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Predictive value of Hajibandeh index in determining peritoneal contamination in acute abdomen:A cohort study and meta-analysis

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2747-2756页

作者： Shahab Hajibandeh Shahin Hajibandeh Louis Evans Bethany Miller Jennifer Waterman Suhaib js Ahmad Jay Hale Adnan Higgi Bethan Johnson Dafydd Pearce Ahmed Hazem Helmy Nader Naguib Andrew Maw Department of General Surgery University Hospital of WalesCardiff CF144XWUnited Kingdom Department of General Surgery Royal Stoke University HospitalStoke-on-Trent ST46QGUnited Kingdom Department of General Surgery Ysbyty GwyneddBangor LL572PWUnited Kingdom Department of General Surgery Royal Glamorgan HospitalPontyclun CF728XRUnited Kingdom Department of General Surgery Glan Clwyd HospitalRhyl LL185UJUnited Kingdom

BACKGROUND Hajibandeh index(HI),derived from combined levels of C-reactive protein,lactate,neutrophils,lymphocytes and albumin,is a modern predictor of peritoneal contamination and mortality in patients with acute abdominal *** To validate the performance of HI in predicting the presence and nature of peritoneal contamination in patients with acute abdominal pathology in a larger cohort study and to synthesis evidence in a systematic review and *** The STROBE guidelines and the PRISMA statement standards were followed to conduct a cohort study(ChiCTR2200056183)and a meta-analysis(CRD420-22306018),*** adult patients undergoing emergency laparotomy for acute abdominal pathology were *** accuracy of the HI was evaluated using receiver operating characteristic(ROC)curve analysis in the cohort study and using weighted summary area under the curve(AUC)under the fixed and random effects modelling in the *** Quality Assessment of Diagnostic Accuracy Studies 2 criteria were used for methodological quality assessment of the included *** A total of 1437 patients were included(700 from the cohort study and 737 from the literature search).ROC curve analysis of the cohort study showed that the AUC of HI for presence of contamination,purulent contamination and feculent contamination were 0.79[95%confidence interval(CI):0.76-0.82,P<0.0001],0.76(95%CI:0.72-0.80,P<0.0001),and 0.83(95%CI:0.79-0.86,P<0.0001),*** meta-analysis showed that the pooled AUC of HI for presence of contamination,purulent contamination and feculent contamination were 0.79(95%CI:0.75-0.83),0.78(95%CI:0.74-0.81),and 0.80(95%CI:0.77-0.83),*** The HI is a strong and accurate predictor of intraperitoneal *** the available evidence is robust,it is limited to the studies conducted by our evidence synthesis *** encourage other researchers to validate performance of HI in predicting the pr

关键词： Hajibandeh index Laparotomy Mortality Peritonitis Contamination

A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM

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Chinese Chemical Letters 1995年第12期6卷 1049-1050页

作者： Wang, FS Cai, H Jing, ZX Yang, js Zhang, YM Univ Agr & Anim Sci PLA Changchun 130062 Peoples R China Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China

The structure of a new triterpenoid, named gonolactone A, isolated from the fruiting body of Ganoderma lucidum,was determined by spectroscopic methods. This compound was identified as 7 beta -hydroxy-3. 11,15-trioxo-l...

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Assessing disease activity using the pediatric Crohn’s disease activity index:Can we use subjective or objective parameters alone?

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World Journal of Gastroenterology 2021年第30期27卷 5100-5111页

作者： Amy Grant Trudy Lerer Anne M Griffiths js Hyams Anthony Otley Division of Pediatrics IWK HealthHalifaxNS B3K6R8Canada Division of Research Connecticut Children's Medical CenterHartfordCT 06106United States Division of Gastroenterology Hepatology and Nutrition The Hospital for Sick ChildrenTorontoON M5G1X8Canada Division of Gastroenterology Connecticut Children's Medical CenterHartfordCT 06106United States Division of Pediatrics Dalhousie UniversityHalifaxNS B3H4C3Canada

BACKGROUND The pediatric Crohn’s disease activity index(PCDAI)is used as a standard tool to assess disease activity in clinical trials for pediatric Crohn’s *** To examine which items on the PCDAI drive assessment of disease activity,and how subgroups of subjective and objective items reflect change in disease state over *** Selective raw data from three prospectively collected datasets were combined,including 703 children with full PCDAI data at baseline,at 3-mo(Q1,n=670),and 1-year(Q4,n=474).Change in individual PCDAI scores from baseline to Q1 and to Q4 were examined using the non-weighted *** Abdominal pain,well-being,weight,and stooling had the highest change scores over *** indicators including albumin,abdominal exam,and height velocity *** scores for well-being and abdominal exam did not explain significant variance at Q1 but were significant predictors at Q4(P<0.001 and P<0.05).Subjective and objective subgroups of items predicted less variance(18%and 22%)on total PCDAI scores at Q1 and Q4 compared to the full PCDAI,or a composite scale(both 32%)containing significant *** Although subjective items on the PCDAI change the most over time,the full PCDAI or a smaller composite of items including a combination of subjective and objective components classifies disease activity better than a subgroup of either subjective or objective items *** on subjective or objective items as stand-alone proxies for disease activity measurement could result in misclassification of disease state.

