Epithelial Sodium and Chloride Channels and Asthma

作     者：Wen Wang, Hong-Long Ji Wang Wen;Ji Hong-Long

作者机构：Department of Respiratory and Critical Care Medicine Beijing Chaoyang Hospital Capital Medical University Beijing Institute of Respiratory Medicine Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders Beijing 100020 China Department of Cellular and Molecular Biology Texas Lung Injury Institute University of Texas Health Science Center at Tyler Tyler Texas 75708 USA 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第16期

页      面：2242-2249页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 1002[医学-临床医学] 07[理学] 09[农学] 0906[农学-兽医学] 071003[理学-生理学] 

基　　金：grants from American Heart Association grant (No. 20130034) and National Natural Science Foundation of China (No. 21307158) 

主　　题：Airway Surface Liquid Asthma Cystic Fibrosis Transmembrane Conductance Regulator Epithelial Sodium Channel Mucociliary Clearance 

摘      要：Objective：To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel （ENaC）/chlorine ion *** Sources：The data analyzed in this review were the English articles from 1980 to 2015 from journal databases,primarily PubMed and Google *** terms used in the literature search were：（1） ENaCs;cystic fibrosis （CF） transmembrane conductance regulator （CFTR）;asthma/asthmatic,（2） ENaC/sodium salt;CF;asthma/asthmatic,（3） CFTR/chlorine ion channels;asthma/asthmatic,（4） ENaC/sodium channel/scnn1a/scnn1b/scnn1g/scnn1d/amiloride-sensitive/amiloride-inhibtable sodium channels/sodium salt;asthma/asthmatic,lung/pulmonary/respiratory/tracheal/alveolar,and （5） CFTR;CF;asthma/asthmatic （ti）.Study Selection：These studies included randomized controlled trials or studies covering asthma pathogenesis and clinical manifestations related to ENaC/chlorine ion channels within the last 25 years （from 1990 to 2015）.The data involving chronic obstructive pulmonary disease and CF obtained from individual studies were also reviewed by the ***：Airway surface liquid dehydration can cause airway inflammation and *** and CFTR are closely related to the airway mucociliary *** transporters may play a critical role in pathogenesis of asthmatic ***：Ion channels have been the center of many studies aiming to understand asthmatic pathophysiological mechanisms or to identify therapeutic targets for better control of the disease.