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Distribution of electric field for carbon nanotube assembly: Experiments (II)

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 121-125页

作者： Soongeun Kwon Soo-Hyun KIM Kwang-ho KIM Myung-chang kang Hyung-woo LEE Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

The distribution effect of electric field on the alignment and attachment of carbon nanotubes （CNTs） were investigated. The experimental results were compared with the simulation results according to three different shaped electrodes. In previous simulation, the round shaped electrodes were expected to be more effective for aligning and attaching a single CNT between two electrodes than conical or rectangular shaped electrodes. To verify the simulation results, three different shaped electrodes were introduced and a single multi-walled carbon nanotube （MWNT） was attached. The optimal conditions for aligning and attaching MWNTs such as the frequency, applied voltage and concentration of MWNTs solution were investigated. Through repeated experiments, frequency of 100 kHz-10 MHz, applied voltage of 0.3-1.3 V^s/~m, concentration of 5 ktg/mL in MWNTs solution were obtained as a possible condition range to attach MWNTs. Under these conditions, the yield of MWNTs attachment between two electrodes was up to 70%. In previous simulation, furthermore, it was verified that the size of the stable or quasi-stable region made CNTs aligned and attached on different shaped electrodes from the comparison of the experimental and simulation results. Most single MWNT attachment was accomplished on the round shaped electrodes.

关键词： carbon nanotubes dielectrophoresis round shaped electrode simulation

Super-resolution morphological dissemination of intercalating dye in single DNA molecules via binding activated localization microscopy

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Chinese Chemical Letters 2018年第3期29卷 505-508页

作者： Guenyoung Park Suresh Kumar Chakkarapani Soyeong Ju Sujin Ahn Seong ho kang Department of Chemistry Graduate School Kyung Hee University Department of Applied Chemistry and Institute of Natural Sciences Kyung Hee University

Fluorescent dye （YOYO-I） intercalated with single DNA molecules were investigated via bindingactivated localization microscopy （BALM） at sub-diffraction limit resolutions. Various dye-to-DNA base pair （bp） ratios were imaged using the blinking property of YOYO-1 dye under optimum BALM switching buffer conditions. Individual DNA molecules exhibited regular/irregular intercalating phenomena with respect to dye-to-DNA bp ratio. The acquired images were reconstructed into super-resolution images by applying a Gaussian fit to the centroid of the point spread function. The YOYO-1 intercalated with λ-DNA possessed a non-homogeneous region due to the different binding modes of YOYO-1 with λ-DNA. Each binding mode was imaged at the sub-diffraction limit super-resolution. The distance between homogenously localized intercalating dyes within the DNA molecules was measured to be 34nm （n= 10; dye：DNAbp= 1：100） without photocleavage in 50mmol/L β-mercaptoethylamine buffer. The results were similar to those of the theoretical values without photocleavage in the base pairs of single DNA molecules below the diffraction limit. The results paved the way for an in-depth microscopic analysis of molecular variation with single λ-DNA molecules. With this method, it should be possible to analyze the exact base pair breakdown during various stages of cell apoptosis.

关键词： λ-DNA Intercalating dye Morphological dissemination Sub-diffraction limit resolution Binding-activated localization microscopy

Studies on Nitrogen Oxides Removal Using Plasma Assisted Catalytic Reactor

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Plasma Science and Technology 2003年第6期5卷 2057-2062页

作者： V.Ravi Young Sun Mok B.S.Rajanikanth ho-Chul kang Department of High Voltage Engineering Indian Institute of Science Bangalore-560 012IndiaDepartment of Chemical EngineeringCheju National UniversityAraCheju 690-756South KoreaDepartment of High Voltage EngineeringIndian Institute of Science Bangalore-560 012IndiaDepartment of Chemical EngineeringCheju National UniversityAraCheju 690-756South Korea

An electric discharge plasma reactor combined with a catalytic reactor wasstudied for removing nitrogen oxides. To understand the combined process thoroughly, dischargeplasma and catalytic process were separately studied first, and then the two processes were combinedfor the study. The plasma reactor was able to oxidize NO to NO_2 well although the oxidation ratedecreased with temperature. The plasma reactor alone did not reduce the NO_x (NO+NO_2) leveleffectively, but the increase in the ratio of NO_2 to NO as a result of plasma discharge led to theenhancement of NO_x removal efficiency even at lower temperatures over the catalyst surface(V_2O_5-WO_3/TiO_2). At a gas temperature of 100℃, the NO_x removal efficiency obtained using thecombined plasma catalytic process was 88% for an energy input of 36 eV/molecule or 30 J/l.