关键词： Crohn’s disease Pediatric Crohn’s disease activity index Patient reported outcome measurement Disease activity Clinical trials Pediatric

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栀子苷立方液晶凝胶的制备、表征及体外评价

湖南中医药大学学报 2024年第1期44卷 38-46页

作者：欧阳威黄星雨王旭易骆慧婷李爽谭颖颜红湖南中医药大学湖南长沙410208 巩义市人民医院河南郑州451200

目的为促进水溶性栀子苷的透皮性能而制备栀子苷立方液晶凝胶(geniposide cubic liquid crystal gel,GE-CLC-G),并对其进行表征及体外评价。方法以甘油单油酸酯(glyceryl monooleate,GMO)为基质材料,采用注入法制备GE-CLC-G,通过三元相... 详细信息

目的为促进水溶性栀子苷的透皮性能而制备栀子苷立方液晶凝胶(geniposide cubic liquid crystal gel,GE-CLC-G),并对其进行表征及体外评价。方法以甘油单油酸酯(glyceryl monooleate,GMO)为基质材料,采用注入法制备GE-CLC-G,通过三元相图筛选出空白立方液晶区域;采用单因素法优选GE-CLC-G的处方及工艺条件;建立栀子苷的HPLC含量测定方法;采用偏光显微镜(polarizing microscope,PLM)、小角X衍射仪(small angle X diffraction,SAXS)对产品进行表征;采用改良Franz扩散池,比较GE-CLC-G与栀子苷软膏的体外透皮特性;采用DHR-2流变仪,对比GE-CLC-G和栀子苷软膏的流变学性质。结果优选的GECLC-G处方及工艺为GMO∶无水乙醇∶水=64∶3∶33,1%栀子苷投药量,1%促渗剂(氮酮:丙二醇=1∶1),60℃涡旋3 min,25℃恒温箱密封、避光3 d。制得的GE-CLC-G为无色、澄明的凝胶状半固体;为立方相,其内部结构为双菱形(Pn3m)晶格;测得产品中栀子苷的含量为(9.94±0.02)mg/g,载药量较大,符合立方液晶的特点。含1%促渗剂的GE-CLC-G 24 h累积透皮率Q(%)和透皮速率常数js明显高于不加促渗剂的栀子苷软膏和不加促渗剂的GE-CLC-G。流变学研究表明,GE-CLC-G属于非牛顿流体,生物黏附性好,结构更稳定。结论GE-CLC-G制备工艺简单,产品外观良好,PLM和SAXS可用于表征立方液晶凝胶,含量测定方法操作简单,专属性好;GE-CLC-G的体外透皮性能和流变学性质均明显优于栀子苷软膏。

关键词：立方液晶凝胶栀子苷三元相图体外透皮流变学

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机载中波红外离轴两反光学系统设计

光学与光电技术 2024年第1期22卷 83-89页

作者：吴超杨利红赵晨曦李敏敏张静静西安工业大学光电工程学院陕西西安710021

为了解决现有的光学系统在机载等领域中的局限性,引入自由度比较丰富的光学自由曲面,设计了一个小F数、大视场、较轻便的机载中波红外离轴两反光学系统。采用反射式的光学系统并通过离轴方式消除光线遮拦,通过XY多项式表达的自由曲面,... 详细信息

为了解决现有的光学系统在机载等领域中的局限性,引入自由度比较丰富的光学自由曲面,设计了一个小F数、大视场、较轻便的机载中波红外离轴两反光学系统。采用反射式的光学系统并通过离轴方式消除光线遮拦,通过XY多项式表达的自由曲面,运用前6阶项有效地平衡了高级像差。最终得到一款焦距为240 mm,视场角为3.8°,F数为3的中波红外光学系统,在全视场范围内系统的调制传递函数(Modulation Transfer Function,MTF)接近衍射极限,各视场的弥散斑均方根(Root Mean Square,RMS)半径在单个探测器像元尺寸15μm以内,整体物理尺寸小于130 mm(X)×180 mm(Y)×240 mm(Z)。最终结果表明,该系统在满足成像质量的同时,其结构简单,轻便性较好,可广泛应用于机载对地侦察成像等领域中。

关键词：机载离轴两反自由曲面小F数 XY多项式

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战时心理卫生救援队职能与运用初探

联勤军事医学 2024年第1期38卷 67-70页

作者：孙志国彭俊卿韦志伟张敏洪家坤刘让华联勤保障部队923医院贵港医疗区办公室广西贵港537100 联勤保障部队923医院贵港医疗区精神科广西贵港537100 联勤保障部队923医院贵港医疗区门诊部广西贵港537100 联勤保障部队923医院贵港医疗区医学心理科广西贵港537100

