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Radiation shielding design of a compact single-room proton therapy based on synchrotron

Nuclear Science and Techniques 2020年第1期31卷 1-12页

作者： Jin-Long wang L.Alberto Cruz Qing-Biao Wu Qiong wang Yao Wei hong-kai wang Guangzhou Concord Cancer Center Guangzhou 510045China University of Florida GainesvilleFL 32611USA Institute of High Energy Physics Chinese Academy of Science(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China National Supercomputing Center Wuxi 210008China Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Nuclear and Radiation Safety Center Ministry of Ecology and EnvironmentBeijing 102400China

A synchrotron-based proton therapy(PT)facility that conforms with the requirement of future development trend in compact PT can be operated without an energy selection *** article demonstrates a novel radiation shielding design for this *** FLUKAbased Monte Carlo simulations have been performed to validate its *** this design,two different shielding scenarios(3-m-thick concrete and 2-m-thick iron–concrete)are proved able to reduce the public annual dose to the limit of 0.1 mSv/*** calculation result shows that the non-primary radiation from a PT system without an inner shielding wall complies with the IEC 60601-2-64 international standard,making a single room a ***,the H/D value of this design decreases from 2.14 to 0.32 mSv/Gy when the distance ranges from 50 to 150 cm from the isocenter,which is consistent with the previous result from another *** establishing a typical time schedule and procedures in a treatment day for a single room in the simulation,a non-urgent machine maintenance time of 10 min after treatment is recommended,and the residual radiation level in most areas can be reduced to 2.5 lSv/*** annual dose for radiation therapists coming from the residual radiation is 1 mSv,which is 20%of the target *** general,this shielding design ensures a low cost and compact facility compared with the cyclotron-based PT system.

关键词： Proton therapy Radiation shielding Monte Carlo FLUKA

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Hi'CT:a pixel sensor-based device for ion tomography

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Nuclear Science and Techniques 2023年第7期34卷 231-241页

作者： Yi-Lun Chen hong-kai wang Shi-Yu Zhang Hai-Bo Yang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China

Carbon ions,commonly referred to as particle therapy,have become increasingly popular in the last *** predicting the range of ions in tissues is important for the precise delivery of doses in heavy-ion *** uncertainty is currently the largest contributor to dose uncertainty in normal tissues,leading to the use of safety margins in treatment *** potential method is the direct relative stopping measurement(RSP)with ***-ion CT(Hi′CT),a compact segmented full digital tomography detector using monolithic active pixel sensors,was designed and evaluated using a 430 MeV/u high-energy carbon ion pencil beam in *** precise position of the individual carbon ion track can be recorded and reconstructed using a 30μm×30μm small pixel pitch *** types of customized image reconstruction algorithms were developed,and their performances were evaluated using three different modules of CAT-PHAN 600-series *** RSP measurement accuracy of the tracking algorithm for different types of materials in the CTP404 module was less than 1%.In terms of spatial resolution,the tracking algorithm could achieve a 20%modulation transfer function normalization value of CTP528 imaging results at 5 lp/cm,which is significantly better than that of the fast imaging algorithm(3 lp/cm).The density resolution obtained using the tracking algorithm of the customized CTP515 was approximately 10.5%.In conclusion,a compact digital Hi'CT system was designed,and its nominal performance was evaluated in a *** RSP resolution and image quality provide potential feasibility for scanning most parts of an adult body or pediatric patient,particularly for head and neck tumor treatment.

关键词： Heavy-ion imaging Computed tomography Silicon pixel detectors Monte Carlo Phantoms Radiotherapy Image-guided Tracking

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Fungal diversity on fallen leaves of Ficus in northern Thailand

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 835-841页

作者： hong-kai wang Kevin D. HYDE Kasem SOYTONG Fu-cheng LIN Biotechnology Institute Zhejiang University Hangzhou 310029 China Fungal Research Group School of Science Mae Fah Luang University Tasud Chiang Rai 571000 Thailand Faculty of Agricultural TechnologT King Mongkut＇s Institute of Technology Ladkrabang Ladkrabang Bangkok 10520 Thailand

Fallen leaves of Ficus altissima, F. virens, F. benjamina, F. fistulosa and F. semicordata, were collected in Chiang Mai Province in northern Thailand and examined for fungi. Eighty taxa were identified, comprising 56 anamorphic taxa, 23 ascomycetes and l basidiomycete. Common fungal species occurring on five host species with high frequency of occurrence were Beltraniella nilgirica, Lasiodiplodia theobromae, Ophioceras leptosporum, Periconia byssoides and Septonema harknessi. Colletotrichum and Stachybotrys were also common genera. The leaves of different Ficus species supported diverse fungal taxa, and the fungal assemblages on the different hosts showed varying overlap. The fungal diversity of saprobes at the host species level is discussed.

关键词： Ficus Fallen leaves Saprobes Fungal diversity

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New and rare lignicolous hyphomycetes from Zhejiang Province, China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 797-801页

作者： Mongkol WONGSAWAS hong-kai wang Kevin D. HYDE Fu-cheng LIN State Key Laboratory for Rice Biology Institute of Biotechnology Zhejiang University Hangzhou 310029 China Fungal Research Group School of Science Mac Fah Luang University Tasud Muang Chiang Rai 57100 Thailand

Sporidesmiopsis zhejiangensis sp. nov. and Spadicoides americana were found on submerged wood from streams in Zhejiang Province, China. Sporidesmiopsis zhejiangensis is characterized by obclavate to fusiform, 5-6-distoseptate, versicolor-ous, verruculose conidia with an apical mucilaginous sheath. Spadicoides americana is a new record to China. These taxa are described and illustrated, and morphological differences between these species and their similar species were summarized.

