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Biodegradable nanocarriers for small interfering ribonucleic acid （siRNA） co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine

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Nano Research 2017年第9期10卷 3049-3067页

作者： Chengbin Yang Kok Ken Chan Wen-Jen Lin Alana Mauluidy Soehartono Guimiao Lin Huiting Toh ho sup yoon Chih-Kuang Chen Ken-Tye Yong School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore Polymeric Biomaterials Lab Department of Fiber and Composite Materials Feng Chia University Taichung 40724 Taiwan China Key Lab of Biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060 China Division of Structural Biology & Biochemistry School of Biological Sciences Nanyang Technological University Singapore 639798Singapore Department of Genetic Engineering College of Life Sciences Kyung Hee University Yongin-si Gyeonggi-do 446701 Republic of Korea

Ribonucleic acid (RNA) interference (RNAi) therapies are promising cancer treatment modalities that can specifically target abnormal proto-oncogenes, thus improving the therapeutic effect. For the treatment of pancreatic cancer, targeting one mutant proto-oncogene by RNAi usually does not yield the desired therapeutic efficiency. Both K-ras gene mutations and Notch1 overexpression are common symptoms in pancreatic cancer patients, and play a crucial role in pancreatic cancer cell drug resistance. In this study, biodegradable charged polyester-based vectors (BCPVs) were synthesized for the co-delivery of K-ras and Notch1 small interfering ribonucleic acid (siRNA) into MiaPaCa-2 cells (pancreatic cancer cell line) to overcome drug resistance to gemcitabine (GEM), a first-line chemotherapeutic drug used in the clinic. BCPVs could effectively absorb negative siRNA to form a capsule-like structure, prevent siRNA from nuclease digestion in the serum, and promote effective siRNA cell internalization and endosomal escape. Through K-ras and Notch1 gene silencing in MiaPaCa-2 cells, BCPV-siRNAK-ras-siRNANotch1 nanocomplexes effectively reversed the epithelia-mesenchymal transition (EMT) in MiaPaCa-2 cells, thereby greatly enhancing the sensitivity of MiaPaCa-2 cells to GEM. MiaPaCa-2 cell proliferation, migration, and invasion were effectively inhibited, and cell apoptosis was also significantly enhanced by the synergistic antitumor effect of BCPV-siRNAK-ras-siRNANotch1 nanocomplexes and GEM. These results suggest that this combination RNAi therapy can be used to improve cancer cell sensitivity to chemotherapeutic drugs. Specifically, this newly developed strategy has a great potential for treating pancreatic cancer.

关键词： pancreatic cancer small interfering ribonucleic acid (siRNA) biodegradable charged polyester-based vector (BCPV) gemcitabine (GEM) epithelia-mesenchymal transition (EMT)

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Predictive modeling of critical temperatures in magnesium compounds using transfer learning

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Journal of Magnesium and Alloys 2024年第4期12卷 1540-1553页

作者： Surjeet Kumar Russlan Jaafreh Subhajit Dutta Jung Hyeon Yoo Santiago Pereznieto Kotiba Hamad Dae ho yoon School of Advanced Materials Science&Engineering Sungkyunkwan University Suwon 16419Republic of Korea

This study presents a transfer learning approach for discovering potential Mg-based superconductors utilizing a comprehensive target ***,a large source dataset(Bandgap dataset)comprising approximately∼75k compounds is utilized for pretraining,followed by fine-tuning with a smaller Critical Temperature(T_(c))dataset containing∼300 ***,there is a significant improvement in the performance of the transfer learning model over the traditional deep learning(DL)model in predicting ***,the transfer learning model is applied to predict the properties of approximately 150k *** are validated computationally using density functional theory(DFT)calculations based on lattice dynamics-related ***,to demonstrate the extended predictive capability of the transfer learning model for new materials,a pool of virtual compounds derived from prototype crystal structures from the Materials Project(MP)database is generated.T_(c) predictions are obtained for∼3600 virtual compounds,which underwent screening for electroneutrality and thermodynamic *** Extra Trees-based model is trained to utilize E_(hull)values to obtain thermodynamically stable materials,employing a dataset containing Ehull values for approximately 150k materials for *** with Ehull values exceeding 5 meV/atom were filtered out,resulting in a refined list of potential Mg-based *** study showcases the effectiveness of transfer learning in predicting superconducting properties and highlights its potential for accelerating the discovery of Mg-based materials in the field of superconductivity.

