检索结果-南通市图书馆

Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 308-325页

作者： Adilson Fonseca Teixeira Yanhong Wang Josephine Iaria Peter ten Dijke hong-jian zhu Department of Surgery(The Royal Melbourne Hospital) The University of MelbourneParkvilleVICAustralia Huagene Institute Kecheng Science and Technology ParkPukou DistrictNanjingJiangsuChina Department of Cell and Chemical Biology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands

Metastasis is the leading cause of cancer-related *** growth factor beta(TGF-β)signaling drives metastasis and is strongly enhanced during cancer ***,the use of on-target TGF-βsignaling inhibitors in the treatment of cancer patients remains unsuccessful,highlighting a gap in the understanding of TGF-βbiology that limits the establishment of efficient anti-metastatic ***,we show that TGF-βsignaling hyperactivation in breast cancer cells is required for metastasis and relies on increased small extracellular vesicle(sEV)*** sEV’s unique role,TGF-βsignaling levels induced by sEVs exceed the activity of matching concentrations of soluble ligand TGF-β.Further,genetic disruption of sEV secretion in highlymetastatic breast cancer cells impairs cancer cell aggressiveness by reducing TGF-βsignaling to nearly-normal ***,TGF-βsignaling activity in non-invasive breast cancer cells is inherently low,but can be amplified by sEVs,enabling invasion and metastasis of poorly-metastatic breast cancer *** the translational potential of inhibiting sEV trafficking in advanced breast cancers,treatment with dimethyl amiloride(DMA)decreases sEV secretion,TGF-βsignaling activity,and breast cancer progression in *** both the sEV trafficking and TGF-βsignaling by combining DMA and SB431542 at suboptimal doses potentiated this effect,normalizing the TGF-βsignaling in primary tumors to potently reduce circulating tumor cells,metastasis,and tumor ***,this study establishes sEVs as critical elements in TGF-βbiology,demonstrating the feasibility of inhibiting sEV trafficking as a new therapeutic approach to impair metastasis by normalizing TGF-βsignaling levels in breast cancer cells.

关键词： metastasis doses invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crude oil cracking in deep reservoirs:A review of the controlling factors and estimation methods

引用

Petroleum Science 2023年第4期20卷 1978-1997页

作者： Yu Qi Chun-Fang Cai Peng Sun Dao-Wei Wang hong-jian zhu Department of Petroleum Engineering School of Vehicle and EnergyYanshan UniversityQinhuangdao066004HebeiChina Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China Key Lab of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan430100HubeiChina School of Energy Resource China University of Geosciences(Beijing)Beijing100083China

The natural cracking of crude oils in deep reservoirs has gained great interest due to continuously increasing depth of petroleum exploration and *** oil compositions and surroundings as well as complicated geological evolutions make oil cracking in nature much more complex than industrial *** far,numerous studies,focused on this topic,have made considerable progress although there still exist some ***,a comprehensive review on crude oil cracking is yet to be *** article systematically reviews the controlling factors of oil cracking from six aspects,namely,oil compositions,temperature and time,pressure,water,minerals and solid organic *** compare previous experimental and modelling results and present new field *** the following,we evaluate the prevailing estimation methods for the extent of oil cracking,and elucidate other factors that may interfere with the application of these estimation *** review will be helpful for further investigations of crude oil cracking and provides a guide for estimation of the cracking extent of crude oils.

关键词： Oil cracking Deep reservoir Controlling factor Gas to oil ratio Diamondoid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma

