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Engineer.d extr.cellular.vesicles: A new ap.r.ach for.tar.eted ther.p. of tumor. and over.oming dr.g r.sistance

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Cancer.Communications 2024年第2期44卷 205-225页

作者： Chen Ming-Kun Chen Zi-xian Cai Mao-p.ng Chen hong Chen Zhuang-Fei Zhao Shan-Chao department of Ur.logy The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China The Thir. Clinical College Southern Medical UniversityGuangzhouGuangdongP.R.China Luoyang key Labor.tor. of Or.anic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyangHenanP.R.China department of Ur.logy Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Tar.eted deliver. of anti-tumor.dr.gs and over.oming dr.g r.sistance in malig-nant tumor.cells r.main significant clinical ***,ther. ar. only few effective methods to addr.ss these *** vesicles(EVs),actively secr.ted by cells,p.ay a cr.cial r.le in inter.ellular.infor.ation tr.nsmis-sion and car.o *** studies have demonstr.ted that engineer.d EVs can ser.e as dr.g deliver. car.ier. and showed p.omising ap.lication ***,ther. is an ur.ent need for.fur.her.imp.ovements in the isolation and p.r.fication of EVs,sur.ace modification techniques,dr.g assem-bly p.ocesses,and p.ecise r.cognition of tumor.cells for.tar.eted dr.g deliver. *** this r.view,we summar.ze the ap.lications of engineer.d EVs in cancer.tr.atment and over.oming dr.g r.sistance,and cur.ent challenges asso-ciated with engineer.d EVs ar. also *** r.view aims to p.ovide new insights and p.tential dir.ctions for.utilizing engineer.d EVs as tar.eted deliver. systems for.anti-tumor.dr.gs and over.oming dr.g r.sistance in the near.futur..

关键词： dr.g deliver. dr.g r.sistance extr.cellular.vesicles nanop.r.icles

Liver.histological changes in untr.ated chr.nic hep.titis B p.tients in indeter.inate p.ase

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Wor.d Jour.al of Hep.tology 2024年第6期16卷 920-931页

作者： De-Liang Huang Qin-xian Cai Guang-De Zhou hong Yu Zhi-Bin Zhu Jing-Han p.ng Jun Chen department of Liver.Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina department of p.thology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China department of p.thology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGr.UND Studies with lar.e size samp.es on the liver.histological changes of indeter.inate p.ase chr.nic hep.titis B(CHB)p.tients wer. not p.eviously *** To assess the liver.histological changes in the indeter.inate p.ase CHB p.tients using liver.*** The clinical and labor.tor. data of 1532 untr.ated CHB p.tients wer. collected,and all p.tients had least once liver.biop.y fr.m Januar. 2015 to December.*** significant differ.nces among differ.nt p.ases of CHB infection wer. comp.r.d with t-test,and the r.sk factor. of significant liver.histological changes wer. analyzed by the multivar.ate logistic r.gr.ssion *** Among 1532 untr.ated CHB p.tients,814(53.13%)p.tients wer. in the indeter.inate *** liver.histological changes(defined as biop.y scor.≥G2 and/or.S2)wer. found in 488/814(59.95%)CHB p.tients in the indete-r.inate *** liver.histological changes wer. significant differ.nces among differ.nt age,p.atelets(p.Ts),and alanine aminotr.nsfer.se(ALT)subgr.up.in indeter.inate *** logistic r.gr.ssion analysis indicated that age≥40 year. old[adjust odd r.sk(aOr.,1.44;95%confidence inter.al(CI):1.06-1.97;p.0.02],p.Ts≤150×10^(9)/L(aOr.2.99;95%CI:1.85-4.83;p.0.0001),and ALT≥up.er.limits of normal(aOr.1.48;95%CI:1.08,2.05,p.0.0163)wer. indep.ndent r.sk factor. for.significant liver.histological changes in CHB p.tients in the indeter.inate *** Our.r.sults suggested that significant liver.histological changes wer. not r.r. among the untr.ated CHB p.tients in indeter.inate p.ase,and additional str.tegies ar. ur.ently r.quir.d for.the management of these p.tients.

关键词： Chr.nic hep.titis B Indeter.inate p.ase Gr.y-zone Liver.biop.y p.thological histology r.sk factor.

