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Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1465-1478页

作者： Yu-Xin Zhao Yan Cui Xin-hong li Wen-hong Yang Shi-Xiang An Jia-Xian Cui Min-Yu Zhang Jing-Kun Lu Xuan Zhang Xiu-Mei Wang li-li Bao Peng-Wei Zhao Department of Anesthesiology Inner Mongolia Chest HospitalThe Fourth HospitalHohhot 010035Inner Mongolia Autonomous RegionChina College of Humanities and Education Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Radiotherapy The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina School of Basic Medical Science Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Medical Oncology The Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHohhot 010050Inner Mongolia Autonomous RegionChina

BACKGROUND Colorectal cancer has a low 5-year survival rate and high ***β-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer *** non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and *** To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 *** CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug *** formation assay was employed to assess the effect of hBD-1 on SW620 cell *** was used to screen potentially biologically significant lncRNAs related to the mTOR ***,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot *** hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to ***-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I ***,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR *** lncRNA TCONS_00014506 was ultimately *** the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein *** hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

关键词： Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin Autophagy

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Harnessing the holobiont to alleviate the stress of aluminum toxicity to rice

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Soil Ecology Letters 2024年第1期6卷 7-9页

作者： hong-Zhe li Yong-Guan Zhu Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Fujian Key Laboratory of Watershed Ecology Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeiing 100085China

Plant microbiome(including the microbiomes in the rhizosphere,phyllosphere,and endosphere)has been hailed as the second genome of the host,and plays a critical role in the health and fitness of the *** to clinical medicine,microbiome transplant has been suggested to improve ecosystem restoration and crop production in degraded environment(Jurburg et al.,2022).This concept aligns with recent findings that emphasize the significant impact of soil and plant-associated microbiomes in agricultural productivity and the health of host plants(Wubs et al.,2016;Carthey et al.,2020;Mazza Rodrigues and Melotto,2023).

关键词： finding Harness soil

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Molecular Chain Flexibility and Dielectric Loss at High-Frequency:Impact of Ester Bond Arrangement in Poly(ester imide)s

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Chinese Journal of Polymer Science 2024年第8期42卷 1122-1133页

作者： Ya-Dong li hong li Lu-Kun Feng Feng Bao Ming-liang Wang Cai-Zhen Zhu Zhao-Hui Zheng Xiao-Bin Ding Jian Xu Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100081China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

The evolution of high-frequency communication has accentuated the significance of controlling dielectric properties in polymer ***,it has been theorized that rigid molecular chains lead to lower dielectric ***,the validity of this proposition at high frequencies remains *** scrutinize the correlation between chain flexibility and dielectric properties,we synthesized six poly(ester imide)s(PEIs)with systematically varied molecular chain flexibilities by modifying the ester's substitution on the aromatic *** introduction of ester bonds bestowed all PEI films with a low dielectric dissipation factor(D_(f)),ranging from 0.0021 to 0.0038 at 10 GHz in dry *** dry D_(f)displayed a pattern consistent with volume polarizability(P/V).Unexpectedly,PI-mmm-T,featu ring the most flexible molecular chain,exhibited the lowest dielectric loss under both dry(0.0021@10 GHz)and hygroscopic(0.0029@10 GHz)***,the observed increase in D_(f)after humidity absorption suggests that the high dielectric loss of PEI in applications may be attributed to its hygroscopic *** simulations and characterization of the aggregation structure revealed that the smaller cavities within flexible molecular chains,after close stacking,impede the entry of water *** sacrificing high-temperature resistance,the precursor exhibited enhanced solubility properties and could be processed into high-quality *** research unveils new insights into the relationship between flexibility and highfrequency dielectric loss,offering innovative perspectives on synthesizing aromatic polymers with exceptional dielectric properties.

关键词： 5G communications Poly(ester imide)s Molecular chain flexibility Dielectric properties Humidity absorption

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Implications for fault reactivation and seismicity induced by hydraulic fracturing

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Petroleum Science 2024年第2期21卷 1081-1098页

作者： Zi-Han Sun Ming-Guang Che li-hong Zhu Shu-Juan Zhang Ji-Yuan Lu Chang-Yu Jin Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil Engineering and Key Laboratory of Liaoning Province on Deep Engineering and Intelligent TechnologyNortheastern UniversityShenyang110819LiaoningChina Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100084China The Exploration and Development Research Institute of Daqing Oilfield limited Company Daqing163458HeilongjiangChina

Evaluating the physical mechanisms that link hydraulic fracturing(HF) operations to induced earthquakes and the anticipated form of the resulting events is significant in informing subsurface fluid injection operations. Current understanding supports the overriding role of the effective stress magnitude in triggering earthquakes, while the impact of change rate of effective stress has not been systematically addressed. In this work, a modified critical stiffness was brought up to investigate the likelihood, impact,and mitigation of induced seismicity during and after hydraulic fracturing by developing a poroelastic model based on rate-and-state fraction law and linear stability analysis. In the new criterion, the change rate of effective stress was considered a key variable to explore the evolution of this criterion and hence the likelihood of instability slip of fault. A coupled fluid flow-deformation model was used to represent the entire hydraulic fracturing process in COMSOL Multiphysics. The possibility of triggering an earthquake throughout the entire hydraulic fracturing process, from fracturing to cessation, was investigated considering different fault locations, orientations, and positions along the fault. The competition between the effects of the magnitude and change rate of effective stress was notable at each fracturing stage. The effective stress magnitude is a significant controlling factor during fracturing events, with the change rate dominating when fracturing is suddenly started or stopped. Instability dominates when the magnitude of the effective stress increases(constant injection at each fracturing stage) and the change rate of effective stress decreases(the injection process is suddenly stopped). Fracturing with a high injection rate, a fault adjacent to the hydraulic fracturing location and the position of the junction between the reservoir and fault are important to reduce the Coulomb failure stress(CFS) and enhance the critical stiffness as

