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Plasma microRNA profiling in nasopharyngeal carcinoma patients reveals miR-548q and miR-483-5p as potential biomarkers

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Chinese Journal of Cancer 2014年第7期33卷 330-338页

作者： Xiao-Hui Zheng Cui Cui hong-lian ruan Wen-Qiong Xue Shao-Dan Zhang Ye-Zhu Hu Xin-Xi Zhou Wei-Hua Jia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Experimental Research Sun Yat-sen University Cancer Center

MicroRNAs(miRNAs), which play a role in tumorigenesis, may also serve as diagnostic or prognostic biomarkers. However, studies on human miRNA profiles in plasma from nasopharyngeal carcinoma(NPC) patients are in their infancy. Here, we used microarrays to perform systematic profiling of human miRNAs in plasma from NPC patients. We subsequently used real-time quantitative polymerase chain reaction(Q-PCR) to validate miRNAs with aberrant expression that could serve as potential biomarkers. By comparing the plasma miRNA profiles of 31 NPC patients and 19 controls, 39 of 887 human miRNAs were found to be aberrantly expressed. Considering the fold change and P value, miR-548q and miR-483-5p were validated in 132 samples from 82 NPC patients and 50 controls. Moreover, high expression of miR-548q and miR-483-5p was further found in 3 NPC cell lines and clinical biopsy tissues from 54 NPC patients and 22 controls. Our results revealed that miR-548q and miR-483-5p are potential biomarkers of NPC. Combining the receiver operating characteristic(ROC) analyses of these 2 miRNAs, an area under the ROC curve(AUC) of 0.737 with 67.1% sensitivity and 68.0% specificity were obtained, showing the preliminary diagnostic value of plasma miRNAs. Moreover, most NPC patients with a poor outcome exhibited high expression(> median) of miR-548q(70.6%) and miR-483-5p(64.7%) in tissue samples, indicating their prognostic value. The high expression levels of miR-548q and miR-483-5p in plasma, cell lines, and clinical tissues of NPC patients indicate that their roles in NPC should be explored in the future.

关键词：生物标志物 microRNA 鼻咽癌患者血浆 miRNA 全国人民代表大会聚合酶链反应

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Alcohol and tea consumption in relation to the risk ofnasopharyngeal carcinoma in Guangdong, China

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Frontiers of Medicine 2010年第4期4卷 448-456页

作者： hong-lian ruan Feng-Hua XU Wen-Sheng LIU Qi-Sheng FENG Li-Zhen CHEN Yi-Xin ZENG Wei-Hua JIA State Key Laboratory of Oncology in Southern China Guangzhou 510060China School of Public Health Sun Yat-Sen UniversityGuangzhou 510080China Department of Experiment Research Sun Yat-sen UniversityCancer CenterGuangzhou 510060China

To investigate whether alcohol and tea con-sumption has an etiological association with nasophar-yngeal carcinoma(NPC)in a high-incident population,a large scale case-control study was *** study included 2846 individuals in Guangdong Province,China,with 1387 newly diagnosed cases of NPC and 1459 frequency-matched *** histories of alcohol and tea consumption were obtained via personal *** regarding socio-demographic charac-teristics(age,sex,education,dialect and household type),family history of NPC,Epstein-Barr virus(EBV)infection,dietary habits and other potential confounding factors was also *** analysis was performed using uncondi-tional logistic regression to calculate odds ratios(OR)and 95%conﬁdence intervals(CI).The risk of NPC was found to be associated with habitual alcohol consumption and tea *** consumption has been associated with a decreased occurrence of NPC(OR=0.62),while con-sumption of alcohol was associated with a complex ***ﬁcally,moderate consumption of alcohol was associated with decreased risk of NPC,while overuse,especially strong distillate spirits,appeared to be a risk factor.

关键词： nasopharyngeal carcinoma case-control study alcohol consumption tea consumption

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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu hong-Xin Long Dan-Dan Zhang Mei-Feng ruan Guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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Injection molding of highly filled microcrystalline cellulose/polycaprolactone composites with the aid of reversible Diels-Alder reaction

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Journal of Materials Science & Technology 2024年第3期170卷 246-254页

作者： Ze Pu Wang Wenhong ruan MinZhi Rong MingQiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of MOE GD HPPC LabIGCMESchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

