is completely coated by SPG,and the calorific value of the material reachs the maximum of 29.094 kJ/*** the design and micro-control of the composite powder,the calorific value of the material can be effectively improved,but the improvement of the mass release rate still depends on the graphene content and surface modification state.

关键词： energetic materials PVDF/Al composites graphene modification energy release combustion

Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang mu-Qi Wang Jiang Deng Ning Gao mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

AG8 Reduces Hypoxia-induced Triple Negative Breast Cancer Metastasis by Stemness Regulation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 54-61页

作者： Lihua mu Yuan Hu hong Yan Rui Jing Ping Liu Department of Pharmacy Medical Supplies Center of Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology the First Medical Centre of Chinese PLA General HospitalBeijing 100853China

Background:AG8,a triterpenoid saponin isolated from Ardisia gigantifolia Stapf.,our previous studies found that AG8 inhibited the proliferation of triple negative breast cancers(TNBCs)by including ROS generation and triggering mitochondrial apoptotic *** stem cells(CSCs)capable of maintain relatively low levels of ROS,are vulnerable to the interference of redox *** capable of generating ROS can affect the finely balanced redox state of CSCs and have potency to selectively kill ***:We selected BT-549 which is most sensitive to AG8 to further study the effects of AG8 on hypoxia-induced proliferation,metastasis and ***:The hypoxia condition was simulated by CoCl2 and cell viability assay of BT-549 cells was performed us-ing *** phenotype were identified using breast CSCs marker(CD24^(−)/low/CD44^(+))and mammosphere formation *** motility was determined via the wound healing assay and transwell *** levels of HIF1-α,Oct-4,SOX-2,c-MYC were tested by western ***:In this study,AG8 showed significant cytotoxic effects on BT-549 triple negative breast cancer cells,but the effects were impaired by HIF1 ***8 inhibited the hypoxia-induced migration and invasion of BT-549 *** studies revealed that hypoxia-induced increases of CD44^(+)CD24^(−)/low and mammosphere population were significantly inhibited by AG8 ***,AG8 decreased the Oct-4 and SOX-2 protein expression without affecting HIF1-αand ***8 significantly inhibited BT-549 xenograft tumors growth in BALB/c nude mice comparing with that of the control ***:In summary,AG8 inhibited hypoxia-induced cell migration and invasion through stemness regula-tions,indicating novel mechanisms for the antitumor effects of AG8 against triple negative breast cancer.

关键词： Triterpenoid saponin TNBC hypoxia CSC Metastasis

Experimental study on the size effect on the equation of state of concretes under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 160-167页

作者： mei Li Jian Cui Yanchao Shi Baijian Tang Xin Chen Key Laboratory of Coast Civil Structural Safety of the Ministry of Education Tianjin UniversityTianjin 300072China School of Civil Engineering Suzhou University of Science and Technology1701 Binhe RoadSuzhou 215011JiangsuChina School of Civil Engineering Tianjin UniversityTianjin 300072China

Adopting the classical theory of hydrocodes,the constitutive relations of concretes are separated into an equation of state(EoS)which describes the volumetric behavior of concrete material and a strength model which depicts the shear properties of *** experiments on the EoS of concrete is always challenging due to the technical difficulties and equipment limitations,especially for the specimen size effect on the *** some researchers investigate the shock properties of concretes by fly-plate impact tests,the specimens used in their tests are usually in one *** this paper,the fly-plate impact tests on concrete specimens with different sizes are performed to investigate the size effect on the shock properties of concrete *** mechanical background of the size effect on the shock properties are revealed,which is related to the lateral rarefaction effect and the deviatoric stress produced in the *** to the tests results,the modified EoS considering the size effect on the shock properties of concrete are proposed,which the bulk modulus of concrete is unpredicted by up to 20% if size effects are not accounted for.

关键词： Concrete Equation of state Size effect Shock wave Fly-plate impact test

Motor cortical circuit adaptations in parkinsonism

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Neural Regeneration Research 2024年第10期19卷 2107-2108页

作者： hong-Yuan Chu Department of Neurodegenerative Science Van Andel Research InstituteGrand RapidsMIUSA Aligning Science Across Parkinson’s(ASAP)Collaborative Research Network

Parkinson's disease is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta,which leads to the featured motor impairment of parki... 详细信息

关键词： parkin impairment rigidity

Responses of plant diversity and soil microorganism diversity to nitrogen addition in the desert steppe,China

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Journal of Arid Land 2024年第3期16卷 447-459页

作者： YE He hong mei XU Xuehui LIANG Zhiwei JIANG Na TU Nare WU Zhendan College of Grassland Resources and EnvironmentInner Mongolia Agricultural UniversityInner Mongolia Key Laboratory of Soil Quality and Nutrient ResourcesHohhot 010018China Key Laboratory of Agricultural Ecological Security and Green Development at University of Inner Mongolia Hohhot 010018China

Nitrogen(N)deposition is a significant aspect of global change and poses a threat to terrestrial *** impact of plant-soil microbe relationships to N deposition has recently attracted considerable *** microorganisms have been proven to provide nutrients for specific plant growth,especially in nutrient-poor desert steppe ***,the effects of N deposition on plant-soil microbial community interactions in such ecosystems remain poorly *** investigate these effects,we conducted a 6-year N-addition field experiment in a Stipa breviflora *** steppe in Inner Mongolia Autonomous Region,*** N treatment levels(N0,N30,N50,and N100,corresponding to 0,30,50,and 100 kg N/(hm2•a),respectively)were applied to simulate atmospheric N *** results showed that N deposition did not significantly affect the aboveground biomass of desert steppe plants.N deposition did not significantly reduce the alfa-diversity of plant and microbial communities in the desert steppe,and low and mediate N additions(N30 and N50)had a promoting effect on *** variation pattern of plant Shannon index was consistent with that of the soil bacterial Chao1 index.N deposition significantly affected the beta-diversity of plants and soil bacteria,but did not significantly affect fungal *** conclusion,N deposition led to co-evolution between desert steppe plants and soil bacterial communities,while fungal communities exhibited strong stability and did not undergo significant *** findings help clarify atmospheric N deposition effects on the ecological health and function of the desert steppe.

关键词： soil microorganisms plant-microbial community interaction plant diversity nitrogen deposition desert steppe