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不同微生物检验法对念珠菌阴道炎患者阴道分泌物的检出效果分析

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系统医学 2024年第4期9卷 110-113页

作者：娄红彭可刘学礼湖北省麻城市人民医院医学检验科湖北黄冈438300

目的研究应用3种不同微生物检验法对念珠菌阴道炎患者阴道分泌物的检测效果。方法选取2021年1月—2022年6月麻城市人民医院收治的96例念珠菌阴道炎患者作为研究对象,采用凝集法、培养法、镜检法,对所有患者的阴道分泌物样本进行检验,... 详细信息

目的研究应用3种不同微生物检验法对念珠菌阴道炎患者阴道分泌物的检测效果。方法选取2021年1月—2022年6月麻城市人民医院收治的96例念珠菌阴道炎患者作为研究对象,采用凝集法、培养法、镜检法,对所有患者的阴道分泌物样本进行检验,比较不同检验方法阳性检出例数及检出率。结果凝集法、培养法、镜检法阳性检出率分别为79.17%、84.38%、92.71%,3种检验方法阳性检出率比较,差异有统计学意义(χ^(2)=7.167,P<0.05)。结论采用镜检法对念珠菌阴道炎患者阴道分泌物进行检查,能够获得更高的阳性检出率,从而为临床诊断和治疗提供更为可靠的依据。

关键词：念珠菌阴道炎阴道分泌物微生物检验

Finite element modeling of consolidation process of Si C fiber-reinforced titanium matrix composites via matrix-coated fiber method

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Rare Metals 2015年第12期34卷 844-850页

作者： Xiang-hong Xu Yan-Qing Yang Xian Luo Lin Qin Ju-hong lou Qing Sun Shazhou Polytechnic Institute of Technology State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The consolidation process of SiCf/Ti-6Al-4V composites by matrix-coated fiber (MCF) method via hot pressing was investigated using finite element modeling (FEM). By analyzing the elastic–plastic contact deformation of the representative aligned coated fibers, the consolidation maps delineating the time–temperature–pressure relationship for full densification were constructed. Both the flow coefficient and the contact area coefficient used to describe the contact deformation were calculated according to the model. In addition, the effect of fiber content on matrix stress distribution was analyzed. The results show that fiber content is a significant factor that influences the densification process. Higher fiber content will lower the consolidation rate.

关键词： Titanium matrix composites Consolidation Finite element modeling Matrix-coated fiber

Effect of Skew Angle of Holes on the Thermal Fatigue Behavior of a Ni-based Single Crystal Superalloy

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 185-192页

作者： Zhong-Jiao Zhou Da-Qian Yu Li Wang Lang-hong lou Superalloys Division Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Division of Micro/Nano Manufacturing State Key Laboratory of Tribology Tsinghua University Beijing 100084 China Material Design and Research Section Beijing Huatsing Gas Turbine & IGCC Technology Co. Ltd. Tsinghua Science Park Beijing 100084 China

In the present work,holes of various skew angles were electrochemically machined in the middle of the plate specimens in a Ni-based single crystal superalloy and crack initiation and propagation around holes during thermal fatigue cycles（20–1100 ℃） were *** was demonstrated that the skew angles had a significant effect on the initiation and propagation of thermal fatigue *** thermal fatigue process,stress concentration occurred at the edge of the *** for skew angles,the maximum stress concentration appeared at the acute side of *** maximum stress concentration resulted in plastic deformation at the acute side of the 30° hole,driving the thermal fatigue cracks to initiate after 220 cycles and propagate along [011] ***,the stresses concentrated at the edge of 90° or 60° holes were not large enough to initiate cracks even after 580 thermal *** work will help to understand the local deformation behavior in the vicinity of cooling holes with various skew angles and have serious design implications for turbine blades.

关键词： Ni-based single crystal superalloy Thermal fatigue properties Holes Skew angles Cracks

Preparation of hollow ceramic microspheres absorbent based on self-reactive quenching technology

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Rare Metals 2015年第5期34卷 344-350页

作者： Jian-Jiang Wang hong-Fei lou Jin-Hua Wen Xu-Dong Cai Advanced Materials Institute Mechanical Engineering College

A1 ＋ BaO2 ＋ Fe2O3 ＋ sucrose and O2 as reaction system and feeding gas, respectively, are used to prepare hollow multiphase ceramic microspheres （HMCMs） absorbent based on self-reactive quenching technology. The morphologies, particle size distribution, hollow structure and phase compositions were characterized by scanning electron microscope （SEM）, X-ray diffraction （XRD） and size analysis. The results show that the quenching products possess high sphere-forming rate, and most of them are hollow structures. Owing to the self-burst, the particle size is between 40 and 70 μm. The phase compositions contain Al2O3, Fe3O4, Fe2O3, Ba2Fe14O22, BaO2 and BaFe4O7. The microwave absorbing tests show that the lowest reflectivity of HMCMs is -19 dB. The frequency bands less than -10 dB are from 13.0 to 15.8 GHz. The reasons for HMCMs possessing good microwave absorbing properties may be their magnetic and electrical properties as well as special hollow structure.

关键词： Self-reactive quenching technology Hollow multiphase ceramic microspheres Microwave absorbing properties

Antifungal variant bis(bibenzyl)s from the liverwort Asterella angusta

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Chinese Chemical Letters 2013年第9期24卷 801-803页

作者： Jian-Bo Qu Ling-Mei Sun hong-Xiang lou School of Pharmaceutical Sciences Shandong University Center for Drug Evaluation SFDA

Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis（bibenzyl）s, riccardin I （1）, and angustatin A （2）. Their structures were established by spectroscopic analysis （1D NMR and 2D NMR, IR, MS）. Compound I is a novel variant riccardin-type bis（bibenzyl）, while compound 2 is the first nonheteratom-containing variant bis（bibenzyl） possessing a bibenzyl-phenanthrene skeleton.

