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World Journal of Gastroenterology 2000年第5期6卷 750-753页

作者： Naoko lida Hideaki Oda Shigetoshi Aiso Takatoshi ishikawa Department of Molecular Pathology Faculty of Medicinethe University of TokyoHongoTokyo 113Japan

INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal *** cancerstended to be advanced at the time of presentation,usually with poor *** recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal ***

关键词： cardia adenocarcinoma/etiology protein P53 gene expression mutation genes p53 polymerase chain reaction DNA risk factors

Reverse current reduction of Ge photodiodes on Si without post-growth annealing

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Chinese Optics Letters 2009年第4期7卷 286-290页

作者： Sungbong Park Shinya Takita Yasuhiko ishikawa Jiro Osaka Kazumi Wada Department of Materials Engineering University of Tokyo

A new approach to reduce the reverse current of Ge pin photodiodes on Si is presented, in which an i-Si layer is inserted between Ge and top Si layers to reduce the electric field in the Ge layer. Without post- growth annealing, the reverse current density is reduced to -10 mA/cm^2 at -1 V, i.e., over one order of magnitude lower than that of the reference photodiode without i-Si layer. However, the responsivity of the photodiodes is not severely compromised. This lowered-reverse-current is explained by band-pinning at the i-Si/i-Ge interface. Barrier lowering mechanism induced by E-field is also discussed. The presented ＂non-thermal＂ approach to reduce reverse current should accelerate electronics-photonics convergence by using Oe on the Si complementary metal oxide semiconductor （CMOS） platform.

关键词： CMOS integrated circuits Electric fields Germanium Metals MOS devices Oxide semiconductors Photodiodes Silicon Silicon on insulator technology

Experimental study of the woody debris trapping efficiency of a steel pipe,open sabo dam

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International Journal of Sediment Research 2020年第5期35卷 431-443页

作者： Ryuhei Tateishi Toshiyuki Horiguchi Yoshimi Sonoda Nobutaka ishikawa Department of Civil and Structural Engineering Kyusyu University Department of Civil Engineering National Defense Academy National Defense Academy

In recent years,the damage caused to human settlements in Japan by large woody debris(LWD) has been *** example,the 2013 Izu Oshima typhoon resulted in a large number of fatalities and missing persons,and the Kagoshima Typhoon Disaster and Northern Kyusyu torrential downpour caused vast infrastructure damage due to the associated *** countermeasures for preventing LWD are insufficient to maintain the safety of residential *** type of protective barrier,the open sabo dam,has been constructed in Japan during the past 30 *** primary function of open sabo dams is to block the flow of boulders,thereby also reducing sediment flow by reducing the gap ***,because Japanese open sabo dams are designed specifically for boulder-trapping,the ability of these dams to trap LWD remains *** particular,many problems have been reported with respect to sediment trapping by driftwood with roots in an open sabo dam *** objective of this study was to examine the trapping efficiency of open sabo dams for LWD and *** experimental approach clarified the influence of driftwood,without and with roots,on sediment trapping for a straight-channel *** flexible roots of the driftwood were shown to have a significant effect on the sediment trapping efficiency of the dam.

关键词： Driftwood Open sabo dam Trapping efficiency Woody debris

Can robotic liver resection compensate for weaknesses of the laparoscopic approach?

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 385-387页

作者： Daisuke Ban Yoshiya ishikawa Minoru Tanabe Department of Hepatobiliary and Pancreatic Surgery Graduate School of MedicineTokyo Medical and Dental UniversityTokyoJapan

In the past decade,the induction of minimal invasive surgery(MIS)has revolutionized liver surgery,because this approach greatly improves the clinical course of postoperative patients(1).

关键词： surgery liver clinical

Formation mechanism of extension fractures induced by excavation of a gallery in soft sedimentary rock,Horonobe area,Northern Japan

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Geoscience Frontiers 2013年第1期4卷 105-111页

作者： Tetsuya Tokiwa Kimikazu Tsusaka Makoto Matsubara Taiki ishikawa Daisuke Ogawa Horonobe Underground Research Unit Japan Atomic Energy AgencyHokkaido 098-3224Japan Geoscience Research Laboratory Kanagawa 242-0014Japan Mitsubishi Materials Techno Corporation Tokyo 102-8205Japan

This paper focuses on the formation mechanism of fractures induced by excavation of a gallery in soft sedimentary rocks in the Horonobe area of Japan. Detailed fracture mapping of the gallery indicates that the fractures consist of both pre-existing shear fractures and excavation damaged zone （EDZ） fractures. EDZ fractures correspond to weak planes associated with bedding planes or transgranular cracks. The EDZ fractures terminate against pre-existing shear fractures. Therefore, even for excavations in soft sedimentary rocks, formation of the EDZ fractures are controlled by pre-existing fractures and earlier weak planes.

关键词： Fracture Excavation damaged zone (EDZ)Weak plane Soft rock Excavation

Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering （SERS） and basic applications of SERS biological sensing

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Frontiers of physics 2014年第1期9卷 31-46页

作者： Yuko S. Yamamoto Mitsuru ishikawa Yukihiro Ozaki Tamitake Itoh Nano-Bioanalysis Research Group Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Takamatsu Kagawa 761-0395 Japan Department of Chemistry Josai University Itado Saitama 350-0295 Japan Department of Chemistry School of Science and Technology Kwansei Gakuin University Sanda Hyogo 669-1337 Japan

We review recent our results in the fundamental study of surface-enhanced Raman scattering （SERS） with emphasis on experiments that attempted to identify the enhancement and blinking mechanism using single Ag nanoparticle dimers attached to dye molecules. These results are quantitatively discussed in the framework of electromagnetic mechanism. We also review recent our results in basic SERS applications for biological sensing regarding detections of cell surface molecules and distinction of disease marker molecules under single cell and single molecule level.