引用

World Journal of Gastrointestinal Oncology 2020年第10期12卷 1167-1176页

作者： Shi-Yuan Liu Muhammad Ahsan Bilal jian-hong zhu Shao-Min Li Department of Thoracic Surgery Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Dermatology and Venereology Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Clinical Laboratory Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Numerous studies have demonstrated that human epididymis protein 4(HE4)is overexpressed in various malignant tissues including ovarian,endometrial,lung,breast,pancreatic,and gastric ***,no study has examined the diagnostic impact of HE4 in patient with esophageal squamous cell carcinoma(ESCC)until *** To analyze the value of four serum tumor markers for the diagnosis of ESCC,and examine the associations of serum levels of HE4 with ESCC patients’clinicopathological *** The case group consisted of 80 ESCC patients,which were compared to a control group of 56 patients with benign esophageal *** levels of HE4,carcinoma embryonic antigen(CEA),alpha fetal protein,and carbohydrate antigen 19-9(CA19-9)were detected by *** associations of serum HE4 levels with ESCC patients’clinicopathological characteristics such as gender,tumor location,and pathological stage were also examined after *** The result of ELISA showed that serum HE4 level was significantly higher in the patients with ESCC than in the controls,and the staining intensity was inversely correlated with the pathological T and N *** HE4 levels had a sensitivity of 66.2%and specificity of 78.6%when the cutoff value was set at 3.9 ng/***,the combined HE4 and CA19-9 increased the sensitivity to 83.33%,and interestingly,the combination of HE4 with CEA led to the most powerful sensitivity of 87.5%.Furthermore,A positive correlation was observed between HE4 serum levels and pathological T and N stages(P=0.0002 and 0.0017,respectively),but there was no correlation between HE4 serum levels and ESCC patient gender(P=0.4395)or tumor location(P=0.6777).CONCLUSION The results of this study suggest that detection of serum HE4 levels may be useful in auxiliary diagnosis and evaluation of the progression of ESCC.

关键词： Human epididymis protein 4 Esophageal squamous cell carcinoma Diagnostic value Histological stage Clinicopathological characteristics Clinical progression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Symptom of the Shrunk-Grain Panicle and the Change Characteristics in Its Grain

引用

Agricultural Sciences in China 2008年第1期7卷 10-18页

作者： ZHANG Zu-jian LANG You-zhong PAN Mei-hong YANG jian-chang zhu Qing-sen Key Laboratory of Crop Genetics and Physiology of jiangsu Province Yangzhou University Yangzhou 225009 P.R.China

Over the past two years, an abnormal growth phenomenon jiangsu Province of China. The phenomenon is described in called shrunk-grain panicle has occurred in a large area in details by figures and characters in this article. The method with a japonica rice Wuyujing 3 as the experimental material, the characteristics of grain morphology distribution and the grain weight were studied. Normal and shrunk-grain panicles were sampled from several representative areas. The length, width, and weight of the normal grains were distributed as regular, continuous, and single peaks. Plant growth typically had a right-leaning tendency. On the contrary, the distribution of the grain morphology and weight were irregular and nearly double that of the shrunk-grain panicle. The proportion of the cumulative distribution in the two kinds of peaks was closely related to the degree of shrunk-grain panicle. The article discusses the phenomenon＇s symptoms, problems, and diagnosis.

关键词： rice japonica shrunk-grain panicle symptom grain weight distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BIM-based framework of automatic tunnel segment assembly and deviation control

引用

Underground Space 2024年第3期16卷 59-78页

作者： jian Gong Tengfei Bao Zheng zhu hong Yu Yangtao Li The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China Zhejiang Design Institute of Water Conservancy and Hydro-Electric Power Hangzhou 310002China

The design of universal segments and deviation control of segment assembly are essential for robust and low-risk tunnel construction.A building information modeling(BIM)-based framework was proposed for parametric modeling,automatic assembly,and deviation control of universal ***,segment models of different levels of detail(LoDs)were built based on BIM visual programming language(VPL)for different project life ***,the geometric constraints,requirements,and procedures for parametric segment assembly were distilled to develop a program that combines a novel typesetting algorithm with a 3D path replanning *** is implemented by introducing a point indication matrix,characterizing segments by sides,and manipulating geometries in a ***,3D path replanning,with non-uniform rational B-splines(NURBS)and arcs as basic shapes,was used to resolve unacceptable deviation situations after ***,the proposed framework was validated on a water diversion line and was found to be more effective and accurate than the previous method.

