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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

一种ICEEMDAN-CNN-SVR滑坡位移组合预测模型

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三峡大学学报（自然科学版） 2025年第1期47卷 37-43页

作者：石化波王刚曾怀恩中煤湖北地质勘察基础工程有限公司武汉430070 中铁建城建交通发展有限公司江苏苏州215000 湖北长江三峡滑坡国家野外科学观测研究站湖北宜昌443002 三峡大学土木与建筑学院湖北宜昌443002

滑坡位移预测是滑坡早期预警系统的重要组成部分,针对位移分解程度与特征选取深入程度不够导致滑坡位移预测精度不高的问题,提出一种ICEEMDAN-CNN-SVR滑坡位移组合预测模型:为了解决位移分解程度不够的问题,该模型首先运用ICEEMDAN分解... 详细信息

滑坡位移预测是滑坡早期预警系统的重要组成部分,针对位移分解程度与特征选取深入程度不够导致滑坡位移预测精度不高的问题,提出一种ICEEMDAN-CNN-SVR滑坡位移组合预测模型:为了解决位移分解程度不够的问题,该模型首先运用ICEEMDAN分解模型对滑坡位移曲线进行分解,将平滑性较好且具有递增趋势的IMF曲线作为趋势项位移,将其他具有波动趋势的IMF曲线总和重构为周期项位移;为了解决特征选取深入程度不够的问题,针对不同位移特性进行了特征变量选取,通过二维平铺与CNN特征提取得到特征变量更深层次的信息,将提取到的特征信息输入SVR预测模型中实现对趋势项位移与周期项位移的精准预测.以典型堆积层滑坡———八字门滑坡为例,选取ZG110与ZG111监测点2007年1月—2012年9月典型变形阶段水平位移数据进行研究,结果表明:ZG110与ZG111监测点预测评价指标R2,ERMSE,EMAE分别为0.9951、0.9989、5.7489、2.7532,4.5091、1.8529,预测效果良好;将模型预测结果与EEMDCNN-SVR预测模型及CNN-SVR预测模型结果作对比,相较其他预测模型,新模型的预测精度有所提升.

关键词：八字门滑坡 ICEEMDAN分解特征提取 CNN-SVR模型对比分析

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Mechanism and control of the long-term performance evolution of structures

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Frontiers of Structural and Civil Engineering 2020年第5期14卷 1039-1048页

作者： Zhiqiang DONG gang WU hong ZHU Haitao WANG Yihua zeng Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China National and Local Joint Engineering Research Center for Intelligent Construction and Maintenance Nanjing 210096China College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

It is well known that structural properties degrade under long-term environmental exposure and loading and that the degradation rate is controlled by inherent physical and chemical degradation *** elucidation of the degradation mechanisms and the realization of effective long-term performance degradation control have been a research frontier in the field of civil engineering in recent ***,the major topics that concern this research frontier include revealing the physical and chemical mechanisms of structural performance evolution under long-term environmental exposure and loading and developing structural performance degradation control technologies based on fiber-reinforced materials,for example,fiber-reinforced polymers(FRPs)and fabric-reinforced cementitious matrix(FRCM).In addition,there are novel structural performance control technologies,such as using a shape memory alloy(SMA)and self-healing *** paper presents a brief state-of-the-art review of this topic,and it is expected to provide a reference for subsequent research.

关键词： degradation mechanism performance evaluation strengthening FRP FRCM

Enhanced Grain Refining Effect of Mg–Zr Master Alloy on Magnesium Alloys via a Synergistic Strategy Involving Heterogeneous Nucleation and Solute‑Driven Growth Restriction

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1354-1366页

作者： gang zeng hong Liu Jing‑Peng Xiong Jian‑Long Li Yong Liu Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province School of Advanced ManufacturingNanchang UniversityNanchang 330031China

Zirconium(Zr)emerges as the most effective grain refiner for magnesium(Mg)alloys incorporating ***,Zr is introduced in the form of an Mg–Zr master ***,within Mg–Zr master alloys,Zr predominantly exists in a particle form,which tends to aggregate due to attractive van der Waals *** clustered Zr is prone to settling,thereby reducing its refining impact on Mg *** this work,a combined pretreatment process for Mg–Zr master alloys was proposed,encompassing the introduction of a physical field to intervene the agglomeration of particle Zr and the employ of high-temperature dissolution and peritectic reactions to promote the solid solution of *** results demonstrate that the particle Zr within the pretreated Mg–Zr master alloy is effectively dispersed and refined,and greater solute Zr levels can be *** subsequent grain refinement ability was studied on a typical Mg–6Zn–0.6Zr(wt%)*** outcome highlights that an improvement in the grain refinement efficacy(32.4%)of Mg–Zr master alloys was obtained with a holding time of 60 *** pretreated Mg–Zr master alloy significantly augments the efficiency of grain refinement for Mg alloys through a synergistic strategy involving heterogeneous nucleation and solute-driven growth *** crucial factor in achieving effective grain refinement of Zr in Mg alloys lies in regulating the presence and morphology of Zr in the Mg–Zr master alloy,distinguishing between particle Zr and solute *** study introduces a novel method for developing more efficient Mg–Zr refiners.

