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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： shi-hao Guan Wen-Jing Hu Xin-Yu Wang Yue-Xia Gu De-Hua Zhou Department of Plastic Surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Gastrointestinal Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

Evaluation of genetic response of mesenchymal stem cells to nanosecond pulsed electric fields by whole transcriptome sequencing

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World Journal of Stem Cells 2024年第3期16卷 305-323页

作者： Jian-Jing Lin Tong Ning shi-Cheng Jia Ke-Jia Li Yong-Can Huang Qiang Liu Jian-hao Lin Xin-Tao Zhang Department of Sports Medicine and Rehabilitation Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Institute of Medical Science The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Biomedical Engineering Institute of Future TechnologyPeking UniversityBeijing 100871China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijing 100044China

BACKGROUND Mesenchymal stem cells(MSCs)modulated by various exogenous signals have been applied extensively in regenerative medicine ***,nanosecond pulsed electric fields(nsPEFs),characterized by short duration and high strength,significantly influence cell phenotypes and regulate MSCs differentiation via multiple ***,we used transcriptomics to study changes in messenger RNA(mRNA),long noncoding RNA(lncRNA),microRNA(miRNA),and circular RNA expression during nsPEFs *** To explore gene expression profiles and potential transcriptional regulatory mechanisms in MSCs pretreated with *** The impact of nsPEFs on the MSCs transcriptome was investigated through whole transcriptome *** were pretreated with 5-pulse nsPEFs(100 ns at 10 kV/cm,1 Hz),followed by total RNA *** transcript was normalized by fragments per kilobase per *** change and difference significance were applied to screen the differentially expressed genes(DEGs).Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to elucidate gene functions,complemented by quantitative polymerase chain reaction *** In total,263 DEGs were discovered,with 92 upregulated and 171 *** were predominantly enriched in epithelial cell proliferation,osteoblast differentiation,mesenchymal cell differentiation,nuclear division,and wound *** cellular components,DEGs are primarily involved in condensed chromosome,chromosomal region,actin cytoskeleton,and *** aspect of molecular functions,DEGs are mainly involved in glycosaminoglycan binding,integrin binding,nuclear steroid receptor activity,cytoskeletal motor activity,and steroid *** real-time polymerase chain reaction confirmed targeted transcript *** Our systematic investigation of the wide-ranging transcriptional pattern modulated by nsPEFs revealed the differential expression of 26

关键词： Nanosecond pulsed electric fields Whole transcriptome sequencing Mesenchymal stem cells Genetic response Stem cell engineering

A CRISPR/RfxC as13d-mediated strategy for efficient RNA knockdown in mouse embryonic development

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Science China Life Sciences 2024年

作者： Lin Zhang shi-Meng Cao hao Wu Meng Yan Jinsong Li Ling-Ling Chen State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular Andrology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of RNA Innovation Science and Engineering CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology University of Chinese Academy of Sciences Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University New Cornerstone Science Laboratory Shenzhen

The growing variety of RNA classes, such as mRNAs, lncRNAs, and circRNAs, plays pivotal roles in both developmental processes and various pathophysiological conditions. Nonetheless, our comprehension of RNA functions in live organisms remains limited due to the absence of durable and effective strategies for directly influencing RNA levels. In this study, we combined the CRISPR-RfxCas13d system with spermlike stem cell-mediated semi-cloning techniques, which enabled the suppressed expression of different RNA species. This approach was employed to interfere with the expression of three types of RNA molecules: Sfmbt2 mRNA, Fendrr lncRNA, and circMan1a2(2,3,4,5,6). The results confirmed the critical roles of these RNAs in embryonic development, as their loss led to observable phenotypes, including embryonic lethality, delayed embryonic development, and embryo resorption. In summary, our methodology offers a potent toolkit for silencing specific RNA targets in living organisms without introducing genetic alterations.

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An Improved Thermal Conductivity Measurement Scheme for Macroscopic Graphitic Films Using the Laser Flash Method

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Journal of Thermal Science 2024年第4期33卷 1480-1490页

作者： ZHANG Peijuan MING Xin LIU Yingjun WANG Xuelong shi Hang hao Yuanyuan LU Jiahao LIU Zheng LAI Haiwen ZHANG Ying GAO Weiwei XU Zhen GAO Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030032China Special Equipment Safety Supervision and Inspection Institute of Jiangsu Province National Graphene Products Quality Inspection and Testing Center(Jiangsu)Wuxi214174China Hangzhou Gaoxi Technol Co. LtdHangzhou311113China China Academy of Aerospace Aerodynamics Beijing100074China

