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Oxidative DNA demethylation mediated by Tet enzymes

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National Science Review 2015年第3期2卷 318-328页

作者： Guo-Liang Xu Jiemin wong Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Institute of Biomedical Sciences and School of Life Sciences East China Normal University

DNA modiication, methylation of cytosine(5m C), and oxidation of 5m C to 5-hydroxymethylcytosine(5hm C), 5-formylcytosine(5f C), and 5-carboxylcytosine(5ca C) can have profound efects on genome function in animals. hese modiications are intricately involved in DNA methylation reprograming dynamics during mammalian development. Together, they contribute to cell lineage restriction and maintenance, while also undergoing dynamic changes during cellular transitions and induced *** last ive years have seen an intense research focus on enzymatic DNA demethylation, triggered by the discovery of 5hm C and Tet dioxygenases. In this review, we evaluate recent indings that have provided new insights into the mechanisms underlying DNA demethylation and its efect on developmental regulation.

关键词： DNA demethylation 5m C oxidation Tet dioxygenase TDG epigenetic reprograming

Coincidence Wecken Property for Nilmanifolds

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Acta Mathematica Sinica,English Series 2019年第2期35卷 239-244页

作者： Daciberg GON?ALVES Peter wong Departamento de Matemática-IME-Universidade de S?o Paulo Rua do Mat?o Department of Mathematics Bates College

Let f, g: X → Y be maps from a compact infra-nilmanifold X to a compact nilmanifold Y with dim X ≥ dim Y. In this note, we show that a certain Wecken type property holds, i.e., if the Nielsen number N(f, g) vanishes then f and g are deformable to be coincidence free. We also show that if X is a connected finite complex X and the Reidemeister coincidence number R(f, g) = ∞ then f ～ f' so that C(f', g) = {x ∈ X | f'(x) = g(x)} is empty.

关键词： Nielsen coincidence theory nilmanifolds

ASYMPTOTICS OF ORTHOGONAL POLYNOMIALS VIA THE RIEMANN-HILBERT APPROACH

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Acta Mathematica Scientia 2009年第4期29卷 1005-1034页

作者： R．wong 赵育求 Department of Mathematics City University of Hong Kong Hong Kong China Department of Mathematics Sun Yat-Sen University Guangzhou 510275 China

In this survey we give a brief introduction to orthogonal polynomials, including a short review of classical asymptotic methods. Then we turn to a discussion of the Riemann-Hilbert formulation of orthogonal polynomials, and the Delft ＆ Zhou method of steepest descent. We illustrate this new approach, and a modified version, with the Hermite polynomials. Other recent progress of this method is also mentioned, including applications to discrete orthogonal polynomials, orthogonal polynomials on curves, multiple orthogonal polynomials, and certain orthogonal polynomials with singular behavior.

关键词： orthogonal polynomials asymptotic methods Riemann-Hilbert approach

Anti-angiogenesis in prostate cancer： knocked down but not out

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Asian Journal of Andrology 2014年第3期16卷 372-377页

作者： Marijo Bilusic Yu-Ning wong Fox Chase Cancer Center Philadelphia Pennsylvania USA.

Angiogenesis is a very complex physiological process, which involves multiple pathways that are dependent on the homeostatic balance between the growth factors （stimulators and inhibitors）. This tightly controlled process is stimulated by angiogenic factors, which are present within the tumor and surrounding tumor-associated stromal cells. The dependence of tumor propagation, invasion and metastasis on angiogenesis makes the inhibitors of new blood vessel formation attractive drugs for treating the malignancies. Angiogenesis can be disrupted by several distinct mechanisms： by inhibiting endothelial cells, by interrupting the signaling pathways or by inhibiting other activators of angiogenesis. This strategy has shown therapeutic benefit in several types of solid tumors, leading to Food and Drug Administration （FDA） approval of anti-angiogenic agents in the treatment of kidney, non-small cell lung, colon and brain cancers. Although no angiogenesis inhibitors have been approved for patients with metastatic prostate cancer, therapies that target new blood vessel formation are still an emerging and Dromising area of prostate cancer research.

