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Anti-programmed cell death ligand 1-based immunotherapy in recurrent hepatocellular carcinoma with inferior vena cava tumor thrombus and metastasis:Three case reports

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World Journal of Clinical Cases 2021年第21期9卷 5988-5998页

作者： Shao-Ru Liu Qing Yan Hao-Ming Lin Guang-Zi Shi Yi Cao hong zeng Chao Liu Rui Zhang Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Biliary-Pancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510288Guangdong ProvinceChina Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina Department of Emergency Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Recurrent hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus is a great challenge for oncologists and has a poor *** date,the safety and efficacy of programmed cell death ligand 1(PD-L1)inhibitors are still *** SUMMARY A 59-year-old male was identified as having a tumor thrombus in the inferior vena cava 3 years after *** patient underwent a second surgery and adjuvant ***,the level of alpha-fetoprotein was elevated after 2 mo,and lung metastases and mediastinal lymph node metastases were *** expression of PD-L1 in HCC and inferior vena cava tumor thrombus tissues was analyzed by ***,the patient received atezolizumab *** level of alpha-fetoprotein dropped to normal,the mediastinal lymph node metastases decreased in size and the lung metastases disappeared after 3 mo of *** patient had no signs of recurrence at 21 mo of follow-up.A 60-year-old male underwent left hepatic tumor resection,inferior vena cava incision and thrombus removal,followed by regular *** patient developed lung and splenic metastases after *** was used for six courses,and the splenic metastasis shrank,after which splenectomy was *** patient continued to receive pembrolizumab for thirteen courses,and the lung metastases showed no progression.A 34-year-old male was diagnosed with liver cancer with inferior vena cava tumor *** patient underwent right hepatectomy and received tislelizumab for three *** is still receiving immunotherapy and in good *** Anti-PD-L1 therapy in HCC patients with inferior vena cava tumor thrombus and metastasis is associated with relatively good patient outcomes.

关键词： Recurrent hepatocellular carcinoma Inferior vena cava tumor thrombus Metastasis Programmed cell death ligand 1 Immunotherapy Case report

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Differences in Toxicokinetics and Maternal Transfer between Lipophilic and Proteinophilic Halogenated Organic Pollutants in Laying Hens

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Environment & Health 2024年第10期2卷 712-720页

作者： Xiao-Jun Luo Qun-Jie Feng Chu-hong Zhu Xi Chen Peng-Peng Chen Yan-hong zeng Bi-Xian Mai State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection and Guangdong-hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640P.R.China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophilic HOPs included polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),and dechlorane plus(DPs),while the proteinophilic HOPs included perfluorocarboxylic acids(PFCAs).The results revealed that most of lipophilic HOPs exhibit lower depuration rate(kd)than *** kd of lipophilic HOPs correlated with the octanol−water partition coefficient(log KOW)values in a V-shaped curve,whereas that of PFCAs correlated with the protein−water partition coefficient(log KPW)values in an inverted V-shaped *** depuration rate,rather than the uptake rate,was a leading factor in determining the bioaccumulation potential of HOPs in *** the dominant factors determining the tissue distribution of the two types of compounds were explicit(fats vs phospholipids),chemical-specific tissue distribution was still *** egg-maternal concentration ratio was dependent on the exposure status,concentration,and maternal tissue *** a single maternal tissue may not be an appropriate method for assessing chemical maternal transfer *** have a greater maternal transfer potential(>80%of the total body burden)than lipophilic HOPs(approximately 30%for BDE209 and DPs,and less than 10%for the others).Their lipophilic and partly proteinophilic nature makes the toxicokinetics and maternal transfer characteristics of BDE209 and DPs different from those of other lipophilic *** findings are crucial for enhancing our understanding of the behavior and fate of HOPs in egg-laying hens.

关键词： halogenated organic pollutants laying hens toxicokinetic maternal transfer

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Psychological and Emotional Responses during Different Stages of the COVID-19 Pandemic Based on a Survey of a Mental Health Hotline

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International Journal of Mental Health Promotion 2022年第5期24卷 711-724页

作者： Shuna Peng Xiaohong Luo Shiyu Liang Fengning Deng Yuning Liu hong zeng Xuesong Yang Department of Psychology Guangzhou UniversityGuangzhou510006China Department of Psychology University of EdinburghEdinburghEH89JZUK Division of Histology and Embryology Key Laboratory for Regenerative Medicine of the Ministry of EducationMedical CollegeJinan UniversityGuangzhou510632China