Total body water.p.r.entage and 3r. sp.ce water.ar. novel r.sk factor. for.tr.ining-r.lated lower.extr.mity muscle injur.es in young males

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Chinese Jour.al of Tr.umatology 2024年第3期27卷 168-172页

作者： Liang Chen ke-Xing Jin Jing Yang Jun-Jjie Ouyang Han-Gang Chen Si-r. Zhou Xiao-Qing Luo Mi Liu Liang Kuang Yang-Li Xie Yan Hu Lin Chen Zhen-hong Ni Xiao-Lan du department of Or.hop.dic Daping HospitalArmy Medical UniversityChongqing400042China department of r.habilitation Medicine Daping HospitalArmy Medical UniversityChongqing400042China department of Wound r.p.ir.and r.habilitation Medicine Center of Bone Metabolism and RepairLaboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of Trauma and Chemical Poisoning.Trauma CenterResearch Instiute of SurgeryDaping HospitalArmy Medical UniversityChongqing.400042China War.Tr.uma Medical Center Daping HospitalArmy Medical UniversityChongqing400042.China department of Militar. Basic Tr.ining and Ar.y Management Army Health Service Training BaseArmy Medical UniversityChongqing400042China department of Ar.y Occup.tional Disease Laboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of Trauma and Chemical PoisoningResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing400042.China

p.r.0}se:To identify the r.sk factor. for.tr.ining-r.lated lower.extr.mity muscle injur.es in young males by a non-invasive method of body comp.sition ***:A total of 282 healthy young male volunteer. aged 18-20 year. p.r.icip.ted in this cohor. *** location,degr.e,and injur. r.te wer. adjusted by a questionnair. based on the over.se injur. assessment methods used in ep.demiological studies of sp.r.s *** occur.ence of tr.ining injur.es is monitor.d and diagnosed by p.ysicians and tr.ated *** body comp.sition was measur.d using the BodyStat QuadScan 4000 multifr.quency Bio-imp.dance system at 5,50,100 and 200 kHz to obtain 4 imp.dance *** Shap.r.-Wilk test was used to check whether.the data confor.ed to a normal *** of normal distr.bution wer. shown as mean±SD and analyzed by t-test,while those of non-normal distr.bution wer. shown as median(Q1,Q3)and analyzed by Wilcoxon r.nk sum *** r.ceiver.op.r.tor.char.cter.stic cur.e and logistic r.gr.ssion analysis wer. p.r.or.ed to investigate r.sk factor. for.develop.ng tr.ining-r.lated lower.extr.mity injur.es and ***:Among the 282 subjects,78(27.7%)develop.d tr.ining *** extr.mity tr.ining injur.es r.vealed the highest incidence,accounting for.23.4%(66 cases).These p.tients showed higher.p.r.entages of lean body mass(p.0.001),total body water.TBW,p.0.006),extr.cellular.water.p.0.020)and intr.cellular.water.p.0.010)as well as a lar.er.r.tio of basal metabolic r.te/total weight(p.0.006),comp.r.d with those without lower.extr.mity muscle *** the contr.r.,the p.r.entage of body fat(p.0.001)and body fat mass index(p.0.002)wer. *** r.gr.ssion analysis showed that TBW p.r.entage>65.35%(p.0.050,odds r.tio=3.114)and 3r. sp.ce water.0.95%(p.0.045,odds r.tio=2.342)wer. indep.ndent r.sk factor. for.lower.extr.mity muscle ***:TBW p.r.entage and 3r. sp.ce water.measur.d with bio-imp.dance method ar. p.tential r.s

关键词： Body comp.sition Tr.ining injur.es Lower.extr.mity Bio-imp.dance

A Note on the Left Essential Sp.ctr. of Op.r.tor.Matr.ces

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Acta Mathematica Sinica,English Ser.es 2007年第12期23卷 2235-2240页

作者： Yuan LI Xiu hong SUN hong ke du College of mathematics and Infor.ation Science Shaanxi Normal University Xi'an 710062 P. R. China department of Basic Cour.es Xi'an University of Science and Technology Xi'an 710054 P. R. China College of mathematics and Infor.ation Science Shaanxi Normal University Xi'an 710062 P. R China

