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LOGISTICS SCHEDULING: ANALYSIS OF TWO-STAGE PROBLEMS

Systems Science and Systems Engineering 2003年第4期12卷 385-407页

作者： Yung-Chia CHANG Chung-yee LEE Davicom America Corporation 1135 Kern Avenue Sunnyvale CA 94085 U.S.A.Department of Industrial Engineering and Engineering Management Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong

This paper studies the coordination effects between stages for scheduling problems where decision-making is a two-stage process. Two stages are considered as one system. The system can be a supply chain that links two stages, one stage representing a manufacturer; and the other, a distributor It also can represent a single manufacturer, while each stage represents a different department responsible for a part of operations. A problem that jointly considers both stages in order to achieve ideal overall system performance is defined as a system problem. In practice, at times, it might not be feasible for the two stages to make coordinated decisions due to (i) the lack of channels that allow decision makers at the two stages to cooperate, and/or (ii) the optimal solution to the system problem is too difficult (or costly) to achieve.Two practical approaches are applied to solve a variant of two-stage logistic scheduling problems. The Forward Approach is defined as a solution procedure by which the first stage of the system problem is solved first, followed by the second stage. Similarly, the Backward Approach is defined as a solution procedure by which the second stage of the system problem is solved prior to solving the first stage. In each approach, two stages are solved sequentially and the solution generated is treated as a heuristic solution with respect to the corresponding system problem. When decision makers at two stages make decisions locally without considering consequences to the entire system, ineffectiveness may result - even when each stage optimally solves its own problem. The trade-off between the time complexity and the solution quality is the main concern. This paper provides the worst-case performance analysis for each approach.

关键词： Logistics scheduling worst case analysis dynamic programming

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Intrahepatic natural killer T cell populations are increased in human hepatic steatosis

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World Journal of Gastroenterology 2011年第13期17卷 1725-1731页

作者： Michael Adler Sarah Taylor Kamalu Okebugwu Herman yee Christine Fielding George Fielding Michael Poles New York University School of Medicine New York NY 10016 United States

AIM: To determine if natural killer T cell (NKT) populations are affected in nonalcoholic fatty liver disease (NAFLD). METhoDS: Patients undergoing bariatric surgery underwent liver biopsy and blood sampling during surgery. The biopsy was assessed for steatosis and immunocyte infiltration. Intrahepatic lymphocytes (IHLs) were isolated from the remainder of the liver biopsy, and peripheral blood mononuclear cells (PBMCs) were isolated from the blood. Expression of surface proteins on both IHLs and PBMCs were quantified using flow cytometry. RESULTS: Twenty-seven subjects participated in thisstudy. Subjects with moderate or severe steatosis had a higher percentage of intrahepatic CD3+/CD56+ NKT cells (38.6%) than did patients with mild steatosis (24.1%, P = 0.05) or those without steatosis (21.5%, P = 0.03). Patients with moderate to severe steatosis also had a higher percentage of NKT cells in the blood (12.3%) as compared to patients with mild steatosis (2.5% P = 0.02) and those without steatosis (5.1%, P = 0.05). CONCLUSION: NKT cells are significantly increased in the liver and blood of patients with moderate to severe steatosis and support the role of NKT cells in NAFLD.

关键词： Nonalcoholic fatty liver disease Natural killer T cells Natural killer T-like cells Lymphocytes Hepatic steatosis

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Inhalation of nanoparticle-based drug for lung cancer treatment:Advantages and challenges

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Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 481-489页

作者： Wing-Hin Lee Ching-yee Loo Daniela Traini Paul M.Young Respiratory Technology Woolcock Institute of Medical Research and Discipline of PharmacologySydney Medical SchoolThe University of SydneyNSW 2037Australia

Ever since the success of developing inhalable insulin,drug delivery via pulmonary administration has become an attractive route to treat chronic *** delivery system for nanotechnology is a relatively new concept especially when applicable to lung cancer ***-based systems such as liposome,polymeric nanoparticles or micelles are strategically designed to enhance the therapeutic index of anti-cancer drugs through improvement of their bioavailability,stability and residency at targeted lung *** with these benefits,nano-based systems also provide additional diagnostic advantages during lung cancer treatment,including imaging,screening and drug ***,delivery of nanobased drugs via pulmonary administration for lung cancer therapy is still in its infancy and numerous challenges are ***,immunology,toxicology and largescale manufacturing(stability and activity of drugs)are some aspects in nanotechnology that should be taken into consideration for the development of inhalable nano-based chemotherapeutic *** review will focus on the current inhalable nano-based drugs for lung cancer treatment.

