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Association between sporting event attendance and self-rated health:an analysis of multiyear cross-sectional national data in Japan

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Global Health Research and Policy 2018年第1期3卷 264-271页

作者： Yuhei inoue Mikihiro Sato Makoto Nakazawa School of Kinesiology University of Minnesota218 Cooke Hall1900 University Ave.SEMinneapolisMN 55455USA Hart School of Hospitality Sport and Recreation ManagementJames Madison UniversityGodwin Hall 355MSC 2305HarrisonburgVA 22807USA Faculty of Health and Sport Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8574Japan

Background:This study examined the extent to which sporting event attendance is associated with self-rated *** from an economic model of health production and psychological research on the health benefits of psychosocial resources,sporting event attendance was hypothesized to have a positive relationship with selfrated ***:A two-level multilevel ordered logistic regression was used to analyze multiyear cross-sectional data collected from national surveys in ***:The results demonstrate that,controlling for the effects of personal and environmental characteristics,sporting event attendance positively correlates with self-rated health over a 12-year ***,when compared to individuals who did not attend any sporting event during the past year,those who attended a sporting event were 33%more likely to indicate a higher level of self-rated ***:These findings provide evidence for a positive association between sport spectatorship and the perception of general health and contribute to the literature examining the relationship between sport spectatorship and health outcomes.

关键词： Leisure Population health Secondary data Spectatorship Spectator sport Sport spectating Well-being

Direct Dimethyl Ether Synthesis

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Journal of Natural Gas Chemistry 2003年第4期12卷 219-227页

作者： Takashi Ogawa Norio inoue Tutomu Shikada Yotaro Ohno DME Development Co LtdShoro-koku ShiranukachHokkaido 088-0563 JapanDME Development CoLtdShoro-koku ShiranukachHokkaido 088-0563 JapanDME Development CoLtdShoro-koku ShiranukachHokkaido 088-0563 JapanDME Development CoLtdShoro-koku ShiranukachHokkaido 088-0563 Japan

Dimethyl ether (DME) is a clean and economical alternative fuel which can beproduced from natural gas through synthesis gas. The properties of DME are very similar to those ofLP gas. DME can be used for various fields as a fuel such as power generation, transportation, homeheating and cooking, etc. It contains no sulfur or nitrogen. It is not corrosive to any metal andnot harmful to human body. An innovative process of direct synthesis of DME from synthesis gas hasbeen developed. Newly developed catalyst in a slurry phase reactor gave a high conversion and highselectivity of DME production. One and half year pilot scale plant (5 tons per day) testing, whichwas supported by METI, had successfully finished with about 400 tons DME production.

关键词： dimethyl ether DME slurry reactor natural gas syn-gas coal clean fuel diesel engine

Clinical applications of 5-aminolevulinic acid-mediated fluorescence for gastric cancer

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World Journal of Gastroenterology 2015年第29期21卷 8769-8775页

作者： Tsutomu Namikawa Tomoaki Yatabe Keiji inoue Taro Shuin Kazuhiro Hanazaki Department of Surgery Kochi Medical School Nankoku Department of Anesthesiology Kochi Medical School Nankoku Department of Urology Kochi Medical School Nankoku

5-aminolevulinic acid(ALA) is a naturally occurring amino acid that is a protoporphyrin IX(Pp IX) precursor and a next-generation photosensitive substance. After exogenous administration of ALA, Pp IX specifically accumulates in cancer cells owing to the impaired metabolism of ALA to Pp IX in mitochondria, which results in a red fluorescence following irradiation with blue light and the formation of singlet oxygen. Fluorescence navigation by photodynamic diagnosis(PDD) using ALA provides good visualization and detection of gastric cancer lesions and is a potentially valuable diagnostic tool for gastric cancer for evaluating both the surgical resection margins and extension of the lesion. Furthermore, PDD using ALA might be used to detect peritoneal metastases during preoperative staging laparoscopy, where it could provide useful information for the selection of a therapeutic approach. Another promising application for this modality is in the evaluation of lymph node metastases. Photodynamic therapy(PDT) using ALA to cause selective damage based on the accumulation of a photosensitizer in malignant tissue is expected to be a non-invasive endoscopic treatment for superficial early gastric cancer. ALA has the potential to be used not only as a diagnostic agent but also as a therapeutic drug, resulting in a new strategy for cancer diagnosis and therapy. Here, we review the current use of PDD and PDT in gastric cancer and evaluate its future potential beyond conventional modalities combined with a light energy upconverter, a light-emitting diode and nearinfrared rays as light sources.

