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Insights on the Emerging Therapeutic Potential of Terpenoids as Anti-inflammatory Agents:A Scoping Review

Journal of Bio-X Research 2024年第1期7卷 20-35页

作者： Mohini Devi Prabhjeet Kaur Bamrah Rajat Goyal Manjusha Choudhary hitesh chopra Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra 136119HaryanaIndia MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-Ambala 133207HaryanaIndia Department of Biosciences Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai 602105Tamil NaduIndia

Background:Inflammatory diseases are among the leading causes of health issues that considerably influence health care *** the notable advancements in medical treatment that have been made in recent years,natural products with biological activity still play essential roles in a variety of anti-inflammatory *** study and identification of novel treatments for the adverse effects of available synthetic anti-inflammatory agents warrant further ***:This study focused on the emerging therapeutic potential of terpenoid products as anti-inflammatory ***:The literature reveals that secondary metabolites obtained from medicinal plants,*** and terpenoids and their nanoformulations,are effective for the treatment of inflammation in *** terpenes are a broad class of secondary metabolites that are rich in monoterpenes,diterpenes,triterpenes,tetraterpenes,ceramides,and sesquiterpenes and have various therapeutic applications,such as antitumor,antibacterial,antimicrobial,analgesic and anti-inflammatory *** studies have shown that terpenes can decrease inflammation-associated symptoms by reducing the release of proinflammatory cytokines,including nuclear transcription factor-kappa B,interleukins,tumor necrosis factor-alpha,and other inflammatory ***:This review describes the latest knowledge of the different terpenoid-derived natural and synthetic compounds that have been isolated from plant sources in recent years and their anti-inflammatory potential and therapeutic mechanism of ***,this study focused on terpenoid-based nanoformulations with enhanced bioavailability and improved therapeutic efficacy as anti-inflammatory agents.

关键词： conditions. formulation considerably

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维普期刊数据库

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Insights from a Brief Study of Renal Calculi:Recent Diagnostic and Treatment Approaches

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Journal of Bio-X Research 2024年第1期7卷 8-19页

作者： Aashish Kumar Rajat Goyal Kajal Garg Sumeet Gupta Kashish Wilson hitesh chopra MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana 133207India Lal Chand Mal College of Education JhansaKurukshetraHaryana 136130India Department of Biosciences Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiTamil Nadu 602105India

Background:Renal calculi,commonly known as kidney stones,is a prevalent urological condition that affects a substantial portion of the population *** formation of kidney stones is a complex process influenced by various factors,including diet,fluid intake,genetics,and metabolic *** pathogenesis of renal calculi involves a complex interplay of multiple factors,including supersaturation of urine with stone-forming constituents,urinary supersaturation,crystallization,and ***:This review aims to provide an overview of the present understanding of renal calculi,their pathophysiology,diagnostic approaches,and available treatment ***:This review discusses the different types of kidney stones,such as calcium oxalate,calcium phosphate,uric acid,and struvite stones,and explores their formation mechanisms and associated risk *** management of renal calculi relies on stone characteristics,patient symptoms,stone size,and ***,counseling and education regarding lifestyle modifications and risk factor management are essential for long-term ***:Accurate diagnosis and appropriate management based on stone characteristics and patient symptoms are essential for successful *** strategies to reduce stone recurrence are vital for long-term management and patient ***,further research is needed to refine diagnostic techniques,improve treatment options,and enhance the understanding of the underlying pathophysiology of renal calculi.

关键词： diagnosis urine treatment

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维普期刊数据库

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Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar Jha Shreesh Ojha Dinesh Kumar Niraj Kumar Jha hitesh chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

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维普期刊数据库

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Targeted Gene Therapy: Promises and Challenges in Disease Management

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生物组学研究杂志(英文) 2024年第2期7卷 81-89页

作者： Vickram Agaram Sundaram Manikandan Sivasubaramanian Richard Titus Lakshmi S. Vidhya chopra hitesh Department of Biosciences Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha Nagar Thandalam Chennai Tamil Nadu India

Targeted gene therapy may revolutionize disease treatment by precisely treating genetic defects. This method targets particular cells or tissues with therapeutic genes to treat a variety of genetic problems, including cancer, hereditary diseases, and viral infections. Viral, nonviral, and genome editing techniques such as CRISPR-Cas9 are used for targeted gene therapy to fix or modify disease-causing genes with minimal off-target effects. The issues of vector immunogenicity, off-target mutations, and gene delivery to target cells persist despite tremendous progress. The successful implementation of targeted gene therapy is further hindered by hereditary illness complexity and genetic background diversity. These difficulties require multidisciplinary cooperation, novel vector design, and thorough preclinical and clinical assessments. The long-term and unforeseen effects of gene editing must also be considered from an ethical viewpoint. Targeted gene therapy has considerable therapeutic promise, but more research and technological advances are needed to overcome limitations and develop safe and successful clinical treatments.

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