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Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex

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Journal of Molecular Cell Biology 2022年第3期14卷 48-60页

作者： yutian Zhang Ya Kong Haoran guo yun Liu yi Zang Jia Li University of Chinese Academy of Sciences Beĳing 100049China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug ScreeningChina Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The nuclear envelope comprises the outer nuclear membrane,inner nuclear membrane(INM),and ***∼60 INM proteins have been identified,only a few of them have been well characterized,revealing their crucial *** group focused on the INM protein transmembrane protein 201(TMEM201),whose role in cellular function remains to be *** this study,we investigated the role of TMEM201 in endothelial cell migration and *** of TMEM201 expression by short hairpin RNA-mediated interference impeded human umbilical vein endothelial cell(HUVEC)angiogenic behavior in tube formation and fibrin gel bead sprouting ***,TMEM201-deficient HUVECs exhibited impaired migration *** next explored the underlying mechanism and found that the N-terminal of TMEM201 interacted with the linker of nucleoskeleton and cytoskeleton complex and was required for regulating endothelial cell migration and *** in vitro findings were further confirmed by using in vivo *** Tmem201-knockout mice,retinal vessel development was arrested and aortic ring sprouting was *** addition,loss of tmem201 impaired zebrafish intersegmental vessel *** summary,TMEM201 was shown to regulate endothelial cell migration and control the process of *** study is the first to reveal the role of INM proteins in the vascular system and angiogenesis.

关键词： transmembrane protein 201 inner nuclear membrane LINC complex endothelial cell migration angiogenesis

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Mapping and Quantitative Trait Loci Analysis of Verticillium Wilt Resistance Genes in Cotton

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Journal of Integrative Plant Biology 2008年第2期50卷 174-182页

作者： hong-Mei Wang Zhong-Xu Lin Xian-Long Zhang Wei Chen Xiao-Ping guo yi-Chun Nie yun-Hai Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Key Laboratory of Cotton Genetic Improvement of the Ministry of Agriculture Cotton Research Institute Chinese Academy of Agricultural Sciences Anyang 455112 China

Verticillium wilt is one of the most serious constraints to cotton production in almost all of the cotton-growing countries. In this study, ＂XinLuZaol＂（XLZl）, a susceptible cultivar Gossypium hirsutum L. and ＂Hai7124＂（H7124）, a resistant line G. barbadense, and their F2：3 families were used to map and study the disease index induced by verticillium wilt. A total of 430 SSR loci were mapped into 41 linkage groups; the map spanned 3 745.9 cM and the average distance between adjacent loci was 8.71 cM. Four and five quantitative trait loci （QTLs） were detected based on the disease index investigated on July 22 and August 24 in 2004, respectively. These nine QTLs explained 10.63-28.83% of the phenotypic variance, six of them were located on the D sub-genome. Two QTLs located in the same marker intervals may partly explain the significant correlation of the two traits. QTLs explaining large phenotypic variation were identified in this study, which may be quite useful in cotton anti-disease breeding.

关键词： cotton molecular marker quantitative trait locus Verticillium wilt.

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Two new diterpenoids from Suregada glomerulata(Blume) Baill

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Chinese Chemical Letters 2011年第5期22卷 580-582页

作者： Ren yi Yan Ruo yun Chen De Quan yu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China

Two new diterpenoids,3,4,18β-cyclopropa-ent-abieta-8（14）,13（15）-dien-16,12-olide（1） and 3-oxojolkinolide B（2）,were isolated from the roots of Suregada glomerulata（Blume） *** structures were determined by sp... 详细信息

关键词： Suregada glomerulata Diterpenoid 3 4 18β-Cyclopropa-ent-abieta-8(14) 13(15)-dien-16 12-olide 3-Oxojolkinolide B Cytotoxicity

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An Efficient Process for Preparing 4-Methyl-2-phenyl Piperazine Hydrochloride and its Derivatives

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Chinese Chemical Letters 2003年第4期14卷 365-367页

作者： Bai Shu guo yu She YANG Ru yun JI Institute of Materia Medica Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031

An improved method for preparation of 4-methyl-2-phenyl piperazine and its derivatives with higher yield and inexpensive reagents was developed, the products were characterized by 1H-NMR and MS.