关键词： Inhalation Lung cancer Liposome Nanoparticle

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A scoping review on traditional medicine for bruxism

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 141-149页

作者： Lin Ang Eunhye Song Myeong Soo Lee yee Ang KM Science Research Division Korea Institute of Oriental MedicineDaejeon34054Republic of Korea Global Cooperation Center Korea Institute of Oriental MedicineDaejeon34054Republic of Korea Conservative Department Faculty of DentistryMAHSA UniversitySelangor42610Malaysia

Objective:To investigate the current evidence on traditional medicine in managing bruxism and its clinical ***:A search was conducted in nine databases to identify potential eligible articles published from the date of inception until August 3,*** clinical studies that used traditional medicine of any type in treating bruxism were eligible for *** authors performed data extraction and quality as-sessments *** data were tabulated and discussed ***:A total of 16 clinical studies were included in this scoping *** the 16 studies,three studies were randomized controlled trials,one was a caseecontrol study,10 were case series,and two were case *** review identified studies of interventions based on herbal medicine and acupuncture-related *** studies reported positive results,but the overall quality of the included studies was typically fair to ***:This study is the first scoping review on traditional medicine for bruxism despite the limited *** research on traditional medicine in bruxism management should be conducted for better clarification and application in daily practice.

关键词： Acupuncture-related therapies Alternative therapy Herbal medicine Parafunctional habit Teeth grinding

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Stem cell aging in adult progeria

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Cell Regeneration 2015年第1期4卷 75-83页

作者： hoi-Hung Cheung Duanqing Pei Wai-yee Chan CUHK-CAS GIBH Joint Research Laboratory on Stem Cell and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong S.A.R.China Chinese Academy of Sciences(CAS)Guangzhou Institutes of Biomedicine and Health(GIBH) GuangzhouChina The Chinese University of hong Kong Room G03ALo Kwee-Seong Intergrated Biomedical Science BuildingShatinN.T.Hong Kong S.A.R.China

Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ofcardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become thefocus in aging research. Natural aging is not regarded as a programmed process. however, accelerated agingdue to inherited genetic defects in patients of progeria is programmed and resembles many aspects ofnatural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilfordprogeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cellaging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigeneticlandscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application ofthe latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

关键词： Werner syndrome Stem cells Aging WRN

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Effects of the sunscreen ultraviolet filter,oxybenzone,on green microalgae

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Advances in Polar Science 2020年第2期31卷 112-123页

作者： Ming-Li TEOH Nur Suhaida SANUSI Ching-yee WONG John BEARDALL School of Biosciences Taylor’s UniversityLakeside Campus47500 Subang JayaSelangor Darul EhsanMalaysia Institute of Ocean and Earth Sciences University of Malaya50603 Kuala LumpurMalaysia National Antarctic Research Centre Institute of Graduate StudiesUniversity of Malaya50603 Kuala LumpurMalaysia School of Biological Sciences Monash UniversityClaytonVictoria 3800Australia

Ultraviolet(UV)filters are widely used in sunscreen and personal care products due to their ability to give protection to our skin from UV ***,commonly known as benzophenone-3,is one type of UV filter found as the active ingredient in many pharmaceutical *** oxybenzone has been extensively studied as an environmental toxicant in the ecosystem,little is known about its toxicity effects on *** effects of oxybenzone on growth(measured as OD620 nm,chlɑand carotenoids)and macromolecular composition of polar microalgae(Chlorella UMACC 400 and Chlorella UMACC 401)and temperate microalgae(Chlorella sp.,Chlamydomonas reinhardtii,Scenedesmus quadricauda)were *** microalgae were cultured in triplicate and exposed to different oxybenzone concentrations(0,100,200,300 and 400 mg·L-1),at 4℃and 18 for polar and temperate species respectively,for 96 *** oxybenzone concentrations used℃represent a range from environmental to extreme concentrations to understand the impact of this toxicant on *** results showed that the highest concentration of oxybenzone(300 and 400 mg·L-1)had adverse effects on growth rate and biomass of these ***,exposure to oxybenzone concentrations ranging from 200 mg·L-1 to 400 mg·L-1 did not have significant effects on *** *** exposure to oxybenzone at higher concentrations also led to changes in cell structure after 96 ***,protein and carbohydrate content of all microalgae except *** increased with increasing oxybenzone *** content increased significantly when cells were exposed to oxybenzone,though effects were greater in the polar species,suggesting that it could be one of the adaptive strategies that enabled these microalgae to tolerate *** investigation is required to determine the effects of oxybenzone on other features of microalgal performance at relevant environmental concentrations.

关键词： polar algae temperate algae Chlorella benzophenone-3 emerging contaminants

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Loco-regional intervention for hepatocellular carcinoma

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Journal of Interventional Medicine 2019年第2期2卷 43-46页

作者： Wan yee Lau Eric C.H.Lai Faculty of Medicine The Chinese University of Hong KongNew TerritoriesHong KongChina

Anatomic location/size and number of lesions,inadequate volume of future liver remnant,or poor coexisting premorbid conditions preclude surgery in the majority of patients with hepatocellular carcinoma(HCC).Liver transplantation can cure some patients with poor liver function,but few patients are eligible because of scarcity of *** specific anti-cancer treatment,the prognosis of HCC is *** locoregional therapies are used to treat patients who are not candidates for surgery,and have emerged as tools for palliation,tumor downstaging,and bridging therapy prior to liver ***,local ablative therapy even competes with partial hepatectomy and liver transplantation as a primary treatment for small *** is well suited to treatment with loco-regional therapy because it has a tendency to stay within the liver,with distant metastasis generally occurring late in the course of *** suggests that an effective local-regional therapy can have a great impact on HCC patients who are not candidates for surgical ***-regional therapy can further be justified because patients with HCC usually die of liver failure consequent to intrahepatic growth resulting in liver tissue destruction,rather than extrahepatic metastases.

