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Biomimetic Fe_(7)S_(8)/Carbon electrocatalyst from[FeFe]-Hydrogenase for improving pH-Universal electrocatalytic hydrogen production Special Collection:Aggregation-Induced Processes and Functions

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Aggregate 2024年第1期5卷 451-459页

作者： Dohun kim Subramani Surendran Sejin Im Jaehyoung Lim Kyoungsuk jin ki Tae Nam Uk Sim Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science&Technology(DGIST)DaeguRepublic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Department of Chemistry Korea UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

Efficient and cost-effective electrocatalysts that can operate across a wide range of pH conditions are essential for green hydrogen *** by biological systems,Fe_(7)S_(8)nanoparticles incorporated on polydopamine matrix electrocatalyst were synthesized by co-precipitation and annealing *** resulting Fe_(7)S_(8)/C electrocatalyst possesses a three-dimensional structure and exhibits enhanced electrocatalytic performance for hydrogen production across various pH ***,the Fe_(7)S_(8)/C electrocatalyst demonstrates exceptional activity,achieving low overpotentials of 90.6,45.9,and 107.4 mV in acidic,neutral,and alkaline environments,*** impedance spectroscopy reveals that Fe_(7)S_(8)/C exhibits the lowest charge transfer resistance under neutral conditions,indicating an improved proton-coupled electron transfer ***-wave electron paramagnetic resonance results confirm a change in the valence state of Fe from 3+to 1+during the hydrogen evolution reaction(HER).These findings closely resemble the behavior of natural[FeFe]-hydrogenase,known for its superior hydrogen production in neutral *** remarkable performance of our Fe_(7)S_(8)/C electrocatalyst opens up new possibilities for utilizing bioinspired materials as catalysts for the HER.

关键词： biomimetic electrocatalyst hydrogen production renewable energy

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Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HER2-negative breast cancer

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Cancer Biology & Medicine 2024年第5期21卷 400-415页

作者： Yuwei Li Yuzheng Xu Caijin Lin Xi jin Ding Ma Zhiming Shao Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Objective:Mammographic calcifications are a common feature of breast cancer,but their molecular characteristics and treatment implications in hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2−)breast cancer remain ***:We retrospectively collected mammography records of an HR+/HER2−breast cancer cohort(n=316)with matched clinicopathological,genomic,transcriptomic,and metabolomic *** the basis of mammographic images,we grouped tumors by calcification status into calcification-negative tumors,tumors with probably benign calcifications,tumors with calcification of lowmoderate suspicion for maligancy and tumors with calcification of high suspicion for *** then explored the molecular characteristics associated with each calcification status across multiple ***:Among the different statuses,tumors with probably benign calcifications exhibited elevated hormone receptor immunohistochemical staining scores,estrogen receptor(ER)pathway activation,lipid metabolism,and sensitivity to endocrine *** with calcifications of high suspicion for malignancy had relatively larger tumor sizes,elevated lymph node metastasis incidence,ki-67 staining scores,genomic instability,cell cycle pathway activation,and may benefit from cyclin-dependent kinase 4 and 6(CDK4/6)***:Our research established links between tumor calcifications and molecular features,thus proposing potential precision treatment strategies for HR+/HER2−breast cancer.

关键词： HR+/HER2−breast cancer mammographic calcifications molecular features precision treatment

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AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy

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Chinese Medical Journal 2024年第2期137卷 222-231页

作者： Yichun Yin Jian Wang Junxuan Yi Kaiyue Zhang Zimeng Yin Shunzi jin Baisong Zheng Public Health of College Jilin UniversityJilinChangchun 130021China Institute of Virology and AIDS Research The First Hospital of Jilin UniversityJilinChangchun 130021China NHC Key Laboratory of Radiobiology(Jilin University) JilinChangchun 130021China

Background:Radiation(IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment(TME).Wee1,a cell cycle regulator,can eliminate G2/M arrest by phosphorylating cyclin-dependent kinase 1(CDK1).Meanwhile,programed death-1/programed death ligand-1(PD-1/PDL-1)blockade is closely related to *** study aims to investigate the effects and mechanisms of Wee1 inhibitor AZD1775 and anti-PD-1 antibody(anti-PD-1 Ab)on radiosensitization of ***:The anti-tumor activity of AZD1775 and IR was determined by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide(MTT)assay on human and mouse hepatoma cells HepG2,Hepa1-6,and *** anti-hepatoma mechanism of AZD1775 and IR revealed by flow cytometry and Western blot in vitro.A hepatoma subcutaneous xenograft mice model was constructed on Balb/c mice,which were divided into control group,IR group,AZD1775 group,IR+AZD1775 group,IR+anti-PD-1 Ab group,and the IR+AZD1775+anti-PD-1 Ab *** CD8^(+)T cells in TME were analyzed by flow ***:Combining IR with AZD1775 synergistically reduced the viability of hepatoma cells in ***1775 exhibited antitumor effects by decreasing CDK1 phosphorylation to reverse the IR-induced G2/M arrest and increasing IR-induced DNA ***1775 treatment also reduced the proportion of PD-1^(+)/CD8^(+)T cells in the spleen of hepatoma subcutaneous xenograft *** studies revealed that AZD1775 and anti-PD-1 Ab could enhance the radiosensitivity of hepatoma by enhancing the levels of interferonγ(IFNγ)^(+)or ki67^(+)CD8 T cells and decreasing the levels of CD8^(+)Tregs cells in the tumor and spleen of the hepatoma mice model,indicating that the improvement of TME was manifested by increasing the cytotoxic factor IFNγexpression,enhancing CD8^(+)T cells proliferation,and weakening CD8^(+)T cells ***:This work suggests that AZD1775 and anti-PD-1 Ab synergistically sensitize hepatoma to radiothera

