Oxidative DNA demethylation mediated by Tet enzymes

作     者：Guo-Liang Xu Jiemin Wong 

作者机构：Institute of Biochemistry and Cell BiologyChinese Academy of Sciences Institute of Biomedical Sciences and School of Life SciencesEast China Normal University 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2015年第2卷第3期

页      面：318-328页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by grants from the National Natural Science Foundation of China(to G.X.31230039 and 31221001) 

主　　题：DNA demethylation 5m C oxidation Tet dioxygenase TDG epigenetic reprograming 

摘      要：DNA modiication, methylation of cytosine(5m C), and oxidation of 5m C to 5-hydroxymethylcytosine(5hm C), 5-formylcytosine(5f C), and 5-carboxylcytosine(5ca C) can have profound efects on genome function in animals. hese modiications are intricately involved in DNA methylation reprograming dynamics during mammalian development. Together, they contribute to cell lineage restriction and maintenance, while also undergoing dynamic changes during cellular transitions and induced *** last ive years have seen an intense research focus on enzymatic DNA demethylation, triggered by the discovery of 5hm C and Tet dioxygenases. In this review, we evaluate recent indings that have provided new insights into the mechanisms underlying DNA demethylation and its efect on developmental regulation.