关键词： Fluorescence imaging 5-aminolevulinic acid Photodynamic diagnosis Photodynamic therapy Gastric cancer

Blue-light-induced rapid chloroplast de-anchoring in Vallisneria epidermal cells

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Journal of Integrative Plant Biology 2015年第1期57卷 93-105页

作者： Yuuki Sakai Shin-Ichiro inoue Akiko Harada Ken-Ichiro Shimazaki Shingo Takagi Department of Biological Sciences Graduate School of Science Osaka University Division of Biological Science Graduate School of Science Nagoya University Department of Biology Osaka Medical College Department of Biology Faculty of Science Kyushu University

In the outer periclinal cytoplasm of leaf epidermal cells of an aquatic angiosperm Vallisneria, blue light induces ＂chloroplast de-anchoring＂, a rapid decline in the resistance of chloroplasts against centrifugal force. Chloroplast de- anchoring is known induced within lmin of irradiation with high-fluence-rate blue light specifically, preceding the com- mencement of chloroplasts migration toward the anticlinal cytoplasm. However, its regulatory mechanism has remained elusive, although pharmacological analysis suggested that a calcium release from intracellular calcium stores is necessary for the response, in search of the responsible photoreceptors, immunoblotting analysis using antibodies against phototropins demonstrated that cross-reactive polypeptides of 120-kDa exist in the plasma-membrane fraction prepared from the leaves. In vitro phosphorylation analysis revealed that 120-kDa polypeptides were phosphorylated by exposure to blue light in a fluence-dependent manner. The blue-light-induced phosphorylation activity was sensitive to a Ser/Thr kinase inhibitor, staurosporine, and unusually was retained at a high level for a long time in darkness. Furthermore, phototropin gene homologs （Vallisneria PHOTOTROPINI and PHOTOTROPIN2） expressed in leaves were isolated. We propose that calcium- regulated chloroplast de-anchoring, possibly mediated by phototropins, is an initial process of the blue-light-induced avoidance response of chloroplasts in Vallisneria.

关键词： Avoidance response of chloroplasts blue-light response chloroplast de-anchoring cytoplasmic calcium phototropin

High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis

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World Journal of Gastroenterology 2016年第26期22卷 6083-6088页

作者： Kazuhiro Shimazu Koji Fukuda Taichi Yoshida Masahiro inoue Hiroyuki Shibata Department of Clinical Oncology Graduate School of Medicine Akita University

AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at ***: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome.

关键词： Bone metastasis Circulating tumor cell Gastric cancer Predictive biomarker Prognostic biomarker

Study on Preparation and Property of Poly-Aminosilicone-Rare Earth Composite

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Journal of Rare Earths 2003年第6期21卷 622-625页

作者：张明邱关明陈海燕周兰香 inoue Shinich OKAMOTO Hiroshi Department of Chemistry and Chemical Engineering Yangzhou University Yang zhou 225002 China Department of Chemistry and Chemical Engineering Yangzhou University Yang zhou 225002 ChinaChangchun College of Optics & Fine Mechanics Changchun 130022 China Aichi Institute of Technology Toyota 470-0392 Japan

The poly-aminosilicone-rare earth composite was prepared by poly-aminosilicone cross-linked with rare earth and active silanol. The thermal stability of the composites was studied by thermogravimetric analysis (TG). Force condition of the composites in electric field was analyzed and relative polarizability was derived. It is found that the composites containing different rare earth ions have different relative polarizability. The experiment results reveal that organosilicon materials with different electrical performance can be obtained by this way. Meanwhile, the absorption and flourescene spectrum of composites were also investigated. Compared to rare earth chloride, the spectrum properties of the composite are changed obviously. The possible reasons for these phenomena were discussed.

