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Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures

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World Journal of Gastroenterology 2013年第1期19卷 86-91页

作者： Katsuya Endo Seiichi Takahashi hisashi Shiga Yoichi Kakuta Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

AIM:To investigate the short and long-term outcomes of endoscopic balloon dilatation(EBD) for Crohn's disease(CD) ***:Between January 1995 and December 2011,47 EBD procedures were performed in 30 patients(8 females and 22 males) with *** patients had strictures through which an endoscope could not pass,and symptoms of these strictures included abdominal pain,abdominal fullness,nausea,and/or *** 47 strictures included 17 anastomotic and 30 de novo *** and dilatation were performed under conscious sedation with intravenous diazepam or *** dilatations were all performed using through-the-scope balloons with diameters from 8 mm to 20 mm on inflation and lengths of 30-80 *** dilatation session consisted of two to four,3-min multistep inflations of the balloon,repeated at intervals of 1 wk until adequate dilatation(up to 15-20 mm in diameter) was *** follow-up data were collected from medical records and analyzed *** success was defined as passage of the scope through the stricture after *** outcomes were analyzed focusing on interventionfree survival and surgery-free survival demonstrated by the Kaplan-Meier method.(Intervention-free meant cases in which neither endoscopic balloon re-dilatation nor surgery was needed after the first dilatation during the observation period).The log rank test was used to evaluate the difference in long-term outcomes between anastomotic and de novo stricture ***:Primary success was achieved in 44 of the 47 strictures(93.6%).Balloon dilatations failed in 3 cases(6.4%).In 1 case,EBD was a technical failure because the guide-wire could not be passed through the stricture which showed severe adhesion and was a flexural lesion of the *** 2 cases,unexpected perforations occurred immediately after balloon *** the 47 treatments,complications occurred in 5(10.6%).All 5 patients had de novo *** suffered bleeding

关键词： Crohn’s disease Endoscopic balloon dilatation Stricture Anastomotic De novo Outcome

日本の寒地,北海道におけるもち米良質育種(日语原文)

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粮油食品科技 2022年第5期30卷 13-25页

作者：丹野久吉村徹平山裕治日本水稲品質・食味研究会日本東京都中央区104-0033 北海道立総合研究機構中央農業試験場遺伝資源部日本北海道滝川073-0013 北海道立総合研究機構上川農業試験場日本北海道比布078-0397

北海道のもち米は,従来,硬化性が低く硬くなりにくいため,おこわや和菓子などに向く。しかし,東北以南の銘柄もち米に比べ,精米蛋白含有率(蛋白質)が高く,精米白度や搗き餅の食味が劣っていた。さらに,近年には需要を広げるため,切り餅... 详细信息

北海道のもち米は,従来,硬化性が低く硬くなりにくいため,おこわや和菓子などに向く。しかし,東北以南の銘柄もち米に比べ,精米蛋白含有率(蛋白質)が高く,精米白度や搗き餅の食味が劣っていた。さらに,近年には需要を広げるため,切り餅·成型餅および米菓に向く搗き餅の硬化性が高い品種の育成も要望された。そこで,新品種の早期開発のために世代促進栽培や葯培養を行い,選抜効率を高めるため初期世代から玄米と精米の白度,蛋白質および硬化性と関係がある糊化特性の機器による分析を,また少量もち米による硬化性を実測し,さらに中期世代からのおこわや搗き餅の食味試験などを行い,農業形質とともに品質改良を進めた。その結果,近年の育成品種では粒大が大きく,穂ばらみ期と開花期の両障害型耐冷性も強く生産の安定性が向上した。さらに,育成年次が新しい品種ほど蛋白質が低く,蛋白質と負の相関関係がある精米白度が高くなった。また,おこわや搗き餅の食味も向上した。一方,搗き餅の硬化性については,従来の低い品種だけで無く,粳品種を母本として硬化性が高い品種も育成された。しかし,東北以南の銘柄もち米には搗き餅の食味や硬化性の高さがまだ及ばず,さらに改良を進める必要がある。

关键词：搗き餅の硬化性精米白度精米蛋白質含有率食味もち米育種寒地

New Test Light Spectrum Design for L/U-Band Extended Optical Fiber Line Testing System

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光学学报 2003年第S1期23卷 57-58页

作者： Nazuki Honda Noriyuki Araki hisashi Izumita Minoru Nakamura NTT Access Network Service Systems Laboratories NTT Corporation JapanNTT Access Network Service Systems Laboratories NTT Corporation JapanNTT Access Network Service Systems Laboratories NTT Corporation JapanNTT Access Network Service Systems Laboratories NTT Corporation Japan

This paper describes a new design for the test light source of an L/U-band extended optical fiber line testing system and the side-band suppresser ratio of the test light should be more than 70 dB.

