检索结果-南通市图书馆

Epithelial Sodium and Chloride Channels and Asthma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第16期128卷 2242-2249页

作者： Wen Wang, hong-long ji Department of Respiratory and Critical Care Medicine Beijing Chaoyang Hospital Capital Medical University Beijing Institute of Respiratory Medicine Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing 100020 China Department of Cellular and Molecular Biology Texas Lung Injury Institute University of Texas Health Science Center at Tyler Tyler Texas 75708 USA

Objective：To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel （ENaC）/chlorine ion *** Sources：The data analyzed in this review were the English articles from 1980 to 2015 from journal databases,primarily PubMed and Google *** terms used in the literature search were：（1） ENaCs;cystic fibrosis （CF） transmembrane conductance regulator （CFTR）;asthma/asthmatic,（2） ENaC/sodium salt;CF;asthma/asthmatic,（3） CFTR/chlorine ion channels;asthma/asthmatic,（4） ENaC/sodium channel/scnn1a/scnn1b/scnn1g/scnn1d/amiloride-sensitive/amiloride-inhibtable sodium channels/sodium salt;asthma/asthmatic,lung/pulmonary/respiratory/tracheal/alveolar,and （5） CFTR;CF;asthma/asthmatic （ti）.Study Selection：These studies included randomized controlled trials or studies covering asthma pathogenesis and clinical manifestations related to ENaC/chlorine ion channels within the last 25 years （from 1990 to 2015）.The data involving chronic obstructive pulmonary disease and CF obtained from individual studies were also reviewed by the ***：Airway surface liquid dehydration can cause airway inflammation and *** and CFTR are closely related to the airway mucociliary *** transporters may play a critical role in pathogenesis of asthmatic ***：Ion channels have been the center of many studies aiming to understand asthmatic pathophysiological mechanisms or to identify therapeutic targets for better control of the disease.

关键词： Airway Surface Liquid Asthma Cystic Fibrosis Transmembrane Conductance Regulator Epithelial Sodium Channel Mucociliary Clearance

Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44^(+)-ENaC signal cascade

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第3期6卷 618-620页

作者： Gibran Ali Mo Zhang Runzhen Zhao Krishan GJain jianjun Chang Satoshi Komatsu Beiyun Zhou jiurong Liang Michael AMatthay hong-long ji Department of Cellular and Molecular Biology University of Texas Health Science Center at TylerTylerTXUSA Institute of Lung and Molecular Therapy Xinxiang Medical UniversityXinxiangHenanChina Institute of Health Sciences China Medical UniversityShenyangLiaoningChina Division of Pulmonary Critical Care and Sleep MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Hastings Center for Pulmonary Research University of Southern CaliforniaLos AngelesCAUSA Norris Comprehensive Cancer Center University of Southern CaliforniaLos AngelesCAUSA Department of Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Medicine and Anesthesia University of California San FranciscoSan FranciscoCAUSA Cardiovascular Research Institute University of California San FranciscoSan FranciscoCAUSA Texas Lung Injury Institute University of Texas Health Science Center at TylerTylerTXUSA

Dear Editor,COVID-19,SARS,and MERS are featured by suppressed *** primary objective of this study was to decipherthe role of the fibrinolytic niche in the progenitor alveolar type 2(AT2)cell-mediated *** expression of Piau inAT2 cells has been confirmed at the mRNA,protein,and functionallevel across *** employed influenza-infected&Plau^(-/-)mice,3D organoids,and polarized monolayers to track AT2 *** found a marked reduction in total AT2 cells and CD44^(+)subpopulation when the fibrinolytic niche was disrupted.

关键词： alveolar CD44 lung

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

间充质干细胞的恶性转化研究进展

中华细胞与干细胞杂志（电子版） 2017年第4期7卷 231-236页

作者：刘聪张墨 hong-long ji 河南省新乡医学院肺病与分子治疗研究所新乡453003 Department of Cellular and Molecular Biology University of Texas Health Science Center at Tylertylertexas75708

间充质干细胞(MSCs)是一种多能干细胞,在体外的特定诱导条件下可以分化为多种组织细胞。其独特的生物学特性,在组织损伤修复与肿瘤靶向治疗等临床应用方面展现出广阔的应用前景。然而有研究表明MSCs在应用过程中有可能发生恶性转化。本... 详细信息

间充质干细胞(MSCs)是一种多能干细胞,在体外的特定诱导条件下可以分化为多种组织细胞。其独特的生物学特性,在组织损伤修复与肿瘤靶向治疗等临床应用方面展现出广阔的应用前景。然而有研究表明MSCs在应用过程中有可能发生恶性转化。本文主要对MSCs发生恶性转化的影响因素、分子机制以及如何预防MSCs发生恶性转化的新近研究进行综述。

关键词：间质干细胞细胞转化,肿瘤

在线全文

学校读者我要写书评

暂无评论

SCNN1基因突变与呼吸系统疾病

国际呼吸杂志 2015年第14期35卷 1105-1108页

作者：苏祯磊 hong-long ji 新乡医学院公共卫生学院 453003 75708 University of Texas Health Science Center at Tyler

SCNN1是编码上皮钠离子通道（ENaC）蛋白的一类基因，目前发现的已经被克隆的哺乳类SCNN1基因包括SCNN1A、SCNN1B、SCNN1G、SCNN1D，分别表达ENaC的α、β、γ、δ亚基。ENaC在维持钠、水平衡中起着重要作用，而SCNN1基因的突变将会影响... 详细信息

SCNN1是编码上皮钠离子通道（ENaC）蛋白的一类基因，目前发现的已经被克隆的哺乳类SCNN1基因包括SCNN1A、SCNN1B、SCNN1G、SCNN1D，分别表达ENaC的α、β、γ、δ亚基。ENaC在维持钠、水平衡中起着重要作用，而SCNN1基因的突变将会影响ENaC的结构与功能，进而导致一系列的疾病。随着研究的深入，人们对SCNN1基因的结构与功能也有了进一步的认识。这篇文章将综述SCNN1基因结构和功能以及它的突变引起的呼吸系统疾病，目的是总结SCNN1基因突变型与呼吸系统疾病表型的关系。

关键词： SCNN1基因上皮钠离子通道呼吸系统疾病

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

在线全文

学校读者我要写书评

暂无评论

法治是中国式现代化的重要保障

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 7-16,F0002页

作者：莫纪宏中国社会科学院法学研究所北京100720

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保... 详细信息

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保障中国式现代化中的能力,推动法治与现代化同频共振、并肩前行发挥了政策引领作用。从法理层面准确认识法治对中国式现代化的保障机制和制度功能,要从历史维度、政治维度、理论维度、比较维度和实践维度“五个维度”有机统一的角度认识中国式现代化的具体特征和制度形态,针对不同层面的中国式现代化目标采取不同性质的法治应对和保障措施。法治在中国式现代化进程中,通过保障制度现代化推进中国式现代化。其中,法治自身也需要现代化。没有法治现代化就没有社会主义现代化。法治在推进中国式现代化过程中,通过不断提升自身效能和保障能力,逐步实现自身的现代化,成为中国式现代化事业的重要组成部分。

关键词：法治中国式现代化历史维度政治维度理论维度比较维度实践维度

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-long Zhou Wei-jin jiang ji Yu Mao-Jun Yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu Shan-hong Tang hong-Wu Zhu Ya-Gang Zhao ji-Luo Liu jian Wang jing-Han Guo Xiao-Mei Zhang Yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-hong Zhong jiang-Shan Huang Fei-long Guo jing-Yu Wu Mao-Xiu Yuan jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management