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Nano Research 2015年第5期8卷 1464-1479页

作者： Chang-Heum Jo Dae-Hyun Cho Hyung-Joo Noh hithshi yashiro Yang-Kook Sun Seung Taek Myung Department of Nano Engineering Sejong University 98 Gunja-dong Gwangjin-gu Seou1143-747 Republic of Korea Department of Chemical Engineering Iwate University Morioka Iwate 020-8551 Japan Department of Energy Engineering Hanyang University Seongdong-gu Seou1133-791 Republic of Korea

Ni富有的李[ Ni 0.6 公司 0.2 Mn 0.2 ]O 2 表面与 H 被修改了 3 PO 4 。在在 80 点的涂层以后？

关键词：锂化合物活性物质纳米层 TOF-SIMS 飞行时间二次离子质谱透射电子显微镜 H3PO4 衍生

Novel biomarkers for early detection of gastric cancer

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World Journal of Gastroenterology 2023年第17期29卷 2515-2533页

作者： Tasuku Matsuoka Masakazu yashiro Molecular Oncology and Therapeutics Osaka Metropolitan University Graduate School of MedicineOsaka 5458585Japan

Gastric cancer(GC)remains a leading cause of cancer-related death *** than half of GC cases are diagnosed at an advanced stage due to its lack of early *** is a heterogeneous disease associated with a number of genetic and somatic *** detection and effective monitoring of tumor progression are essential for reducing GC disease burden and *** current widespread use of semi-invasive endoscopic methods and radiologic approaches has increased the number of treatable cancers:However,these approaches are invasive,costly,and ***,novel molecular noninvasive tests that detect GC alterations seem to be more sensitive and specific compared to the current *** technological advances have enabled the detection of blood-based biomarkers that could be used as diagnostic indicators and for monitoring postsurgical minimal residual *** biomarkers include circulating DNA,RNA,extracellular vesicles,and proteins,and their clinical applications are currently being *** identification of ideal diagnostic markers for GC that have high sensitivity and specificity would improve survival rates and contribute to the advancement of precision *** review provides an overview of current topics regarding the novel,recently developed diagnostic markers for GC.

关键词： Gastric cancer Diagnostic biomarkers Early detection Liquid biopsy

Performance and stability analysis of SOFC containing thin and dense gadolinium-doped ceria interlayer sintered at low temperature

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Journal of Materiomics 2022年第2期8卷 347-357页

作者： Yige Wang Chuan Jia Zewei Lyu Minfang Han Junwei Wu Zaihong Sun Fumitada Iguchi Keiji yashiro Tatsuya Kawada Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China Department of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen518055China Suzhou Huatsing Jingkun New Energy Technology Co.Ltd Jiangsu215314China Tohoku University Sendai 980-8579Japan

Gadolinium-doped ceria(GDC)interlayers are required to prevent the interfacial reaction between La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)cathode and Y_(2)O_(3)-stabilized ZrO 2(YSZ)electrolyte in solid oxide fuel cells(SOFCs).However,it's difficult to prepare a thin and dense GDC interlayer on the sintered half-cell at a low *** this study,the physical vapor deposition(PVD)method was employed to success-fully manufacture dense GDC interlayers with the thickness of 1 m *** influences of GDC sintering temperature(900℃,1000℃ and 1100℃)on cell performance characteristics and degradation behavior were *** cell with GDC interlayer sintered at 1100?C showed the lowest degradation rate during the 216-h *** best stability was attributed to the most effective inhibition of Sr diffusion by the GDC interlayer,which was demonstrated by the almost unchanged Ohmic and polari-zation resistances during the aging stage and the negligible Sr enrichment at YSZ/GDC *** to the conventional screen-printed GDC interlayers(sintered above 1250℃),the GDC inter-layer prepared by the PVD method and sintered at 1100℃ was significantly denser and thinner,showing a promising application prospect due to its benefits for cell stability.