关键词： FBG nm test New Test Light Spectrum Design for L/U-Band Extended Optical Fiber Line Testing System for

Impact of friction stir welding on recrystallization of oxide dispersion strengthened ferritic steel

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Journal of Materials Science & Technology 2018年第1期34卷 209-213页

作者： Wentuo Han Pingping Liu Xiaoou Yi Qian Zhan Farong Wan Kiyohiro Yabuuchi hisashi Serizawa Akihiko Kimura School of Materials Science and Engineering University of Science and Technology Beijing. Beijing 100083. China Institute of Advanced Energy. Kyoto University Gokasho Uji Kyoto 611-0011Japan Joining and Welding Research Institute. Osaka University Ibaraki Osaka567-0047Japan

Oxide dispersion strengthened （ODS） steels can be used as the structural materials in the future fusion reactors and the fuel cladding materials in the advanced fission reactors. However, the weldability of ODS steels is a severe problem. In the present study, defect-free joints of the 15Cr-ODS ferritic steel were achieved by friction stir welding at different rotation speeds. The recrystallization, hardness and tensile properties are highly related with the rotation speed of the stir tool. The higher rotation speed results in coarser grains in the top SZ, while the grain size exhibits more complicated relation with the rotation speed in the SZ center. The joint welded at 250 rpm exhibits a maximum tensile strength of 974 MPa that reaches about 84% of that of the base metal.

关键词： ODS ferritic steel Friction stir welding Recrystallization behavior Electron backscatter diffraction Vickers hardness

The TLR Expression Pattern on Monocyte-Derived Macrophages for Lipopolysaccharid Stimulation of Calves

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Agricultural Sciences in China 2009年第7期8卷 864-871页

作者： GUO Yi-jie ZHAO Guo-Qi HUO Yong-jiu Sachi Tanaka hisashi Aso Takahiro Yamaguchi Laboratory of Animal Nutrition Graduate School of Animal Science and Technology Yangzhou University Yangzhou 225009 P.R. China Laboratory of Functional Morphology Graduate School of Agricultural Science Tohoku University 1-1 Tsutsumidori-Amamiyamachi Aobaku 981-8555 Sendai Japan

In this paper, toll-like receptor expression pattern in monocytes-derived macrophages by lipopolysaccharid （LPS） stimulation was examined. Jugular venous blood samples from 4 Japanese calves were obtained and the peripheral blood mononuclear cells （PBMC） were isolated. The PBMC were cultured for 7 d so as to collect monocytes-derived macrophages in Repcell. The PBMC were stimulated by LPS for 24 h and the mRNA expression pattern of TLR and cytokines in monocytes-derived macrophages （Mod-Mφ） was analyzed. Results showed that LPS stimulation of Mod-Mφ could increase the mRNA levels of the genes of TNF-α, IL-6, and IL-8. In addition, the mRNA levels of the genes of TNF-α and IL-6 in the group of LPS stimulation were most significantly （P 〈 0.01） higher than those in control group and the mRNA levels of TLR1, 3, 5, 8, and 10 were significantly （P 〈 0.05） decreased after LPS stimulation. There was no difference in the mRNA expressions of TLR2, 4, 6, and 7 between the groups of the control and LPS stimulation. Besides, expression of TLR9 was not found. It suggested that monocytes-derived macrophages could respond to LPS and they might take an important role in the innate immunity. The important function of the cells might contribute to better disease treatment.

关键词： TLR bovine macrophage LPS

Formation and characterization of phthalocyanine dimer/C60 solar cells

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Progress in Natural Science:Materials International 2011年第1期21卷 27-30页

作者： Akihiro takeda Akira MINOWA Takeo OKU Atsushi SUZUKI Kenji KIKUCHI Yasuhiro YAMASAKI Department of Materials Science The University of Shiga Prefecture2500HassakaHikoneShiga 522-8533Japan Orient Chemical Industries Co.Ltd.Department of New Business8-1Sanra-Higashi-MachiNeyagawaOsaka 572-8581Japan

Organic solar cells withμ-oxo-bridged gallium phthalocyanine dimer(GaPc dimer) and fullerene were produced by an evaporation method.A device based on the GaPc dimer provided a conversion efficiency of 4.2×10-3%,which is better compared to a device based on phthalocyanine *** effect was discussed with a molecular orbital calculation,and the crystalline phases of the present solar cells were investigated by X-ray *** improvement of the efficiency was discussed on the basis of the experimental results.