关键词： Methyl-2-phenyl piperazine mirtazapine intermediate.

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Extracellular matrix from human umbilical cordderived mesenchymal stem cells as a scaffold for peripheral nerve regeneration

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Neural Regeneration Research 2016年第7期11卷 1172-1179页

作者： Bo Xiao Feng Rao Zhi-yuan guo Xun Sun yi-guo Wang Shu-yun Liu Ai-yuan Wang Quan-yi guo Hao-ye Meng Qing Zhao Jiang Peng yu Wang Shi-bi Lu Institute of Orthopedics Chinese PLA General HospitalBeijingChina Beijing Key Laboratory of Regenerative Medicine in Orthopedics BeijingChina The Neural Regeneration Co-innovation Center of Jiangsu Province NantongJiangsu ProvinceChina Department of Orthopedics First Affiliated HospitalSchool of MedicineShihezi UniversityShiheziXinjiang Uygur Autonomous RegionChina Department of Orthopedics Cangzhou Central HospitalCangzhouHebei ProvinceChina

The extracellular matrix,which includes collagens,laminin,or fibronectin,plays an important role in peripheral nerve ***,a Schwann cell-derived extracellular matrix with classical biomaterial was used to mimic the neural ***,extensive clinical use of Schwann cells remains limited because of the limited origin,loss of an autologous nerve,and extended in vitro culture *** the present study,human umbilical cord-derived mesenchymal stem cells（h UCMSCs）,which are easily accessible and more proliferative than Schwann cells,were used to prepare an extracellular *** identified the morphology and function of h UCMSCs and investigated their effect on peripheral nerve *** with a non-coated dish tissue culture,the h UCMSC-derived extracellular matrix enhanced Schwann cell proliferation,upregulated gene and protein expression levels of brain-derived neurotrophic factor,glial cell-derived neurotrophic factor,and vascular endothelial growth factor in Schwann cells,and enhanced neurite outgrowth from dorsal root ganglion *** findings suggest that the h UCMSC-derived extracellular matrix promotes peripheral nerve repair and can be used as a basis for the rational design of engineered neural niches.

关键词： umbilical Schwann regeneration scaffold neurotrophic biomaterial niche fibronectin glial engineered

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A New Flavanone from the Bark of Morus macoura Miq.

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Chinese Chemical Letters 2001年第3期12卷 231-232页

作者： Sheng guo SUN Ruo yun CHEN De Quan yu Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

A new flavanone named macrouroine C (1) was isolated from the bark of Morus macroura Miq.. The structure of 1 was elucidated mainly on the basis of spectroscopic evidence.

关键词： Morus macroura Miq. flavanone macrourone C.

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A study on wrinkling characteristics and dynamic mechanical behavior of membrane

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Acta Mechanica Sinica 2012年第1期28卷 201-210页

作者： yun-Liang Li Ming-yu Lu Hui-Feng Tan yi-Qiu Tan School of Transportation Science and Engineering Harbin Institute of Technology150090 HarbinChina Post-doctoral Research Center in Civil Engineering Harbin Institute of Technology150090 HarbinChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina Center for Composite Materials and Structure Harbin Institute of Technology150001 HarbinChina

An eigenvalue method considering the membrane vibration of wrinkling out-of-plane deformation is introduced, and the stress distributing rule in membrane wrinkled area is analyzed. A dynamic analytical model of rectangular shear wrinkled membrane and its numerical analysis approach are also developed. Results indicate that the stress in wrinkled area is not uniform, i.e. it is larger in wrinkling wave peaks along wrinkles and two ends of wrinkle in vertical direction. Vibration modes of wrinkled membrane are strongly correlated with the wrinkling configurations. The rigidity is larger due to the heavier stress in the part of wrinkling wave peaks. Therefore, wave peaks are always located at the node lines of vibration mode. The vibration frequency obviously increases with the vibration of wave peaks.