关键词： Variant bis(bibenzyl)s Asterella angusta Antifungal activity

Old fusidane-type antibiotics for new challenges:Chemistry and biology

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Chinese Journal of Natural Medicines 2022年第2期20卷 81-101页

作者： TIAN Chuan WANG Ke ZHANG Xuan LI Gang lou hong-Xiang Department of Natural Medicinal Chemistry and Pharmacognosy School of PharmacyQingdao UniversityQingdao 266071China Department of Natural Product Chemistry Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Shandong Provincial Key Laboratory of Synthetic Biology Key Laboratory of BiofuelsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China

The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the *** deal with these“new challenges”,scientists tend to re-pick up“old antibiotics”.Fusidane-type antibiotics have been known for nearly 80 years as potent antibacterial agents against gram-positive bacteria,especially Staphylococci,and represent the only triterpene-derived antibiotic class in clinical *** attractive characteristics have drawn renewed attention on fusidane-type antibiotics in recent ***,characterization,biological evaluation,as well as chemical modifications of fusidane-type antibiotics are increasingly being *** biosynthesis of this type of antibiotics has been successfully utilized not only for elucidating the biosynthetic pathways,but also for expanding their structural *** isolated and synthetic compounds exhibit comparable or even more potent biological activity than fusidic *** review provides an overview of progress on the studies of structure and biology of fusidane-type antibiotics from 1943 to April *** informative structure-activity relationship is also highlighted.

关键词： Fusidane-type antibiotics Fusidic acid Biosynthesis Structural modification Biological activity

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外泌体在膝关节骨性关节炎中的研究进展

中国药理学通报 2024年第6期40卷 1020-1024页

作者：谢希石晔邓汉清杨旭霞谭旭芳娄宏君李玲高曦黑龙江中医药大学第一临床医学院黑龙江哈尔滨150040 湖南中医药大学中西医结合学院湖南中医药大学第一中医临床学院湖南长沙410208 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

膝关节骨性关节炎(knee osteoarthritis,KOA)的发病率逐年升高,严重影响患者健康。间充质干细胞(mesenchymal stem cells,MSCs)是一种具有多重分化作用的细胞,其释放的外泌体能搭载各种“货物”到相应细胞和组织发挥生物学功能,在KOA的... 详细信息

膝关节骨性关节炎(knee osteoarthritis,KOA)的发病率逐年升高,严重影响患者健康。间充质干细胞(mesenchymal stem cells,MSCs)是一种具有多重分化作用的细胞,其释放的外泌体能搭载各种“货物”到相应细胞和组织发挥生物学功能,在KOA的治疗中表现出极大的临床运用潜力。该研究就骨髓、脂肪、滑膜等不同组织来源的间充质干细胞分泌的外泌体在KOA的治疗效应及机制进行综述,发现microRNA(miRNA)是发挥抗KOA效应的重要的外泌体生物学成分,并进一步讨论了工程化外泌体在KOA中的研究进展,提出了目前外泌体运用于临床的挑战,如外泌体的标准化获取、靶向作用等,以期为外泌体治疗KOA的基础研究与临床运用提供一定参考。

关键词：膝关节骨性关节炎外泌体间充质干细胞 miRNA 研究进展综述

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Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats

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Chinese Journal of Natural Medicines 2015年第4期13卷 257-263页

作者： LIU An-Chang ZHAO Li-Xia YU Shu-Wen lou hong-Xiang Qilu hospital of Shandong University Jinan Central Hospital Affiliated to Shandong University School of Pharmaceutical Sciences Shandong University

The present study was designed to determine the effects of puerarin pre-treatment on the pharmacokinetics of the oral anticoagulant agent warfarin and the antiplatelet agent clopidogrel in rats. In the treatment group, rats was gavaged with warfarin or clopidogrel after repeated treatment with puerarin at intraperitoneal doses of 20, 60, or 200 mg·kg-1 for 7 days, while rats in the control group were administrated only with the same dose warfarin or clopidogrel. Plasma samples were obtained at the prescribed times and analyzed by liquid chromatography tandem mass spectrometry(LC-MS/MS). The results showed that rats treated with puerarin at all the test doses of 20, 60 and 200 mg·kg-1 were found to affect the pharmacokinetics of warfarin, but not clopidogrel, suggesting a potential herb-drug interaction between puerarin and warfarin.

关键词： Puerarin Warfarin Clopidogrel Pharmacokinetics Drug interaction

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玻璃纤维在石墨制化工装备上的应用探析

全面腐蚀控制 2024年第1期38卷 71-74页

作者：张娄红缪世阳陈燕江苏省特种设备安全监督检验研究院江苏南京226011 南通星球石墨股份有限公司江苏南通226541

玻璃纤维材料作为一种高性能复合材料,其机械性能、热性能、电性能、化学性质相较于石墨,具有较大的量级差异性。因此,玻璃纤维材料应用于石墨制化工装备时,能够极大地弥补石墨材料的不足之处,使石墨制化工装备同时具备石墨和玻璃纤维... 详细信息

玻璃纤维材料作为一种高性能复合材料,其机械性能、热性能、电性能、化学性质相较于石墨,具有较大的量级差异性。因此,玻璃纤维材料应用于石墨制化工装备时,能够极大地弥补石墨材料的不足之处,使石墨制化工装备同时具备石墨和玻璃纤维的优点。本文围绕玻璃纤维在石墨制化工装备中的应用原理、应用工艺的优缺点展开分析,希望为从业人员提供一定的参考。

关键词：玻璃纤维石墨化工装备缠绕工艺