检索结果-南通市图书馆

Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

Direct visualization of postoperative aortobronchial fistula on computed tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2024年第8期16卷 337-347页

作者： Nanae Tsuchiya hitoshi Inafuku Satoko Yogi Yuko Iraha Gyo Iida Mizuki Ando Takaaki Nagano Shotaro Higa Tatsuya Maeda Yuya Kise Kojiro Furukawa Koji Yonemoto Akihiro Nishie Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Thoracic and Cardiovascular Surgery Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Biostatistics School of Health SciencesFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

BACKGROUND Postoperative aortobronchial fistula(ABF)is a rare complication that can occur in 0.3%-5.0%of patients over an extended period of time after thoracic aortic *** visualization of the fistula via imaging is *** To investigate the relationship between computed tomography(CT)findings and the clinical signs/symptoms of ABF after thoracic aortic *** Six patients(mean age 71 years,including 4 men and 2 women)with suspected ABF on CT(air around the graft)at our hospital were included in this retrospective study between January 2004 and September *** CT findings included direct confirmation of ABF,peri-graft fluid,ring enhancement,dirty fat sign,atelectasis,pulmonary hemorrhage,and bronchodilation,and the clinical course were retrospectively *** proportion of each type of CT finding was *** ABF detection after surgery was found to have a mean and median of 14 and 13 years,*** signs and symptoms were asymptomatic in 4 patients,bloody sputum was found in 1 patient,and fever was present in 1 *** complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 *** the 6 patients,3 survived,2 died,and 1 was lost to *** locations of the ABFs were as follows:1 in the ascending aorta;1 in the aortic arch;2 in the aortic arch leading to the descending aorta;and 2 in the descending *** were directly confirmed by CT in 4/6(67%)***-graft dirty fat(4/6,67%)and peri-graft ring enhancement(3/6,50%)were associated with graft infection,endoleaks and pseudoaneurysms were associated with hemoptysis(2/6,33%).CONCLUSION Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest *** is useful for the diagnosis of ABF and its complications.

关键词： Peri-graft air Aortobronchial fistula Chest computed tomography Postoperative Thoracic endovascular aortic repair Complication Thoracic aorta surgery

Comparison between surgical outcomes of colorectal cancer in younger and elderly patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第12期17卷 1642-1648页

作者： Longxue Jin Norio Inoue Naoki Sato Susumu matsumoto hitoshi Kanno Yuko Hashimoto Kazuhiro Tasaki Kinya Sato Shun Sato Katsutoshi Kaneko Center for Digestive Diseases Northern Fukushima Medical Center Fukushima 960-0502 Japan Department of Pathology Fukushima Medical University Hospital Fukushima 960-1295 Japan Division of Anesthesiology Northern Fukushima Medical Center Fukushima 960-0502 Japan

AIM:To compare the outcome of surgical treatment of colorectal adenocarcinoma in elderly and younger ***:The outcomes of 122 patients with colorectal adenocarcinoma who underwent surgical treatment between January 2004 and June 2009 were *** clinicopathological and blood biochemistry data of the younger group(<75 years) and the elderly group (≥75 years) were ***:There were no significant differences between the two groups in operation time,intraoperative blood loss,hospital stay,time to resumption of oral intake,or *** elderly group had a significantly higher rate of hypertension and cardiovascular *** perioperative serum total protein and albumin levels were significantly lower in the elderly than in the younger *** serum carcinoembryonic antigen level was lower in the elderly than in the younger group,and there was a significant decreasing trend after the operation in the elderly ***:The short-term outcomes of surgical treatment in elderly patients with colorectal adenocarcinoma were *** treatment in elderly patients was considered a selectively effective approach.

关键词： Colorectal tumor Elderly patient Morbidity Carcinoembryonic antigen C-reactive protein

Acetylene Vacuum Carburizing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料热处理学报 2004年第5期25卷 370-374页

作者： hitoshi Iwata JH CORPORATION Aichi Japan

Almost 30 years has passed since the publication of materials on vacuum carburizing technology, and is attracting a great deal of attention as a technology capable of being used as a substitute for gas carburizing technology. However, the technology was not popular except in specific fields. The main reason for this is due to a variety of harmful influences accompanying the sooting problems caused by CH4 or C3H8. We have succeeded in that the occurrence of sooting was suppressed by utilizing acetylene, at extremely low pressure for carburizing (below 1 kPa). This process is now showing the excellent quality and prospects for this technology in terms of quality, economy and safety. At present almost 70 practical mass production furnaces are used in production lines, in Japan and abroad. At this time, we will report summary of the present acetylene vacuum carburizing process and the actual results obtained by these acetylene vacuum carburizing furnaces for mass production.