When A ∈ B（H） and B ∈ B（K） ar. given, we denote by Me the op.r.tor.matr.x acting on the infinite dimensional sep.r.ble Hilber. sp.ce H ＋ K of the for. Me = （ A C O B）. In this p.p.r. a necessar. and sufficient condition for.Me to be left Fr.dholm for.some C ∈ F（K, H）（C ∈ Inv（K, H）） is given, wher. F（K,H） and Inv（K, H） denote r.sp.ctively, the set of Fr.dholm op.r.tor. and the set of inver.ible op.r.tor. of B（K, H）. In addition, we give a necessar. and sufficient condition for.Me to be left Fr.dholm for.all C ∈ Inv（K, H）.

关键词： left essential sp.ctr.m 2×2 op.r.tor.matr.x p.r.ur.ations of sp.ctr.

受欺负、欺负容忍及认知情绪调节策略对儿童青少年焦虑抑郁的影响

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中国儿童保健杂志 2024年第3期32卷 268-272,279页

作者：赵科尹绍清刘虹云南师范大学教育学部云南昆明650550 德宏师范高等专科学校教育学院云南芒市678400 楚雄师范学院教育学院云南省教育科学研究院

目的分析受欺负、欺负容忍与儿童青少年焦虑抑郁的关系及认知情绪调节策略对欺负容忍影响焦虑抑郁的调节效应,为进行干预提供依据。方法2019年1月—2020年7月,采用儿童欺负问卷、中小学生欺负容忍问卷、认知情绪调节问卷中文版和28项一... 详细信息

目的分析受欺负、欺负容忍与儿童青少年焦虑抑郁的关系及认知情绪调节策略对欺负容忍影响焦虑抑郁的调节效应,为进行干预提供依据。方法2019年1月—2020年7月,采用儿童欺负问卷、中小学生欺负容忍问卷、认知情绪调节问卷中文版和28项一般健康问卷对1768名儿童青少年学生进行测查。结果儿童青少年学生受欺负现象较为普遍,受言语欺负、关系欺负和身体欺负的比例分别为57.64%(1019/1768)、36.60%(647/1768)和22.40%(396/1768)。不同性别(t=2.00)、学段(F=101.38)和学习成绩(F=27.91)儿童青少年焦虑抑郁得分差异具有统计学意义(p.0.05)。受欺负、欺负容忍正向预测效应焦虑抑郁(β=0.14、0.13,p.0.01)。积极策略、消极策略对欺负容忍与焦虑抑郁关系具有调节作用(β=-0.10、0.08,p.0.01)。简单斜率分析结果表明,高积极策略水平上欺负容忍对焦虑抑郁无预测效应(p.0.05),而低积极策略水平上欺负容忍正向预测焦虑抑郁(β=0.28,p.0.01);高消极策略水平上欺负容忍正向预测焦虑抑郁(β=0.25,p.0.01),而低消极策略水平上欺负容忍对焦虑抑郁则无预测效应(p.0.05)。结论受欺负、欺负容忍正向预测儿童青少年焦虑抑郁,高积极策略和低消极策略能有效抑制欺负容忍对焦虑抑郁的风险而低积极策略和高消极策略则会放大欺负容忍对焦虑抑郁的风险。

关键词：青少年受欺负欺负容忍认知情绪调节策略焦虑抑郁

On the Index of Fr.dholm p.ir. of Idemp.tents

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Acta Mathematica Sinica,English Ser.es 2009年第4期25卷 679-686页

作者： Yue Qing WANG hong ke du Yan Ni DOU department of mathematics and p.ysics Chongqing University of Science and Technology Chongqing 400042 P. R. China College of mathematics and Infor.ation Science Shaanxi Normal University Xi'an 710062 P. R. China

Using the technique of block-op.r.tor., in this note, we p.ove that if p.and Q ar. idemp.tents and （p.- Q）^2n＋1 is in the tr.ce class, then （p.- Q）^2m＋1 is also in the tr.ce class and tr.p.- Q）^2m＋1 = dim（k（p. ∩ k（Q）^⊥） -dim（k（p.^⊥ N k（Q））, for.all m ≥ n. Mor.over. we p.ove that dim（k（p.∩ k（Q）^⊥） = dim（k（p.^⊥ ∩k（Q）） if and only if ther. exists a unitar. U such that Up.= QU and p. = UQ, wher. k（T） denotes the r.nge of T. keywor.s Fr.dholm, or.hogonal p.ojection, p.sitive op.r.tor

关键词： Fr.dholm or.hogonal p.ojection p.sitive op.r.tor

Γ-inver.es of Bounded Linear.Op.r.tor.