关键词： superconductivity Critical temperature Transfer learning Crystal structure features Thermodynamic stability

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi hongdae Lee Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon Kim Bong Kyun Kang Gun Jang Dae ho yoon ho Seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g-1 and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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Flower morphology of Allium(Amaryllidaceae)and its systematic significance

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Plant Diversity 2024年第1期46卷 3-27页

作者： Ju Eun Jang Shukherdorj Baasanmunkh Nudkhuu Nyamgerel Seung-yoon Oh Jun-ho Song Ziyoviddin Yusupov Komijlon Tojibaev Hyeok Jae Choi Department of Biology and Chemistry Changwon National UniversityChangwon51140Republic of Korea Department of Forest Biodiversity and Herbarium Korea National ArboretumPocheon11186Republic of Korea Department of Biology Chungbuk National UniversityCheongju28644Republic of Korea International Joint Lab for Molecular Phylogeny and Biogeography Institute of BotanyAcademy of Sciences of UzbekistanTashkent100125Uzbekistan

Allium is a complicated genus that includes approximately 1000 *** its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly ***,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian *** then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS *** results confirm that floral morphology provides key taxonomic information to assess species delimitation in *** found that perianth color is an important characteristic within the ***,Polyprason,and *** ***,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal *** species in ***,the key taxonomic character is ovule number(only one ovule in per locule).In the ***,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in *** results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,***(***)and ***(***).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa.

关键词： Allium Flower morphology Pistil character Statistical analysis Significant characteristic Species level

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Aggregation-induced emission （ALE） dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation

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Nano Research 2015年第5期8卷 1563-1576页

作者： Rui Hu Chengbin Yang Yucheng Wang Guimiao Lin Wei Qin Qingling Ouyang Wing-Cheung Law Quoc Toan Nguyen ho sup yoon Xiaomei Wang Ken-Tye Yong Ben Zhong Tang School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore The Engineering Lab of Synthetic Biology and the Key Lab of Biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060 China Department of Chemistry The Hang Kong University of Science and Technology Clear Water Bay Kowloon Hang Kong China Department of Industrial and Systems Engineering The Hang Kong Polytechnic University Hung Ham Kowloon Hang Kong China Division of Structural Biology & Biochemistry School of Biological Sciences Nanyang Technological University Singapore 539798 Singapore

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Unusual case of emphysematous cystitis mimicking intestinal perforation:A case report

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世界临床病例杂志 2023年第28期11卷 6943-6948页

作者： Hye yoon Kang Dae-sup Lee Donghyoun Lee Department of Surgery Samsung Medical CenterSeoul 06338South Korea Department of Emergency Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Jeju National University HospitalJeju National University College of MedicineJeju 63241South Korea

BACKGROUND Emphysematous cystitis(EC)is a bladder condition commonly caused by gasgenerating bacterial *** that increase the risk for developing this condition include female gender,age≥60 years,and diabetes mellitus,glycosuria,and urinary *** symptoms of EC often lack specificity,making diagnostic imaging techniques crucial for accurate identification of the *** SUMMARY This report presents an unusual case of EC that mimicked intestinal *** it was initially challenging to differentiate between intestinal perforation and EC on admission,the patient managed to avoid unnecessary surgery and made a good recovery solely through antibiotic *** Successful treatment of the patient described herein highlights the importance of accurately diagnosing EC,which can be difficult to differentiate from intestinal perforation.

关键词： Emphysematous cystitis Intestinal Bowel Perforation Bladder Case report

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Geometric-phase intraocular lenses with multifocality

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Light(Science & Applications) 2022年第11期11卷 2805-2816页

作者： Seungmin Lee Gayeon Park Senho Kim Yeonghwa Ryu Jae Woong yoon ho Sk Hwang In Seok Song Chang Sun Lee Seok ho Song Department of Physics Hanyang UniversitySeoul 04763Republic of Korea Department of Ophthalmology Catholic University of KoreaSeoul 07345Republic of Korea Seoul Ophthalmic Clinic Goyang 10463Republic of Korea Koryoeyetech In.Seoul 06093Republic of Korea Tigernics IncSeoul 04763Republic of Korea

We demonstrate a new type of multifocal and extended depth of focus(EDOF)intraocular lenses(IOLs)embeddingμm-thin geometric phase(GP)lens *** an emerging approach for lens phase design,the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL *** number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each *** and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal *** characterizing the defocus image and modulation transfer function of the GP IOLs,it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs,blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.