关键词：乙炔真空渗碳大量生产低压

维普期刊数据库

The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： hitoshi TANAKA Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

维普期刊数据库

特朗普政府及新冠疫情对全球经济的影响回顾——聚焦中美关系

在线全文

学校读者我要写书评

暂无评论

日本研究 2024年第1期 74-87页

作者： [日]平川均张帅(译) 日本名古屋大学南开大学辽宁大学《日本研究》编辑部沈阳110136

由于美国前总统特朗普的“美国优先”对华政策,2018年开始的中美贸易战以及随后的新冠疫情促使中美贸易摩擦尖锐化。这场因贸易逆差引发的冲突不仅升级为两国之间的关税争端,还扩大到知识产权争端、不公平产业政策、技术霸权、国家安全... 详细信息

由于美国前总统特朗普的“美国优先”对华政策,2018年开始的中美贸易战以及随后的新冠疫情促使中美贸易摩擦尖锐化。这场因贸易逆差引发的冲突不仅升级为两国之间的关税争端,还扩大到知识产权争端、不公平产业政策、技术霸权、国家安全风险、人权问题、国家体制和意识形态问题等。2021年上台的美国拜登政府尝试扩展以民主价值观为纽带的联盟体系,制衡发展中的中国。另一方面,中国希望通过自身努力实现国内产业结构升级,提出“一带一路”倡议推动国际合作。世界经济正朝着形成独立经济集团的方向发展,中美两国在争夺先进战略产业和企业的同时,也有可能诞生一个新的经济集团。政治上意识形态的冲突将加剧,但在全球经济领域,中美两国之间的竞争将推动围绕“一带一路”倡议的非洲—欧亚经济基础设施的发展。

关键词：中美贸易战 “特朗普交易” 贸易逆差知识产权技术霸权

维普期刊数据库博看期刊

On systematic development of FSI solvers in the context of particle methods

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2022年第3期34卷 395-407页

作者： Abbas Khayyer hitoshi Gotoh Yuma Shimizu Department of Civil and Earth Resources Engineering Kyoto UniversityKyotoJapan

This paper presents a review on state-of-the-art of developments corresponding to fluid-structure interaction(FSI)solvers developed within the context of particle *** paper reviews and highlights the potential robustness of entirely Lagrangian meshfree FSI solvers in reproducing FSI corresponding to extreme events and portrays the future perspectives for systematic developments towards reliable engineering applications with respect to rapid advances in technology and emergence of so-called advanced materials that can result in complex and highly non-linear structural ***,the paper highlights the necessity for reproduction of comprehensive structural responses,including viscoelastic,elastoplastic and progressive damages/failures,by the advanced FSI solvers developed within the context of particle *** this regard,extensions of the structure model are suggested to be conducted in a variationally consistent framework to ensure stability,accuracy and physical reliability including thermodynamic *** paper reviews basics of mathematical and numerical modelling for entirely Lagrangian meshfree hydroelastic FSI solvers and presents a brief background on extensions of such solvers towards reproducing viscoelastic structural *** preliminary numerical results on structural viscoelasticity achieved by an extended Hamiltonian SPH(HSPH)model are *** vision paper also concisely portrays the future perspectives for systematic development of particle-based FSI solvers.

关键词： Fluid-structure interaction(FSI) entirely Lagrangian meshfree smoothed particle hydrodynamics(SPH) Hamiltonian SPH(HSPH) viscoelasticity

Morrey Spaces for Non-doubling Measures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2005年第6期21卷 1535-1544页

作者： Yoshihiro SAWANO hitoshi TANAKA Graduate. School of Mathematical Sciences The University of Tokyo 3-8-1 KomabaMeguro-ku Tokyo 153-8914 Japan

The authors give a natural definition of Morrey spaces for Radon measures which may be non-doubling but satisfy certain growth condition, and investigate the boundedness in these spaces of some classical operators in ... 详细信息

关键词： Morrey space non-doubling measure vector-valued

维普期刊数据库

ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2019年第5期11卷 424-435页

作者： Hiroaki Takaya Tadashi Namisaki Naotaka Shimozato Kosuke Kaji Mitsuteru Kitade Kei Moriya Shinya Sato Hideto Kawaratani Takemi Akahane Masanori matsumoto hitoshi Yoshiji Third Department of Internal Medicine Nara Medical University Department of Blood Transfusion Medicine Nara Medical University

BACKGROUND Many advanced hepatocellular carcinoma(HCC) patients are receiving sorafenib treatment. Sorafenib reportedly improves overall survival(OS) significantly in patients with HCC. Prediction of sorafenib response and prognosis in patients with HCC receiving sorafenib treatment are important due to the potentially serious side effects of sorafenib. A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13(ADAMTS13) and von Willebrand factor(VWF) are associated with the pathophysiology of liver cirrhosis and HCC through their roles in hypercoagulability; they are also associated with angiogenesis via vascular endothelial growth factor(VEGF). The imbalance between ADAMTS13 and VWF was associated with prognosis of various cancers in patients undergoing *** To investigate ADAMTS13 and VWF as potential biomarkers for sorafenib response and prognosis in patients with HCC receiving sorafenib *** Forty-one patients with HCC receiving sorafenib treatment were included in this study. The initial daily sorafenib dose was 400 mg in all patients. ADAMTS13 activity(ADAMTS13:AC), VWF antigen(VWF:Ag), VEGF levels were determined by enzyme-linked immunosorbent assay. Univariate andmultivariate analyses were used to determine predictive factors for sorafenib response and prognosis in patients with HCC receiving sorafenib *** ADAMTS13:AC was significantly higher in patients with stable disease(SD),partial response(PR), and complete response(CR) than in those with progressive disease(PD)(P < 0.05). In contrast, VWF:Ag and the VWF:Ag/ADAMTS13:AC ratio were significantly lower in patients with SD, PR, and CR than in those with PD(P < 0.05 for both). Multivariate analysis showed that the VWF:Ag/ADAMTS13:AC ratio was the only predictive factor for sorafenib response and ADAMTS13:AC was the only prognostic factor in patients with HCC receiving sorafenib treatment. The patients with a low ADAMTS13:AC(<78.0) had significantly h

关键词： ADAMTS13 Von Willebrand factor Biomarkers Hepatocellular carcinoma Sorafenib