关键词： Space membrane structure Wrinkle Vibration

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Coral-shaped and Core-Shell Structure Copolyethylene Nanocomposites Particles Prepared by in situ Coordination Polymerization

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Chinese Journal of Polymer Science 2015年第12期33卷 1650-1660页

作者： Jing Wang hong-ming Li Jiang-ping guo 黄启谷 Jian-jun yi yun-fang Liu Ke-jing Gao Wan-tai Yang State Key Laboratory of Chemical Resource Engineering Key Laboratory of Carbon Fiber and Functional PolymersMinistry of Education Beijing University of Chemical Technology Lab for Synthetic Resin Research Institution of Petrochemical Technology China National Petroleum Corporation

The example of the preparation ofnano- and micro-scaled, coral-shaped and core-shell topological morphology of copolyethylene particles promoted by the novel heterogeneous non-metallocene catalyst （m-CH3PhO）TiC13/carbon nanotubes （CNTs） was reported. Mass fraction of titanium component of the catalyst was 4.0 wt% determined by ICP analysis. The catalyst system can effectively catalyze polymerization of ethylene and eopolymerization of ethylene with 1-hexene. Morphological examination of the obtained polymer particles was carried out by scanning electron microscope （SEM） and high resolution transmission electron microscope （HR-TEM） technique. The results revealed that the morphology of the nascent copolyethylene particles looked like coral shape with size in micro-scaled and featured the core-shell structure consisting of CNTs as the core and copolyethylene as the shell.

关键词： Catalysts Composites Copolymers.

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Direct Pyrolysis of Molybdophosphate-based Ionic Salt for One-step Synthesis of N,P Co-doped Carbon/Mo03-x Hybrids with Superior Lithium Storage Performance

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Chemical Research in Chinese Universities 2019年第5期35卷 842-847页

作者： ZHANG Lifeng SHEN Kechao JIANG Yongtao guo yu LIU yi guo Shouwu School of Materials Science and Engineering Shaanxi University of Science and TechnologyXian 710021P.R.China Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials Shaanxi University of Science and TechnologyXi'an 710021P.R.China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240P.R.China

N, P co-doped carbon/MoO3-x hybrids(NPC/MoO3-x) were synthesized via one-step pyrolysis of molybdophosphate-based ionic salt precursor. Doped carbon and oxygen vacancies(OVs) were synchronously introduced into the NPC/MoO3-x hybrids without any other redundant procedure. As anodes for lithium-ion batteries, the NPC/MoO3-x hybrids delivered a high initial Coulombic efficiency(ICE) of 81% as well as high charge capacity of 516 mA·h/g after 100 cycles at 1 A/g, indicating the excellent reversibility and rate capability. The enhanced lithium storage performance was attributed to the rational combination of surface engineering and OVs, which is beneficial to the more active sites and fast ionic/electronic transport.

关键词： Lithium ion battery Anode Molybdenum oxide Doped carbon Oxygen vacancy

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An experimental study on effects of temperature gradient on microstructure of a 308L stainless steel manufactured by directed energy deposition

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Journal of Iron and Steel Research International 2024年第8期31卷 2031-2040页

作者： Ting Dai De-yu Gu yu-wen Qiu Wei guo Hui Ding yi-wei Sun School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial temperature gradient on the microstructural evolution of a 308L stainless steel during the directed energy deposition(DED)process was experimentally investigated.A novel cooling system was designed and incorporated to a DED system in order to control the temperature gradient along the deposition direction during *** deposition,the workpiece was placed on a lifting platform,and as the deposition process proceeded,the platform and workpiece were gradually lowered into cooling water so that the temperature gradient along the deposition direction could be controlled and maintained stable during the deposition *** microstructure characterization results indicated that a deposition strategy with higher G and G/R values(where G is temperature gradient and R is solidification rate)produced finer cellular grains that were better aligned with the deposition direction,while a deposition strategy with lower G and G/R values produced columnar grains with larger primary arm spacing and less aligned with the deposition direction.

关键词： Additive manufacturing Directed energy deposition Stainless steel Microstructure Temperature gradient

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