关键词： organic material poly-aminosilicone-rare earth composite cross-linked with rare earth physical property rare earths

Fatigue Resistance of Filled NR with PMMA-Wrapped and Rare Earth-Doped Alumina-Siloxane Gel

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Journal of Rare Earths 2002年第4期20卷 278-281页

作者：张明邱关明周兰香陈海燕 inoue Shinich OKAMOTO Hiroshi Department of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225002 China Changchun College of Optics & Fine Mechanics Changchun 130022 China Aichi Institute of Technology Toyota 470-0392 Japan

Poly (methyl methacrylate) (PMMA) was used to wrap alumina-siloxane sol which was produced by water glass, aluminum nitrate and α-methacrylic acid, and as a result, alumina-siloxane gel wrapped by PMMA was obtained. Meanwhile, rare earth ions were employed to dope in the course of reaction, and the formed rare earth doped PMMA microcapsule powder was filled into natural rubber (NR). It is found through the analysis of mechanical properties that Young′s modulus universally improves and a remarkable resistance to fatigue is displayed. Retention rate of tensile strength is twice that of the controlled sample after ten thousand times of extension fatigue.

关键词： rare earths alumina-siloxane sol natural rubber(NR) mechanical properties resistance to fatigue

Characterization of the genes involved in nitrogen cycling in wastewater treatment plants using DNA microarray and most probable number-PCR

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Frontiers of Environmental Science & Engineering 2016年第4期10卷 61-70页

作者： Junqin PANG Masami MATSUDA Masashi KURODA Daisuke inoue Kazunari SEI Kei NISHIDA Michihiko IKE Division of Sustainable Energy and Environmental Engineering Graduate School of Engineering Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan International Research Centre for River Basin Environment University of Yamanashi 4-3-11 Takeda Kofu Yamanashi 400-8511 Japan

To improve nitrogen removal performance of wastewater treatment plants （WWTPs）, it is essential to understand the behavior of nitrogen cycling communities, which comprise various microorganisms. This study characterized the quantity and diversity of nitrogen cycling genes in various processes of municipal WWTPs by employing two molecular-based methods：most probable number-polymerase chain reaction （MPN-PCR） and DNA microarray. MPN-PCR analysis revealed that gene quantities were not statistically different among processes, suggesting that conventional actwated sludge processes （CAS） are similar to nitrogen removal processes in their ability to retain an adequate population of nitrogen cycling microorganisms. Furthermore, most processes in the WWTPs that were researched shared a pattern：the nitS and the bacterial amoA genes were more abundant than the nirK and archaeal amoA genes, respectivelv. DNA microarray analysis revealed that several kinds of nitrification and denitrification genes were detected in both CAS and anaerobic-oxic processes （AO）, whereas limited genes were detected in nitrogen removal processes. Results of this study suggest that CAS maintains a diverse community of nitrogen cycling microorganisms; moreover, the microbial communities in nitrogen removal processes may be specific.

关键词： DNA microarray analysis Nitrogen cycling functional genes Most probable number-polymerase chainreaction (MPN-PCR)Wastewater treatment plants (WWTPs)

Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen

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World Journal of Gastroenterology 2013年第20期19卷 3165-3168页

作者： Keisuke Maeshima Koji Ishii Megumi inoue Katsuro Himeno Masataka Seike Department of Internal Medicine I Faculty of MedicineOita UniversityOita 879-5593Japan

Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn's disease,and in other ***,aseptic abscesses associated with Beh et's disease are extremely *** report a Japanese male diagnosed with an incomplete type of Beh et's disease who developed multiple aseptic abscesses of the spleen and *** 2002,the spleen abscesses were accompanied by paroxysmal oral aphthous ulcers and erythema *** the patient's response to antibiotic treatment was inadequate,a splenectomy was *** inflammatory cell infiltration,largely of polymorphonuclear neutrophils,was observed without evidence of bacterial or fungal *** the patient had no history of ocular symptoms or genital ulcers,a diagnosis of incomplete Beh et's disease was made according to the Japanese diagnostic criteria because of the presence of paroxysmal arthritis and epididymitis since *** 2005,multiple liver abscesses developed with right hypochondrial pain and seemed to be attributed to Beh et's disease because the abscesses yielded negative results during a microbiologic investigation and failed to go into remission under antibiotic *** prednisone(15 mg/d) was started in May 2006,and the abscesses dramatically disappeared 4 wk after *** the patient had a relapse of the liver abscesses in association with the tapering of prednisone,the augmentation of prednisone dosage yielded a *** abscesses of the liver and spleen were strongly suggested to be attributed to Beh et's *** should be aware of the existence of aseptic abscesses as uncommon manifestations of Beh et's disease.

关键词： Beh et’s disease Aseptic abscess Spleen Liver Prednisone