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Nanoemulsion containing a synergistic combination of curcumin and quercetin for nose-to-brain delivery:In vitro and in vivo studies

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Asian Pacific Journal of Tropical Biomedicine 2021年第11期11卷 510-518页

作者： hitendra s.mahajan Nayana D Patil r.3.patel institute of pharmaceutical education and research shirpurdist-dhule(m.s)india

Objective:To characterize a nanoemulsion containing a synergistic combination of curcumin(CUR)and quercetin(QUE)for brain targeting through the ***:The synergistic activity of the combination of two phytoconstituents,curcumin and quercetin(CUR-QUE)was determined at a 2:1 *** containing the synergistic combination were prepared using high-pressure homogenization *** formulation was characterized for globule size,drug content,thermodynamic stability,zeta potential measurement,and drug *** studies were performed using isolated nasal mucosa of ***,in vivo studies using allograft model were ***:CUR-QUE in a 2:1 ratio combination showed the lowest combination index values 0.99(combination indexstoma U373-MG *** combination inhibited the growth of human glioblastoma U373 MG *** significant drug targeting efficiency percentage(178.25±2.86 for CUR and 170.54±6.11 for QUE)and nose to brain drug direct transport percentage(44.05±0.93 for CUR and 38.25±0.83 for QUE)of optimized nanoemulsion(F9)indicated effective central nervous system targeting via the intranasal *** vivo anticancer study using allograft model of nude mice demonstrated potential anticancer activity of the synergistic combination of CUR-QUE as compared to ***:This study demonstrates that synergistic combination of CUR-QUE was optimal for treatment of human ***,significant site-specific delivery to the brain was achieved by administering nanoemulsion through the *** study also reveals that intranasal delivery of nanoemulsion containing synergistic combination of CUR and QUE could be a promising strategy for brain tumor treatment.

关键词： Curcumin Quercetin Nanoemulsion Brain tumor synergism

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Modelling of electronegative collisional warm plasma for plasma-surface interaction process

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Plasma science and Technology 2021年第4期23卷 48-54页

作者： Rajat DHAWAN hitendra K MALIK Plasma science and Technology Laboratory Department of PhysicsIndian Institute of Technology DelhiNew Delhi—110016India

An electronegative collisional plasma having warm and massive positive ions,non-extensive distributed electrons and Boltzmann distributed negative ions is modelled for the plasma-surface interaction process that is used for the surface *** the sheath formation is evaluated through the Bohm’s criterion,which is found to be modified,and the variation of the sheath thickness and profiles of the density of plasma species and the net space charge density in the sheath region in addition to the electric *** effect of ion temperature,nonextensivity and collisional parameter is examined in greater detail considering the collisional cross-section to obey power-law dependency on the positive ion *** positive ions are found to enter in the sheath region at lower velocities in the collisional plasma compared to the case of collision-less plasma;this velocity sees minuscule reduction with increasing *** increasing ion temperature and collisional parameter lead to the formation of sheath with smaller thickness.

关键词： electronegative sheath ion temperature non-extensivity sheath thickness power-law dependency collisions

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Can epigenetic and inflammatory biomarkers identify clinically aggressive prostate cancer?

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World Journal of Clinical Oncology 2020年第2期11卷 43-52页

作者： Pedro Bargao santos hitendra Patel Rui Henrique Ana Felix Department of Urology Prof.Doutor Fernando Fonseca HospitalAmadora 2720-276Portugal Department of Urology University Hospital North NorwayTromsø9019Norway Department of Urology St George’s University HospitalsTootingLondon SW170QTUnited Kingdom Departments of Pathology and Cancer Biology and Epigenetics Group-Research Center Portuguese Oncology Institute of PortoPorto 4200-072Portugal Department of Pathology and Molecular Immunology Institute of Biomedical Sciences Abel SalazarUniversity of PortoPorto 4099-002Portugal Department of Pathology Portuguese Oncology Institute of LisbonLisbon 1099-023Portugal Department of Pathology NOVA Medical SchoolLisbon 1169-056Portugal

Prostate cancer(PCa)is a highly prevalent malignancy and constitutes a major cause of cancer-related morbidity and *** emerges through the acquisition of genetic and epigenetic *** modifications include DNA methylation,histone modifications and micro RNA *** generate heritable transformations in the expression of genes but do not change the DNA *** in DNA methylation(hypo and hypermethylation)are the most characterized in *** lead to genomic instability and inadequate gene *** and minor-specific modifications in chromatin recasting are involved in PCa,with signs suggesting a dysfunction of enzymes modified by *** RNA deregulation also contributes to the initiation of PCa,including involvement in androgen receptor signalization and *** influence of inflammation on prostate tumor carcinogenesis is currently much better *** discoveries about microbial species resident in the urinary tract suggest that these are the initiators of chronic inflammation,promoting prostate inflammatory atrophy and eventually leading to *** characterization of the relationship between the urinary microbiome and prostatic chronic inflammation will be crucial to develop plans for the prevention of *** prevalent nature of epigenetic and inflammatory alterations may provide potential biomarkers for PCa diagnosis,treatment decisions,evaluation of prognosis and posttreatment surveillance.

关键词： Prostate cancer Epigenetics DNA methylation Histone modifications Micro RNAs Inflammation Initiation and progression Prognosis

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组织因子途径抑制物—2抗肿瘤作用的研究

组织因子途径抑制物—2抗肿瘤作用的研究

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第九届全国实验血液学会议

作者：杜新 hitendra s.Chand Hector DavidInzunza steven Brodie Walter Kisiel 深圳市第二人民医院 Department of Pathology and Internal Medicine University of New Mexico Health Sciences Center Albuquerque New Mexico 87106 U.S.A.

目的探讨组织因子途径抑制物-2(Tissue Factor Pathway Inhibitor-2,TFPI-2)在体内抑制肿瘤生长和转移的作用。方法1.质粒构建TFPI-2 cDNA克隆至真核细胞载体pcDNA3。2.细胞转染已构建质粒(实验组)及载体(对照组)分别转染人纤维母细胞...

目的探讨组织因子途径抑制物-2(Tissue Factor Pathway Inhibitor-2,TFPI-2)在体内抑制肿瘤生长和转移的作用。方法1.质粒构建TFPI-2 cDNA克隆至真核细胞载体pcDNA3。2.细胞转染已构建质粒(实验组)及载体(对照组)分别转染人纤维母细胞瘤细胞株HT-1080。3.动物模型将5×10转染的HT1080细胞皮下接种至Blab/c sCID雄性裸鼠。每组12只。每周观察肿瘤大小,连续5周。至5周末收集肿块和肺脏供实验用。4.组织化学与免疫组织化学染色观察肿瘤生长和肺内转移以及

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