关键词： Hepatocellular carcinoma Hepatectomy Loco-regional therapy TACE Local ablation

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Phenol photocatalytic degradation over mesoporous TUD-1-supported chromium oxide-doped titania photocatalyst

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Chinese Journal of Catalysis 2016年第11期37卷 1871-1881页

作者： yee Khai Ooi Leny Yuliati Siew Ling Lee 马来西亚工艺大学理学院化学系马来西亚新山81310 马来西亚工艺大学科学与工业研究所可持续纳米材料中心马来西亚新山81310

Mesoporous Technische Universiteit Delft（TUD-1）-supported chromium oxide-doped titania（Cr-TiO2） was developed as a promising photocatalyst for phenol photodegradation under visible light ***-angle X-ray diffraction and Fourier transform infrared spectroscopy results confirmed the amorphous and mesoporous silicate framework of TUD-1 in TUD-1-supported *** mesostructure of TUD-1 was further verified via N2 adsorption-desorption analysis,which showed a type-IV isotherm with a narrow average pore size distribution of 3.9 nm and high surface area of 490 m^2/*** electron microscopy analysis results indicated that TUD-1-supported Cr-TiO2 contained nanoparticles and porous *** increase in band gap energy was observed after loading Cr-TiO2 into *** with that of unsupported Cr-TiO2,TUD-1-supported Cr-TiO2 showed higher photocatalytic activity for phenol degradation under visible light *** TUD-1 supported Cr-TiO2 photocatalyst with a Si/Ti molar ratio of 30 exhibited the highest photodegradation of phenol（82%） of the prepared *** photodegradation of phenol by the supported catalyst followed the Langmuir adsorption isotherm with first-order kinetics.

关键词： Phenol TUD-1 Titania Photocatalyst Mesoporous

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An Improved Differential Evolution and Its Industrial Application

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Journal of Intelligent Learning Systems and Applications 2012年第2期4卷 81-97页

作者： Johnny Chung yee Lai Frank Hung Fat Leung Sai ho Ling Edwin Chao Shi Centre for Health Technologies Faculty of Engineering and IT University of Technology Sydney Sydney Australia. Centre for Signal Processing Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Hong Kong China

In this paper, an improved Differential Evolution (DE) that incorporates double wavelet-based operations is proposed to solve the Economic Load Dispatch (ELD) problem. The double wavelet mutations are applied in order to enhance DE in exploring the solution space more effectively for better solution quality and stability. The first stage of wavelet operation is embedded in the DE mutation operation, in which the scaling factor is governed by a wavelet function. In the second stage, a wavelet-based mutation operation is embedded in the DE crossover operation. The trial population vectors are modified by the wavelet function. A suite of benchmark test functions is employed to evaluate the performance of the proposed DE in different problems. The result shows empirically that the proposed method out-performs signifycantly the conventional methods in terms of convergence speed, solution quality and solution stability. Then the proposed method is applied to the Economic Load Dispatch with Valve-Point Loading (ELD-VPL) problem, which is a process to share the power demand among the online generators in a power system for minimum fuel cost. Two different conditions of the ELD problem have been tested in this paper. It is observed that the proposed method gives satisfactory optimal costs when compared with the other techniques in the literature.

关键词： Differential Evolution Evolutionary Algorithm Economic Load Dispatch

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Mediating effect of e-learning quality on learning outcomes through student satisfaction in nursing education

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Frontiers of Nursing 2023年第3期10卷 261-271页

作者： Woan Ching Chang Wei Fern Siew Bit-Lian yee Nursing Division School of Health SciencesInternational Medical UniversityKuala Lumpur 57000Malaysia Community Medicine Division School of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia Nursing Division Faculty of Allied SciencesOpen University MalaysiaKuala Lumpur 50480Malaysia

Objective:This study aimed to determine the relationships between e-learning quality,student satisfaction,and learning outcomes and the mediating effect of student ***:A cross-sectional quantitative correlational study using a predictive design and multivariate analysis method was employed in this study.A sample of 241 nursing students were recruited through an online survey based on a stratified random sampling *** variance-based Par tial Least Squares Structural Modeling analysis method was used to test the possible relationship and mediating effect among the ***:The findings revealed statistical y significant relationships between e-learning quality,student satisfaction,and learning outcomes.A mediating effect of 37.2%is predicted for e-learning quality on learning outcomes through student ***:This study emphasizes the learning needs of working nurses and the impact on their learning outcomes in e-learning nursing undergraduate *** in e-learning education have assisted nurses to be more self-sufficient in their pursuit of lifelong learning.

关键词： system quality information quality service quality learning outcome student satisfaction

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