Background:The coronavirus(COVID-19)outbreak in 2019 triggered psychological and emotional *** research investigates the psychological status and emotional problems of those who sought psychological assistance during the epidemic period by calling a mental health ***:This study aims to combine qualitative and quantitative *** analysis was used for undertaking qualitative *** ana-lyzed the data from group 1(n=706),in which the people used the mental health hotline from 25 January 2020 to 23 June 2020.A self-designed questionnaire was developed in accordance with the classiﬁcation and sum-marized items from group 1’s psychological problems and emotional *** implement the quantitative research,we conducted a cross-sectional descriptive survey and used the self-compiled scale and HADS to inves-tigate group 2(n=553)from May 2020 to June ***:Descriptive statistics and comparative analysis revealed that:①Visitors mainly reported behavior,emotional,family relationship problems and sleep disorders.②Anxiety,comorbidities,sleep disorders and coping problems were the most frequently reported problems.③There were signiﬁcant differences in the number of visitors experiencing various problems or exhibiting harmful behaviors(sorrow,worry,fear,depression,sleep disorders,self-harm or suicide,and coping problems,anxiety,hypochondria,and comorbidity)in the four stages of the epidemic.④More than a quarter of participants still suffered from anxiety or depression in the later stages of the ***:Different problems manifested at different stages of the epidemic,and psychological interventions and assistance should be tailored to reﬂect this.

关键词： COVID-19 comorbidities different stages psychological intervention

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Basilic vein variation encountered during surgery for arm vein port:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2086-2091页

作者： Cheng-Da Hu Rui Lv Ya-Xin Zhao Ming-Hao Zhang hong-Dou zeng Yi-Wen Mao Department of Breast Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Venous variations are uncommon and usually hard to identify,and basilic vein variation is particularly *** vein variation usually presents without any clinical symptoms and is often regarded as a benign *** case was a patient with congenital basilic vein variation encountered during surgery for an infusion *** SUMMARY We documented and analyzed an uncommon anatomical variation in the basilic vein encountered during arm port *** peculiarity has hitherto remained undescribed in the *** offer remedial strategies for addressing this anomaly in the future and precautionary measures to circumvent its *** conducted a comprehensive review of analogous cases in the literature,offering pertinent therapeutic recommendations and solutions,with the aim of enhancing the efficacy and safety of future arm port *** Venous variation is rare and requires detailed intraoperative and postoperative examination to ensure accuracy,so as not to affect subsequent treatment.

关键词： Totally implantable venous access ports Arm ports Venous variation Postoperative breast cancer Systematic review Case report

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流动注射化学发光法测定诺氟沙星

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光谱学与光谱分析 2005年第12期25卷 1938-1942页

作者：廖素兰谢增鸿福州大学化学系

在酸性条件下,Ce(Ⅳ)与诺氟沙星(NFLX)能产生弱的化学发光反应,十二烷基硫酸钠(SDS)对其有较强的增敏作用。据此建立了一种简单、快速、町连续测定诺氟沙星的流动注射化学发光新方法。该法线性范围7．78×10-8-5-82×106g·mL-1,检测... 详细信息

在酸性条件下,Ce(Ⅳ)与诺氟沙星(NFLX)能产生弱的化学发光反应,十二烷基硫酸钠(SDS)对其有较强的增敏作用。据此建立了一种简单、快速、町连续测定诺氟沙星的流动注射化学发光新方法。该法线性范围7．78×10-8-5-82×106g·mL-1,检测限(3σ)为1．57×10-8g·mL-1,对1．94×106g·mL-1的 NFLX标准溶液平行测定10次,相对标准偏差为1．7％。该法成功应用于诺氟沙星胶囊的测定,还对其机理进行了初步探讨。

关键词：化学发光诺氟沙星流动注射

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Synthesis of Cell Adhesive Motif RGD Tripeptide by a Novel Chemical Method and Its Purification

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Chemical Research in Chinese Universities 2006年第5期22卷 612-616页

作者： WANG Hua ZHAO Mi-feng MA Cheng-yun JING Wei HUANG Yi-bing HOU Rui-zhen zeng hong-bin XU Li ZHANG Xue-zhong Key Laboratory of Molecular Enzymology and Engineering Jilin University Changchun 130021 P. R. China China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China First Hospital of Jilin University Changchun 130021 P. R. China

The cell adhesive motif RGD tripeptide was synthesized by using a novel chemical method. First, Gly-Asp（GD） was synthesized in two steps including the chloroacetylation of free L-aspartic acid and the ammonolysis of the chloroacetylated L-aspartic acid. The yield of chloroacetylated L-aspartic acid was 83.0%. For the ammonolysis of chloroacetylated L-aspartic acid, the yield of the ammonolyzed product was 92. 3%. Second, the coupling between Arg and Gly-Asp was carried out by using the NCA method. The maximum yield of RGD was about 50% at 0℃ and pH = 9. 5. The prepared RGD tripeptide was confirmed by using amino acid component analysis and mass spectrographic analysis.