关键词： Magnesium alloy Mg-Zr master alloy Grain refinement Heterogeneous nucleation Solute-driven growth restriction Synergistic strategy

Optimization of flow uniformity control device for six-stream continuous casting tundish

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Journal of Iron and Steel Research International 2020年第9期27卷 1035-1044页

作者： Xin-gang Ai Dong Han Sheng-li Li hong-bo zeng Hui-ya Li Key Laboratory of Chemical Metallurgy Engineering Liaoning Province University of Science and Technology LiaoningAnshan 114051LiaoningChina

For a multistream tundish,the uniformity among the streams plays a significant role in the quality of molten *** to analyze the uniformity quantitatively and optimize structures of a multistream tundish is an important research content for a multistream tundish.A new approach was proposed to quantify the uniformity among the *** a physical study and a numerical study were carried out to optimize the structure of the diversion hole based on the prototype of a six-stream tundish in a steel *** the basis of average residence time,the uniformity of each flow was considered fully and then the optimal structure of the diversion hole was obtained by means of the comprehensive analysis of temperature field and velocity *** results show that the optimum structural parameters adopted for diversion holes are height of 20 mm,angle of 15°and diameter of 80 mm.

关键词： Multistream tundish Uniformity Diversion hole Physical simulation Numerical simulation

Spatial Organization of Innovation in the Oil Equipment Manufacturing Industry: Case of Dongying, China

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Chinese Geographical Science 2020年第2期30卷 324-339页

作者： WANG Qiuyu zeng gang The Center for Modern Chinese City Studies East China Normal UniversityShanghai 200062China

As innovation and technological change have become increasingly important for the competitiveness and sustainable growth of firms,cooperative innovation is now crucial for traditional industries in the context of *** paper proposes a framework for analyzing the spatial pattern of cooperative innovation for traditional industries in developing *** on in-depth interviews with 35 firms in the oil equipment manufacturing industry in Dongying City,China,this study argues that different firms in the innovation pyramid have various innovation activity preferences and spatial *** with high innovation abilities tend to cooperate with various partners that are geographically dispersed and continuously expanding,while firms with inferior abilities usually cooperate with nearby fixed *** to the differences in innovation environment and actor locations,firms tend to make different choices regarding innovation types and models,which highlight the importance of personnel training and basic scientific research at the global scale and practical product research and development at the national ***,talent flow is the most important way to realize relationships for firm innovation activity.

关键词： spatial organization open innovation external knowledge linkages oil equipment manufacturing industry(OEMI) Dongying,China

3D Rigid-Plastic Finite Element Analysis for Skew Rolling Process of the Stepped Part

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Journal of Materials Science & Technology 2003年第z1期19卷 38-40页

作者： gang FANG Pan zeng Department of Mechanical Engineering Tsinghua University Beijing 100084 China Department of Mechanical Engineering Tsinghua University Beijing 100084 China

Based on rigid-plastic finite element method, a skew rolling process of stepped part is simulated. Considering nodesaving and effective remeshing, the tetrahedron solid elements are used to discrete workpiece. The workpiece material adopts rigid-plastic model, where the flow stress is function of effective strain, effective strain rate and *** thermomechanical coupling is considered in the simulation. To model the spinning workpiece undergoing plastic deformation, a novel solution is presented and applied in this paper. The stress state in the workpiece and forming characteristic of skew rolling are analyzed. The forming load, including roller torque and forces in three directions are predicted. The above analyses are helpful to understanding of forming mechanisms and improving of process and die design.

关键词： FEM, Skew rolling, Stepped part, Spinning part, Fracture

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang zeng Jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Simultaneous removal of NO and SO_2 from dry gas stream using non-thermal plasma

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Journal of Environmental Sciences 2007年第11期19卷 1393-1397页

作者： YU Qi YANG hong-min zeng Ke-si ZHANG Zhen-wei YU gang College of Chemical Engineering Wuhan University of Science and Engineering Wuhan 430073 China Department of Power Engineering Nanjing Normal University Nanjing 210042 China Department of Man-Machine and Environment Engineering College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In order to investigate the feasibility of sequential removal NO and SO2 using non-thermal plasma and adsorbent simultaneously, the removal of NO and SO2 from dry gas stream （NO/SO2/N2/O2） with very little O2 using non-thermal plasma was investigated using a coaxial dielectric barrier discharge. Comparative experiments were carried out in the dry gas stream with and without Ar respectively at O2 concentration of 0.1%. The results showed that NO could be removed remarkably and it would be enhanced in the presence of Ar in the dry gas stream. It seems that SO2 could not be removed unless there is Ar in the dry gas stream. The mechanism of removal of NO and SO2 in the dry gas stream was discussed.

关键词： NO SO2 non-thermal plasma dry gas stream simukaneous removal