关键词： Hepatoma Radiation AZD1775 Anti-PD-1 antibody DNA damage Tumor microenvironment

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Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1026-1039页

作者： Yoo-jin Park Won-ki Pang Myung-Geol Pang Department of Animal Science&Technology and BET Research Institute Chung-Ang UniversityAnseongGyeonggi‑do17546Republic of Korea

Background Comparative and comprehensive omics studies have recently been conducted to provide a comprehensive understanding of the biological mechanisms underlying ***,because these huge omics datasets often contain irrelevant information,editing strategies for summarizing and filtering the data are necessary prerequisite steps for identifying biomarkers of male ***,we attempted to integrate omics data from spermatozoa with normal and below-normal fertility from boars and bulls,including transcriptomic,proteomic,and metabolomic *** enrichment analysis was conducted and visualized using g:Profiler,Cytoscape,EnrichmentMap,and AutoAnnotation to determine fertility-related biological functions according to *** In particular,gamete production and protein biogenesis-associated pathways were enriched in bull spermatozoa with below-normal fertility,whereas mitochondrial-associated metabolic pathways were enriched in boar spermatozoa with normal *** results indicate that below-normal fertility may be determined by aberrant regulation of protein synthesis during spermatogenesis,and the modulation of reactive oxygen species generation to maintain capacitation and the acrosome reaction governs boar sperm *** Overall,this approach demonstrated that distinct molecular pathways drive sperm fertility in mammals in a species-dependent ***,we anticipate that searching for species-specific signaling pathways may aid in the discovery of fertility-related biomarkers within large omics datasets.

关键词： Integrated signaling pathways Male fertility Metabolomics Proteomics Spermatozoa transcriptomics

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Weitiao No. 3 (微调3号方) enhances the efficacy of anti-programmed cell death protein-1 immunotherapy by modulating the intestinal microbiota in an orthotopic model of gastric cancer mice

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Journal of Traditional Chinese Medicine 2024年

作者： HUANG Xiaona LI Yuzhen ZHU Chenyang ZHU Hengzhou JIANG Chenyu ZHU Xiaodan ZHANG Chencen jin Chunhui Department of Oncology Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine (Wuxi Hospital of Traditional Chinese Medicine)

OBJECTIVE: To explore the effects of Weitiao No. 3 （微调3号方， WD-3） on anti-programmed cell death protein-1 （PD-1） immunotherapy in gastric cancer （GC）.METHODS: The intestinal microbiota was analyzed by 16S rDNA sequencing of fecal samples from three groups: healthy people （Health）， GC patients （GC）， and WD-3-treated GC patients （WD-3）. Next， we established an orthotopic model of GC mice， which were treated with anti-PD-1， WD-3， or an inoculation of intestinal bacteria. Immune markers CD3， CD4， CD8， and forkhead box protein P3 （FOXP3）， and the cell proliferation marker ki67， were evaluated by immunohistochemistry. Cell apoptosis in GC tumors was assessed by terminal-deoxynucleotidyl-transferase-mediated deoxyuridine triphosphate nick end labeling staining. Enzyme-linked immunosorbent assays （ELISAs） were performed to analyze the serum levels of the following cytokines in GC mice: tumor necrosis factor （TNF）-α， interleukin （IL）-2， IL-6， IL-10， interferon （IFN）-γ， and transforming growth factor （TGF）-β. RESULTS: Sequencing data showed that there were significant differences in the composition of the gut microbial community among the three human groups. The gut bacteria in the three groups mainly comprised the phyla Firmicutes， Proteobacteria， Bacteroidetes， and Actinobacteria. At the genus level， the relative abundances of Bifidobacterium and Coprococcus showed significant decreases in the GC group， and an obvious increase in the WD-3 group， compared with the Health group. Interestingly， the relative abundance of Saccharopolyspora was only detected in the WD-3 group. The results of in vivo experiments in GC mice showed that WD-3 or anti-PD-1 treatment increased the levels of CD3+，CD4+， and CD8+T cells， but decreased the levels of FOXP3+regulatory T cells. Furthermore， WD-3 or PD-1 antibody treatment inhibited proliferation and promoted apoptosis of GC tumor cells. ELISA analysis showed that WD-3 or PD-1 antibody treatment facilitated TNF-α， IL-2， and IFN-γ expression， wh

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Analysis of Quenching Resistor Effect to Improve Stability of TIA Circuit for APD-A Secondary Publication