关键词： non-thermal plasma catalytic process oxidation NO_x removal

Minimally invasive vs open pancreatectomy for nonfunctioning pancreatic neuroendocrine tumors

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1133-1145页

作者： Juwan Kim ho Kyoung Hwang Woo Jung Lee Chang Moo kang Department of Surgery Yonsei University College of MedicineSeoul 03722South Korea

BACKGROUND The mainstay of treating nonfunctioning-pancreatic neuroendocrine tumors(NFPNETs)is surgical ***,minimally invasive approaches to pancreatic resection for treating NF-PNETs are not widely accepted,and the longterm oncological outcomes of such approaches remain *** To determine the short-and long-term outcomes of minimally invasive pancreatic resection conducted in patients with *** Prospective databases from Severance hospital were searched for 110 patients who underwent curative resection for NF-PNETs between January 2003 and August *** The proportion of minimally invasive surgery(MIS)procedures performed for NF-PNET increased to more than 75%after *** was no significant difference in post-operative complications(P=0.654),including pancreatic fistula(P=0.890)and delayed gastric emptying(P=0.652),between MIS and open *** statistically significant difference was found in disease-free survival between the open approach group and the MIS group(median follow-up period,28.1 mo;P=0.428).In addition,the surgical approach(MIS vs open)was not found to be an independent prognostic factor in treating NF-PNET patients[Exp(β)=1.062;P=0.929].CONCLUSION Regardless of the type of surgery,a minimally invasive approach can be safe and feasible for select NF-PNET patients.

关键词： Nonfunctioning-pancreas neuroendocrine tumor Pancreatic neuroendocrine tumor Minimally invasive surgery Oncologic outcome Laparoscopic pancreaticoduodenectomy Laparoscopic distal pancreatectomy

Transplantation of mesenchymal stem cells from human umbilical cord versus human umbilical cord blood for peripheral nerve regeneration

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Neural Regeneration Research 2010年第11期5卷 838-845页

作者： kang-Mi Pang Mi-Ae Sung Mohammad S.Alrashdan Sang Bae Yoo Samir Jabaiti Soung-Min Kim Sung-June Kim Myung-Jin Kim Jeong won Jahng Jong-ho Lee Department of Oral Maxillofacial Surgery Seoul National University Seoul 110-768 Korea Department of Craniofacial Structure & Functional Biology Seoul National University Seoul 110-768 Korea Dental Research Institute School of Dentistry Seoul National University Seoul 110-768 Korea Department of Plastic and Reconstructive Surgery Faculty of Medicine Jordan University Hospital Amman 11942 Jordan Department of Electrical Engineering School of Electrical and Computer Science Seoul National University Seoul 110-768 Korea