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Acta Mathematica Sinica,English Ser.es 2014年第4期30卷 675-680页

作者： Xiao Ming XU hong ke du Xiao Chun FANG School of Science Shanghai Institute of Technology College of mathematics and Infor.ation Science Shaanxi Normal University department of mathematics Tongji University

Let B（Н） be the algebr. of all the bounded linear.op.r.tor. on a Hilber. sp.ce Н. For.A, p.and Q in B（Н）, if ther. exists an op.r.tor.X ∈ B（Н） such that Ap.QA = A, XQAp. = X, （QAp.）^＊ = QAp. and （XQAp.^＊ = XQAp. then X is said to be the F-inver.e of A associated with p.and Q, and denoted by A^＋p.Q. In this note, we p.esent some necessar. and sufficient conditions for.which A^＋p.Q exists, and give an exp.icit r.p.esentation of A^＋p. （if A^＋p.Q exists）.

关键词： Gener.lized inver.e F-inver.e Moor.-p.nr.se inver.e

Using GIS Sp.tial Distr.bution to p.edict Soil Or.anic Car.on in Subtr.p.cal china

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p.dosp.er. 2004年第4期14卷 425-431页

作者： CHENGxian-Fu SHIXue-Zheng YUDong-Sheng p.Nxian-Zhang WANGhong-Jie SUNWei-Xia StatekeyLabor.tor.ofSoilandSustainableAgr.cultur. InstituteofSoilScienceChineseAcademyofSciencesNanjing210008（China）. departmentofgeogr.p.y AnhuiNormalUniversityWuhu241000（China）

Sp.tial distr.bution of or.anic car.on in soils is difficult to estimatebecause of inher.nt sp.tial var.ability and insufficient data. A soil-landscap. model for.a r.gion,based on 151 samp.es for.p.r.nt mater.al and top.gr.p.ic factor., was established using a GISsp.tial analysis technique and a digital elevation model (DEM) to r.veal sp.tial distr.butionchar.cter.stics of soil or.anic car.on (SOC). Cor.elations between or.anic car.on and top.gr.p.icfactor. wer. analyzed and a r.gr.ssion model was established to p.edict SOC content. r.sults for.ur.ace soils (0-20 cm) showed that the aver.ge SOC content was 12.8 g kg^(-1), with the SOC contentbetween 6 and 12 g kg^(-1) occup.ing the lar.est ar.a and SOC over.24 g kg^(-1) the smallest. Also,soils der.ved fr.m p.yllite wer. the highest in the SOC content and ar.a, while soils develop.d onp.r.0}e shale the lowest. Although p.r.nt mater.al, elevation, and slop. exp.sur. wer. allsignificant top.gr.p.ic var.ables (p.p. exp.sur. had the highest cor.elation to SOCcontent (r.= 0.66). Using a multip.e r.gr.ssion model (r.2 = 0.611) and DEM (with a 30 m X 30 mgr.d), sp.tial distr.bution of SOC could be for.casted.

关键词： digital elevation model p.r.nt mater.al r.gr.ssion model soil or.aniccar.on top.gr.p.y

The r.p.esentations of Gener.lized Inver.es of Lower.Tr.angular.Op.r.tor.

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Acta Mathematica Sinica,English Ser.es 2009年第12期25卷 2107-2118页

作者： Chun Fang SHAO hong ke du Shu Feng JI Jun Lian XU College of mathematics and Infor.ation Science Shaanxi Normal University Xi'an 710062 P. R. China department of mathematics Ankang University Ankang 725000 P. R. China

In this note, the exp.icit r.p.esentations of Moor.-p.nr.se inver.es of lower.tr.angular.op.r.tor.matr.ces ar. established. As an ap.lication, the exp.icit r.p.esentations of Bott-duffin inver.es of bounded linear.op.... 详细信息

关键词： Moor.-p.nr.se inver.e lower.tr.angular.op.r.tor.matr.x Bott-duffin inver.e