关键词： plasmonics surface-enhanced Raman scattering (SERS) surface-enhanced fluorescence,Ag nanoparticle

Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer

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Journal of Cancer Therapy 2014年第1期5卷 11-20页

作者： Shinichi Yamauchi Satoru Iida Megumi Ishiguro Toshiaki ishikawa hiroyuki Uetake Kenichi Sugihara Department of Surgical Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan Department of Translational Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan

Platelet-derived growth factors (PDGFs) are known to be associated with tumor growth and angiogenesis through their activation of the receptor tyrosine kinases, PDGF receptors alpha and beta. Several studies revealed the participation of the PDGF family in colorectal cancer (CRC). However, the role of platelet derived growth factor-C (PDGFC) in CRC is less well studied. This study aimed to determine the correlation between PDGFC expression and the prognosis of patients with CRCs. Tumor samples were obtained from patients with CRC who underwent surgical resection between 2002 and 2006. The mRNA expression of PDGFC was investigated by quantitative reverse transcription-polymerase chain reaction in 85 patients with stage I-IV CRC. PDGFC protein expression was analyzed by immunohistochemistry, and the relationship between PDGFC protein expression and clinicopathologic features was investigated in 245 patients with stage I-III CRC. PDGFC mRNA expression in cancer tissues was significantly higher in patients with distant metastases than in those without metastases (P = 0.016). PDGFC protein overexpression was associated with significantly worse overall and relapse-free survival (P P < 0.0001, respectively). Moreover, PDGFC protein overexpression was an independent risk factor for CRC recurrence (relative risk = 3.395, 95% confidence interval = 1.895 - 6.081, P < 0.001). In the present study, PDGFC overexpression appeared to be predictive of recurrence and poor prognosis in patients with CRC.

关键词： Platelet-Derived Growth Factor-C Colorectal Cancer Prognosis mRNA Expression Immunohistochemistry

Glass melt inclusion in clinopyroxene from Linqu Cenozoic basalt,Shandong Province,China

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Chinese Science Bulletin 2006年第15期51卷 1869-1876页

作者： ZHANG Hongfu Eizo Nakamura ZHANG Jin ishikawa Akira State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute for Study of the Earth's Interior Okayama University at Misasa Tottori 682-0193 Japan

Cenozoic basalts from the Linqu County, Shandong Province, China entrain some clinopy- roxene crystals, of which many contain abundant glass melt inclusions. These melt inclusions are ex- tremely irregular in shape with most grain sizes in a range of 10-50 μm and coexist with low-Mg# olivines, labradorites and Ca-rich potassium feldspars. In-situ major and trace element analyses show that the glass melt inclusions are high in alkalis (Na2O+K2O > 10 wt%), SiO2 (>54 wt%), CaO and FeO (>4 wt%), but low in MgO (Mg# 2), thus having phonoli- tic compositions. The compositional features of cli- nopyroxene crystals, glass melt inclusions and their coexistent minerals suggest that these melt inclu- sions were exotic melts in clinopyroxenes trapped prior to their entrainment in the host basalt. The dis- covery of these melt inclusions provides a new ap- proach to further investigating the evolution of Meso- zoic lithospheric mantle beneath the southeastern North China Craton.

关键词：新生代玄武岩斜辉石玻璃熔体地壳资源山东

Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

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Acta Pharmaceutica Sinica B 2014年第2期4卷 141-145页

作者： Ryuji Uchida Seiko ishikawa Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyo 108-8641Japan School of Pharmacy Kitasato UniversityTokyo 108-8641Japan

2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/***,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells.

关键词： 2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor Melanine formation B16 melanoma cells

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乔木布局对川西林盘微气候的影响

四川林业科技 2024年第4期45卷 45-53页

作者：李荣佳黎秋杉石川幹子四川大学-香港理工大学灾后重建与管理学院成都610207 日本中央大学理工学院东京都164-8601

全球气候变化导致持续升温和极端气候事件的频发,给人类居住环境带来了严峻挑战。传统聚落作为经历了自然选择与进化的人居环境形态,形成了一系列适应当地气候的独特建筑模式。因此,深入研究传统聚落的保护和规划,特别是其乔木空间对微... 详细信息

全球气候变化导致持续升温和极端气候事件的频发,给人类居住环境带来了严峻挑战。传统聚落作为经历了自然选择与进化的人居环境形态,形成了一系列适应当地气候的独特建筑模式。因此,深入研究传统聚落的保护和规划,特别是其乔木空间对微气候的影响机制,对于探索地域低能耗的气候适应性理论和方法,以及提高未来人居环境建设的舒适性至关重要。基于实地调查和数值模拟的方法,以川西林盘及其衍生模型为研究对象,对其微气候进行了模拟,重点关注空气温度、相对湿度、风速、风向以及热舒适度等气象参数的空间分布特征与趋势,旨在分析乔木的空间格局与配置对聚落环境微气候的影响机制,探索基于自然的气候适应性解决方案。研究发现:随着乔木覆盖率的增加,林盘内部降温增湿效果越显著,但对空气流动具有限制作用,从而导致局部热浪效应和不适感。此外,乔木的数量和布局对气候适应性也具有较强的调节作用,分布于林盘上风向时可阻挡外部热空气进入并提供舒适感,但分布于林盘下风向时可能限制空气流动并增加内部热感受。

关键词：传统聚落川西林盘乔木布局微气候 ENVI-met