关键词： Solid oxide fuel cell Gadolinium-doped ceria Interlayer Sr diffusion Stability analysis

Molecular-targeted therapy toward precision medicine for gastrointestinal caner:Current progress and challenges

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 366-390页

作者： Tasuku Matsuoka Masakazu yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Gastrointestinal(GI)cancer remains the deadliest cancer in the *** current standard treatment for GI cancer focuses on 5-fluorouracil-based chemotherapeutic regimens and surgery,and molecular-targeted therapy is expected to be a more effective and less toxic therapeutic strategy for GI *** is wellestablished evidence for the use of epidermal growth factor receptor-targeted and vascular endothelial growth factor-targeted antibodies,which should routinely be incorporated into treatment strategies for GI *** potential therapeutic targets involve the PI3K/AKT pathway,tumor growth factor-βpathway,mesenchymal-epithelial transition pathway,WNT pathway,poly(ADP-ribose)polymerase,and immune *** clinical trials assessing the agents of targeted therapy are underway and have presented promising and thoughtprovoking *** the development of molecular biology techniques,we can identify more targetable molecular alterations in larger patient populations with GI *** these molecules will allow us to reach the goal of precision medicine and improve the outcomes of patients with GI cancer.

关键词： Gastrointestinal cancer Esophageal cancer Gastric cancer Colorectal cancer Targeted therapy Precision medicine

Biomarkers of gastric cancer:Current topics and future perspective

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World Journal of Gastroenterology 2018年第26期24卷 2818-2832页

作者： Tasuku Matsuoaka Masakazu yashiro Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 545-8585Japan

Gastric cancer(GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling.

关键词： Biomarkers Ccancer diagnosis Prognostic marker Predictive marker Gastric cancer

Precision medicine for gastrointestinal cancer:Recent progress and future perspective

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 1-20页

作者： Tasuku Matsuoka Masakazu yashiro Department of Gastroenterological Surgery Osaka City University Graduate School of MedicineOsaka 5458585Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of MedicineOsaka 5458585Japan

Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate *** significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal *** is an urgent need for new diagnostic and therapeutic *** technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI *** we review the application and status of precision medicine in GI *** of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with *** the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI *** the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted *** progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine.

关键词： Gastrointestinal cancer Esophageal cancer Gastric cancer Colorectal cancer Precision medicine Liquid biopsy Gene panel Precision surgery Biomarkers

Recent advances in the HER2 targeted therapy of gastric cancer

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World Journal of Clinical Cases 2015年第1期3卷 42-51页

作者： Tasuku Matsuoka Masakazu yashiro Department of Surgical Oncology Osaka City University Graduate School of Medicine Osaka 545-8585 Japan Oncology Institute of Geriatrics and Medical Science Osaka City University Graduate School of Medicine Osaka 545-8585 Japan

Recent advances in molecular targeted therapies, including targeting human epidermal growth factor receptor 2(HER2), had a major forward step in the therapy for gastric cancer patients. Application of HER2-targeted therapies, in particular trastuzumab in combination with chemotherapy in metastatic HER2-positive gastric cancers, resulted in improvements in response rates, time to progression and overall survival. Nevertheless, as with breast cancer, many patients with gastric cancer develop resistance to trastuzumab. Several promising therapies are currently being developed in combination with chemotherapy to increase the efficacy and overcome the cancerresistance. Here we review the current overview of clinical application of agents targeting HER2 in gastric cancer. We also discuss the ongoing trials supporting the use of HER2-targeted agents combined with cytotoxic agents or other monoclonal antibodies.

关键词： Human epidermal growth factor receptor 2 Gastric cancer Targeting therapy Trastuzumab

The role of shrub(Potentilla fruticosa)on ecosystem CO_(2) fluxes in an alpine shrub meadow

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Journal of Plant Ecology 2010年第2期3卷 89-97页

作者： Yuichiro yashiro Yoko Shizu Mitsuru Hirota Ayako Shimono Toshiyuki Ohtsuka River Basin Research Center Gifu University1-1 YanagidoGifuGifu 501-1193Japan Graduate School of Life and Environmental Science University of Tsukuba1-1-1 TennodaiIbaraki 305-8521Japan Department of Ecology and Environmental Science Umea UniversityUmea 901-87Sweden

