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Leukocyte immunoglobulin-like receptor B2:A promising biomarker for colorectal cancer

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World Journal of Gastroenterology 2024年第4期30卷 421-423页

作者： Wen-Zhuo Zhao hong-gang wang Xiao-Zhong Yang Department of Gastroenterology The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical UniversityHuai'an 223300Jiangsu ProvinceChina

According to the latest global cancer statistics,colorectal cancer(CRC)has emerged as the third most prevalent malignant tumor across the *** recent decades,the medical field has implemented several levels of CRC screening tests,encompassing fecal tests,endoscopic examinations,radiological examinations and blood *** studies have shown that leukocyte immunoglobulin-like receptor B2(LILRB2)is involved in inhibiting immune cell function,immune evasion,and promoting tumor progression in acute myeloid leukemia and nonsmall cell lung ***,its interaction with CRC has not been reported ***,a study published in the World Journal of Gastroenterology revealed that LILRB2 and its ligand,angiopoietin-like protein 2,are markedly overexpressed in *** overexpression is closely linked to tumor progression and is indicative of a poor *** study highlights the potential of utilizing the concentration of LILRB2 in serum as a promising biomarker for ***,there is still room for discussion regarding the data processing and analysis in this research.

关键词： Colorectal cancer Leukocyte immunoglobulin-like receptor B2 Angiopoietinlike protein 2 Therapeutic target Noninvasive screening biomarker

Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

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World Journal of Gastroenterology 2024年第35期30卷 3985-3995页

作者： Xin Zhang Wei-Wei Jin hong-gang wang Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Nutrition Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Gastroenterology Taizhou Municipal HospitalTaizhou 524333Zhejiang ProvinceChina

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient *** To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with *** Patients diagnosed with IBS between January 2022 and January 2023 were selected for the *** individuals undergoing routine check-ups during the same period served as the control *** were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS *** IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy *** gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine ***,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel *** The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

关键词： Gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis Relationship study

Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis

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Genes & Diseases 2024年第4期11卷 65-68页

作者： Carson A.Wills Xiaoming Liu Longgui Chen Yuanjun Zhao Zhenqiu Liu Vladimir S.Spiegelman Jeffrey Sundstrom hong-gang wang Department of Pediatrics Division of Pediatric Hematology and OncologyThe Pennsylvania State University Collegeof MedicinePA 17033USA Department of Ophthalmology The Pennsylvania State University College of MedicinePA 17033USA Department of Public Health Sciences The Pennsylvania StateUniversityCollegeofMedicinePA 17033USA

Neuroblastoma is the most common extracranial solid tumor in children,accounting for more than 10%of cancerrelated deaths in this *** standard of care for patients diagnosed with medium-to high-risk neuroblastoma,incl... 详细信息

关键词： neuroblastoma metastatic metastasis

Quark Transport Properties in the Region of Coexistence of Both Hadronic and QGP Phases

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Communications in Theoretical Physics 2001年第7期36卷 47-52页

作者： CHEN Xiang-Jun LI hong wang gang ZHANG Wei-Ning HUO Lei Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China Department of Physics Harbin Institute of Technology Harbin 150001 China

The physical picture of coexistence of both hadronic and QGP phases is given by Friedberg and T.D. Lee's nontopology soliton model. The transport properties of quark in color space and spin space in a system of two-ph... 详细信息

关键词： hadron, quark-gluon plasma, soliton, transport property

Effective immune-inflammation index for ulcerative colitis and activity assessments

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World Journal of Clinical Cases 2021年第2期9卷 334-343页

作者： Meng-Hui Zhang Han wang hong-gang wang Xin Wen Xiao-Zhong Yang Department of Gastroenterology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’an 223300Jiangsu ProvinceChina

BACKGROUND The inverse association between systemic immune-inammation index(SII)and overall survival in tumors has been *** To evaluate the hematological indexes for assessing the activity of ulcerative colitis(UC).METHODS In this case-control study,172 UC patients and healthy participants were *** were made among groups of white blood cells,hemoglobin,platelets,neutrophils,lymphocytes,monocytes,SII,neutrophil-tolymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR).The relationship with hematological inflammation was verified by Spearman correlation *** efficiency of SII,NLR,and PLR for distinguishing between UC and severe disease status was assessed by the receiver operator curve and logistic regression *** The values of SII,NLR,and PLR were higher in UC patients than in controls(P<0.001)and were positively correlated with the Mayo endoscopic score,extent,Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score,and Ulcerative Colitis Endoscopic Index of Severity(UCEIS).The cut-off NLR value of 562.22 predicted UC with a sensitivity of 79.65%and a specificity of 76.16%.Logistic regression analysis revealed that patients with SII and NLR levels above the median had a significantly higher risk of UC(P<0.05).Risk factors independently associated with DUBLIN≥3 included SII≥1776.80[odds ratio(OR)=11.53,P=0.027]and NLR value of 2.67-4.23(OR=2.96,P=0.047)on multivariate *** with the first quartile,SII≥1776.80 was an independent predictor of UCEIS≥5(OR=18.46,P=0.012).CONCLUSION SII has a certain value in confirming UC and identifying its activity.