关键词： layer phase alignment

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Sutureless contact lens-type amniotic membrane for persistent epithelial defects after infectious keratitis

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1404-1406页

作者： Jung Hye Shin Young-ho Jung Hyun Beom Song Mee Kum Kim Chang ho yoon Department of Ophthalmology Seoul National University Hospital101 Daehak-roJongno-guSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Laboratory of Ocular Regenerative Medicine and Immunology Biomedical Research InstituteSeoul National University Hospital101 Daehak-roJongno-guSeoul 03080Republic of Korea Department of Medical Science Seoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea

Dear Editor,We are writing to present two case reports of persistent epithelial defect after infectious keratitis successfully treated with sutureless contact lens-type amniotic membrane(AM)*** keratitis is one of the leading causes of corneal *** disrupts the normal corneal healing process and induces inflammation,limbal cell dysfunction,and corneal surface irregularity,which can lead to corneal opacities or persistent epithelial defects(PEDs)[1].Untreated PED can cause corneal thinning,resulting in corneal perforation.

关键词： keratitis healing corneal

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Sodium-Coordinated Polymeric Phthalocyanines as Stable High-Capacity Organic Anodes for Sodium-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 22-30页

作者： Jeongyeon Lee yoonbin Kim Soyong Park Kang ho Shin Gun Jang Min Jun Hwang Daekyu Kim Kyung-Ah Min ho Seok Park Byungchan Han Dennis K.P.Ng Lawrence yoon Suk Lee Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloon Hong Kong SAR China Department of Chemistry The Chinese University of Hong KongShatinNew Territories Hong Kong SAR China Convergence Research Center for Energy and Environmental Sciences Sungkyunkwan UniversitySuwon Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon Korea

Sodium-ion batteries(SIBs)have attracted considerable interest as an alternative to lithium-ion batteries owing to their similar electrochemical performance and superior long-term cycle *** materials are regarded as promising anode materials for constructing SIBs with high capacity and good ***,utilization of organic materials is rather limited by their low energy density and poor stability at high current *** overcome these limitations,we utilized a novel polymeric disodium phthalocyanines(pNaPc)as SIB anodes to provide stable coordination sites for Na ions as well as to enhance the stability at high current *** varying the linker type during a one-pot cyclization and polymerization process,two pNaPc anodes with O-(O-pNaPc)and S-linkers(S-pNaPc)were prepared,and their structural and electrochemical properties were *** O-pNaPc binds Na ions with a lower binding energy compared with S-pNaPc,which leads to more facile Na-ion coordination/dissociation when engaged as SIB *** use of O-pNaPc significantly improves the redox kinetics and cycle stability and allows the fabrication of a full cell against Na_(3)V_(2)(PO_(4))_(2)F_(3)/C cathode,which demonstrates its practical application with high energy density(288 Wh kg^(-1))and high power density(149 W kg^(-1)).

关键词： coordination chemistry organic anode phthalocyanine polymerization sodium ion battery

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Indications of external radiotherapy for hepatocellular carcinoma from updated clinical guidelines: Diverse global viewpoints

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World Journal of Gastroenterology 2020年第4期26卷 393-403页

作者： Sunmin Park Won sup yoon Chai hong Rim Department of Radiation Oncology Ansan Hospital Korea University Medical College

significantly vary among *** standard treatments commonly require multidisciplinary approaches,including applications of up-to date medicine and advanced procedures,and necessitate the support of socioeconomic *** these reasons,a number of clinical guidelines for HCC from different associations and regions have been *** beam radiation therapy was contraindicated for HCC until a few decades ago,but with the development of new technologies,its application has rapidly increased as selective irradiation for tumorous lesions became *** of the guidelines had been opposed or indifferent to radiotherapy in the past,but several guidelines have introduced indications and recommendations for radiotherapy in their updated *** review will discuss the characteristics of important guidelines and their contents regarding radiotherapy and will also provide guidance to physicians who are considering applications of locoregional modalities that include radiotherapy.

关键词： Hepatocellular carcinoma Clinical guideline Radiotherapy Radiation therapy Liver neoplasm Stereotactic body radiotherapy

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