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Trace element composition in tuite decomposed from natural apatite in high-pressure and high-temperature experiments

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Science China Earth Sciences 2014年第12期57卷 2922-2927页

作者： ZHAI ShuangMeng XUE WeiHong Daisuke yamazaki MA Fang Key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of Sciences School of Earth and Space Sciences Peking University Institute for Study of the Earth's Interior Okayama University

Tuite has been suggested as a potential reservoir for trace elements in the deep mantle,but no evidence confirms this *** using a natural apatite as starting material,the trace-element-bearing tuite large crystals were obtained under highpressure and high-temperature conditions(15 GPa and 1800 K).X-ray diffraction pattern and Micro-Raman spectrum of the run product confirm that tuite was *** concentrations of trace elements in tuite crystals were analyzed by laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS).The rare earth element patterns of tuite show enrichment of light rare earth elements relative to heavy rare earth *** shows high concentrations of Th and Sr,and negative anomalies of Rb,Nb,and *** results show that tuite can accommodate a large amount of trace *** might be an important host to accommodate trace elements if there is much apatite subducted into the deep mantle.

关键词： tuite trace elements high-pressure and high-temperature

Deoxynortryptoquivaline:A unique antiprostate cancer agent

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Oncology Research 2023年第6期31卷 845-853页

作者： YOHKO yamazaki MANABU KAWADA ISAO MOMOSE Institute of Microbial Chemistry(BIKAKEN) Numazu BranchMicrobial Chemistry Research FoundationNumazu410-0301Japan Institute of Microbial Chemistry(BIKAKEN) Laboratory of OncologyMicrobial Chemistry Research FoundationShinagawa-ku141-0021Japan

The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new ARinhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as ascreening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that thefermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cellswithout cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline(DNT) being identified as a novel inhibitor of AR function. DNT showed potent inhibition of androgen-dependentgrowth of human prostate cancer LNCaP cells. The AR competitor assay was performed, and DNT did not act as anAR antagonist. However, DNT inhibited AR-dependent transcriptional activity and AR nuclear translocation, itsuggested that the suppression of AR function leads to inhibition activity against androgen-dependent growth.

关键词： Anticancer antibiotics Prostate cancer Androgen receptor Androgen dependency

Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11607-11616页

作者： Ryosuke Sato Kazuyuki Matsumoto Hiromitsu Kanzaki Akihiro Matsumi Kazuya Miyamoto Kosaku Morimoto hiroyuki Terasawa Yuki Fujii Tatsuhiro yamazaki Daisuke Uchida Koichiro Tsutsumi Shigeru Horiguchi Hironari Kato Gastroenterology and Hepatology Okayama University HospitalOkayama 700-8558Japan

BACKGROUND Gastric linitis plastica(GLP)is a subset of gastric cancer with a poor *** is difficult to obtain a definitive diagnosis by endoscopic mucosal biopsies,and the usefulness of an endoscopic ultrasonography-guided fine-needle biopsy(EUSFNB)for GLP has been recently ***,autoimmune diseases are occasionally known to coexist with malignant tumors as paraneoplastic *** herein report the usefulness of an EUS-FNB for detecting GLP and the possibility of paraneoplastic syndrome coexisting with *** SUMMARY An 81-year-old man was admitted to our hospital for a 1-mo history of epigastric pain that increased after *** laboratory data revealed high levels of serum carbohydrate antigen 19-9 and *** examinations showed giant gastric folds and reddish mucosa;however,no epithelial changes were *** gastric lumen was not distensible by air inflation,suggesting *** tomography showed the thickened gastric wall,the diffuse enlargement of the pancreas,and the peripancreatic rim,which suggested autoimmune pancreatitis(AIP)coexisting with *** the pathological findings of the endoscopic biopsy showed no malignancy,he underwent an EUSFNB and was diagnosed with *** received chemotherapy for unresectable gastric cancer due to peritoneal metastasis,after which both the gastric wall thickening and diffuse enlargement of the pancreas were *** An EUS-FNB for GLP with a negative endoscopic biopsy is useful,and AIP may develop as a paraneoplastic syndrome.

关键词： Endoscopic ultrasound-guided fine needle aspiration Linitis plastica Autoimmune pancreatitis Paraneoplastic syndromes Case report

Synchrotron X-ray diagnostics of cutoff shape of nonthermal electron spectrum at young supernova remnants

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Research in Astronomy and Astrophysics 2014年第2期14卷 165-178页

作者： Ryo yamazaki Yutaka Ohira Makoto Sawada Aya Bamba Department of Physics and Mathematics Aoyama Gakuin University5-10-1 FuchinobeSagamihara 252-5258Japan

Synchrotron X-rays can be a useful tool to investigate electron accelera- tion at young supemova remnants （SNRs）. At present, since the magnetic field con- figuration around the shocks of SNRs is uncertain, it is not clear whether electron acceleration is limited by SNR age, synchrotron cooling, or even escape from the ac- celeration region. We study whether the acceleration mechanism can be constrained by the cutoff shape of the electron spectrum around the maximum energy. We derive analytical formulae of the cutoff shape in each case where the maximum electron en- ergy is determined by SNR age, synchrotron cooling and escape from the shock. They are related to the energy dependence of the electron diffusion coefficient. Next, we discuss whether information on the cutoff shape can be provided by observations in the near future which will simply give the photon indices and the flux ratios in the soft and hard X-ray bands. We find that if the power-law index of the electron spectrum is independently determined by other observations, then we can constrain the cutoff shape by comparing theoretical predictions of the photon indices and/or the flux ratios with observed data which will be measured by NuSTAR and/or ASTRO-H. Such study is helpful in understanding the acceleration mechanism. In particular, it will supply another independent constraint on the magnetic field strength around the shocks of SNRs.