To tackle the challenge of producing highly filled polymer composites using the traditional injection molding technique,which is characterized by the fairly high melt viscosity that makes mold filling difficult,the authors propose a solution based on dynamic covalent *** demonstrated by the proof-of-concept experiments,the 4-arm starshaped polycaprolactone(PCL)oligomers and microcrystalline cel-lulose(MCC)are crosslinked by the reversible Diels-Alder(DA)*** flowability of the compounds greatly decreases due to the dissociation of the intercomponent DA bonds at the retro-reaction tempera-ture,and the networked architecture is reconstructed during cooling as a result of the forward DA ***,the high-loading MCC fillers are well distributed in the matrix and covalently bonded to the nearby PCL,forming a striking contrast to the control in which linear PCL acts as the *** DA bonds crosslinked biodegradable PCL composites exhibit decent mechanical strength(20.7 MPa)even at the MCC fraction of 65 wt%,which is superior to those(5-12.2 MPa)of the highly filled PCL composites(with filler contents of 50-63.8 wt%)reported so *** proposed approach has sufficient expansibility for the fabrication of the highly filled polymer composites constructed by other types of matrix and fillers.

关键词： Polymer composites Microcrystalline cellulose Polycaprolactone Injection molding Dynamic reversible chemistry

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Design of Ca-type todorokite catalysts with highly active for the selective reduction of NO_(x) by NH_(3) at low temperatures

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Journal of Environmental Sciences 2024年第4期138卷 697-708页

作者： Chuang Chang Zidi Yan Chunlei Zhang Yanshuang Zhang Miao Jiang Luna ruan Min Xiao Yunbo Yu hong He School of Rare Earths University of Science and Technology of ChinaHefei 230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Ca-type todorokite catalysts were designed and prepared by a simple redox method and applied to the selective reduction of NO_(x) by NH_(3)(NH_(3)-SCR)for the first *** with the Na-type manjiroite prepared by the same method,the todorokite catalysts with different Mn/Ca ratios showed greatly improved catalytic activity for NO_(x) *** them,Mn8Ca4 catalyst exhibited the best NH_(3)-SCR performance,achieving 90%NO_(x) conversion within temperature range of 70-275℃ and having a high sulphur *** to the Na-type manjiroite sample,Ca-type todorokite catalysts possessed an increased size of tunnel,resulting in a larger specific surface *** increased the amounts of Ca doping,the Na content in Ca-type todorokite catalysts significantly decreased,providing larger amounts of Bronsted acid sites for NH_(3) adsorption to produce NH_(4)^(+).The NH_(4)^(+)species were highly active for reaction with NO+O_(2),playing a determining role in NH_(3)-SCR process at low ***,larger amounts of surface adsorbed oxygen contained over the Ca-doping samples than that over Na-type manjiroite,promoting the oxidation of NO and fast SCR *** the Ca-type todorokite catalysts,furthermore,nitrates produced during the flow of NO+O_(2),were more active for reaction with NH_(3) than that over Na-type manjiroite,benefiting the occurrence of NH_(3)-SCR *** study provides novel insights into the design of NH_(3)-SCR catalysts with high performance.

关键词： NO_(x) NH_(3)-SCR Mn-based oxides Ca-type todorokite Bronsted acid sites

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BSAlign:A Library for Nucleotide Sequence Alignment

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 135-142页

作者： Haojing Shao Jue ruan Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Increasing the accuracy of the nucleotide sequence alignment is an essential issue in genomics *** classic dynamic programming(DP)algorithms(e.g.,Smith–Waterman and Needleman–Wunsch)guarantee to produce the optimal result,their time complexity hinders the application of large-scale sequence *** optimization efforts that aim to accelerate the alignment process generally come from three perspectives:redesigning data structures[e.g.,diagonal or striped Single Instruction Multiple Data(SIMD)implementations],increasing the number of parallelisms in SIMD operations(e.g.,difference recurrence relation),or reducing search space(e.g.,banded DP).However,no methods combine all these three aspects to build an ultra-fast *** this study,we developed a Banded Striped Aligner(BSAlign)library that delivers accurate alignment results at an ultra-fast speed by knitting a series of novel methods together to take advantage of all of the aforementioned three perspectives with highlights such as active F-loop in striped vectorization and striped move in banded *** applied our new acceleration design on both regular and edit distance pairwise *** achieved 2-fold speed-up than other SIMD-based implementations for regular pairwise alignment,and 1.5-fold to 4-fold speed-up in edit distance-based implementations for long *** is implemented in C programing language and is available at https://***/ruanjue/bsalign.