关键词： phthalocyanine dimmer fullerene solar cell

Exploiting scattering media for exploring 3D objects

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Light(Science & Applications) 2016年第1期5卷 202-208页

作者： Alok Kumar Singh Dinesh N Naik Giancarlo Pedrini Mitsuo takeda Wolfgang Osten Institut für Technische Optik(ITO)and Stuttgart Research Center of Photonic Engineering(SCoPE) University of StuttgartPfaffenwaldring 970569 StuttgartGermany School of Physics University of HyderabadHyderabad 500046India Center for Optical Research and Education(CORE) Utsunomiya UniversityYoto 7-1-2UtsunomiyaTochigi321-8585Japan

Scattering media,such as diffused glass and biological tissue,are usually treated as obstacles in *** cope with the random phase introduced by a turbid medium,most existing imaging techniques recourse to either phase compensation by optical means or phase recovery using iterative algorithms,and their applications are often limited to two-dimensional *** contrast,we utilize the scattering medium as an unconventional imaging lens and exploit its lens-like properties for lensless threedimensional(3D)imaging with diffraction-limited *** spatially incoherent lensless imaging technique is simple and capable of variable focusing with adjustable depths of focus that enables depth sensing of 3D objects that are concealed by the diffusing ***-field imaging with diffraction-limited resolution is verified experimentally by a single-shot recording of the 1951 USAF resolution test chart,and 3D imaging and depth sensing are demonstrated by shifting focus over axially separated objects.

关键词： intensity correlation technique lensless imaging scattering media 3D imaging

Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation

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Cancer Communications 2021年第1期41卷 83-87页

作者： hisashi Tanaka Kageaki Taima Tomonori Makiguchi Junichi Nakagawa Takenori Niioka Sadatomo Tasaka Department of Respiratory Medicine Hirosaki University Graduate School of MedicineAomori 036-8562Japan Department of Pharmacy Hirosaki University HospitalAomori 036-8562Japan

Tepotinib is a key drug for cancer patients with mesenchymal-epithelial transition receptor tyrosine kinase proto-oncogene(MET)exon 14 skipping ***,its bioavailability in the cerebrospinal fluid(CSF)in humans has not been fully ***,information about the efficacy of tepotinib in patients with leptomeningeal metastasis is ***,we present the case of a 56-year-old man who was diagnosed with lung adenocarcinoma with MET exon 14 skipping *** was urgently hospitalized due to leptomeningeal *** administered tepotinib 500 mg/day as the second-line therapy and observed improvement in leptomeningeal metastasis and performance *** tepotinib concentrations reached 1,648 ng/mL in the plasma and 30.6 ng/mL in the CSF,with a penetration rate(CSF/plasma)of 1.83%.These demonstrate tepotinib could achieve a high rate of central nervous system transition and could be effective against leptomeningeal metastasis.

关键词： cerebrospinal fluid IC50 leptomeningeal metastasis MET exon 14 skipping mutation non-small cell lung carcinoma performance status pharmacokinetics tepotinib

A Study of Hie and LBP: The First Step to Improve Subjective Well-Being

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Health 2023年第10期15卷 1013-1023页

作者： Mayumi Watanabe Chikako Tomiyama Takuya Nikaido Masae Ryufuku Nozom Mandai Tokimasa takeda Tsutomu Komine Faculty of Science and Engineering Chuo University Tokyo Japan Faculty of Health Sciences Kansai University of Health Sciences Osaka Japan Graduate School of Health Sciences Niigata University Niigata Japan Department of Orthopaedic Surgery School of Medicine Fukushima Medical University Fukushima Japan Translational Research Center Fukushima Medical University Fukushima Japan Faculty of Nursing Science Tsuruga Nursing University Tsuruga Japan Zinbunken Kyoto University Kyoto Japan

Backgrounds: Health does not only physical health, therefore, we need to study it from various viewpoints. Many Japanese female complain of a Hie or a low back pain (LBP), which they reduce their subjective well-being. We analyze. Those patients often have acupuncture therapy. In this study, we analyze the characteristics of Hie and LBP, the satisfaction level of alternative therapy and we pursue a tip to improve subjective well-being. Methods: Of 1000 women, Hie (+)/Hie (−) or LBP (+)/LBP (−), we compared their body temperature (BT) (axilla) and body mass index (BMI). Furthermore, the Chi test identified ten factors of “body” and seven “mind” information. Results: In the result of BT (axilla) while LBP indicated a significant difference. Both Hie and LBP showed difference in the opposite direction. Hie did now show such clear differences in “body” information. However, interestingly, all seven questions in the “mind” information showed statistical difference. Discussion and conclusion: One reason why those patients have acupuncture therapy may acupuncture therapy traditionally has not separate “mind” and “body” and it has the concept of “mind-body unity”. To improve subjective well-being, first we need to focus on “Mind” as well as “mind-body unity”. Mental-health support is important for patients with Hie or LBP to reduce physiological stress.

关键词： Hie Low Back Pain (LBP) Subjective Well-Being Body Temperature (BT)