关键词： acceleration of particles -- ISM: cosmic rays -- ISM: supernova rem-nants -- turbulence -- X-rays: ISM

Chronic heat stress induces renal fibrosis and mitochondrial dysfunction in laying hens

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2002-2011页

作者： Fumika Nanto‑Hara Makoto yamazaki Hitoshi Murakami Haruhiko Ohtsu Division of Meat Animal and Poultry Research Institute of Livestock and Grassland ScienceNational Agriculture and Food Research Organization(NILGS)2 IkenodaiTsukubaIbaraki 305‑0901Japan

Background Heat stress in laying hens negatively affects egg production and shell quality by disrupting the homeo-stasis of plasma calcium and phosphorus *** the kidney plays an important role in calcium and phos-phorus homeostasis,evidence regarding the effect of heat stress on renal injury in laying hens is yet to be ***,the aim of this study was to evaluate the effects of chronic heat stress on renal damage in hens during laying *** A total of 16 white-leghorn laying hens(32 weeks old)were randomly assigned to two groups(n=8).One group was exposed to chronic heat stress(33°C for 4 weeks),whereas the other group was maintained at 24°*** Chronic heat exposure significantly increased plasma creatinine and decreased plasma albumin levels(P<0.05).Heat exposure also increased renal fibrosis and the transcription levels of fibrosis-related genes(COLA1A1,αSMA,and TGF-β)in the *** results suggest that renal failure and fibrosis were induced by chronic heat exposure in laying *** addition,chronic heat exposure decreased ATP levels and mitochondrial DNA copy number(mtDNA-CN)in renal tissue,suggesting that renal mitochondrial dysfunction occurs under conditions of heat *** mitochondria leak mtDNAs into the cytosol and mtDNA leakage may activate the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling *** results showed that chronic heat exposure activated the cGAS-STING pathway as indicated by increased expression of MDA5,STING,IRF7,MAVS,and NF-κB ***,the expression of pro-inflammatory cytokines(IL-12)and chemokines(CCL4 and CCL20)was upregulated in heat-stressed *** These results suggest that chronic heat exposure induces renal fibrosis and mitochondrial damage in laying *** damage by heat stress may activate the mtDNA-cGAS-STING signaling and cause subse-quent inflammation,which contributes to the progression of renal fibrosis and

关键词： cGAS-STING Heat stress Laying hens Mitochondrial DNA Renal fibrosis

Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling

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Oncology Research 2023年第6期31卷 833-844页

作者： MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI yamazaki SHINGO DAN NAOSHI DOHMAE hiroyuki OSADA Biomolecular Characterization Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Chemical Resource Development Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Chemical Biology Research Group RIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Molecular Structure Characterization Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Institute of Microbial Chemistry(BIKAKEN) NumazuMicrobial Chemistry Research FoundationShizuoka410-0301Japan Division of Molecular Pharmacology Cancer Chemotherapy CenterJapan Foundation for Cancer ResearchTokyo135-8550Japan Department of Pharmaceutical Sciences University of ShizuokaShizuoka422-8526Japan

Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune *** study presents the identification of a potent DHODH inhibitor by proteomic ***-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer *** profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic ***,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic *** results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell ***,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases.

关键词： Anticancer agents Differentiating agents Drug target identification

Strategy for the control of drug-induced liver injury due to investigational treatments/drugs for COVID-19

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World Journal of Gastroenterology 2021年第48期27卷 8370-8373页

作者： Ken Sato Yuichi yamazaki Toshio Uraoka Department of Gastroenterology and Hepatology Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan

Investigational treatments/drugs for coronavirus disease 2019(COVID-19)have been applied,with repurposed or newly developed drugs,and their effectiveness has been *** of these drugs may be hepatotoxic,and each monotherapy or combination therapy may increase the risk of drug-induced liver injury(DILI).We should aim to control dysregulation of liver function,as well as the progression of COVID-19,as much as *** discussed the potential risks of investigational treatments/drugs and promising drugs for both COVID-19 and DILI due to investigational treatments/drugs.

关键词： Coronavirus disease 2019 Drug-induced liver injury Cytochrome P450 Drug-drug interaction Drug-disease interaction Cytokine

Preconditioning Schur Complement Systems of Highly-Indefinite Linear Systems for a Parallel Hybrid Solver

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Numerical Mathematics(Theory,Methods and Applications) 2010年第3期3卷 352-366页

作者： I.yamazaki E.G.Ng Lawrence Berkeley National Laboratory BerkeleyCaliforniaUSA

A parallel hybrid linear solver based on the Schur complement method has the potential to balance the robustness of direct solvers with the efficiency of preconditioned iterative ***,when solving large-scale highly-indefinite linear systems,this hybrid solver often suffers from either slow convergence or large memory requirements to solve the Schur complement *** overcome this challenge,we in this paper discuss techniques to preprocess the Schur complement systems in parallel. Numerical results of solving large-scale highly-indefinite linear systems from various applications demonstrate that these techniques improve the reliability and performance of the hybrid solver and enable efficient solutions of these linear systems on hundreds of processors,which was previously infeasible using existing state-of-the-art solvers.

关键词： Schur complement method preconditioning matrix preprocessing.

Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma

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World Journal of Gastroenterology 2015年第27期21卷 8458-8461页

作者： Akiko Tomonari Akio Katanuma Tomoaki Matsumori Hajime yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki Takahashi Toshiya Shinohara hiroyuki Maguchi Center for Gastroenterology Teine-Keijinkai Hospital Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Department of Pathology Teine-Keijinkai Hospital

Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically.

关键词： Endoscopic ultrasonography-guided fine needle aspiration Tumor seeding Pancreatic cancer