BACKGROUND： Mesenchymal stem cells （MSCs） appear to be a good alternative to Schwann cells in the treatment of peripheral nerve injury. Fetal stem cells, like umbilical cord blood （UCB） and umbilical cord （UC） stem cells, have several advantages over adult stem cells. OBJECTIVE： To assess the effects of UC-derived MSCs （UCMSCs） and UCB-derived MSCs （UCBMSCs） in repair of sciatic nerve defects. DESIGN, TIME AND SETTING： A randomized controlled animal experiment was performed at the laboratory of Department of Oral and Maxillofacial Surgery, Seoul National University Dental hospital, from July to December 2009. MATERIALS： UCMSCs were provided by the Research Institute of Biotechnology, Dongguk University. UCBMSCs were provided by the Laboratory of Stem Cells and Tumor Biology, College of Veterinary Medicine, Seoul National University. Dulbecco＇s modified Eagle＇s medium （DMEM） was purchased from Gibco-BRL, USA. METhoDS： Seven-week-old Sprague-Dawley rats were randomly and evenly divided into three groups： DMEM, UCBMSCs, and UCMSCs. A 10-mm defect in the left sciatic nerve was constructed in all rats. DMEM （15 μL） containing 1×10^6 UCBMSCs or UCMSCs was injected into the gap between nerve stumps, with the surrounding epineurium as a natural conduit. For the DMEM group, simple DMEM was injected. MAIN OUTCOME MEASURES： At 7 weeks after sciatic nerve dissection, dorsal root ganglia neurons were labeled by fluorogold retrograde labeling. At 8 weeks, electrophysiology and histomorphometry were performed. At 2, 4, 6, and 8 weeks after surgery, sciatic nerve function was evaluated using gait analysis. RESULTS： The UCBMSCs group and the UCMSCs group exhibited similar sciatic nerve function and electrophysiological indices, which were better than the DMEM group, as measured by gait analysis （P 〈 0.05）. Fluorogold retrograde labeling of sciatic nerve revealed that the UCBMSCs group demonstrated a higher number of labeled neurons; however, the differences were not significant. His

关键词： peripheral nerve regeneration umbilical cord mesenchymal stem cell umbilical cord blood mesenchymal stem cell axotomy defect stem cells

Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves

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Neural Regeneration Research 2012年第26期7卷 2018-2027页

作者： Mi-Ae Sung Hun Jong Jung Jung-Woo Lee Jin-Yong Lee kang-Mi Pang Sang Bae Yoo Mohammad S. Alrashdan Soung-Min Kim Jeong won Jahng Jong-ho Lee Department of Craniofacial Structure & Functional Biology School of Dentistry Seoul National University Seoul Republic of Korea Department of Occupation and Environment Postgraduate College of Medicine Konkuk University Choong-ju Republic of Korea Department of Oral & Maxillofacial Surgery School of Dentistry Seoul National University Seoul Republic of Korea Department of Dentistry Oral and Maxillofacial Surgery Ajou University School of Medicine Suwon Republic of Korea Dental Research Institute Seoul National University Seoul Republic of Korea

Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury. however, the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells in guiding peripheral nerve regeneration remain poorly understood. This study was designed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells on neural regeneration using a rat sciatic nerve crush injury model. Human umbilical cord blood-derived mesenchymal stem cells （1 ~ 106） or a PBS control were injected into the crush-injured segment of the sciatic nerve. Four weeks after cell injection, brain-derived neurotrophic factor and tyrosine kinase receptor B mRNA expression at the lesion site was increased in comparison to control. Furthermore, sciatic function index, Fluoro Gold-labeled neuron counts and axon density were also significantly increased when compared with control. Our results indicate that human umbilical cord blood-derived mesenchvmal stem cells promote the functinnal r~.RcJv^rv nf P.n I^h-inillr^4 ~r^i~tit, n^r~e

关键词： human umbilical cord blood-derived mesenchymal stem cells sciatic nerve crush injury FluoroGold stem cells peripheral nerve regeneration regeneration neural regeneration

智慧养老服务高质量发展:现实障碍、建设逻辑与实现路径

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西北人口 2024年第5期45卷 1-11页

作者：蒲新微张馨康吉林大学哲学社会学院长春130012 吉林大学国家智能社会治理吉林大学研究院长春130012

打造高质量的智慧养老服务是顺应时代发展、积极应对人口老龄化的必然要求。然而囿于养老服务的技术斥老化、主体碎片化、模式分层化和保障空心化等问题,老年人并未在智慧养老领域中获得较好的数字化服务体验。文章对当前我国智慧养老... 详细信息

