Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen
Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen作者机构：Department of Internal Medicine IFaculty of MedicineOita UniversityOita 879-5593Japan
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第20期
页 面：3165-3168页
主 题：Beh et’s disease Aseptic abscess Spleen Liver Prednisone
摘 要：Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn s disease,and in other diseases.However,aseptic abscesses associated with Beh et s disease are extremely rare.We report a Japanese male diagnosed with an incomplete type of Beh et s disease who developed multiple aseptic abscesses of the spleen and liver.In 2002,the spleen abscesses were accompanied by paroxysmal oral aphthous ulcers and erythema nodosum.As the patient s response to antibiotic treatment was inadequate,a splenectomy was performed.Severe inflammatory cell infiltration,largely of polymorphonuclear neutrophils,was observed without evidence of bacterial or fungal growth.Although the patient had no history of ocular symptoms or genital ulcers,a diagnosis of incomplete Beh et s disease was made according to the Japanese diagnostic criteria because of the presence of paroxysmal arthritis and epididymitis since 2002.In 2005,multiple liver abscesses developed with right hypochondrial pain and seemed to be attributed to Beh et s disease because the abscesses yielded negative results during a microbiologic investigation and failed to go into remission under antibiotic therapy.Oral prednisone(15 mg/d) was started in May 2006,and the abscesses dramatically disappeared 4 wk after treatment.Although the patient had a relapse of the liver abscesses in association with the tapering of prednisone,the augmentation of prednisone dosage yielded a response.The abscesses of the liver and spleen were strongly suggested to be attributed to Beh et s disease.Clinician should be aware of the existence of aseptic abscesses as uncommon manifestations of Beh et s disease.
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