Aims Recent studies have shown that alpine meadows on the Qinghai-Tibetan plateau act as significant CO_(2)*** the plateau,alpine shrub meadow is one of typical grassland *** major alpine shrub on the plateau is Potentilla fruticosa L.(Rosaceae),which is distributed widely from 3200 to 4000 *** species play an important role on carbon sequestration in grassland *** addition,alpine shrubs are sensitive to climate change such as global *** global warming,the biomass and productivity of *** will increase on Qinghai-Tibetan ***,understanding the carbon dynamics in alpine shrub meadow and the role of shrubs around the upper distribution limit at present is essential to predict the change in carbon sequestration on the ***,the role of shrubs on the carbon dynamics in alpine shrub meadow remains *** objectives of the present study were to evaluate the magnitude of CO_(2)exchange of *** shrub patches around the upper distribution limit and to elucidate the role of *** on ecosystem CO_(2)fluxes in an alpine *** We used the static acrylic chamber technique to measure and estimate the net ecosystem productivity(NEP),ecosystem respiration(Re),and gross primary productivity(GPP)of *** shrub patches at three elevations around the species’upper distribution *** CO_(2)fluxes and environmental factors were measured from 17 to 20 July 2008 at 3400,3600,and 3800 m *** examined the maximum GPP at infinite light(GPPmax)and maximum Re(Remax)during the experimental time at each elevation in relation to aboveground biomass and environmental factors,including air and soil temperature,and soil water *** Findings Patches of *** around the species’upper distribution limit absorbed CO_(2),at least during the *** NEP at infinite light(NEPmax)and GPPmax of shrub patches in the alpine meadow varied among the three elevations,with t

关键词： alpine meadow ecosystem respiration gross primary productivity net ecosystem productivity Potentilla fruticosa shrub patch

Molecular dynamics simulation of injection of polyethylene fluid in a variable cross-section nano-channel

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Chinese Science Bulletin 2011年第17期56卷 1848-1856页

作者： FENG Jie LIAO Qiang ZHU Xun WU Rui WANG Hong DING YuDong yashiro Kisaragi Institute of Engineering Thermophysics Chongqing University Chongqing 400030 China Key Laboratory of Low-grade Energy Utilization Technologies and Systems Ministry of Education Chongqing 400030 China College of Mechanical Engineering Kobe University Kobe 657-8501 Japan

Numerical simulation of injection of polyethylene fluid in a variable cross-section nano-channel was carried out using the molecular dynamics *** effects of the nano-channel cross-section and the external force on the rheological behavior and structural properties of the polyethylene fluid were *** was found that an absorbed layer appeared near the wall and the thickness of the absorbed layer increased with increasing cone angle of the *** injection distance of the polyethylene fluid decreased with increasing cone angle and decreasing external *** the nano-channel with cone angle 45°,polyethylene particles uniformly filled the whole channel and were stretched along the flow *** stretching of particles was enhanced when the external force was strengthened,which facilitates injection of the polyethylene fluid into the nano-channel.

关键词：纳米通道分子动力学模拟聚乙烯变截面注射液分子动力学方法颗粒增强数值模拟

Improving the activity and stability of Ni-based electrodes for solid oxide cells through surface engineering:Recent progress and future perspectives

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Materials Reports(Energy) 2021年第2期1卷 35-47页

作者： Junxian Pan Yongjian Ye Mengzhen Zhou Xiang Sun Yihan Ling Keiji yashiro Yan Chen School of Environment and Energy State Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhou510006PR China School of Materials Science and Physics China University of Mining and TechnologyXuzhou221116PR China Graduate School of Environmental Studies Tohoku UniversitySendai980-8577Japan

Solid oxide cells(SOCs)have attracted great attention in the past decades because of their high conversion efficiency,low environmental pollution and diversified fuel ***-based catalysts are the most widely used fuel electrode materials for SOCs due to the low price and high ***,when hydrocarbon fuels are employed,nickel-based electrodes face serious carbon deposition challenges,leading to a rapid decline of cell *** efforts have been devoted to understanding the occurrence of the coking reaction,and to improving the stability of the electrodes in hydrocarbon *** this review,we summarize recent research progress of utilizing surface modification to improve the stability and activity of Ni-based electrodes for SOCs by preventing carbon *** review starts with a briefly introduction about the reaction mechanism of carbon deposition,followed by listing several surface modification technologies and their working *** we introduce representative works using surface modification strategies to prevent carbon coking on Ni-based ***,we highlight future direction of improving electrode catalytic activity and anti-coking performance through surface engineering.

关键词： Solid oxide cells Ni-based electrodes Carbon coking Surface engineering