关键词： RGD tripeptide Chemical synthesis Purification Arg-Gly-Asp

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Anesthetic management of a parturient with amyotrophic lateral sclerosis undergoing cesarean section

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Chinese Medical Journal 2020年第11期133卷 1371-1372页

作者： Jiao Li hong zeng Min Li Jun Wang Department of Anesthesiology Peking University Third HospitalBeijing 100191China

To the Editor:Amyotrophic lateral sclerosis(ALS)is a relentlessly progressive neuromuscular disease associated with the degeneration of both upper and lower motor *** eventually leads to muscle weakness,atrophy,and death within 3 to 5 years,most commonly from respiratory *** appropriate anesthetic management of these patients,especially parturients pose various challenges to anesthesiologists.

关键词： degeneration sclerosis respiratory

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风洞侧壁干扰控制与修正方法研究

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实验流体力学 2010年第6期24卷 73-76,87页

作者：惠增宏柳雯西北工业大学翼型叶栅空气动力学国家重点实验室西安710072

风洞侧壁干扰是影响风洞实验数据准确度的一个重要因素,洞壁边界层的存在会使二维翼型升力线斜率的测量值下降,在风洞设计和实验中采用多种方法来减小其干扰。简述了减小或消除侧壁干扰的实验原理、实验方法、优缺点及国内外研究进展,... 详细信息

风洞侧壁干扰是影响风洞实验数据准确度的一个重要因素,洞壁边界层的存在会使二维翼型升力线斜率的测量值下降,在风洞设计和实验中采用多种方法来减小其干扰。简述了减小或消除侧壁干扰的实验原理、实验方法、优缺点及国内外研究进展,重点介绍了侧壁抽吸、侧壁吹除控制与修正方法,最后介绍了判断控制和修正效果的准则。侧壁抽吸与侧壁吹除方法在实际应用中取得了良好的效果,对抑制侧壁边界层效应有一定作用,能够提高实验结果的精确性。

关键词：侧壁干扰侧壁抽吸侧壁吹除判断准则

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Robust Sliding-mode Filtering for a Class of Uncertain Nonlinear Discrete-time State-delayed Systems

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自动化学报 2006年第1期32卷 96-100页

作者： WU Li-Gang WANG Chang-hong zeng Qing-Shuang GAO Hui-Jun Space Control and Inertial Technology Research Center Harbin Institute of Technology Harbin 150001

This paper is concerned with the problem of robust sliding-mode filtering for a class of uncertain nonlinear discrete-time systems with time-delays. The nonlinearities are assumed to satisfy global Lipschitz conditions and parameter uncertainties are supposed to reside in a polytope. The resulting filter is of the Luenberger type with the discontinuous form. A sufficient condition with delay-dependency is proposed for existence of such a filter. And the desired filter can be found by solving a set of matrix inequalities. The resulting filter adapts for the systems whose noise input is real functional bounded and not be required to be energy bounded. A numerical example is given to illustrate the effectiveness of the proposed design method.

关键词：鲁棒控制滑动模式滤波器离散系统状态延迟线性矩阵不等式

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Effects of SiC interfacial coating on mechanical properties of carbon fiber needled felt reinforced sol-derived Al2O3 composites

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Transactions of Nonferrous Metals Society of China 2020年第2期30卷 463-471页

作者： Kuan-hong zeng Qing-song MA Xing-yu GU Science and Technology on Advanced Ceramic Fibers&Composites Laboratory National University of Defense TechnologyChangsha 410073China

3D carbon fiber needled felt and polycarbosilane-derived SiC coating were selected as reinforcement and interfacial coating,respectively,and the sol-impregnation-drying-heating(SIDH)route was used to fabricate C/Al2O3 *** effects of Si C interfacial coating on the mechanical properties,oxidation resistance and thermal shock resistance of C/Al2O3 composites were *** is found that the fracture toughness of C/Al2O3 composites was remarkably superior to that of monolithic Al2O3 *** introduction of SiC interfacial coating obviously improved the strengths of C/Al2O3 composites although the fracture work diminished to some *** to the tight bonding between SiC coating and carbon fiber,the C/SiC/Al2O3 composites showed much better oxidation and thermal shock resistance over C/Al2O3 composites under static air.

关键词： alumina carbon fiber reinforcement interfacial coating mechanical properties oxidation resistance thermal shock resistance

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