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Stability-indicating assay method for determination of actarit,its process related impurities and degradation products:Insight into stability profile and degradation pathways

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Journal of Pharmaceutical Analysis 2014年第6期4卷 374-383页

作者： A.Abiramasundari Rahul P.Joshi hitesh b.jalani Jayesh A.Sharma Dhaivat H.Pandya Amit N.Pandya Vasudevan Sudarsanam Kamala K.Vasu Department of Medicinal Chemistry B.V. Pat el PERD Centre Ahmedcibad Gujarat 380054 India

The stability of the drug actarit was studied under different stress conditions like hydrolysis（acid,alkaline and neutral）,oxidation,photolysis and thermal degradation as recommended hy International Conference on Harmonization（ICH） *** was found to be unstable in acidic,basic and photolytic conditions and produced a common degradation product while oxidative stress condition produced three additional degradation *** was impassive to neutral hydrolysis,dry thermal and accelerated stability *** products were identified,isolated and characterized by different spectroscopic *** and the degradation products were synthesized by a new route using green *** chromatographic separation of the drug and its impurities was achieved in a phenomenex luna C18 column employing a step gradient elution by high performance liquid chromatography coupled to photodiode array and mass spectrometry detectors（HPLC-PDAMS）.A specilic and sensitive stability-indicating assay method for the simultaneous determination of the drug *** process related impurities and degradation products was developed and validated.

关键词： Actarit Forced degradation Stability-indicating assay method

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Insights on the Emerging Therapeutic Potential of Terpenoids as Anti-inflammatory Agents:A Scoping Review

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Journal of bio-X Research 2024年第1期7卷 20-35页

作者： Mohini Devi Prabhjeet Kaur bamrah Rajat Goyal Manjusha Choudhary hitesh Chopra Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra 136119HaryanaIndia MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-Ambala 133207HaryanaIndia Department of biosciences Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai 602105Tamil NaduIndia

background:Inflammatory diseases are among the leading causes of health issues that considerably influence health care *** the notable advancements in medical treatment that have been made in recent years,natural products with biological activity still play essential roles in a variety of anti-inflammatory *** study and identification of novel treatments for the adverse effects of available synthetic anti-inflammatory agents warrant further ***:This study focused on the emerging therapeutic potential of terpenoid products as anti-inflammatory ***:The literature reveals that secondary metabolites obtained from medicinal plants,*** and terpenoids and their nanoformulations,are effective for the treatment of inflammation in *** terpenes are a broad class of secondary metabolites that are rich in monoterpenes,diterpenes,triterpenes,tetraterpenes,ceramides,and sesquiterpenes and have various therapeutic applications,such as antitumor,antibacterial,antimicrobial,analgesic and anti-inflammatory *** studies have shown that terpenes can decrease inflammation-associated symptoms by reducing the release of proinflammatory cytokines,including nuclear transcription factor-kappa b,interleukins,tumor necrosis factor-alpha,and other inflammatory ***:This review describes the latest knowledge of the different terpenoid-derived natural and synthetic compounds that have been isolated from plant sources in recent years and their anti-inflammatory potential and therapeutic mechanism of ***,this study focused on terpenoid-based nanoformulations with enhanced bioavailability and improved therapeutic efficacy as anti-inflammatory agents.

关键词： conditions. formulation considerably

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Macrophage phenotypes correspond with remodeling outcomes of various acellular dermal matrices

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Open Journal of Regenerative Medicine 2012年第3期1卷 51-59页

作者： hitesh Agrawal Sunil S. Tholpady Anthony E. Capito David b. Drake Adam J. Katz Department of Plastic and Reconstructive Surgery University of Virginia Health System Charlottesville USA

Macrophages have recently been characterized as having an M1 or M2 phenotype based on receptor expression, mechanism of activation and function. The effects of macrophage phenotype upon tissue remodeling following implantation of an acellular dermal matrix (ADM) is largely unknown. The purpose of this study was to compare the macrophage phenotype and tissue remodeling elicited by four different ADMs (DermaMatrix, AlloDerm, Integra and Der mACELL). ADM samples were wrapped around the inferior epigastric vessels of a rat and were harvested on 7, 14, 21 and 42 days post implantation. Immunohistologic methods were used to identify macrophage surface markers CD68 (pan macrophage), CCR7 (M1 profile), and CD206 (M2 profile). All human derived ADMs showed a bell shaped curve for distribution of CD68+ macrophages with peaks for DermaMatrix occurring at day 14 and peak influx for AlloDerm occurring on day 21. In contrast, bovine derived Integra showed an increasing trend of macrophages with time. DermACELL had the highest influx of macro- phages while Integra had the lowest. A quantitative analysis of phenotype of macrophages in AlloDerm showed that the cells were predominantly M1 at 7, 14, 21 and 42 days post implantation. In contrast, Integra showed a mixed M1/M2 population of macrophages at all time points. The histopathologic evaluation showed that a predominantly M1 macrophage response was associated with a more inflamematory type tissue remodeling outcome in AlloDerm while a mixed M1/M2 macrophage response was associated with a more constructive tissue remodeling response seen in the other substrates.

关键词： Acellular Dermal Matrix Derma Matrix AlloDerm Integra Derm Acell

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Cell thickness dependence of electrically tunable infrared reflectors based on polymer stabilized cholesteric liquid crystals

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Science China Materials 2018年第5期61卷 745-751页

作者： Xiaowen Hu Laurens T. de Haan hitesh Khandelwal Albertus P.H.J. Schenning Li Nian Guofu Zhou SCNU-TUE Joint Laboratory of Device Integrated Responsive Materials （DIRM） National Center for International Research on Green Optoelectronics South China Normal University No 378 West Waihuan Road Guangzhou Higher Education Mega Center Guangzhou 510006 China Laboratory of Functional Organic Materials ＆ Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology P. O. Box 513 5600 MB Eindhoven The Netherlands Institute of Electronic Paper Displays and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Guangzhou 510006 China Shenzhen Guohua Optoelectronics Tech. Co. Ltd. Shenzhen 518110 China

We reported here the fabrication of the elec- trically tunable infrared （IR） reflectors based on the polymer stabilized cholesteric liquid crystal （PSCLC） with negative dielectric anisotropy. A systematic study of the influence of cell gap on the electrically tunable reflection bandwidth was performed. When a direct current （DC） electric field was ap- plied, the reflection bandwidth red shifted in the cells with small cell gap, whereas the bandwidth broadening was ob- served in the cells with large cell gap. It is therefore reasonable to deduct that the reflection is dictated by the pitch gradient steepness which strongly relies on the cell thickness. The re- sults reveal that for making PSCLC based IR reflector windows with electrically induced bandwidth broadening, a minimal cell gap thickness is required. The resulted IR reflectors pos- sess a short native switching time and long-term operation stability, and are potentially applicable as smart energy saving windows in buildings and automobiles.

关键词： cholesteric cell gap polymer network electric reg-ulating infrared reflector

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