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Journal of Electronic Research and Application 2024年第2期8卷 54-61页

作者： Dong-Han ki Yu-Rin jin Sung-Mi kim Seong-Ik Cho Department of Electronics Engineering Jeonbuk National UniversityJeollabuk-doRepublic of Korea

In this paper,since the Avalanche Photo Diode(APD)for Light-to-Voltage LTV conversion uses a high voltage in the operating range unlike other Photo Diodes(PD),the quenching resistor must be connected in series to prevent overcurrent when using the Transimpedance Amplifier(TIA).In such a case,quenching resistance may affect the transfer function of the TIA circuit,resulting in serious ***,in this paper,by analyzing the effect of APD quenching resistance on the voltage and current loop transfer function of TIA,we proposed a loop analysis and a method for determining the quenching resistance value to improve stability.A TIA circuit with quenching resistance was designed by the proposed method and its operational stability was verified through simulation and chip fabrication.

关键词： APD TIA Quenching resistor Stability Transfer function

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Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum Park Hye-jin Cho Sang Rin Moon Kyoung jin Choi Won Hoon Jung ki Young kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

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Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae jin Park Hee jin Lee Tae Kyung kim Sung Hwan Hong Wei-Min Wang Taek Jib Choi ki Buem kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

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Heat shock protein family D member 1 in boar spermatozoa is strongly related to the litter size of inseminated sows

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1045-1055页

作者： Won-ki Pang Ji-Hyun Son Do-Yeal Ryu Md Saidur Rahman Yoo-jin Park Myung-Geol Pang Department of Animal Science&Technology and BET Research Institute Chung-Ang UniversityAnseongGyeonggi-do 17546Republic of Korea

Background:Sperm quality evaluation is the logical first step in increasing field *** contain cytoplasmic organelles and biomolecules known as sperm-intrinsic factors,which play key roles in sperm maturation,sperm-oocyte fusion,and embryo *** particular,sperm membrane proteins[e.g.,arginine vasopressin receptor 2,beta-actin,prohibitin,and heat shock protein family D member 1(HSPD1)]and RNA could be used as functional indicators of male *** sought to clarify the effects of differential mRNA expression of selected genes on several fertilisation parameters,including sperm motility,motion kinematics,capacitation,and litter size,in a porcine ***:Our results demonstrated that HSPD1 expression was significantly correlated with male fertility,as measured by the litter size of inseminated *** expression of HSPD1 mRNA was linked to sperm motility and other motion kinematic ***,HSPD1 had a 66.7%overall accuracy in detecting male fertility,and the high-litter size group which was selected with the HSPD1 marker had a 1.34 greater litter size than the lowlitter size ***:Our findings indicate that HSPD1 might be a helpful biomarker for superior boar selection for artificial insemination,which could boost field fertility.

关键词： Fertilisation HSPD1 Male fertility Sperm motility Sperm RNA

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Anal cancer screening in women with a history of human papillomavirusrelated lower genital tract cancers:a pilot study

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 88-93页

作者： Isobel Mary Poynten Fengyi jin Rhonda Farell Trevor Tejada-Berges Carmella Law Richard Hillman Jennifer Roberts Andrew Grulich The kirby Institute University of New South WalesSydneyNew South WalesAustralia Chris O'Brien Lifehouse SydneyNew South WalesAustralia ADysplasia prince of Wales Private Hospital RandwickNew South WalesAustralia Dysplasia and Anal Cancer Services St Vincent's Hospital SydneyDarlinghurstNewSouthWalesAustralia Douglass Hanly Moir Pathology SydneyNew South WalesAustralia

Objectives Women diagnosed with a history of lower genital tract cancer(LGTC)and precancer are at increased risk of anal *** for anal cancer in a manner analogous to cervical cancer may detect precursor anal high-grade squamous intraepithelial lesions(HSILs)and prevent progression to *** In a pilot study of anal cancer screening,women with previous LGTC and aged≥18 years in Sydney,Australia underwent a digital anorectal examination,anal swab for human papillomavirus(HPV)and p16/ki67 testing and completeda *** with positive HPV and/or p16/ki67 results were referred for a high-resolution anoscopy(HRA)and evaluation of their *** Of 52 participants,46 agreed to screening and 6 provided demographic information *** age was 46.5 years(IQR:36.059.0).Anal high-risk HPV(HRHPV)was detected in only seven(15.2%)participants(three HPV16).Eight(17.4%)had positive p16/ki67 dual staining,with invalid results for 25(54.4%).0f 10 women referred for HRA,9 attended and 3 had HSILs,representing 6.5%of the screened *** were completed by 41 participants(89.1%).The majority reported that being screenedwas reassuring(97.5%)and was positive for their health(95.1%).Conclusion This pilot study demonstrated a lower-than-expected prevalence of anal *** with HRHPV and p16/ki67 staining identified anal HSILs in 6.5%of ***,screeningwas viewed as beneficial by almost all *** utility of p16/ki67dual staining was low,suggesting it may not be a suitable anal cancer screening methodology.

关键词： pilot Sydney screening

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