Achieving efficient thermal management urges to exploit high-thermal-conductivity materials to satisfy the boosted demand of heat *** is critical to adopt standardized characterization protocols to evaluate the intrinsic thermal conductivity of thermal management ***,for the most representative laser flash method,the lack of standard measurement methodology and systematic description on the thermal diffusivity and influencing factors has led to significant deviations and confusion of the thermal conduction performance in the emerging thermal management ***,the measurement error factors of thermal diffusivity by the common laser flash analyzer(LFA)are *** high-thermal-conductivity graphitic film(GF)as a typical case,the key factors are analyzed to guide the measurement protocol of related carbon-based thermal management *** basic principle of the LFA measurement,actual pre-processing conditions,instrument parameters setting,and data analysis are elaborated for accurate ***,the graphene thick films and common isotropic materials are also extended to meet various thermal measurement *** on the existing practical problems,we propose a feasible test flow to achieve a unified and standardized thermal conductivity measurement,which is beneficial to the rapid development of carbon-based thermal management materials.

关键词： thermal management graphitic film laser flash method thermal conductivity thermal diffusivity

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Blastic plasmacytoid dendritic cell neoplasm in Jinhua,China:Two case reports

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World Journal of Clinical Cases 2024年第22期12卷 5263-5270页

作者： Jia-Wei Cai Meng-Yao Li Wei-hao Wang hong-Qi shi Yi-Hui Yang Jia-Jun Chen Department of Pathology Jinhua HospitalJinhua 321000Zhejiang ProvinceChina Department of Pathology Shaoxing People’s HospitalShaoxing 312000Zhejiang ProvinceChina Department of Urology Shaoxing People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare and clinically aggressive hematologic malignancy originating from the precursors of plasmacytoid dendritic *** often involves the skin,lymph nodes,and bone marrow,with rapid clinical progression and a poor *** BPDCN diagnosis is mainly based on the *** SUMMARY In this paper,we retrospectively analyzed 2 cases of *** patients were elderly *** lesions manifested as skin *** manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous *** staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were *** In this paper,we retrospectively analyzed 2 cases of *** patients were elderly *** lesions manifested as skin *** manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous *** staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were positive.

关键词： Blastic plasmacytoid dendritic cell neoplasm Skin Clinical pathology Immunophenotype Hematopoietic stem cell transplantation Case report

Mechanical and damping performances of TPMS lattice metamaterials fabricated by laser powder bed fusion

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China Foundry 2024年第4期21卷 327-333页

作者： Yan-peng Wei Huai-qian Li Jing-jing Han Ying-chun Ma hao-ran Zhou Jing-chang Cheng Jian shi Zhi-quan Miao Bo Yu Feng Lin National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China

Lattice metamaterials based on three-period minimum surface(TPMS)are an effective means to achieve lightweight and high-strength materials which are widely used in various fields such as aerospace and ***,its vibration and noise reduction,and damping properties have not been fully ***,in this study,the TPMS structures with parameterization were designed by the method of surface migration,and the TPMS structures with high forming quality was manufactured by laser powder bed fusion(LPBF).The mechanical properties and energy absorption characteristics of the beam and TPMS structures were studied and compared by quasi-static *** modal shapes of the beam lattice structures and TPMS structures were obtained by the free modal analysis,and the damping properties of two structures were obtained by modal *** the two structures after heat treatment with the same porosity of 70%,the yield strength of the beam lattice structure reaches 40.76 MPa,elastic modulus is 20.38 GPa,the energy absorption value is 32.23 MJ·m^(-3),the damping ratio is 0.52%.The yield strength,elastic modulus,energy absorption value,and damping ratio of the TPMS structure are 50.74 MPa,25.37 GPa,47.34 MJ·m^(-3),and 0.99%,*** results show that TPMS structures exhibit more excellent mechanical properties and energy absorption,better damping performance,and obvious advantages in structural load and vibration and noise reduction compared with the beam lattice structures under the same porosity.

关键词： lattice metamaterials TPMS energy absorption damping laser powder bed fusion

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Sandwich-like Heterochromophore Metallo-Supramolecules Based on Dense Chromophore Arrangements with Energy and Chirality Transfer Properties

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CCS Chemistry 2024年第5期6卷 1264-1277页

作者： Ningxu Han Jianjun Ma hao Yu Junjuan shi Qixia Bai Xin Jiang Zhe Zhang Pingshan Wang Jing Yu Ming Wang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilin 130012 Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhouGuangdong 510006 School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798

Multichromophoric architectures with wellorganized chromophoric arrangements are of vital importance to gain insights into interchromophoric ***,we report a novel heteroleptic self-assembly strategy and construct three achiral and one chiral sandwich-like heterochromophore complexes(Zn_(4)L^(G)L^(A-C)_(2)and Zn_(4)L_(G)L^(D)_(2)).Possible dynamic products,including homoleptic oligomers and isomers,are eliminated,producing achiral complexes with exceptional *** are observed in chiral complexes due to the flexible geometry of *** aligned chromophore arrangements with precise spacing and orientations are evidenced by single-crystal X-ray *** distinct segments in the ligands lead to different interchromophoric ***,energy transfer and tunable emission,including white-light emission,are achieved for Zn_(4)L^(G)L^(A)_(2)and Zn_(4)L^(G)L^(B)_(2).In addition,chirality transfer is observed for Zn_(4)L_(G)L^(D)_(2),due to conformational restriction from chiral LD,leading to chiral rotational conformations of tetraphenylethylene moiety in LG.