关键词： Pairwise alignment Edit distance Striped vectorization Banded dynamic programming F evaluation

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Dynamic Response of Foundations during Startup of High-Frequency Tunnel Equipment

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 821-844页

作者： Dawei ruan Mingwei Hu College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518060China State Key Laboratory of Intelligent Geotechnics and Tunnelling Shenzhen UniversityShenzhen518060China Key Laboratory of Coastal Urban Resilient Infrastructures of Ministry of Education Shenzhen UniversityShenzhen518060China Underground Polis Academy Shenzhen UniversityShenzhen518060China Shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen518060China

The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex *** vibration caused by the high-frequency units during regular operation is supported by the foundation of the units,and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts,leading to variations in the dynamic response of the *** high-frequency units yield significantly diverse outcomes under different startup conditions and times,resulting in failure to meet operational requirements,influencing the normal function of the tunnel,and causing harm to the foundation structure,personnel,and property in severe *** article formulates a finite element numerical computation model for solid elements using three-dimensional elastic body theory and integrates field measurements to substantiate and ascertain the crucial parameter configurations of the finite element *** proposing a comprehensive startup timing function for high-frequency dynamic machines under different startup conditions,simulating the frequency andmagnitude variations during the startup process,and suggesting functions for changes in frequency and magnitude,a simulated startup schedule function for high-frequency machines is created through *** into account the selection of the transient dynamic analysis step length,the dynamic response results for the lower dynamic foundation during its fundamental frequency crossing process are *** validation checks if the structural magnitude surpasses the safety threshold during the critical phase of unit startup traversing the structural resonance *** design recommendations for high-frequency units’dynamic foundations are provided,taking into account the startup process of the machine and ensuring the safe operation of the tunnel.

关键词： Tunnel equipment high-frequency units startup conditions transient dynamics dynamic response foundation design

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Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang ruan Wen-Jun Kong Qian Fan hong-Wei Dong Wei Zhang Wen-Bin Wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

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A microphysical investigation of different convective cells during the precipitation event with sustained high-resolution observations

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Frontiers of Earth Science 2024年第2期18卷 279-295页

作者： Ziheng HUANG Zheng ruan Debin SU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China Key Laboratory of Atmospheric Sounding China Meteorological AdministrationChengdu 610225China

The growth and breakup processes of raindrops within a cloud influence the rain intensity and the sizes of raindrops on the *** Doppler velocity spectrum acquired by a vertically pointing radar(VPR)contains information on atmospheric turbulence and the size classification of falling *** this study,the four types of Convective Cells(CC)during precipitation events with more than 700 mm of precipitation in southern China are *** characteristics of four types of CCs correspond to the isolated convection,the early stage,the mature stage,and the decline stage of organizational convection,in that *** analysis using retrieval of vertical air motion(Vair)and raindrop evolution in clouds from Doppler velocity spectra collected by C-band VPR revealed the growth and breakup of falling raindrops with dynamic *** raindrops appear in the early stages and are accompanied by ice particles,which are impacted by the falling path᾽s *** aggregation,which is primarily related to the alternation of updraft and downdraft,accounts for the mature stage᾽s high efficiency of surface *** CCs in the decline stage originate from the shallow uplift in the weak and broad downdraft under conditions of enough water *** updraft dominates the stage of isolated *** of convective cells could be more accurately represented in model evaluations.

关键词： cloud microphysics convective systems convective cell vertically pointing radar observations Doppler velocity spectrum

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Emerging perovskite materials for supercapacitors:Structure,synthesis,modification,advanced characterization,theoretical calculation and electrochemical performance

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Journal of Energy Chemistry 2024年第2期89卷 41-70,I0003页

作者： Yuehua Qian Qingqing ruan Mengda Xue Lingyun Chen Department of Applied Chemistry School of Chemistry and Chemical EngineeringChongqing UniversityChongqing 401331China

As a new generation electrode materials for energy storage,perovskites have attracted wide attention because of their unique crystal structure,reversible active sites,rich oxygen vacancies,and good *** this review,the design and engineering progress of perovskite materials for supercapacitors(SCs)in recent years is ***,the review will focus on four types of perovskites,perovskite oxides,halide perovskites,fluoride perovskites,and multi-perovskites,within the context of their intrinsic structure and corresponding electrochemical performance.A series of experimental variables,such as synthesis,crystal structure,and electrochemical reaction mechanism,will be carefully analyzed by combining various advanced characterization techniques and theoretical *** applications of these materials as electrodes are then featured for various ***,we look forward to the prospects and challenges of perovskite-type SCs electrodes,as well as the future research direction.

关键词： Perovskite Modification engineering Oxygen vacancy Theoretical calculation methodology Supercapacitor

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