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Headaches Associated with N95 Mask Usage amongst Healthcare Workers in Operating Theatres during COVID-19 Pandemic: A Cross-Sectional Study

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Open Journal of Anesthesiology 2022年第5期12卷 184-195页

作者： Lydia Weiling Li Daryl Jian An Tan terry hong lee teo Jinlin Lin Department of Anaesthesiology and Surgical Intensive Care Changi General Hospital Singapore Department of Orthopaedic Surgery Changi General Hospital Singapore Department of General Upper GI and Bariatric Surgery Changi General Hospital Singapore

Introduction: N95 respirator masks are a cornerstone in the fight against the ongoing COVID-19 pandemic. However, its use has side effects such as headaches. The primary aim of this study is to identify factors that may contribute to higher occurrences of headaches with wearing N95 masks. Methods: A cross-sectional study was conducted across healthcare providers in operating theatres of a tertiary hospital based in Singapore involved in the care of COVID-19 patients. The study involved a self-administered online questionnaire completed by all participants. Results: 176 participants were included into the study, of which 65 (36.9%) reported headaches associated with wearing N95 masks. Out of the 65 participants who experienced headaches, 28 (43.1%) reported experiencing “mild” headache, 30 (46.2%) reported experiencing “moderate” headache, and 7 (10.7%) reported experiencing “severe” headache. 44 participants (67.7%) reported that the headache has affected their work, and 20 participants (30.8%) required analgesia to relieve the headaches. Other symptoms associated with N95 mask usage include skin damage (12.3%), breathlessness (15.4%), giddiness (6.2%), nausea (6.2%) and ear pain (3.1%). Multivariate logistic regression analysis showed that participants younger than 32 years old (p = 0.001) and history of pre-existing headache disorders (p = 0.001) were associated with higher occurrences of headaches with wearing N95 masks. Conclusion: Our study showed that younger age and history of pre-existing headache disorders contribute to higher occurrences of headaches with N95 mask usage. These associations could be useful in identifying at-risk individuals so that precautions may be taken to reduce the occurrence of headaches when wearing N95 masks.

关键词： N95 Masks Headache COVID-19 Health-Care Workers Operating Theatre

Higher-order Mond-Weir converse duality in multiobjective programming involving cones

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Science China Mathematics 2013年第11期56卷 2389-2392页

作者： YANG XinMin YANG Jin YIP Tsz Leung teo Kok Lay Department of Mathematics Chongqing Normal University Department of Applied Mathematics The Hong Kong Polytechnic University Department of Logistics and Maritime Studies The Hong Kong Polytechnic University Department of Mathematics and Statistics Curtin UniversityW.A. 6845 Australia

In this work, we established a converse duality theorem for higher-order Mond-Weir type multiob- jective programming involving cones. This fills some gap in recently work of Kim et al. [Kim D S, Kang H S, lee Y J, et ... 详细信息

关键词： multiobjective programming higher order Mond-Weir dual model converse duality theorem cones

Upfront consolidation treatment with 131I-mIBG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma

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Pediatric Investigation 2020年第3期4卷 168-177页

作者： Jianhua Feng Frankie WT Cheng Alex WK Leung Vincent lee Eva WM Yeung Hoi Ching Lam Jeanny Cheung Grace KS Lam terry TW Chow Carol LS Yan Chi Kong Li Department of Paediatrics The Chinese University of Hong KongHong KongChina Department of Paediatrics The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Paediatrics and Adolescent Medicine Hong Kong Children’s HospitalHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Importance:131I-metaiodobenzylguanidine(131I-mIBG)has a significant targeted antitumor effect for ***,currently there is a paucity of data for the use of 131I-mIBG as a"front-line"therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy(MAC).Objective:To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation(HSCT)in high-risk neuroblastoma ***:A retrospective,single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease(PD)after the completion of induction *** received 131I-mIBG infusion and MAC followed by ***:A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at *** receiving this sequential consolidation treatment,3 of 13 patients who were in partial response(PR)before 131I-mIBG treatment achieved either complete response(CR)(n=1)or very good partial response(VGPR)(n=2)after *** a median follow-up duration of 13.0 months after 131I-mIBG therapy,the 5-year event-free survival and overall survival rates estimated were 29%and 38%for the entire cohort,and 53%and 67%for the patients who were in CR/VGPR at the time of 131I-mIBG ***:Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients,however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment.

关键词： Neuroblastoma 131I-mIBG Transplantation

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Trends in Suicide by Poisoning in China 2000-2006: Age, Gender, Method, and Geography

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Biomedical and Environmental Sciences 2008年第3期21卷 253-256页

作者： XING ZHANG HAI-SHAN LI QIU-hong ZHU JING ZHOU SHUANG ZHANG LIN ZHANG CHENG-YE SUN National Institute for Occupational Health and Poison Control Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective This study analyzed patterns of suicide and suicide attempts by poisoning as reported through a national poison control system for the purpose of improving intervention and prevention. Methods During the period of 2000 to 2006, 6440 cases of poisoning suicide were reported to the telephone consultation service system of The National Center for Poisoning Control （Chinese Center for Disease Control and Prevention）. Among these records, 4728 cases had completed data for this analysis in terms of age, sex, trend of time and location, and type of poisons. Results There were 60.6% female cases with the age from 10 to 90 years old. The age of cases from 20 to 39 years accounted for 54.5% of all age groups. Both the numbers and percentage in record related to poisoning consultation of oral poisoning suicide showed an increasing tendency during the 7 years. In particular, there was a drastic increase from 2004 to 2006. In addition, the high frequency of cases occurred from May to October. Hebei, Shandong, Henan, and Anhui Provinces had the highest number of cases. Pesticide poisonings were the most common method in these cases of consultation for suicide and suicide attempts. Conclusion This study describes epidemiological characteristics in the oral poisoning suicide cases and provides scientific basis for suicide prevention interventions.

关键词： Suicide by poisoning Tendency Pesticide Intervene

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD ***,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

美国华人新移民大学生性心理和性行为的调查研究

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中国性科学 2010年第5期19卷 3-7页

作者：邓明昱王友平李青莲李勇杨登明袁弘陈黎龚蕾唐静杨彼得徐安娜李特里劳玛丽周茜董琳达美国东西方性学研究所仁爱医科大学华人心理健康报旧金山高级性学研究院哥伦比亚大学医学院纽约华人社区咨询中心耶鲁大学医学院纽约市立大学皇后学院西北大学心理学系

目的:了解美国华人新移民大学生的性心理和性行为的现状,探讨在华人大学生中开展性心理咨询和性教育的重要性。方法:采用"大学生性心理和性行为调查问卷",对美国5所高校的126名华人大学生进行问卷调查。结果:大部分华人大学生对学生时... 详细信息

目的:了解美国华人新移民大学生的性心理和性行为的现状,探讨在华人大学生中开展性心理咨询和性教育的重要性。方法:采用"大学生性心理和性行为调查问卷",对美国5所高校的126名华人大学生进行问卷调查。结果:大部分华人大学生对学生时期性行为有一定顾虑,在面对性行为有可能引起的后果方面相对谨慎。华人新移民大学生在中国较少接受过系统的性教育,性知识比较缺乏,但有了解性知识的愿望。结论:大学是公众教育的最后一站。在华人新移民大学生性知识较缺乏的情况下,大学应成为性心理咨询和性教育的重要渠道。需要在华人新移民大学生中展开系统全面的性教育。

关键词：华人大学生新移民性心理性行为性知识性教育