Old fusidane-type antibiotics for new challenges:Chemistry and biology
作者机构：Department of Natural Medicinal Chemistry and PharmacognosySchool of PharmacyQingdao UniversityQingdao 266071China Department of Natural Product ChemistryKey Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Shandong Provincial Key Laboratory of Synthetic BiologyKey Laboratory of BiofuelsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2022年第20卷第2期
页 面：81-101页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Nos.81903494 and 81903483)
主 题：Fusidane-type antibiotics Fusidic acid Biosynthesis Structural modification Biological activity
摘 要：The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the *** deal with these“new challenges,scientists tend to re-pick up“old antibiotics.Fusidane-type antibiotics have been known for nearly 80 years as potent antibacterial agents against gram-positive bacteria,especially Staphylococci,and represent the only triterpene-derived antibiotic class in clinical *** attractive characteristics have drawn renewed attention on fusidane-type antibiotics in recent ***,characterization,biological evaluation,as well as chemical modifications of fusidane-type antibiotics are increasingly being *** biosynthesis of this type of antibiotics has been successfully utilized not only for elucidating the biosynthetic pathways,but also for expanding their structural *** isolated and synthetic compounds exhibit comparable or even more potent biological activity than fusidic *** review provides an overview of progress on the studies of structure and biology of fusidane-type antibiotics from 1943 to April *** informative structure-activity relationship is also highlighted.
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