关键词： heterochromophore complexes fluorescence single crystal dissymmetrical ligands chirality

Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang Liu hao Wang Bo Gao Ting-Ting Xu Qing-Gang Yuan shi-Zhen Zhou Chao Ding Ji Miao Wen-Xian Guan Department of General Surgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional status(CONUT)score effectively reflects a patient’s nutritional status,which is closely related to cancer *** study invest-igated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer,and compared the predictive ability of the CONUT score with other *** To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative *** This retrospective analysis included 217 patients with newly diagnosed *** CONUT score was calculated based on the serum albumin level,total lymphocyte count,and total cholesterol *** cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic *** associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression *** Using the cutoff value of the CONUT score,patients were stratified into CONUT low(n=189)and CONUT high groups(n=28).The CONUT high group had worse overall survival(OS)(P=0.013)and relapse-free survival(RFS)(P=0.015).The predictive performance of CONUT was superior to the modified Glasgow prognostic score,the prognostic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances of CONUT+tumor node metastasis(TNM)stage for 3-year OS[area under the receiver operating characteristics curve(AUC)=0.803]and 3-year RFS(AUC=0.752)were no less than skeletal muscle mass index(SMI)+TNM *** CONUT score was negatively correlated with SMI(P<0.01).CONCLUSION As a nutritional indicator,the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer,and its predictive ability was superior to other *** correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.

关键词： Controlling nutritional status Colorectal cancer Prognostic marker Sarcopenia Skeletal muscle

Anion cascade reactions Ⅲ:Synthesis of 3-isoquinuclidone bridged polycyclic lactams

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Chinese Chemical Letters 2024年第2期35卷 426-430页

作者： Zhiguo Zhang Bingbing shi Xiyang Cao Nana Ma hao Wu Xingjie Zhang Guisheng Zhang Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Centre of Henan Province for Green Manufacturing of Fine ChemicalsNMPA Key Laboratory for Research and Evaluation of Innovative DrugSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

Bridged polycyclic lactams are important structural units in organic functional materials,natural products,and pharmaceuticals.A flexible and efficient anion cascade reaction was developed for the preparation of bridged polycyclic lactams from readily available malonamides and 1,4‑*** highly substituted bridged polycyclic lactams were synthesized in good to excellent yields by tandem nucleophilic sequences in the presence of t BuOK in commercially available EtOH solvent at 60℃.Notably,the simple reactions can be run on a gram ***,bis-Michael addition reaction and hemiaminalization reactions are involved in the tandem transformation.

关键词： Anion cascade reactions 3-Isoquinuclidone Bridged polycyclic lactams Bis-Michael addition reaction Hemiaminalization

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Endoscopic ultrasonography-related diagnostic accuracy and clinical significance on small rectal neuroendocrine neoplasms

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World Journal of Gastroenterology 2024年第7期30卷 774-778页

作者： Jun Weng Yu-Fan Chen Shu-Han Li Yan-Hua Lv Ruo-Bing Chen Guo-Liang Xu shi-Yong Lin Kun-hao Bai Department of Endoscopy Sun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina State Key Laboratory of Oncology in South China Guangzhou 510060Guangdong ProvinceChina Guangdong Provincial Clinical Research Center for Cancer Guangzhou 510060Guangdong ProvinceChina Department of Management Clinical Medical College of Tianjin Medical UniversityTianjin 300000China Cancer Prevention Center Sun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

This research aimed to examine the diagnostic accuracy and clinical significance of endoscopic ultrasonography(EUS)in the context of small rectal neuroendocrine neoplasms(NENs).A total of 108 patients with rectal subepithelial lesions(SELs)with a diameter of<20 mm were included in the *** diagnosis and depth assessment of EUS was compared to the histology *** prevalence of NENs in rectal SELs was 78.7%(85/108).The sensitivity of EUS in detecting rectal NENs was 98.9%(84/85),while the specificity was 52.2%(12/23).Overall,the diagnostic accuracy of EUS in identifying rectal NENs was 88.9%(96/108).The overall accuracy rate for EUS in assessing the depth of invasion in rectal NENs was 92.9%(78/84).Therefore,EUS demonstrates reasonable diagnostic accuracy in detecting small rectal NENs,with good sensitivity but inferior *** may also assist physicians in assessing the depth of invasion in small rectal NENs before endoscopic excision.

关键词： Rectal neuroendocrine neoplasms Endoscopic ultrasonography Diagnosis Depth of invasion