关键词： Ulcerative colitis Systemic immune-inflammation index Endoscopic score Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Disease activity

Synthesis and characterization of novel polypropylene paper releasing anion

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Chinese Chemical Letters 2009年第4期20卷 483-486页

作者： Li Qiu wang Qing Shan Li Hui Peng Ma Xiao Feng Guo Rui hong wang gang Yao College of Environmental and Chemical Engineering State Key Laboratory of Metastable Materials Science and Technology Yanshan University State Key Laboratory of Metastable Materials Science and Technology Qinhuangdao 066004 China

Polypropylene synthetic paper releasing anion was prepared from polypropylene resin, anion additives, titanium dioxide, etc., by calendar forming method. The synthetic paper was tested by anion detector, SEM, AFM, etc. Tensile strength, elongation at break, fight angle tear strength of the polypropylene synthetic paper reached the GB 13022 or QB/T1130 Standard. The synthetic paper was water and oil resistance, and released anions 10,530 cm^-3. It was environment-friendly, and a kind of good material for human＇s health.

关键词： Synthetic paper Polypropylene Functional polymer Health material Anions releasing

Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation

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World Journal of Gastroenterology 2021年第21期27卷 2834-2849页

作者： Xin Wen hong-gang wang Min-Na Zhang Meng-Hui Zhang Han wang Xiao-Zhong Yang Department of Gastroenterology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai'an 223300Jiangsu ProvinceChina

BACKGROUND Emerging evidence has demonstrated that fecal microbiota transplantation(FMT)has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis(UC),although the mechanism of FMT is *** To evaluate the protective effect of FMT on UC and clarify its potential dependence on the gut microbiota,through association analysis of gut microbiota with colon transcriptome in *** Dextran sodium sulfate(DSS)-induced experimental colitis was established and fecal microbiota was transplanted by *** of colon inflammation was measured by body weight,disease activity index,colon length and histological *** microbiota alteration was analyzed through 16S ribosomal ribonucleic acid *** differentially expressed genes(DEGs)in the colon were obtained by transcriptome *** activation status of colonic T lymphocytes in the lamina propria was evaluated by flow *** Compared with the DSS group,the weight loss,colon length shortening and inflammation were significantly alleviated in the FMT *** scores of disease activity index and colon histology decreased obviously after *** restored the balance of gut microbiota,especially by upregulating the relative abundance of Lactobacillus and downregulating the relative abundance of Clostridium_sensu_stricto_1 and *** the transcriptomic analysis,128 DEGs intersected after DSS treatment and *** annotation analysis suggested that these DEGs were mainly involved in T-lymphocyte *** the DSS group,there was an increase in colonic T helper CD4^(+)and T cytotoxic CD8^(+)cells by flow *** selectively downregulated the ratio of colonic CD4^(+)and CD8^(+)T cells to maintain intestinal ***,Clostri dium_sensu_stricto_1 was significantly related to inflammation-related genes including REG3G,CCL8 and *** FMT ameliorated DSS-induced colitis in mice via regulating the g

关键词： Fecal microbiota transplantation Colitis Gut microbiota Transcriptome sequencing T lymphocyte

Bunch-length measurement at a bunch-by-bunch rate based on time–frequency-domain joint analysis techniques and its application

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Nuclear Science and Techniques 2024年第4期35卷 165-175页

作者： hong-Shuang wang Xing Yang Yong-Bin Leng Yi-Mei Zhou Ji-gang wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

This paper presents a new technique for measuring the bunch length of a high-energy electron beam at a bunch-by-bunch rate in storage *** technique uses the time–frequency-domain joint analysis of the bunch signal to obtain bunch-by-bunch and turn-by-turn longitudinal parameters,such as bunch length and synchronous *** bunch signal is obtained using a button electrode with a bandwidth of several *** data acquisition device was a high-speed digital oscilloscope with a sampling rate of more than 10 GS/s,and the single-shot sampling data buffer covered thousands of *** bunch-length and synchronous phase information were extracted via offline calculations using Python *** calibration coefficient of the system was determined using a commercial streak ***,this technique was tested on two different storage rings and successfully captured various longitudinal transient processes during the harmonic cavity debugging process at the Shanghai Synchrotron Radiation Facility(SSRF),and longitudinal instabilities were observed during the single-bunch accumulation process at Hefei Light Source(HLS).For Gaussian-distribution bunches,the uncertainty of the bunch phase obtained using this technique was better than 0.2 ps,and the bunch-length uncertainty was better than 1 *** dynamic range exceeded 10 *** technology is a powerful and versatile beam diagnostic tool that can be conveniently deployed in high-energy electron storage rings.

关键词： Bunch-by-bunch diagnostic Bunch-length measurement Synchronous phase measurement Joint time–frequency-domain analysis Longitudinal instability

Prevalence and clinical characteristics of COVID-19 in inpatients with schizophrenia in Wuhan,China

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World Journal of Psychiatry 2022年第1期12卷 140-150页

作者： hong-Wei Sheng hong-gang wang Chun-Zhi wang Jiang Wu Li-Jian Huo Ruo-Xi wang Yong-Jie Zhou Xiang-Yang Zhang Department of Psychiatry Wuhan Youfu HospitalWuhan 430070Hubei ProvinceChina Qingdao Mental Health Center Qingdao UniversityQingdao 266000Shandong ProvinceChina CAS Key Laboratory of Mental Health Chinese Academy of SciencesBeijing 10000China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430070Hubei ProvinceChina Department of Psychiatric Rehabilitation Shenzhen Kangning HospitalShenzhen 510810Guangdong ProvinceChina

BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric *** prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are *** To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric *** We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan’s Youfu *** Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison *** overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were *** most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for *** patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between *** Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.

关键词： Mental health Schizophrenia Inpatient Epidemiology