关键词： angiogenesis clinical trials prostate cancer

Type Ⅰ interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

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Zoological Research 2018年第1期39卷 3-14页

作者： Gary wong Xiang-Guo Qiu Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 518020China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Special Pathogens Program National Microbiology LaboratoryPublic Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical Microbiology and Infectious Diseases University of ManitobaWinnipegManitoba R3E 0J9Canada

Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

关键词： Ifnar Mice Animal model Flavivirus Filovirus Arenavirus Bunyavirus Henipavirus Togavirus

Traditional Chinese Medicine in Malaysia: A Brief Historical Overview of Laws and Regulations

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Chinese Medicine and Culture 2019年第3期2卷 162-165页

作者： hon Foong wong Shih Chau Ng Wen Tien Tan Huiying Wang Xun Lin Si Woei Goh Bao Ling Hoo Chyong En Chai Jun Liu International Education College Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Although traditional Chinese medicine(TCM)has been a part of the Malaya and the Malaysia people’s method of maintaining health and well-being for many centuries,it was never been enrolled in the public health-care ***,the rising cost of Western drugs and the increasing number of people frequenting TCM has driven the government to search for cheaper options and to look into its safe *** 1992,the government mandated all TCM herbal products to be registered with the National Pharmaceutical Control *** TCM products sold in Malaysia are now Good Manufacturing Practice *** government has also established a Traditional and Complementary Medicine Division within the Ministry of *** 2008 and 2014,a traditional and complementary medicine unit was set up in major hospitals in all *** is one of the main services offered by the *** 2016,the government enacted the Traditional and Complementary Medicine Act to regulate the TCM ***,a 10-vear blueprint has been drawn to support the development of all traditional and complementary medicines in *** article aims to provide a brief overview on the regulatory development of TCM in Malaysia.

关键词： Development of traditional Chinese medicine historical overview laws and regulations Malaysia Traditional Chinese medicine

Enhanced optical Kerr nonlinearity of MoS2 on silicon waveguides

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Photonics Research 2015年第5期3卷 206-209页

作者： Linghai Liu Ke Xu Xi Wan Jianbin Xu Chi Yan wong hon Ki Tsang Department of Electronic Engineering The Chinese University of Hong Kong Department of Electronic and Information Engineering Shenzhen Graduate SchoolHarbin Institute of Technology

A quasi-two-dimensional layer of MoS2 was placed on top of a silicon optical waveguide to form a MoS2–silicon hybrid structure. Chirped pulse self-phase modulation measurements were carried out to determine the optica Kerr nonlinearity of the structure. The observed increase in the spectral broadening of the optical pulses in the MoS2–silicon waveguide compared with the silicon waveguides indicated that the third-order nonlinear effect in MoS2 is about 2 orders of magnitude larger than that in silicon. The measurements show that MoS2 has an effective optical Kerr coefficient of about 1.1 × 10-16m2∕W. This work reveals the potential application of MoS2 to enhance the nonlinearity of hybrid silicon optical devices.

关键词： Mo Enhanced optical Kerr nonlinearity of MoS2 on silicon waveguides mode

Fundamental Groups of Graphs of Cyclic Subgroup Separable and Weakly Potent Groups

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Algebra Colloquium 2021年第1期28卷 119-130页

作者： M.S.M.Asri K.B.wong P.C.wong Institute of Mathematical Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

We give a characterization of the cyclic subgroup separability and weak potency of the fundamental group of a graph of polycyclic-by-finite groups and free-by-finite groups amalgamating edge subgroups of the form×D,w... 详细信息

关键词： HNN extensions fundamental groups of graphs of groups weakly potent residually finite

Did ZIKV evolve to be more dangerous? A new clue towards neurovirulence

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National Science Review 2018年第2期5卷 121-122页

作者： Gary wong George F.Gao Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Third People's Hospital CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Before 2015,Zika virus(ZIKV)was a little-known flavivirus that caused sporadic symptomatic infections in humans(under 20 reported cases,but likely manymore unreported asymptomatic cases)in the decades following its di... 详细信息

关键词： ZIKA virus FLAVIVIRUSES EPIDEMICS