关键词： Hydraulic fracturing Coulomb failure stress Rate-and-state fraction model linear stability analysis Critical stiffness Seismically induced fault

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Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 124-133页

作者： Yang liu Xian-Xue Wang Yu-lin li Wen-Tao He hong li Hua Chen Department of General Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Anesthesiology Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)is increasing *** radical resection of CRC is a minimally invasive procedure preferred in clinical *** To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed *** control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 *** in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were *** Thirty patients from both groups were successfully *** PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than ***-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before *** 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation gro

关键词： Colorectal cancer Laparoscopic Open surgery Inflammatory reaction Immune function Propensity score

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Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： hong-Wei li Chen-Peng Hao Zhi-Jiang Chen li Gong Yi-Fei Lu Yang Wang Jia-Ji li Chun-Mei Zhang Rong Wang Zhen-Qiang Yin Qing-Yu Cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

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Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-Xia Hao hong-Xia li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

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Ground state of Rydberg-dressed Bose gas confined in a toroidal trap

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Communications in Theoretical Physics 2024年第1期76卷 29-35页

作者： lin-Xue Wang hong-li Yang Hui liu Si-lin Chen Ya-Jun Wang Xiao-Fei Zhang Department of Physics School of Physics and Information ScienceShaanxi University of Science and TechnologyXi'an 710021China Department of Basic Sciences Air Force Engineering UniversityXi'an 710051China

The experimental realization of Rydberg dressing technology in ultracold atomic systems provides another superior platform for studying novel states of matter and macroscopic quantum *** this work,based on the mean-field theory,we have investigated the ground-state phases of a two-component Bose–Einstein condensate with Rydberg interaction and confined in a toroidal *** effects of the Rydberg interaction and external potential,especially the Rydberg blockade radius,on the ground-state structure of such a system have been investigated in full parameter *** results show that the Rydberg blockade radius,which can be regarded as another controllable parameter,can be used to obtain a variety of ground-state *** interestingly,it is found that for weak Rydberg interactions,the Rydberg blockade radius breaks the spontaneous rotational symmetry of the system,leading to the formation of a discrete unit cell *** strongly interacting cases,it can be used to realize different orders of discrete rotational symmetry breaking.

关键词： Bose-Einstein condensate Rydberg dressing toroidal trap

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ESM Cloud Toolkit: A Copilot for Energy Storage Material Research

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Chinese Physics Letters 2024年第5期41卷 40-46页

作者：许晶肖睿娟李泓 Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Searching and designing new materials play crucial roles in the development of energy storage devices. In today's world where machine learning technology has shown strong predictive ability for various tasks, the combination with machine learning technology will accelerate the process of material development. Herein, we develop ESM Cloud Toolkit for energy storage materials based on Mat Elab platform, which is designed as a convenient and accurate way to automatically record and save the raw data of scientific research. The ESM Cloud Toolkit includes multiple features such as automatic archiving of computational simulation data, post-processing of experimental data, and machine learning applications. It makes the entire research workflow more automated and reduces the entry barrier for the application of machine learning technology in the domain of energy storage materials. It integrates data archive, traceability, processing, and reutilization, and allows individual research data to play a greater role in the era of AI.

关键词： Toolkit Storage ESM

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Time-resolved ultra-small-angle X-ray scattering beamline(BL10U1)at SSRF

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Nuclear Science and Techniques 2024年第2期35卷 6-19页

作者： Wen-Qiang Hua Chun-Ming Yang Ping Zhou Feng Tian Jin-You lin Yu-Zhu Wang Xiao-Yun li Xia-Ran Miao Chun-Xia hong Qiu-Shi Huang Xin-Tong Zhao Yong-Feng Men Jie Wang Xing-Yu Gao Xiu-hong li Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Key Laboratory of Advanced Micro Structural Materials MOEInstitute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The construction of a new beamline,BL10U1,was completed at the Shanghai synchrotron radiation facility in *** multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),wide-angle X-ray scattering,and microfocus SAXS(μSAXS)for a broad user *** realize fast time-resolved USAXS experiments,the beamline adopted an in-vacuum undulator with a total length of 1.6 m as the photon *** in-house cryogenic-cooled double multilayer monochromator was installed to deliver a photon flux of approximately 10^(13) photons/s at a photon energy of 10 *** three-year successful operation of this beamline demonstrated that the monochromator operated smoothly,as ***10U1 has three end stations in succession:USAXS end station,μSAXS end station,and end station for industrial *** minimum scattering vector q~0.0042 nm^(-1) at 10 keV can be achieved at the USAXS end station equipped with a 28 m-long and 1.8 m-diameter vacuum flight *** theμSAXS end station,a beam spot of less than 10×8μm was achieved for micro-SAXS *** contrast,in situ experimental instruments up to 5 m high and 8 m wide can be mounted at the industrial application end station,which offers industrial scientists the opportunity to use their large industrial ***10U1 opens up a new capability to investigate phenomena such as non-equilibrium and dynamic processes of materials with a wide length scale from angstroms to micrometers with millisecond time *** this paper,we also report beamline design considerations and commissioning results.

关键词： Synchrotron radiation Ultra-small-angle X-ray scattering Micro small-angle X-ray scattering USAXS Time resolved μSAXS

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