关键词： Parametric generative design BIM Deviation control Typesetting 3D path replanning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sequence structure controllable polymerization-induced self-assembly

引用

Science China Chemistry 2024年第1期67卷 390-397页

作者： Zi-Xuan Chang Ren-Man zhu Chun-Yan hong Wen-jian Zhang Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province Anhui UniversityHefei 230601China

Polymerization-induced self-assembly(PISA)combines synthesis and self-assembly of artificial polymers in one-pot,which brings us one step closer to emulating ***,the reported PISA formulations primarily focus on developing nano-objects with new chemical compositions and rarely on structural regulation of polymers with specific ***,sequence structure controllable polymerization-induced self-assembly(SCPISA)is reported by using 7-(2-methacryloyloxyethoxy)-4-methylcoumarin(CMA)as a *** the copolymerization of 2-hydroxyethyl methacrylate(HEMA)and CMA,controlled incorporation of CMA units into the polymer chains can be realized by programmable light/heat ***-based P(HEMA-co-CMA)copolymers with the same composition but different sequence structures generate a range of ***,the morphologies of the resultant nano-objects can also be controlled by regulating the feed molar ratio of CMA and HEMA,which is similar to the conventional PISA,but the synthesis procedure is obviously simplified in *** versatility of the methodology is further demonstrated by the fabrication of different functional nano-objects with sequence structure-dependent morphologies in SCPISA systems with different functional monomers.

关键词： polymerization-induced self-assembly sequence-controlled polymers PET-RAFT polymerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films

引用

Chinese Journal of Polymer Science 2024年第6期42卷 805-814页

作者： hong-Tao Shan Jia-Xin He Bing-Yan zhu Xue-Ting Cao Ying-Ying Yan jian-Jun Zhou hong Huo Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

In this work,poly(3-hexylthiophene)(P3HT)ultrathin films(P3HT-T)were prepared by spin-coating a dilute P3HT solution(in a toluene:o-dichlorobenzene(Tol:ODCB)blend with a volume ratio of 80:20)with ultrasonication and the addition of the nucleating agent bicycle[2.2.1]heptane-2,3-dicarboxylic acid disodium salt(HPN-68L)on glass,Si wafers and indium tin oxide(ITO)*** electrical and mechanical properties of the P3HT-T ultrathin films were investigated,and it was found that the conductivity and crack onset strain(COS)were simultaneously improved in comparison with those of the corresponding pristine P3HT film(P3HT-0,without ultrasonication and nucleating agent)on the same substrate,regardless of what substrate was ***,the conductivity of P3HT-T ultrathin films on different substrates was similar(varying from 3.7 S·cm^(-1)to 4.4 S·cm^(-1)),yet the COS increased from 97%to 138%by varying the substrate from a Si wafer to *** grazing-incidence wide-angle X-ray diffraction(GIXRD),UV-visible(UV-Vis)spectroscopy and atomic force microscopy(AFM),we found that the solid order and crystallinity of the P3HT-T ultrathin film on the Si wafer are highest,followed by those on glass,and much lower on ***,the surface energy and roughness of three substrates were investigated,and it was found that the polar component of the surface energyγp plays a critical role in determining the crystalline microstructures of P3HT ultrathin films on different *** work indicates that the P3HT ultrathin film can obviously improve the stretchability and simultaneously retain similar electrical performance when a suitable substrate is *** findings offer a new direction for research on stretchable CP ultrathin films to facilitate future practical applications.

关键词： P3HT ultrathin film Substrate Crystalline microstructures Polar component of the surface energy Electrical and stretchable performances

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites

引用

Rare Metals 2024年第10期43卷 5202-5215页

作者： Zhong-Hua Li Liang Liu Xin You jian-hong Yi Rui Bao Ming-Yi zhu Song Lu Jun-Jun Pai Faculty of Materials Science and Engineering Kunming University of Science and Technology Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Strengthening interface bonding between boron nitride nanosheets(BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites(CMCs) with high strength and wear resistance. Herein, BNNS/Cu composites were fabricated by the powder metallurgy route, matrix-alloying(adding 1.0 wt% Ti) strategy was adopted to improve the interfacial wettability and strengthen interface adhesion. A typical "sandwich"-like multiply interface structure involving TiN transition layers, BNNS and Cu matrix had been well constructed through the rational heat treatment(900℃for 120 min). Additionally, nano-sized TiB whisker was in situ formed in the vicinity of the interface, it had linked the BNNS-Cu-TiN multiply interface, which played a role of "threading the needle" and significantly strengthened the multi-interfaces bonding. This specific interface structure was finely characterized, and the formation mechanism of solid-state interfacial reaction feature was proposed. The results demonstrated that the ultimate tensile strength(UTS) of BNNS/Cu-(Ti)-900℃ increased from 248 to 530 MPa(increased by 114%), and the coefficient of friction(COF) decreased from 0.51 to 0.28 than pure Cu. This work highlights the importance of interface configuration design, which contributes to the development of CMCs with prominent comprehensive properties.