目的探索战时心理卫生救援队的职能、组织框架及主要工作策略。方法通过文献回顾与历年演训任务经验,同时在工作实践中提炼成果,总结战时心理卫生救援队的职能、组织框架及主要工作策略。结果初步归纳了战时心理卫生救援队的8项主要工... 详细信息

目的探索战时心理卫生救援队的职能、组织框架及主要工作策略。方法通过文献回顾与历年演训任务经验,同时在工作实践中提炼成果,总结战时心理卫生救援队的职能、组织框架及主要工作策略。结果初步归纳了战时心理卫生救援队的8项主要工作内容、组织框架与工作效能,以及一般性支持策略、物理康复与作业治疗、战斗应激反应(combat and operational stress reaction,COSR)“CALM-DOWNS”干预策略。结论心理卫生救援队是部队的机动卫勤力量,是战时和平时参与非战争军事行动应急卫勤支援保障力量体系的重要组成部分,在战时为降低心理伤减员和增强部队战斗力提供了专业支撑,及时梳理总结并进行研究,对心理卫生救援队的建设意义重大。

关键词：军事应激战斗应激反应心理急救危机干预干预策略

Effects of sediment particle morphology on adsorption of phosphorus elements

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International Journal of Sediment Research 2013年第2期28卷 246-253页

作者： hong-wei FANG Ming-hong CHEN Zhi-he CHEN Hui-ming ZHAO Guo-jian HE Department of Hydraulic Engineering the State Key Laboratory of Hydro Science and EngineeringTsinghua University College of Water Resources and Civil Engineering China Agricultural University Department of Water Resources and Environment Sun Yat-sen University

Sediment particle surface morphology affects phosphorus *** paper studied the phosphorus adsorption on sediment particle by using a Scanning Electron Microscope(SEM) and an Energy Dispersive X-ray Spectroscopy (EDS).Sediment samples from the Yangtze,Yellow and Yongding rivers in China were chosen to measure the particle surface morphology,surface gray scale and element distribution *** samples were firstly cleaned and put into phosphate solution for *** the Langmuir equation and Freundlich equation were used for descriptions of adsorption-desorption isotherms for *** were then dried and *** results show that the adsorption of phosphorus depends on the surface morphology of *** exists mostly in the ridges and channels,while a few exist in the slopes,and casually in the peaks,passes and pits.

关键词： Surface morphology Scanning electron microscope Adsorption Element distribution

Avian influenza virus directly infects human natural killer cells and inhibits cell activity

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Virologica Sinica 2017年第2期32卷 122-129页

作者： Huawei Mao Yinping Liu Sin Fun Sia js Malik Peiris Yu-Lung Lau Wenwei Tu Department of Paediatrics The University of Hong Kong - Shenzhen Hospital Shenzhen 518000 China Department of Paediatrics & Adolescent Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Department of Microbiology The University of Hong Kong Hong Kong SAR China Shenzhen Engineering Laboratory of PID Diagnosis & Therapy Technology Shenzhen 518000 China

Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.

关键词：生来的杀手(NK ) 房间鸟的流行性感冒病毒(AIV ) immunoevasion 方向感染抑制 cytotoxicity

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自适应双光融合人体摔倒检测方法研究

制造业自动化 2024年第3期46卷 138-141,216页

作者：谷湘煜刘晓岚罗洪伟饶爽李国胜深圳市朗驰欣创科技股份有限公司深圳518000 长江三峡技术经济发展有限公司北京101100 西南科技大学信息工程学院绵阳621000

针对基于可见光图像的人体摔倒检测方法在光照变化情况下性能不佳,无法满足全天候工况的问题,提出一种适用于变化光照条件下全天候工况的双光融合人体摔倒检测方法。首先利用Sobel算子提取可见光图像的边缘特征,通过非线性灰度变换增强... 详细信息

针对基于可见光图像的人体摔倒检测方法在光照变化情况下性能不佳,无法满足全天候工况的问题,提出一种适用于变化光照条件下全天候工况的双光融合人体摔倒检测方法。首先利用Sobel算子提取可见光图像的边缘特征,通过非线性灰度变换增强红外图像的对比度;同时,将可见光图像从RGB空间转换到HSI空间并根据归一化亮度进行自适应双光融合;最后,将融合的双光图像作为CenterNet检测器的输入样本,完成人体姿态检测任务。在自建双光数据集上开展验证实验,自适应光照融合策略在SSIM指标上达到了0.77,在MI指标上达到了1.21。在CenterNet检测模型上融合后,平均检测精度mAP提升了9.71%。实验结果证明了方法的有效性。

关键词：特征提取自适应策略双光融合摔倒检测