打造高质量的智慧养老服务是顺应时代发展、积极应对人口老龄化的必然要求。然而囿于养老服务的技术斥老化、主体碎片化、模式分层化和保障空心化等问题,老年人并未在智慧养老领域中获得较好的数字化服务体验。文章对当前我国智慧养老服务低效运行现象隐含的底层冲突和诱发的现实原因进行了系统深入分析,基于主体性和嵌入性的建设逻辑,从多个维度探寻应对问题的有效良方:一是针对数字技术进行适老改造,使老年人摆脱被动型数字化,消解其与数字社会的双向互斥,实现老年友好型数字社会的建设构想;二是侧重服务主体、强调包容协同,从整体性视角出发,整合各方利益诉求,调配多元角色站位,落实主体本位职责,推动服务开发升级;三是围绕服务模式展开耦合创新,根植于多种养老模式的性质与类型差异,巧妙化解资源整合困难、资源配置效率低下等矛盾现象,实现模式机制的共生共创;四是立足保障制度深化要素改革,完善养老保障体系建设,提升政策支撑力度,扩大福利配套范围,强化老年群体的服务购买能力与意愿,优化智慧养老结构。在此基础上,合理维持多重举措间的动态平衡与辩证调整,为老龄群体享受高质量的老年生活、破解数字时代老年人急需解决的服务难题提供一条可供参考的实践路径。

关键词：数字社会智慧养老服务急难愁盼问题高质量发展

The origin of gate bias stress instability and hysteresis in monolayer WS2 transistors

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Nano Research 2020年第12期13卷 3278-3285页

作者： Changyong Lan Xiaolin kang You Meng Renjie Wei Xiuming Bu SenPo Yip Johnny C.ho State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong999077China Key Laboratory of Advanced Materials Processing&Mold of Ministry of Education Zhengzhou UniversityZhengzhou450002China

Due to the ultra-thin nature and moderate carrier mobility,semiconducting two-dimensional(2D)materials have attracted extensive attention for next-generation ***,the gate bias stress instability and hysteresis are always observed in these 2D materials-based transistors that significantly degrade their reliability for practical ***,the origin of gate bias stress instability and hysteresis for chemical vapor deposited monolayer WS2 transistors are investigated *** transistor performance is found to be strongly affected by the gate bias stress time,sweeping rate and range,and *** on the systematical study and complementary analysis,charge trapping is determined to be the major contribution for these observed ***,due to these charge trapping effects,the channel current is observed to decrease with time;hence,a rate equation,considering the charge trapping and time decay effect of current,is proposed and developed to model the phenomena with excellent consistency with experimental *** these results do not only indicate the validity of the charge trapping model,but also confirm the hysteresis being indeed caused by charge ***,this simple model provides a sufficient explanation for the charge trapping induced gate bias stress instability and hysteresis in monolayer WS2 transistors,which can be also applicable to other kinds of transistors.

关键词： charge trapping gate bias stress instability hysteresis WS2 transistor

A proposal:a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

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Chinese Journal of Cancer 2011年第6期30卷 363-367页

作者： Pearl S. Huang Peter T. ho kang Zhang Beigene Ltd. Beijing 102206 P. R. China Molecular Medicine Center West China Hospital Sichuan University Chengdu SJchuan 610041 P. R. China Institute for Genomic Medicine and Shiley Eye Center University of California at San Diego La Jolla CA 92093 USA.

Cancer is a collection of complex diseases in which cell proliferation and apoptosis are dysregulated due to the acquisition of genetic changes in cancer *** genetic changes,combined with the interrelated physiologic adaptations of neo-angiogenesis,recruitment of stromal support tissues,and suppression of immune recognition,are measurable characteristics in tumor gene expression profiles and biochemical *** measures can lead to identification of disease drivers and,ultimately,can be used to assign *** advances in RNA sequencing technologies,the ability to simultaneously measure all genetic and gene expression changes with a single technology is now *** ability to create a comprehensive catalog of genotypic and phenotypic changes in a collection of histologically similar but otherwise distinct tumors should allow for a more precise positioning of existing targeted therapies and identification of new targets for intervention.

关键词：药物发现肿瘤基因表达谱开发抗癌中国平台基因变化