关键词： Boron nitride nanosheets Copper matrix composites Interface structure Mechanical and frictional properties

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Anesthesia,Anesthetics,and Postoperative Cognitive Dysfunction in Elderly Patients

引用

Current Medical Science 2024年第2期44卷 291-297页

作者： hong-yu zhu jian-li YAN Min ZHANG Tian-yun XU Chen CHEN Zhi-lin WU Department of Anesthesiology Linhe District People's HospitalBayannur 015000China Department of Neurosurgery Xinzhou District People's HospitalWuhan 430408China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Postoperative cognitive dysfunction(POCD)remains a major issue that worsens the prognosis of elderly surgery *** article reviews the current research on the effect of different anesthesia methods and commonly utilized anesthetics on the incidence of POCD in elderly patients,aiming to provide an understanding of the underlying mechanisms contributing to this condition and facilitate the development of more reasonable anesthesia protocols,ultimately reducing the incidence of POCD in elderly surgery patients.

关键词： anesthesia anesthetics postoperative cognitive dysfunction elderly patients

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanogeology in China:A review

引用

China Geology 2018年第2期1卷 286-303页

作者： Yi-wen Ju Cheng Huang Yan Sun Cai-neng Zou hong-ping He Quan Wan Xue-qiu Wang Xian-cai Lu Shuang-fang Lu jian-guang Wu hong-tai Chao Hai-ling Liu Jie-shan Qiu Fei Huang hong-jian zhu jian-chao Cai Yue Sun Key Laboratory of Computational Geodynamics Chinese Academy of SciencesCollege of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049 China Key Laboratory of Marginal Sea Geology of South China Sea Institute of Oceanology Chinese Academy of SciencesCruangzhou 510301China Carbon Research Laboratory School of Chemical EngineeringDalian University of TechnologyDalian 116012China Key Laboratory of Ministry of Education on Safe Mining of Deep MetalMines School of Resources and Civil EngineeringNorthwestern UniversityShenyang 110819China Institute of Geophysies and Geomatics China University ofGeosciences(Wuhan)Wuhan 430074China School of Earth Sciences and Engineering State Key Laboratory for Mineral Deposits ResearchNanjing UniversityNanjing 210093China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Institute of Geophysical and Geochemical Exploration CAGSKey Laboratory of Geochemical ExplorationMinistry of Land and ResourcesLangfang 065000China Research Institute of UnconventionalPetroleum and Renewable Energy Chinese University of Petroleum (East China)Qingdao 266580China China United CoalbedMethane Co. Ltd.Beijing 100011China Earthquake Administration of Shandong Province Jinan 250014China

Nanogeology is a subject that is a combination of geology and nanoscale science,and it has been a frontier field in recent *** is also a new subject with the features of intersectionality and multidisciplinary. Digging deeper into geological problems and nanoscale phenomena helps better revealing the more essential mechanisms and processes in geological science,which is also an evitable path in the development of *** this paper,we elaborate the concept,feature and main subdisciplines,and summarize three stages ofnanogeology development from preliminary research in the 1990s to subject formation in *** summarizing the researchers'achievements in this field,we illustrate some primary research progresses of nanogeology in China as eight *** the basis of the above content,we propose the development prospect of nanogeology in *** are many geologic problems with scientific values and economic benefits,such as research of geologic fundamental problems,resource exploration and development,mechanism study and prediction of geological activities (disasters),mechanism research and management of environmental pollution and *** has a great potential in China to solve all of these *** a result,the theories and methods of nanogeology will become enriching and *** offers important theoretical basis and technological methods to deal with major issues concerning the national economy and the people's livelihoods,such as the prediction of geological activities,as well as resource dislribution and its exploration and utilization.

关键词： Nanogeology Nanoparticle Nanostructure Scientific frontier Research progress Research prospect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：