关键词： Freshwater fungi Sporidesmiopsis zhejiangensis Spadicoides americana Taxonomy

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Hformer:highly efficient vision transformer for low-dose CT denoising

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Nuclear Science and Techniques 2023年第4期34卷 161-174页

作者： Shi-Yu Zhang Zhao-Xuan wang Hai-Bo Yang Yi-Lun Chen Yang Li Quan Pan hong-kai wang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China School of Cybersecurity Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021China

In this paper,we propose Hformer,a novel supervised learning model for low-dose computer tomography(LDCT)*** combines the strengths of convolutional neural networks for local feature extraction and transformer models for global feature *** performance of Hformer was verified and evaluated based on the AAPM-Mayo Clinic LDCT Grand Challenge *** with the former representative state-of-the-art(SOTA)model designs under different architectures,Hformer achieved optimal metrics without requiring a large number of learning parameters,with metrics of33.4405 PSNR,8.6956 RMSE,and 0.9163 *** experiments demonstrated designed Hformer is a SOTA model for noise suppression,structure preservation,and lesion detection.

关键词： Low-dose CT Deep learning Medical image Image denoising Convolutional neural networks Selfattention Residual network Auto-encoder

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Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia, a systematic review and meta-analysis

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Asian Journal of Andrology 2015年第2期17卷 281-284,I0010页

作者： Qi Yang Yan-Ping Huang hong-Xiang wang kai Hu Yi-Xin wang Yi-Ran Huang Bin Chen Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai institute of Andrology Shanghai 200127 China.

Noninvasive parameters for predicating sperm retrieval rate （SRR） are desirables. Follicle-stimulating hormone （FSH） has been an important predictor since the first years of testicular sperm extraction. Recent studies showed continuous interests in FSH, with both pros and cons. Thus, we conducted a meta-analysis to evaluate the diagnostic value of FSH as a predictor for patients with nonobstructive azoospermia （NOA） taking testicular sperm retrieval. Eligible diagnosis tests were identified from electronic databases （Cochrane Central Register of Controlled Trials, Medline, and EMBASE） without language restrictions. The database search, quality assessment, and data extraction were performed independently by two reviewers. The reference standard was the sperm retrieval result. Diagnostic value of FSH were explored by area under receiver operation characteristics （ROC） curve using Review Manager, version 5.1.0 （Cochrane Collaboration, Oxford, UK） and Meta-DiSc, version 1.4. Meta regression will be done if there is heterogeneity. Then, we find 11 tests including a total of 1350 patients met the inclusion criteria. Our pooled analysis showed that the area under ROC curve of FSH was 0.72 ~ 0.04. Meta regression analyses showed that region and average age have an influence on the diagnostic value. FSH showed more diagnostic value with patients in East Asia and with younger patients. We concluded that FSH had moderate value in independently predicating SRR in men with NOA （area under curve 〉0.7）. More detailed diagnosis tests should be anticipated in the future to confirm the diagnostic value of other noninvasive parameters.

关键词： follicule-stimulating hormone meta-analysis nonobstructive azoospermia testicular sperm retrieval

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu Yi wang hong‑Wei Liang hong‑Bang Liu Ye Tian hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang hong‑kai wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan wang Jia wang Jin‑Xiang wang Qi‑Lin wang Yong‑Sheng wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang hong Yin hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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Coxsackievirus B3-induced apoptosis and Caspase-3

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Cell Research 2003年第3期13卷 203-209页

作者： JIAN PING YUAN,WEI ZHAO,hong TAO wang,kai Yu WU,TAO LI,XIAO KUI GUO,SHAN QING TONGDepartment of Microbiology and Parasitology,Shanghai Second Medical University,Shanghai 200025,China Department of Microbiology and Parasitology Shanghai Second Medical University Shanghai China

Cell death can be classified into two categories: apoptosis and necrosis. Apoptotic pathway can beeither caspase-dependent or caspase-independent. Caspase-independent cytopathic effect (CPE) has beendescribed. In order to evaluate the pattern of HeLa cell death induced by Coxsackievirus B3 (CVB3)and whether apoptosis involves caspase activation, we co-cultivated HeLa cells with CVB3 and detectedthe cytopathic changes, the alteration of mRNA and protein expression of caspase-3 gene plus caspase-3activity, as well as analyzing DNA fragmentation before and after caspase-3 activity inhibition. Accordingto the results, we propose that CVB3 may induce apoptosis and necrosis in HeLa cells, the latter appearingmuch earlier. Caspase-3 is activated at the levels of both transcription and translation, and procaspase-3 isproteolytically cleaved, thus leading to the continuous increasing of both caspase-3 precursor protein and itssubunit. However, besides CPE, apoptosis induced by CVB3 is not a direct consequence of

关键词： Coxsackievirus B3 (CVB3) apoptosis. caspase-3.

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu kai Zhao Guoqiang Liu Youming Lu Xinyan Li kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen wang kai Rong Shanlei Chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

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